| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeffrey Luo, Anjani Darai, Thanapat Pongkulapa, Brian Conley, Letao Yang, Inbo Han, Ki-Bum Le. Injectable bioorthogonal hydrogel (BIOGEL) accelerates tissue regeneration in degenerated intervertebral discs. Bioactive materials. vol 23. 2022-12-30. PMID:36582500. |
while traditional growth factor therapies (e.g., tgfβ) are effective at transiently reversing degenerated disc by stimulation of matrix synthesis, it is increasingly accepted that bioscaffolds are required for sustained, complete ivd regeneration. |
2022-12-30 |
2023-08-14 |
Not clear |
| Jeffrey Luo, Anjani Darai, Thanapat Pongkulapa, Brian Conley, Letao Yang, Inbo Han, Ki-Bum Le. Injectable bioorthogonal hydrogel (BIOGEL) accelerates tissue regeneration in degenerated intervertebral discs. Bioactive materials. vol 23. 2022-12-30. PMID:36582500. |
current scaffolds (e.g., metal/polymer composites, non-mammalian biopolymers) can be improved in one or more ivd regeneration demands: biodegradability, noninvasive injection, recapitulated healthy ivd biomechanics, predictable crosslinking, and matrix repair induction. |
2022-12-30 |
2023-08-14 |
Not clear |
| Garrett W D Easson, Alireza Savadipour, Akila Anandarajah, Leanne E Iannucci, Spencer P Lake, Farshid Guilak, Simon Y Tan. Modulation of TRPV4 protects against degeneration induced by sustained loading and promotes matrix synthesis in the intervertebral disc. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 2. 2022-12-30. PMID:36583692. |
the transient receptor potential vanilloid 4 (trpv4) ion channel activated in isolated ivd cells initiates extracellular matrix (ecm) gene expression, while trpv4 ablation reduces cytokine production in response to circumferential stretching. |
2022-12-30 |
2023-08-14 |
Not clear |
| Xiao-Tao Wu, Yong-Xiang Wang, Xin-Min Feng, Min Feng, Hui-Hui Su. Update on the roles of macrophages in the degeneration and repair process of intervertebral discs. Joint bone spine. 2022-12-18. PMID:36529418. |
the process of ivd degeneration involves a complex of pathologic changes on both extracellular matrix degradation and resident cell apoptosis. |
2022-12-18 |
2023-08-14 |
Not clear |
| Rui Ran, Yi Wu, Hai-Hong Zhan. Acid-Sensing Ion Channels: Implications For Intervertebral Disc Degeneration. Current pharmaceutical biotechnology. 2022-12-12. PMID:36503387. |
matrix acidity potentially negatively affects gene expression, activity, proliferation, and apoptosis of ivd cells. |
2022-12-12 |
2023-08-14 |
Not clear |
| Morena Francesca Fiordalisi, Joana Rita Ferreira, Marta Laranjeiro Pinto, Cláudia Ribeiro-Machado, Marta Teixeira Pinto, Maria José Oliveira, Mário Adolfo Barbosa, Raquel Madeira Gonçalves, Joana Caldeir. The impact of matrix age on intervertebral disc regeneration. Biomaterials advances. vol 143. 2022-11-20. PMID:36403438. |
with the lack of effective treatments for low back pain, the use of extracellular matrix (ecm)-based biomaterials have emerged with undeniable promise for ivd regeneration. |
2022-11-20 |
2023-08-14 |
cattle |
| Sheng Guo, Chenglong Wang, Changming Xiao, Qinwen Gu, Longhai Long, Xiaoqiang Wang, Houping Xu, Sen L. Role of the mechanosensitive piezo1 channel in intervertebral disc degeneration. Clinical physiology and functional imaging. 2022-11-18. PMID:36400723. |
intervertebral disc degeneration (idd) is a multifactorial skeletal disease involving mechanical, genetic, systemic, and biological factors, and it is characterized by apoptosis of the nucleus pulposus cells and breakdown of the extracellular matrix (ecm), which will impair the structure and function of the intervertebral disc(ivd), and cause low back pain. |
2022-11-18 |
2023-08-14 |
Not clear |
