| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tibo Nico Emmie Volleman, Jordy Schol, Kosuke Morita, Daisuke Sakai, Masahiko Watanab. Wnt3a and wnt5a as Potential Chondrogenic Stimulators for Nucleus Pulposus Cell Induction: A Comprehensive Review. Neurospine. vol 17. issue 1. 2020-09-28. PMID:32252152. |
low back pain is generally associated with intervertebral disc (ivd) degeneration, a process involving the deterioration of nucleus pulpous (np) cells and ivd matrix. |
2020-09-28 |
2023-08-13 |
Not clear |
| Letizia Penolazzi, Michela Pozzobon, Leticia Scussel Bergamin, Stefania D'Agostino, Riccardo Francescato, Gloria Bonaccorsi, Pasquale De Bonis, Michele Cavallo, Elisabetta Lambertini, Roberta Piv. Extracellular Matrix From Decellularized Wharton's Jelly Improves the Behavior of Cells From Degenerated Intervertebral Disc. Frontiers in bioengineering and biotechnology. vol 8. 2020-09-28. PMID:32292779. |
in the present study, we investigated the potential of decellularized wharton's jelly matrix (dwjm) from human umbilical cord to act as an ecm-based scaffold for ivd cell culturing. |
2020-09-28 |
2023-08-13 |
human |
| Nathan Piazza, Mehdi Dehghani, Thomas R Gaborski, Karin Wuertz-Koza. Therapeutic Potential of Extracellular Vesicles in Degenerative Diseases of the Intervertebral Disc. Frontiers in bioengineering and biotechnology. vol 8. 2020-09-28. PMID:32363187. |
msc-derived evs not only promote extracellular matrix synthesis and proliferation in ivd cells, but also reduce apoptosis and inflammation, hence having multifunctional beneficial effects that seem to be mediated by specific mirnas (such as mir-233 and mir-21) within the evs. |
2020-09-28 |
2023-08-13 |
Not clear |
| Gianluca Vadalà, Luca Ambrosio, Fabrizio Russo, Rocco Papalia, Vincenzo Denar. Interaction between Mesenchymal Stem Cells and Intervertebral Disc Microenvironment: From Cell Therapy to Tissue Engineering. Stem cells international. vol 2019. 2020-09-28. PMID:32587618. |
its primary cause seems to be intervertebral disc degeneration (idd): a chronic and progressive process characterized by loss of viable cells and extracellular matrix (ecm) breakdown within the intervertebral disc (ivd) especially in its inner region, the nucleus pulposus (np). |
2020-09-28 |
2023-08-13 |
Not clear |
| Aleksandra Sadowska, Birsen Altinay, Wolfgang Hitzl, Stephen J Ferguson, Karin Wuertz-Koza. Hypo-Osmotic Loading Induces Expression of IL-6 in Nucleus Pulposus Cells of the Intervertebral Disc Independent of TRPV4 and TRPM7. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32714187. |
painful intervertebral disc (ivd) degeneration is an age-related process characterized by reduced tissue osmolarity, increased catabolism of the extracellular matrix, and elevated levels of pro-inflammatory molecules. |
2020-09-28 |
2023-08-13 |
Not clear |
| Brian Fiani, Christian Noblett, Jacob M Nanney, Neha Gautam, Elisabeth Pennington, Thao Doan, Daniel Nikolaidi. The Impact of "Vaping" Electronic Cigarettes on Spine Health. Cureus. vol 12. issue 6. 2020-09-28. PMID:32742873. |
additionally, nicotine in e-liquids negatively impacts ivd health by creating hypoxic environments that degenerate the ivd vasculature and cellular matrix. |
2020-09-28 |
2023-08-13 |
human |
| Feng Cai, Xin Hong, Xiang Tang, Nai-Cheng Liu, Feng Wang, Lei Zhu, Xin-Hui Xie, Zhi-Yang Xie, Xiao-Tao W. ASIC1a activation induces calcium-dependent apoptosis of BMSCs under conditions that mimic the acidic microenvironment of the degenerated intervertebral disc. Bioscience reports. vol 39. issue 11. 2020-09-25. PMID:31696219. |
