| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Defang Li, Qingmin Zeng, Zengxin Jiang, Lei Ding, Wei Lu, Mengxuan Bian, Jingping W. Induction of notochordal differentiation of bone marrow mesenchymal‑derived stem cells via the stimulation of notochordal cell‑rich nucleus pulposus tissue. Molecular medicine reports. vol 23. issue 2. 2021-05-06. PMID:33355376. |
transplanting proper cells into the ivd may sustain cell numbers, resulting in the synthesis of new matrix; this represents a minimally invasive regenerative therapy. |
2021-05-06 |
2023-08-13 |
Not clear |
| S Zhang, B Hu, W Liu, P Wang, X Lv, S Chen, Z Sha. The role of structure and function changes of sensory nervous system in intervertebral disc-related low back pain. Osteoarthritis and cartilage. vol 29. issue 1. 2021-05-03. PMID:33007412. |
with the progress of ivdd, ivd cell exhaustion and extracellular matrix degradation result in ivd structural damage, while neovascularization, innervation and inflammatory activation further deteriorate the microenvironment of ivd. |
2021-05-03 |
2023-08-13 |
Not clear |
| Shambo Bhattacharya, Devendra K Dube. Effect of aggrecan degradation on the nanomechanics of hyaluronan in extra-fibrillar matrix of annulus fibrosus: A molecular dynamics investigation. Journal of the mechanical behavior of biomedical materials. vol 107. 2021-04-26. PMID:32278311. |
intervertebral disc (ivd) degeneration is one of the primary causes of low back pain among the adult population - the most significant cause being the degradation of aggrecan present in the extra-fibrillar matrix (efm). |
2021-04-26 |
2023-08-13 |
Not clear |
| Daphne Hingert, Phonphan Nawilaijaroen, Karin Ekström, Adad Baranto, Helena Brisb. Human Levels of MMP-1 in Degenerated Disks Can Be Mitigated by Signaling Peptides from Mesenchymal Stem Cells. Cells, tissues, organs. vol 209. issue 2-3. 2021-04-02. PMID:32829335. |
degradation of extracellular matrix (ecm) in intervertebral disks (ivds) during ivd degeneration plays a vital role in low back pain (lbp). |
2021-04-02 |
2023-08-13 |
human |
| Xinhua Li, Shuting Yang, Lin Han, Keya Mao, Shuying Yan. Ciliary IFT80 is essential for intervertebral disc development and maintenance. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 5. 2021-01-22. PMID:32227389. |
deletion of ift80 in type ii collagen-positive cells resulted in cilia loss in gp and ep, and disrupted ivd structure with disorganized and decreased gp, ep, and internal af (iaf), and less compact and markedly decreased gel-like matrix in the np. |
2021-01-22 |
2023-08-13 |
mouse |
| Andrea De Pieri, Ann M Byerley, Catherine R Musumeci, Fatemeh Salemizadehparizi, Maya A Vanderhorst, Karin Wuertz-Koza. Electrospinning and 3D bioprinting for intervertebral disc tissue engineering. JOR spine. vol 3. issue 4. 2021-01-05. PMID:33392454. |
tissue engineering strategies, especially those based on 3d bioprinting and electrospinning, have emerged as possible alternatives by producing cell-seeded scaffolds that replicate the structure of the ivd extracellular matrix. |
2021-01-05 |
2023-08-13 |
Not clear |
| Erica K Wagner, Armin Vedadghavami, Timothy D Jacobsen, Shakti A Goel, Nadeen O Chahine, Ambika G Bajpaye. Avidin grafted dextran nanostructure enables a month-long intra-discal retention. Scientific reports. vol 10. issue 1. 2020-12-21. PMID:32694557. |
the avascular nature and the dense matrix of this tissue make it challenging for systemically administered drugs to reach their target cells inside the nucleus pulposus (np), the central gelatinous region of the intervertebral disc (ivd). |
2020-12-21 |
2023-08-13 |
Not clear |