| Rafał Staszkiewicz, Dorian Gładysz, Marcin Gralewski, Michał Garczarek, Marcin Gadzieliński, Beniamin Oskar Grabare. Pathomechanism of the IVDs degeneration and the Role of Neurotrophic Factors and Concentration of Selected Elements in Genesis of Low Back Pain. Current pharmaceutical biotechnology. 2022-10-25. PMID:36281863. |
a phenomenon that is closely related to the process of lowering the ph of the extracellular matrix degenerating the intervertebral disc (ivd) is the precipitation of calcium salts, especially pyrophosphate dehydrate and hydroxyapatite. |
2022-10-25 |
2023-08-14 |
human |
| Yuying Ge, Yuying Chen, Chijiao Guo, Huan Luo, Fangda Fu, Weifeng Ji, Chengliang Wu, Hongfeng Rua. Pyroptosis and Intervertebral Disc Degeneration: Mechanistic Insights and Therapeutic Implications. Journal of inflammation research. vol 15. 2022-10-20. PMID:36263145. |
in this review, we summarize the characteristics of pyroptosis and emphasize the effects of ivd cell pyroptosis on the pathological progression of ivdd, including secretion of cytokines, nucleus pulposus cell apoptosis and autophagy, accelerated extracellular matrix degradation, annulus fibrosus rupture, cartilage endplate calcification, vascularization, sensory and sympathetic fiber neoinnervation, and infiltrating lymphatic vessels. |
2022-10-20 |
2023-08-14 |
Not clear |
| Shangbin Cui, Wenyue Li, Graciosa Q Teixeira, Cornelia Neidlinger-Wilke, Hans-Joachim Wilke, Lisbet Haglund, Hongwei Ouyang, R Geoff Richards, Sibylle Grad, Mauro Alini, Zhen L. Neoepitope fragments as biomarkers for different phenotypes of intervertebral disc degeneration. JOR spine. vol 5. issue 3. 2022-10-07. PMID:36203866. |
during the intervertebral disc (ivd) degeneration process, initial degenerative events occur at the extracellular matrix level, with the appearance of neoepitope peptides formed by the cleavage of aggrecan and collagen. |
2022-10-07 |
2023-08-14 |
Not clear |
| Hai-Wei Chen, Jian-Wei Zhou, Guang-Zhi Zhang, Zhang-Bin Luo, Lei Li, Xue-Wen Kan. Emerging role and therapeutic implication of mTOR signalling in intervertebral disc degeneration. Cell proliferation. 2022-10-04. PMID:36193577. |
a series of factors, including inflammatory response, oxidative stress, autophagy, abnormal mechanical stress, nutritional deficiency, and genetics, lead to reduced extracellular matrix (ecm) synthesis by intervertebral disc (ivd) cells and accelerate idd progression. |
2022-10-04 |
2023-08-14 |
Not clear |
| Xiankun Cao, Xin Wang, Kewei Rong, Kexin Liu, Xiao Yang, Tangjun Zhou, Pu Zhang, Jiadong Guo, Hui Ma, An Qin, Jie Zha. Specific PFKFB3 Inhibitor Memorably Ameliorates Intervertebral Disc Degeneration via Inhibiting NF- Oxidative medicine and cellular longevity. vol 2022. 2022-10-03. PMID:36187335. |
specific pfkfb3 inhibitor memorably ameliorates intervertebral disc degeneration via inhibiting nf- intervertebral disc (ivd) degeneration (ivdd) is a characteristic of the dominating pathological processes of nucleus pulposus (np) cell senescence, abnormal synthesis and irregular distribution of extracellular matrix (ecm), and tumor necrosis factor- |
2022-10-03 |
2023-08-14 |
Not clear |
| Kaiqiang Sun, Jialin Jiang, Yuan Wang, Xiaofei Sun, Jian Zhu, Ximing Xu, Jingchuan Sun, Jiangang Sh. The role of nerve fibers and their neurotransmitters in regulating intervertebral disc degeneration. Ageing research reviews. 2022-09-16. PMID:36113765. |
abnormal apoptosis, senescence, and pyroptosis of ivd cells, extracellular matrix (ecm) degradation, and infiltration of immune cells are the major molecular alternations during ivdd. |
2022-09-16 |
2023-08-14 |
Not clear |
| Tae-Won Kim, An-Gi Kim, Kwang-Ho Lee, Min-Ho Hwang, Hyuk Cho. Microfluidic Electroceuticals Platform for Therapeutic Strategies of Intervertebral Disc Degeneration: Effects of Electrical Stimulation on Human Nucleus Pulposus Cells under Inflammatory Conditions. International journal of molecular sciences. vol 23. issue 17. 2022-09-09. PMID:36077518. |
