| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Devante A Horne, Peter D Jones, Matthew S Adams, Jeffrey C Lotz, Chris J Diederic. LIPUS far-field exposimetry system for uniform stimulation of tissues in-vitro: development and validation with bovine intervertebral disc cells. Biomedical physics & engineering express. vol 6. issue 3. 2021-11-15. PMID:33438678. |
therapeutic low-intensity pulsed ultrasound (lipus) has been applied clinically for bone fracture healing and has been shown to stimulate extracellular matrix (ecm) metabolism in numerous soft tissues including intervertebral disc (ivd). |
2021-11-15 |
2023-08-13 |
cattle |
| Christopher J Panebianco, Arpit Dave, Daniel Charytonowicz, Robert Sebra, James C Iatridi. Single-cell RNA-sequencing atlas of bovine caudal intervertebral discs: Discovery of heterogeneous cell populations with distinct roles in homeostasis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 11. 2021-11-12. PMID:34591994. |
clusters np3, np5, oaf2, and oaf3 expressed various extracellular matrix (ecm)-associated genes, suggesting their role in maintaining ivd structure. |
2021-11-12 |
2023-08-13 |
cattle |
| Zuo-Long Wu, Qi-Qi Xie, Tai-Cong Liu, Xing Yang, Guang-Zhi Zhang, Hai-Hong Zhan. Role of the Wnt pathway in the formation, development, and degeneration of intervertebral discs. Pathology, research and practice. vol 220. 2021-11-09. PMID:33647863. |
however, the activation of the wnt pathway after birth promotes ivd cell senescence, apoptosis, and degradation of the extracellular matrix and induces the production of inflammatory factors, thereby accelerating the ivdd process. |
2021-11-09 |
2023-08-13 |
Not clear |
| Songhyun Lim, Seong Bae An, Mungyo Jung, Hari Prasad Joshi, Hemant Kumar, Cheesue Kim, Seuk Young Song, Ju-Ro Lee, Mikyung Kang, Inbo Han, Byung-Soo Ki. Local Delivery of Senolytic Drug Inhibits Intervertebral Disc Degeneration and Restores Intervertebral Disc Structure. Advanced healthcare materials. 2021-11-05. PMID:34699690. |
the strategy results in the selective elimination of senescent cells from the degenerative ivd, reduces expressions of pro-inflammatory cytokines and matrix proteases in the ivd, inhibits progression of ivdd, and even restores the ivd structure. |
2021-11-05 |
2023-08-13 |
rat |
| Ana P Peredo, Sarah E Gullbrand, Harvey E Smith, Robert L Mauc. Putting the Pieces in Place: Mobilizing Cellular Players to Improve Annulus Fibrosus Repair. Tissue engineering. Part B, Reviews. vol 27. issue 4. 2021-10-28. PMID:32907498. |
the intervertebral disc (ivd) is an integral load-bearing tissue that derives its function from its composite structure and extracellular matrix composition. |
2021-10-28 |
2023-08-13 |
Not clear |
| Brian Fiani, Alden Dahan, Mohamed H El-Farra, Michael W Kortz, Juliana M Runnels, Yasmine Suliman, Anita Miranda, Austin Ngu. Cellular transplantation and platelet-rich plasma injections for discogenic pain: a contemporary review. Regenerative medicine. vol 16. issue 2. 2021-10-28. PMID:33650437. |
it is a pathologic condition associated with aging and is believed to result from catabolic excess in the intervertebral discs' (ivd) extracellular matrix. |
2021-10-28 |
2023-08-13 |
human |
| Brian Fiani, Alden Dahan, Mohamed H El-Farra, Michael W Kortz, Juliana M Runnels, Yasmine Suliman, Anita Miranda, Austin Ngu. Cellular transplantation and platelet-rich plasma injections for discogenic pain: a contemporary review. Regenerative medicine. vol 16. issue 2. 2021-10-28. PMID:33650437. |
since ddd results from the ivd extracellular matrix's unmitigated catabolism, cellular injections are used to induce regeneration and homeostasis in the ivd. |
2021-10-28 |