in the degenerated intervertebral disc (ivd), matrix acidity challenges transplanted bone marrow mesenchymal stem cells (bmscs). |
2020-09-25 |
2023-08-13 |
Not clear |
| Undurti N Da. Bioactive lipids in intervertebral disc degeneration and its therapeutic implications. Bioscience reports. vol 39. issue 10. 2020-09-15. PMID:31533969. |
recent studies showed that ivd degeneration could be an inflammatory condition characterized by increased production of matrix metalloproteinases, tnf-α, nitric oxide, il-6, il-17, il-9, and prostaglandin e2, and decreased formation of anti-inflammatory molecules such as lipoxin a4. |
2020-09-15 |
2023-08-13 |
Not clear |
| Hsien-Ta Hsu, Chung-Tai Yue, Ming-Sheng Teng, I-Shiang Tzeng, Tin-Chou Li, Po-An Tai, Kuo-Feng Huang, Cheng-Yu Chen, Yu-Lin K. Immuohistochemical score of matrix metalloproteinase-1 may indicate the severity of symptomatic cervical and lumbar disc degeneration. The spine journal : official journal of the North American Spine Society. vol 20. issue 1. 2020-09-11. PMID:31408735. |
in the context of ivd degeneration, matrix metalloproteinase-1 (mmp-1), which is upregulated and activated by leptin, is the most abundant catabolic enzyme. |
2020-09-11 |
2023-08-13 |
Not clear |
| Changli Zhang, Madeline P Smith, George K Zhou, Alon Lai, Robert C Hoy, Victoria Mroz, Olivia M Torre, Damien M Laudier, Elizabeth W Bradley, Jennifer J Westendorf, James C Iatridis, Svenja Illien-Jünge. Phlpp1 is associated with human intervertebral disc degeneration and its deficiency promotes healing after needle puncture injury in mice. Cell death & disease. vol 10. issue 10. 2020-08-20. PMID:31582730. |
at 2 and 8 months after injury, phlpp1 deficiency also had protective effects on ivd cellularity, matrix production, and collagen structure as measured with histological and immunohistochemical analyses. |
2020-08-20 |
2023-08-13 |
mouse |
| Changli Zhang, Madeline P Smith, George K Zhou, Alon Lai, Robert C Hoy, Victoria Mroz, Olivia M Torre, Damien M Laudier, Elizabeth W Bradley, Jennifer J Westendorf, James C Iatridis, Svenja Illien-Jünge. Phlpp1 is associated with human intervertebral disc degeneration and its deficiency promotes healing after needle puncture injury in mice. Cell death & disease. vol 10. issue 10. 2020-08-20. PMID:31582730. |
specifically, phlpp1-deletion resulted in enhanced nucleus pulposus matrix production and more chondrocytic cells at 2 months, and increased ivd height, nucleus pulposus cellularity, and extracellular matrix deposition 8 months after injury. |
2020-08-20 |
2023-08-13 |
mouse |
| C M Disney, A Eckersley, J C McConnell, H Geng, A J Bodey, J A Hoyland, P D Lee, M J Sherratt, B K Ba. Synchrotron tomography of intervertebral disc deformation quantified by digital volume correlation reveals microstructural influence on strain patterns. Acta biomaterialia. vol 92. 2020-07-01. PMID:31082569. |
the intervertebral disc (ivd) has a complex and multiscale extracellular matrix structure which provides unique mechanical properties to withstand physiological loading. |
2020-07-01 |
2023-08-13 |
rat |
| Sidong Yang, Feng Zhang, Jiangtao Ma, Wenyuan Din. Intervertebral disc ageing and degeneration: The antiapoptotic effect of oestrogen. Ageing research reviews. vol 57. 2020-06-30. PMID:31669486. |
oestrogen can decrease ivd cell apoptosis in multiple ways, including the inhibition of the inflammatory cytokines il-1β and tnf-α, reducing catabolism because of inhibition of matrix metalloproteinases, upregulating integrin α |
2020-06-30 |
2023-08-13 |
Not clear |
