| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shirley Tang, Justin Richards, Safdar Khan, Judith Hoyland, Daniel Gallego-Perez, Natalia Higuita-Castro, Benjamin Walter, Devina Purmessu. Nonviral Transfection With Brachyury Reprograms Human Intervertebral Disc Cells to a Pro-Anabolic Anti-Catabolic/Inflammatory Phenotype: A Proof of Concept Study. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 37. issue 11. 2020-02-14. PMID:31286562. |
intervertebral disc (ivd) degeneration is a major contributor to chronic low back pain and is characterized by decreases in cellularity and proteoglycan synthesis, upregulation of matrix degradation, and increases in pro-inflammatory factors with neurovascular invasion. |
2020-02-14 |
2023-08-13 |
human |
| Takao Imanishi, Koji Akeda, Koichiro Murata, Akihiro Sud. Effect of diminished flow in rabbit lumbar arteries on intervertebral disc matrix changes using MRI T2-mapping and histology. BMC musculoskeletal disorders. vol 20. issue 1. 2020-02-14. PMID:31351455. |
however, it has not been experimentally demonstrated that impaired lumbar artery flow directly induces intervertebral disc (ivd) degeneration by affecting ivd matrix metabolism. |
2020-02-14 |
2023-08-13 |
rabbit |
| Tomohiko Sano, Koji Akeda, Junichi Yamada, Norihiko Takegami, Takao Sudo, Akihiro Sud. Expression of the RANK/RANKL/OPG system in the human intervertebral disc: implication for the pathogenesis of intervertebral disc degeneration. BMC musculoskeletal disorders. vol 20. issue 1. 2019-12-30. PMID:31101043. |
however, the effect of the rank/rankl/opg system on the matrix metabolism of human ivd cells, especially on the expression of catabolic factors relevant to ivd degeneration, remains unknown. |
2019-12-30 |
2023-08-13 |
human |
| Yasin Emre Kaya, Numan Karaarslan, Duygu Yasar Sirin, Hanefi Ozbek, Necati Kaplan, Ibrahim Yilma. Investigation of the Effects of Methylphenidate, an Amphetamine Derivative, on Intervertebral Disc Tissue Cell Cultures and Matrix Structures. Turkish neurosurgery. vol 29. issue 5. 2019-12-16. PMID:31353439. |
to investigate the effects of methylphenidate (mph), on intervertebral disc tissue (ivd) cell cultures and extracellular matrix structures. |
2019-12-16 |
2023-08-13 |
Not clear |
| Yasin Emre Kaya, Numan Karaarslan, Duygu Yasar Sirin, Hanefi Ozbek, Necati Kaplan, Ibrahim Yilma. Investigation of the Effects of Methylphenidate, an Amphetamine Derivative, on Intervertebral Disc Tissue Cell Cultures and Matrix Structures. Turkish neurosurgery. vol 29. issue 5. 2019-12-16. PMID:31353439. |
changes in the expression of some important marker genes involved in anabolic and catabolic mechanisms of ivd extracellular matrix formation were also evaluated. |
2019-12-16 |
2023-08-13 |
Not clear |
| Catarina Leite Pereira, Graciosa Q Teixeira, Cláudia Ribeiro-Machado, Joana Caldeira, Madalena Costa, Francisco Figueiredo, Rui Fernandes, Paulo Aguiar, Sibylle Grad, Mário A Barbosa, Raquel M Gonçalve. Mesenchymal Stem/Stromal Cells seeded on cartilaginous endplates promote Intervertebral Disc Regeneration through Extracellular Matrix Remodeling. Scientific reports. vol 6. 2019-11-20. PMID:27652931. |
intervertebral disc (ivd) degeneration is characterized by significant biochemical and histomorphological alterations, such as loss of extracellular matrix (ecm) integrity, by abnormal synthesis of ecm main components, resultant from altered anabolic/catabolic cell activities and cell death. |
2019-11-20 |
2023-08-13 |
human |
| Catarina Leite Pereira, Graciosa Quelhas Teixeira, Joana Rita Ferreira, Matteo D'Este, David Eglin, Maulo Alini, Sibylle Grad, Mário Adolfo Barbosa, Raquel Madeira Gonçalve. Stromal Cell Derived Factor-1-Mediated Migration of Mesenchymal Stem Cells Enhances Collagen Type II Expression in Intervertebral Disc. Tissue engineering. Part A. 2019-11-20. PMID:29916307. |
intervertebral disc (ivd) degeneration is characterized by an unbalanced cell catabolic/anabolic activity and cell death, resulting in the degradation of extracellular matrix components and water loss. |
2019-11-20 |
2023-08-13 |