2023-08-13 |
human |
| Carla Cunha, Catarina Leite Pereira, Joana R Ferreira, Cláudia Ribeiro-Machado, Sibylle Grad, Susana G Santos, Raquel M Gonçalve. Therapeutic Strategies for IVD Regeneration through Hyaluronan/SDF-1-Based Hydrogel and Intravenous Administration of MSCs. International journal of molecular sciences. vol 22. issue 17. 2021-10-28. PMID:34502517. |
intervertebral disc (ivd) degeneration involves a complex cascade of events, including degradation of the native extracellular matrix, loss of water content, and decreased cell numbers. |
2021-10-28 |
2023-08-13 |
Not clear |
| Daniel J Flagler, Chun-Yuh Huang, Tai-Yi Yuan, Zhongmin Lu, Herman S Cheung, Wei Yong G. Intracellular Flow Cytometric Measurement of Extracellular Matrix Components in Porcine Intervertebral Disc Cells. Cellular and molecular bioengineering. vol 2. issue 2. 2021-10-20. PMID:20161070. |
the objective of this study was to develop and demonstrate the utility of a novel method of evaluating intracellular levels of extracellular matrix (ecm) components in intervertebral disc (ivd) cells using flow cytometry. |
2021-10-20 |
2023-08-12 |
Not clear |
| James C Iatridis, A J Michalek, D Purmessur, C L Koreck. Localized Intervertebral Disc Injury Leads to Organ Level Changes in Structure, Cellularity, and Biosynthesis. Cellular and molecular bioengineering. vol 2. issue 3. 2021-10-20. PMID:21179399. |
new results on effects of 25g needle injection of saline into a bovine ivd organ culture model demonstrated a loss of cellularity and down-regulation of matrix gene expression, providing a specific example of how a minor injury affects the ivd organ response. |
2021-10-20 |
2023-08-12 |
cattle |
| Hai-Jun Zhang, Hai-Yang Liao, Deng-Yan Bai, Zhi-Qiang Wang, Xing-Wen Xi. MAPK /ERK signaling pathway: A potential target for the treatment of intervertebral disc degeneration. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 143. 2021-10-13. PMID:34536759. |
it is closely related to changes in the tissue structure and function, including the progressive destruction of extracellular matrix, cell aging, cell death of the intervertebral disc (ivd), inflammation, and impairment of tissue biomechanical function. |
2021-10-13 |
2023-08-13 |
Not clear |
| Hai-Jun Zhang, Hai-Yang Liao, Deng-Yan Bai, Zhi-Qiang Wang, Xing-Wen Xi. MAPK /ERK signaling pathway: A potential target for the treatment of intervertebral disc degeneration. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 143. 2021-10-13. PMID:34536759. |
furthermore, the mitogen-activated protein kinase (mapk)/extracellular signal-regulated kinase (erk) signaling pathway is closely related to various pathological processes in idd, and the activation of the mapk/erk pathway promotes the degradation of the ivd extracellular matrix, cell aging, apoptosis, and inflammatory responses. |
2021-10-13 |
2023-08-13 |
Not clear |
| Panpan Xu, Jingjing Guan, Yu Chen, Hui Xiao, Tianhao Yang, Hengheng Sun, Nan Wu, Changchun Zhang, Yingji Ma. Stiffness of photocrosslinkable gelatin hydrogel influences nucleus pulposus cell propertiesin vitro. Journal of cellular and molecular medicine. vol 25. issue 2. 2021-10-11. PMID:33289319. |
however, in advanced ddd, due to structural damage of the ivd and scaffold mechanical properties, the transplanted cells are less viable and secrete less extracellular matrix, and thus, are unable to efficiently promote np regeneration. |
2021-10-11 |
2023-08-13 |
Not clear |
| M Khandaker, H Kotturi, H Progri, S Tummala, S Nikfarjam, P Rao, A Hosna, D T Arasu, W Williams, A M Halee. Biomedical materials (Bristol, England). vol 16. issue 4. 2021-10-11. PMID:33915528. |
