| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Gansau, C T Buckle. Priming as a strategy to overcome detrimental pH effects on cells for intervertebral disc regeneration. European cells & materials. vol 41. 2021-08-02. PMID:33565057. |
overall, the study demonstrated that cells could be equipped to sustain the harsh environment of the ivd and promote accumulation of np-like matrix through priming. |
2021-08-02 |
2023-08-13 |
Not clear |
| J R Ferreira, G Q Teixeira, E Neto, C Ribeiro-Machado, A M Silva, J Caldeira, C Leite Pereira, S Bidarra, A F Maia, M Lamghari, M A Barbosa, R M Gonçalve. IL-1β-pre-conditioned mesenchymal stem/stromal cells' secretome modulates the inflammatory response and aggrecan deposition in intervertebral disc. European cells & materials. vol 41. 2021-08-02. PMID:33877647. |
mscsec down-regulated ivd gene expression of pro-inflammatory cytokines (bil-6, bil-8) and matrix degrading enzyme bmmp1, while bmmp3 and btimp2 were up-regulated, at 48 h. after 14 d, mscsec-treated ivds revealed increased aggrecan deposition, although no differences in other ecm components were observed. |
2021-08-02 |
2023-08-13 |
human |
| A Adoungotchodo, L M Epure, F Mwale, S Leroug. Chitosan-based hydrogels supplemented with gelatine and Link N enhance extracellular matrix deposition by encapsulated cells in a degenerative intervertebral disc environment. European cells & materials. vol 41. 2021-08-02. PMID:33945627. |
the hypothesis of the study was that the biological response of the encapsulated cells can be further increased by adding gelatine and link n (ln, a naturally occurring peptide present in cartilage and ivd extracellular matrix), known to increase cell adhesion and proteoglycan production, respectively. |
2021-08-02 |
2023-08-13 |
human |
| Hirokazu Ishino, Iwao Sakonj. Expression of metalloproteinases and their inhibitors in degenerated and extruded intervertebral disks in chondrodystrophic dogs. The Journal of veterinary medical science. vol 83. issue 4. 2021-07-28. PMID:33551382. |
these results suggest that metalloproteinase may play a role in extracellular matrix degradation in ivd degeneration. |
2021-07-28 |
2023-08-13 |
Not clear |
| Young Mi Kang, Eun Jung Shin, Byung Ho Lee, Jae Ho Yang, Hwan Mo Lee, Seong Hwan Moo. Hypoxia Regulates the Extracellular Matrix via Mitogen-Activated Protein Kinases Pathway in Cells Retrieved from the Human Intervertebral Disc. Yonsei medical journal. vol 62. issue 8. 2021-07-26. PMID:34296551. |
the present study aimed to identify the physiological characteristics of cells by investigating the change in gene expression and protein levels during extracellular matrix (ecm) synthesis in the intervertebral disc (ivd) under hypoxic conditions. |
2021-07-26 |
2023-08-13 |
human |
| Guang-Zhi Zhang, Ming-Qiang Liu, Hai-Wei Chen, Zuo-Long Wu, Yi-Cheng Gao, Zhan-Jun Ma, Xue-Gang He, Xue-Wen Kan. NF-κB signalling pathways in nucleus pulposus cell function and intervertebral disc degeneration. Cell proliferation. vol 54. issue 7. 2021-07-12. PMID:34028920. |
a series of factors, such as inflammation, oxidative stress and mechanical stress, promote degradation of the extracellular matrix (ecm) of the intervertebral discs (ivd), leading to dysfunction and structural destruction of the ivd. |
2021-07-12 |
2023-08-13 |
Not clear |
| Judith-Johanna Pfannkuche, Wei Guo, Shangbin Cui, Junxuan Ma, Gernot Lang, Marianna Peroglio, R Geoff Richards, Mauro Alini, Sibylle Grad, Zhen L. Intervertebral disc organ culture for the investigation of disc pathology and regeneration - benefits, limitations, and future directions of bioreactors. Connective tissue research. vol 61. issue 3-4. 2021-07-07. PMID:31556329. |