| Tom Hodgkinson, Jasmine Z Stening, Lisa J White, Kevin M Shakesheff, Judith A Hoyland, Stephen M Richardso. Microparticles for controlled growth differentiation factor 6 delivery to direct adipose stem cell-based nucleus pulposus regeneration. Journal of tissue engineering and regenerative medicine. vol 13. issue 8. 2020-06-19. PMID:31066515. |
this study demonstrates the effective encapsulation and controlled delivery of rhgdf6, which maintained its activity and induced asc differentiation to np cells and synthesis of an np-like matrix suggesting suitability of microparticles for controlled growth factor release in regenerative strategies for treatment of ivd degeneration. |
2020-06-19 |
2023-08-13 |
human |
| Li Ni, Yixin Zheng, Tingting Gong, Chunmei Xiu, Kun Li, Saijilafu, Bin Li, Huilin Yang, Jianquan Che. Proinflammatory macrophages promote degenerative phenotypes in rat nucleus pulpous cells partly through ERK and JNK signaling. Journal of cellular physiology. vol 234. issue 5. 2020-03-30. PMID:30367477. |
we found that mФcm caused molecular changes associated with ivd degeneration, including increased expression of key matrix catabolic genes (adamts4, adamts5, mmp3, and mmp13), reduced the expression of major matrix-associated anabolic genes ( sox9, acan, and col2a1), and upregulated transcription of inflammation-related genes ( il-1b, il-6, ccl2, and ccl3), in rnp cells. |
2020-03-30 |
2023-08-13 |
rat |
| Anja Beierfuß, Monika Hunjadi, Andreas Ritsch, Christian Kremser, Claudius Thomé, Demissew Shenegelegn Mer. APOE-knockout in rabbits causes loss of cells in nucleus pulposus and enhances the levels of inflammatory catabolic cytokines damaging the intervertebral disc matrix. PloS one. vol 14. issue 11. 2020-03-19. PMID:31751427. |
we analysed in lumbar nucleus pulposus (np) of apoe-knockout rabbits the cell viabilities and the intracellular levels of inflammatory, catabolic, anti-catabolic and anabolic proteins derogating ivd matrix. |
2020-03-19 |
2023-08-13 |
mouse |
| Michele Baldoni, Weiyong G. Effect of fixed charge density on water content of IVD during bed rest: A numerical analysis. Medical engineering & physics. vol 70. 2020-03-04. PMID:31248789. |
the fixed charge density (fcd) in the intervertebral disc (ivd) matrix is essential for its capacity of absorbing water, particularly during overnight bed rest. |
2020-03-04 |
2023-08-13 |
human |
| Masahiro Nakahashi, Mariko Esumi, Yasuaki Tokuhash. Detection of apoptosis and matrical degeneration within the intervertebral discs of rats due to passive cigarette smoking. PloS one. vol 14. issue 8. 2020-02-28. PMID:31454348. |
ivd from rats exposed to 8 weeks of passive cigarette smoking were stained with elastica van gieson, and exhibited marked destruction of the supportive structure of the reticular matrix in the nucleus pulposus (np). |
2020-02-28 |
2023-08-13 |
rat |
| Masahiro Nakahashi, Mariko Esumi, Yasuaki Tokuhash. Detection of apoptosis and matrical degeneration within the intervertebral discs of rats due to passive cigarette smoking. PloS one. vol 14. issue 8. 2020-02-28. PMID:31454348. |
this leads to reduction of the ecm in the np, destroying the np matrix, which can then progress to ivd degeneration. |
2020-02-28 |
2023-08-13 |
rat |
| Ricardo B V Fontes, Josemberg S Baptista, Said R Rabbani, Vincent C Traynelis, Edson A Libert. Normal aging in human lumbar discs: An ultrastructural comparison. PloS one. vol 14. issue 6. 2020-02-14. PMID:31220091. |
the normal aging of the extracellular matrix and collagen content of the human lumbar intervertebral disc (ivd) remains relatively unknown despite vast amounts of basic science research, partly because of the use of inadequate surrogates for a truly normal, human ivd. |
2020-02-14 |
2023-08-13 |
human |