| Dominik Nörz, André Frontzek, Ulrich Eigner, Lisa Oestereich, Dominic Wichmann, Stefan Kluge, Nicole Fischer, Martin Aepfelbacher, Susanne Pfefferle, Marc Lütgehetman. Pushing beyond specifications: Evaluation of linearity and clinical performance of the cobas 6800/8800 SARS-CoV-2 RT-PCR assay for reliable quantification in blood and other materials outside recommendations. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. vol 132. 2020-12-04. PMID:33011643. |
in this study we evaluate clinical performance and linear range for the sars-cov-2 ivd (cobas6800/8800 system, a fully automated sample-to-result platform) in different clinically relevant matrix materials outside official specifications. |
2020-12-04 |
2023-08-13 |
Not clear |
| Johannes Kupka, Annika Kohler, Karima El Bagdadi, Richard Bostelmann, Marco Brenneis, Christoph Fleege, Danny Chan, Frank Zaucke, Andrea Meurer, Marcus Rickert, Zsuzsa Jenei-Lanz. Adrenoceptor Expression during Intervertebral Disc Degeneration. International journal of molecular sciences. vol 21. issue 6. 2020-12-01. PMID:32197418. |
furthermore, human ivd samples and spine sections of wildtype mice (wt) and of a mouse line that develops spontaneous ivd degeneration (ivdd, in sm/j mice) were stained for ars and extracellular matrix (ecm) components. |
2020-12-01 |
2023-08-13 |
mouse |
| Weiyu Ni, Feizhou Zhang, Lin Zheng, Lili Wang, Yi Liang, Yuhong Ding, Jasper H N Yik, Dominik R Haudenschild, Shunwu Fan, Ziang H. Cyclin-Dependent Kinase 9 (CDK9) Inhibitor Atuveciclib Suppresses Intervertebral Disk Degeneration via the Inhibition of the NF-κB Signaling Pathway. Frontiers in cell and developmental biology. vol 8. 2020-10-06. PMID:33015073. |
in addition, rat intervertebral disk (ivd) explants were used to determine the role of cdk9 inhibition in extracellular matrix degradation. |
2020-10-06 |
2023-08-13 |
human |
| Koji Akeda, Junichi Yamada, Erikka T Linn, Akihiro Sudo, Koichi Masud. Platelet-rich plasma in the management of chronic low back pain: a critical review. Journal of pain research. vol 12. 2020-10-01. PMID:30881089. |
several animal studies have shown that the injection of prp into degenerated ivds is effective in restoring structural changes (ivd height) and improving the matrix integrity of degenerated ivds as evaluated by magnetic resonance imaging (mri) and histology. |
2020-10-01 |
2023-08-13 |
Not clear |
| Chin-Yu Lin, Samuel Thomas Crowley, Satoshi Uchida, Yuji Komaki, Kazunori Kataoka, Keiji Itak. Treatment of Intervertebral Disk Disease by the Administration of mRNA Encoding a Cartilage-Anabolic Transcription Factor. Molecular therapy. Nucleic acids. vol 16. 2020-10-01. PMID:30889482. |
the disk degeneration is not only a destruction of ivd structure but also is related to a disorder of the turnover of the disk matrix, leading the jelly-like ivd core to be replaced by fibrous components. |
2020-10-01 |
2023-08-13 |
rat |
| Jin-Wei Ying, Tian-Yong Wen, Shi-Shen Pei, Ling-Hao Su, Di-Ke Rua. Stromal cell-derived factor-1α promotes recruitment and differentiation of nucleus pulposus-derived stem cells. World journal of stem cells. vol 11. issue 3. 2020-10-01. PMID:30949297. |
intervertebral disc (ivd) degeneration is a condition characterized by a reduction in the water and extracellular matrix content of the nucleus pulposus (np) and is considered as one of the dominating contributing factors to low back pain. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jinwei Ying, Zhihua Han, Yang Zeng, Yanan Du, Shishen Pei, Linghao Su, Dike Ruan, Chun Che. Evaluation of intervertebral disc regeneration with injection of mesenchymal stem cells encapsulated in PEGDA-microcryogel delivery system using quantitative T2 mapping: a study in canines. American journal of translational research. vol 11. issue 4. 2020-10-01. PMID:31105815. |
ivd height change on plain radiograph, pfirrmann grade and t2 relaxation time on mri, histological change, and extracellular matrix (ecm)-associated proteins were evaluated during the 24-week follow-up period. |