the physiologic ivd microenvironment features a highly complex interaction of biochemical and mechanical factors influencing cell metabolism and extracellular matrix turnover and is therefore difficult to simulate for research purposes on ivd pathology. |
2021-07-07 |
2023-08-13 |
human |
| Xiao-Bo Zhang, Yi-Cun Hu, Peng Cheng, Hai-Yu Zhou, Xiang-Yi Chen, Ding Wu, Rui-Hao Zhang, De-Chen Yu, Xi-Dan Gao, Jin-Tao Shi, Kai Zhang, Shao-Long Li, Peng-Jie Song, Ke-Ping Wan. Targeted therapy for intervertebral disc degeneration: inhibiting apoptosis is a promising treatment strategy. International journal of medical sciences. vol 18. issue 13. 2021-07-06. PMID:34220308. |
the pathogenesis is complicated, and the main pathological changes are ivd cell apoptosis and extracellular matrix (ecm) degradation. |
2021-07-06 |
2023-08-13 |
Not clear |
| Sebastian Wangler, Amir Kamali, Christina Wapp, Karin Wuertz-Kozak, Sonja Häckel, Claudia Fortes, Lorin M Benneker, Lisbet Haglund, R Geoff Richards, Mauro Alini, Marianna Peroglio, Sibylle Gra. Uncovering the secretome of mesenchymal stromal cells exposed to healthy, traumatic, and degenerative intervertebral discs: a proteomic analysis. Stem cell research & therapy. vol 12. issue 1. 2021-07-05. PMID:33413584. |
in intervertebral disc (ivd) cells, application of msc secretome has been shown to decrease the apoptosis rate, induce proliferation, and promote production of extracellular matrix (ecm). |
2021-07-05 |
2023-08-13 |
Not clear |
| Julie M Brent, Zuozhen Tian, Frances S Shofer, John T Martin, Lutian Yao, Christian Acharte, Youhai H Chen, Ling Qin, Motomi Enomoto-Iwamoto, Yejia Zhan. Influence of Genetic Background and Sex on Gene Expression in the Mouse ( Comparative medicine. vol 70. issue 2. 2021-07-01. PMID:32156324. |
we hypothesized that extracellular matrix gene expression in response to ivd injury differs between mice of different genetic backgrounds and sex. |
2021-07-01 |
2023-08-13 |
mouse |
| J Du, R G Long, T Nakai, D Sakai, L M Benneker, G Zhou, B Li, D Eglin, J C Iatridis, M Alini, S Grad, Z L. Functional cell phenotype induction with TGF-β1 and collagen-polyurethane scaffold for annulus fibrosus rupture repair. European cells & materials. vol 39. 2021-06-24. PMID:31899537. |
in the ex vivo ivd organ culture model with physiologically relevant mechanical loading, tgf-β1 supplement in the transplanted constructs induced the functional af cell phenotype and enhanced collagen matrix synthesis. |
2021-06-24 |
2023-08-13 |
human |
| Juliane D Glaeser, Khosrowdad Salehi, Linda E A Kanim, Zachary NaPier, Michael A Kropf, Jason M Cuéllar, Tiffany G Perry, Hyun W Bae, Dmitriy Shey. NF-κB inhibitor, NEMO-binding domain peptide attenuates intervertebral disc degeneration. The spine journal : official journal of the North American Spine Society. vol 20. issue 9. 2021-06-22. PMID:32413485. |
nonphysiological mechanical loading and inflammation are both critically involved in intervertebral disc (ivd) degeneration, which is characterized by an increase in cytokines and matrix metalloproteases (mmps) in the nucleus pulposus (np). |
2021-06-22 |
2023-08-13 |
Not clear |
| G Chao-Yang, C Peng, Z Hai-Hon. Roles of NLRP3 inflammasome in intervertebral disc degeneration. Osteoarthritis and cartilage. vol 29. issue 6. 2021-06-14. PMID:33609693. |
with the exploration of the mechanism of ivdd, recent studies have shown that activation of the nlrp3 inflammasome is associated with intervertebral disc (ivd) inflammation, pyroptosis, extracellular matrix degradation and apoptosis of ivd cells. |
2021-06-14 |
2023-08-13 |
Not clear |