this study compared pegda and polycaprolactone (pcl) nanofiber matrix (nfm) coated pegda, referred to as pcl-pegda, scaffolds for their application in multiple tissue repair such as articular cartilage, nucleus pulposus of the intervertebral disc (ivd). |
2021-10-11 |
2023-08-13 |
Not clear |
| M F Fiordalisi, A J Silva, M Barbosa, R M Gonçalves, J Caldeir. Intervertebral disc decellularisation: progress and challenges. European cells & materials. vol 41. 2021-10-07. PMID:34613611. |
over the last few years, several researchers have focused on the optimisation of ivd decellularisation methods, combining physical, chemical and enzymatic treatments, in order to successfully develop a cell-free matrix. |
2021-10-07 |
2023-08-13 |
Not clear |
| Xinhua Li, Shuting Yang, Ling Qin, Shuying Yan. Type II collagen-positive embryonic progenitors are the major contributors to spine and intervertebral disc development and repair. Stem cells translational medicine. vol 10. issue 10. 2021-09-29. PMID:34032373. |
moreover, postnatal deletion col2+ cells in spine resulted in a shorter growth plate and endplate cartilage, defected inner annulus fibrosus, a less compact and markedly decreased gel-like matrix in the nucleus pulposus and disorganized cell alignment in each compartment of ivd. |
2021-09-29 |
2023-08-13 |
mouse |
| Xiaobin Wang, Dan Li, Hailin Wu, Fusheng Liu, Fubin Liu, Qianshi Zhang, Jing L. LncRNA TRPC7-AS1 regulates nucleus pulposus cellular senescence and ECM synthesis via competing with HPN for miR-4769-5p binding. Mechanisms of ageing and development. vol 190. 2021-09-13. PMID:32585234. |
intervertebral disc (ivd) degeneration (idd) is identified as an abnormal, cell-mediated, age-dependent and genetics-dependent molecular degeneration process in which npcs (nucleus pulposus cells) senesce and the balance of ecm (extracellular matrix) synthesis and catabolism is disrupted. |
2021-09-13 |
2023-08-13 |
Not clear |
| Fangda Fu, Ronghua Bao, Sai Yao, Chengcong Zhou, Huan Luo, Zhiguo Zhang, Huihao Zhang, Yan Li, Shuxin Yan, Huan Yu, Weibin Du, Yanping Yang, Hongting Jin, Peijian Tong, Zhi-Tao Sun, Ming Yue, Di Chen, Chengliang Wu, Hongfeng Rua. Aberrant spinal mechanical loading stress triggers intervertebral disc degeneration by inducing pyroptosis and nerve ingrowth. Scientific reports. vol 11. issue 1. 2021-08-25. PMID:33437038. |
lsi administration led to the histologic change of disc degeneration, disruption of the matrix metabolism, promotion of apoptosis of ivd cells and invasion of sensory nerves into annulus fibrosus, as well as induction of pyroptosis. |
2021-08-25 |
2023-08-13 |
mouse |
| Beth G Ashinsky, Sarah E Gullbrand, Chao Wang, Edward D Bonnevie, Lin Han, Robert L Mauck, Harvey E Smit. Degeneration alters structure-function relationships at multiple length-scales and across interfaces in human intervertebral discs. Journal of anatomy. vol 238. issue 4. 2021-08-16. PMID:33205444. |
ivd degeneration is a progressive cascade of cellular, compositional, and structural changes, which results in a loss of disc height, disorganization of extracellular matrix architecture, tears in the annulus fibrosus which may involve herniation of the nucleus pulposus, and remodeling of the bony and cartilaginous endplates (cep). |
2021-08-16 |
2023-08-13 |
human |
| T D Jacobsen, P A Hernandez, N O Chahin. Inhibition of toll-like receptor 4 protects against inflammation-induced mechanobiological alterations to intervertebral disc cells. European cells & materials. vol 41. 2021-08-04. PMID:34013512. |
intervertebral disc (ivd) degeneration is associated with elevated levels of inflammatory cytokines implicated in disease aetiology and matrix degradation. |
2021-08-04 |
2023-08-13 |
cattle |