human |
| Sarah E Duclos, Arthur J Michale. Mapping of Intervertebral Disc Annulus Fibrosus Compressive Properties is Sensitive to Specimen Boundary Conditions. Journal of biomechanical engineering. 2019-11-20. PMID:30673069. |
previous studies confirmed that residual strains in the annulus fibrosus (af) of the ivd, which result from non-uniform extracellular matrix deposition in response to in-vivo loads, vary by anatomical region (anterior, posterior, and lateral) and zone (inner, middle, and outer). |
2019-11-20 |
2023-08-13 |
cattle |
| Ulf Krister Hofmann, Jessica Steidle, Marina Danalache, Florian Bonnaire, Christian Walter, Bernd Rolauff. Chondrocyte death after mechanically overloading degenerated human intervertebral disk explants is associated with a structurally impaired pericellular matrix. Journal of tissue engineering and regenerative medicine. vol 12. issue 9. 2019-11-08. PMID:30053767. |
a type vi collagen-rich pericellular matrix (pcm) encloses both intervertebral disk (ivd) and articular cartilage chondrocytes. |
2019-11-08 |
2023-08-13 |
human |
| Min Ho Hwang, Hyeong Guk Son, Jae Won Lee, Chang Min Yoo, Jae Hee Shin, Hyo Geun Nam, Hyun Jung Lim, Seung Min Baek, Jeong Hun Park, Joo Han Kim, Hyuk Cho. Photobiomodulation of extracellular matrix enzymes in human nucleus pulposus cells as a potential treatment for intervertebral disk degeneration. Scientific reports. vol 8. issue 1. 2019-10-16. PMID:30076336. |
intervertebral disc (ivd) degeneration is associated with imbalances between catabolic and anabolic responses, regulated by extracellular matrix (ecm)-modifying enzymes such as matrix metalloproteinases (mmps) and their endogenous tissue inhibitors of metalloproteinases (timps). |
2019-10-16 |
2023-08-13 |
human |
| Letizia Penolazzi, Elisabetta Lambertini, Leticia Scussel Bergamin, Tosca Roncada, Pasquale De Bonis, Michele Cavallo, Roberta Piv. MicroRNA-221 silencing attenuates the degenerated phenotype of intervertebral disc cells. Aging. vol 10. issue 8. 2019-10-04. PMID:30130742. |
we established a relatively quick protocol to minimize artifacts from extended in vitro culture, without selecting the different types of cells from intervertebral disc (ivd) or completely disrupting extracellular matrix (ecm), but by using the whole cell population with a part of resident ecm. |
2019-10-04 |
2023-08-13 |
Not clear |
| Naimisha Beeravolu, Jared Brougham, Irfan Khan, Christina McKee, Mick Perez-Cruet, G Rasul Chaudhr. Human umbilical cord derivatives regenerate intervertebral disc. Journal of tissue engineering and regenerative medicine. vol 12. issue 1. 2019-10-02. PMID:27690334. |
significant improvement in the histology, cellularity, extracellular matrix proteins, and water and glycosaminoglycan contents in ivd recipients of cpcs was observed compared to mscs. |
2019-10-02 |
2023-08-13 |
human |
| Xue Yin, Silvia Gonzales, Somya Sha, Howard Levene, Chun-Yuh Huan. The Effect of Adenosine on Extracellular Matrix Production in Porcine Intervertebral Disc Cells. Cells, tissues, organs. vol 206. issue 1-2. 2019-09-19. PMID:30703766. |
the objectives of this study were to investigate the effects of exogenous adenosine on the production of extracellular matrix (ecm; i.e., collagen type ii and aggrecan) and atp of ivd cells and explore the underlying mechanism of action. |
2019-09-19 |
2023-08-13 |
Not clear |
| Takuya Kameda, Joel Zvick, Miriam Vuk, Aleksandra Sadowska, Wai Kit Tam, Victor Y Leung, Kata Bölcskei, Zsuzsanna Helyes, Lee Ann Applegate, Oliver N Hausmann, Juergen Klasen, Olga Krupkova, Karin Wuertz-Koza. Expression and Activity of TRPA1 and TRPV1 in the Intervertebral Disc: Association with Inflammation and Matrix Remodeling. International journal of molecular sciences. vol 20. issue 7. 2019-07-30. PMID:30974795. |
the aims of this study were to investigate (1) the expression of trp channels in intervertebral disc (ivd) cells in normal and inflammatory conditions and (2) the function of transient receptor potential ankyrin 1 (trpa1) and transient receptor potential vanilloid 1 (trpv1) in ivd inflammation and matrix homeostasis. |