2020-10-01 |
2023-08-13 |
Not clear |
| Tom Hodgkinson, Bojiang Shen, Ashish Diwan, Judith A Hoyland, Stephen M Richardso. Therapeutic potential of growth differentiation factors in the treatment of degenerative disc diseases. JOR spine. vol 2. issue 1. 2020-10-01. PMID:31463459. |
intervertebral disc (ivd) degeneration is a major contributing factor to chronic low back pain and disability, leading to imbalance between anabolic and catabolic processes, altered extracellular matrix composition, loss of tissue hydration, inflammation, and impaired mechanical functionality. |
2020-10-01 |
2023-08-13 |
Not clear |
| Joseph W Snuggs, Rebecca E Day, Frances C Bach, Matthew T Conner, Rowena A D Bunning, Marianna A Tryfonidou, Christine L Le Maitr. Aquaporin expression in the human and canine intervertebral disc during maturation and degeneration. JOR spine. vol 2. issue 1. 2020-10-01. PMID:31463463. |
the intervertebral disc (ivd) is a highly hydrated tissue, the rich proteoglycan matrix imbibes water, enabling the disc to withstand compressive loads. |
2020-10-01 |
2023-08-13 |
human |
| Daniela A Frauchiger, Rahel D May, Ezgi Bakirci, Adel Tekari, Samantha C W Chan, Michael Wöltje, Lorin M Benneker, Benjamin Gantenbei. Genipin-Enhanced Fibrin Hydrogel and Novel Silk for Intervertebral Disc Repair in a Loaded Bovine Organ Culture Model. Journal of functional biomaterials. vol 9. issue 3. 2020-09-29. PMID:29937524. |
followed by assessing dna and matrix content, qpcr and histology, the injured discs were compared to an uninjured control ivd that underwent the same loading profiles. |
2020-09-29 |
2023-08-13 |
human |
| Leslie Frapin, Johann Clouet, Vianney Delplace, Marion Fusellier, Jérôme Guicheux, Catherine Le Visag. Lessons learned from intervertebral disc pathophysiology to guide rational design of sequential delivery systems for therapeutic biological factors. Advanced drug delivery reviews. vol 149-150. 2020-09-28. PMID:31445063. |
finally, we hypothesize that a sequential delivery strategy that i) firstly targets the inflammatory, pro-catabolic microenvironment with release of anti-inflammatory or anti-catabolic cytokines; ii) secondly increases cell density in the less hostile microenvironment by endogenous cell recruitment or exogenous cell injection, and finally iii) enhances cellular synthesis of extracellular matrix with release of pro-anabolic factors, would constitute an innovative yet challenging approach to ivd regeneration. |
2020-09-28 |
2023-08-13 |
Not clear |
| Yu-Hsiang Hsu, Ruey-Mo Lin, Yi-Shu Chiu, Wen-Lung Liu, Kuo-Yuan Huan. Effects of IL-1β, IL-20, and BMP-2 on Intervertebral Disc Inflammation under Hypoxia. Journal of clinical medicine. vol 9. issue 1. 2020-09-28. PMID:31947928. |
we found that the expression of il-1β, il-20, bmp-2, hypoxia-inducible factor (hif)-1α, il-6, il-8, angiogenetic factor (vascular endothelial growth factor (vegf)), chemotactic factor (monocyte chemoattractant protein 1 (mcp-1)), and matrix metalloproteinase-3 (mmp-3) was upregulated in ivd cells under hypoxia conditions. |
2020-09-28 |
2023-08-13 |
Not clear |
| Yizhong Peng, Donghua Huang, Sheng Liu, Jinye Li, Xiangcheng Qing, Zengwu Sha. Biomaterials-Induced Stem Cells Specific Differentiation Into Intervertebral Disc Lineage Cells. Frontiers in bioengineering and biotechnology. vol 8. 2020-09-28. PMID:32117935. |
stem cell therapy, which promotes stem cells differentiation toward specialized cell types, increases the resident population and production of extracellular matrix, and can be used to achieve intervertebral disc (ivd) repair, has drawn great attention for the development of ivd-regenerating materials. |
2020-09-28 |
2023-08-13 |
Not clear |