ivd degeneration is characterized by the abnormal expression of inflammatory cytokines and matrix degradation enzymes secreted by ivd cells. |
2022-09-09 |
2023-08-14 |
human |
| Wen Yang, Chunwang Jia, Long Liu, Yu Fu, Yawei Wu, Zhicheng Liu, Ruixuan Yu, Xiaojie Ma, Ao Gong, Fangming Liu, Yanni Xia, Yong Hou, Yuhua Li, Lei Zhan. Hypoxia-Inducible Factor-1α Protects Against Intervertebral Disc Degeneration Through Antagonizing Mitochondrial Oxidative Stress. Inflammation. 2022-09-06. PMID:36064808. |
in vivo results demonstrated that after establishment of ivdd model in rabbit, disc height and ivd extracellular matrix were decreased in a time-dependent manner, mri analysis showed a tendency for decreased t2 values in a time-dependent manner and supplementation of hif-1α improved histological and imaginative ivdd while downregulation of hif-1α exacerbated this degeneration. |
2022-09-06 |
2023-08-14 |
mouse |
| Bo Hu, Xiao Lv, Leixin Wei, Yunhao Wang, Genjiang Zheng, Chen Yang, Fazhi Zang, Jianxi Wang, Jing Li, Xiaodong Wu, Zhihao Yue, Qiangqiang Xiao, Zengwu Shao, Wen Yuan, Jinsong Li, Peng Cao, Chen Xu, Huajiang Che. Sensory Nerve Maintains Intervertebral Disc Extracellular Matrix Homeostasis Via CGRP/CHSY1 Axis. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2022-09-01. PMID:36047655. |
here, this study shows that sensory nerve orchestrates intervertebral disc (ivd) homeostasis by regulating its extracellular matrix (ecm) metabolism. |
2022-09-01 |
2023-08-14 |
mouse |
| E D Rivera Tapia, J R Meakin, T P Holsgrov. In-vitro models of disc degeneration - A review of methods and clinical relevance. Journal of biomechanics. vol 142. 2022-08-26. PMID:36027637. |
degeneration of the ivd includes alterations in the biomechanics, extracellular matrix (ecm), and cellular activity. |
2022-08-26 |
2023-08-14 |
human |
| Liang Kang, Huaqing Zhang, Chongyu Jia, Renjie Zhang, Cailiang She. Targeting Oxidative Stress and Inflammation in Intervertebral Disc Degeneration: Therapeutic Perspectives of Phytochemicals. Frontiers in pharmacology. vol 13. 2022-07-29. PMID:35903342. |
they induce the destruction of the extracellular matrix in ivd and reduce the number of living cells and functional cells, thereby destroying the function of ivd and promoting the occurrence and development of idd. |
2022-07-29 |
2023-08-14 |
Not clear |
| Paola Bermudez-Lekerika, Katherine B Crump, Sofia Tseranidou, Andrea Nüesch, Exarchos Kanelis, Ahmad Alminnawi, Laura Baumgartner, Estefano Muñoz-Moya, Roger Compte, Francesco Gualdi, Leonidas G Alexopoulos, Liesbet Geris, Karin Wuertz-Kozak, Christine L Le Maitre, Jérôme Noailly, Benjamin Gantenbei. Immuno-Modulatory Effects of Intervertebral Disc Cells. Frontiers in cell and developmental biology. vol 10. 2022-07-18. PMID:35846355. |
idd is often caused by structural and biochemical changes in intervertebral discs (ivd) that prompt a pathologic shift from an anabolic to catabolic state, affecting extracellular matrix (ecm) production, enzyme generation, cytokine and chemokine production, neurotrophic and angiogenic factor production. |
2022-07-18 |
2023-08-14 |
Not clear |
| K Josh Briar, John G McMorran, Diane E Gregor. Delamination of the Annulus Fibrosus of the Intervertebral Disc: Using a Bovine Tail Model to Examine Effect of Separation Rate. Frontiers in bioengineering and biotechnology. vol 10. 2022-07-15. PMID:35837552. |
the intervertebral disc (ivd) is a complex structure, and recent evidence suggests that separations or delamination between layers of the annulus may contribute to degeneration development, a common cause of low back pain the purpose of the present experiment was to quantify the mechanical response of the layer-adjoining interlamellar matrix at different rates of separation. |
2022-07-15 |
2023-08-14 |
cattle |