| Morteza Saberi, Xiaolei Zhang, Ali Mobasher. Targeting mitochondrial dysfunction with small molecules in intervertebral disc aging and degeneration. GeroScience. vol 43. issue 2. 2021-05-31. PMID:33634362. |
intervertebral disc (ivd) degeneration, which is characterized by disc dehydration, anatomical alterations, and extensive changes in extracellular matrix (ecm) composition, is an important contributor to lbp. |
2021-05-31 |
2023-08-13 |
Not clear |
| Cosimo Ligorio, Marie O'Brien, Nigel W Hodson, Aleksandr Mironov, Maria Iliut, Aline F Miller, Aravind Vijayaraghavan, Judith A Hoyland, Alberto Saian. TGF-β3-loaded graphene oxide - self-assembling peptide hybrid hydrogels as functional 3D scaffolds for the regeneration of the nucleus pulposus. Acta biomaterialia. vol 127. 2021-05-31. PMID:33831573. |
intervertebral disc (ivd) degeneration is a process that starts in the central nucleus pulposus (np) and leads to inflammation, extracellular matrix (ecm) degradation, and progressive loss of disc height. |
2021-05-31 |
2023-08-13 |
cattle |
| Beth G Ashinsky, Sarah E Gullbrand, Edward D Bonnevie, Chao Wang, Dong Hwa Kim, Lin Han, Robert L Mauck, Harvey E Smit. Sacrificial Fibers Improve Matrix Distribution and Micromechanical Properties in a Tissue-Engineered Intervertebral Disc. Acta biomaterialia. vol 111. 2021-05-14. PMID:32447064. |
these findings demonstrate that the inclusion of a sacrificial peo fiber fraction in the daps af region improves cellular colonization, matrix elaboration, and in vitro and in vivo function of an engineered ivd implant. |
2021-05-14 |
2023-08-13 |
rat |
| Ganjun Feng, Zhanpeng Zhang, Ming Dang, Kunal J Rambhia, Peter X M. Nanofibrous spongy microspheres to deliver rabbit mesenchymal stem cells and anti-miR-199a to regenerate nucleus pulposus and prevent calcification. Biomaterials. vol 256. 2021-05-14. PMID:32736170. |
furthermore, injection of msc/hp-anti-mir-199a/ns/nf-sms can stay in place, produce functional extracellular matrix, maintain disc height and prevent intervertebral disc (ivd) calcification in a rabbit lumbar degeneration model. |
2021-05-14 |
2023-08-13 |
rabbit |
| Tyler J DiStefano, Jennifer O Shmukler, George Danias, Theodor Di Pauli von Treuheim, Warren W Hom, David A Goldberg, Damien M Laudier, Philip R Nasser, Andrew C Hecht, Steven B Nicoll, James C Iatridi. Development of a two-part biomaterial adhesive strategy for annulus fibrosus repair and ex vivo evaluation of implant herniation risk. Biomaterials. vol 258. 2021-05-14. PMID:32823020. |
this strategy bonds injectable hydrogels to ivd extracellular matrix proteins, is optimized to seal af defects, and shows promise for ivd repair. |
2021-05-14 |
2023-08-13 |
cattle |
| Dongbo Liang, Dinggang Hong, Fuyu Tang, Yuan Wang, Jianfeng Li, Linqing Li, Huaming Che. Upregulated lnc‑HRK‑2:1 prompts nucleus pulposus cell senescence in intervertebral disc degeneration. Molecular medicine reports. vol 22. issue 6. 2021-05-13. PMID:33174041. |
intervertebral disc (ivd) degeneration is a complicated physiological change involving cellular senescence, inflammation and the degradation of the extracellular matrix. |
2021-05-13 |
2023-08-13 |
Not clear |
| Defang Li, Qingmin Zeng, Zengxin Jiang, Lei Ding, Wei Lu, Mengxuan Bian, Jingping W. Induction of notochordal differentiation of bone marrow mesenchymal‑derived stem cells via the stimulation of notochordal cell‑rich nucleus pulposus tissue. Molecular medicine reports. vol 23. issue 2. 2021-05-06. PMID:33355376. |
the degeneration of intervertebral disc (ivd) tissue, initiated following the disappearance of notochordal cells (ncs), is characterized by the decreased number of nucleus pulposus (np) cells (npcs) and extracellular matrix. |
2021-05-06 |
2023-08-13 |
Not clear |