2019-07-30 |
2023-08-13 |
mouse |
| Takuya Kameda, Joel Zvick, Miriam Vuk, Aleksandra Sadowska, Wai Kit Tam, Victor Y Leung, Kata Bölcskei, Zsuzsanna Helyes, Lee Ann Applegate, Oliver N Hausmann, Juergen Klasen, Olga Krupkova, Karin Wuertz-Koza. Expression and Activity of TRPA1 and TRPV1 in the Intervertebral Disc: Association with Inflammation and Matrix Remodeling. International journal of molecular sciences. vol 20. issue 7. 2019-07-30. PMID:30974795. |
the primary ivd cell cultures were stimulated with either interleukin-1 beta (il-1β) or tumor necrosis factor alpha (tnf-α) alone or in combination with trpa1/v1 agonist allyl isothiocyanate (aitc, 3 and 10 µm), followed by analysis of calcium flux and the expression of inflammation mediators (rt-qpcr/elisa) and matrix constituents (rt-qpcr). |
2019-07-30 |
2023-08-13 |
mouse |
| Takuya Kameda, Joel Zvick, Miriam Vuk, Aleksandra Sadowska, Wai Kit Tam, Victor Y Leung, Kata Bölcskei, Zsuzsanna Helyes, Lee Ann Applegate, Oliver N Hausmann, Juergen Klasen, Olga Krupkova, Karin Wuertz-Koza. Expression and Activity of TRPA1 and TRPV1 in the Intervertebral Disc: Association with Inflammation and Matrix Remodeling. International journal of molecular sciences. vol 20. issue 7. 2019-07-30. PMID:30974795. |
trpa1 might be expressed in developing ivd, downregulated during its maturation, and upregulated again in degenerative disc disease, participating in matrix homeostasis. |
2019-07-30 |
2023-08-13 |
mouse |
| Hiroto Makino, Shoji Seki, Yasuhito Yahara, Shunichi Shiozawa, Yukihiko Aikawa, Hiraku Motomura, Makiko Nogami, Kenta Watanabe, Takeshi Sainoh, Hisakatsu Ito, Noriyuki Tsumaki, Yoshiharu Kawaguchi, Mitsuaki Yamazaki, Tomoatsu Kimur. A selective inhibition of c-Fos/activator protein-1 as a potential therapeutic target for intervertebral disc degeneration and associated pain. Scientific reports. vol 7. issue 1. 2019-07-29. PMID:29208967. |
the transcription factor c-fos/activator protein-1 (ap-1) controls the expression of inflammatory cytokines and matrix metalloproteinases (mmps) that contribute to the pathogenesis ivd degeneration. |
2019-07-29 |
2023-08-13 |
human |
| M H Gay, A Mehrkens, M Rittmann, M Haug, A Barbero, I Martin, S Schaere. Nose to back: compatibility of nasal chondrocytes with environmental conditions mimicking a degenerated intervertebral disc. European cells & materials. vol 37. 2019-07-18. PMID:30900738. |
cells were cultured in a combination of low glucose, hypoxia, acidity and inflammation for 28 d. depending on the conditions, cells were either cultured in the absence of instructive growth factors or underwent chondrogenic instructional priming by addition of transforming growth factor β1 (tgfβ1) for the first 7 d. histology, immunohistochemistry, biochemistry, enzyme-linked immunosorbent assay (elisa) and quantitative real-time reverse transcriptase-polymerase chain reaction (qrt-pcr) analyses demonstrated limited cell maintenance and accumulation of cartilaginous extracellular matrix for mscs in ivd conditions. |
2019-07-18 |
2023-08-13 |
Not clear |
| Joana Caldeira, Cátia Santa, Hugo Osório, Maria Molinos, Bruno Manadas, Raquel Gonçalves, Mário Barbos. Matrisome Profiling During Intervertebral Disc Development And Ageing. Scientific reports. vol 7. issue 1. 2019-07-01. PMID:28912585. |
degeneration occurs with age and is accompanied by extracellular matrix (ecm) depletion, culminating in nucleus pulpous (np) extrusion and ivd destruction. |
2019-07-01 |
2023-08-13 |
cattle |
| Mohamed Amine Chetoui, Olivier Boiron, Moncef Ghiss, Abdelwaheb Dogui, Valérie Deplan. Assessment of intervertebral disc degeneration-related properties using finite element models based on [Formula: see text]-weighted MRI data. Biomechanics and modeling in mechanobiology. vol 18. issue 1. 2019-05-27. PMID:30074099. |
to this end, proton density ([formula: see text])-weighted mri sequences of a porcine lumbar ivd were carried out to develop two biphasic swelling models with hyperelastic extracellular matrix behavior. |
2019-05-27 |
2023-08-13 |
Not clear |