| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shuo Zhang, Weijian Liu, Songfeng Chen, Baichuan Wang, Peng Wang, Binwu Hu, Xiao Lv, Zengwu Sha. Extracellular matrix in intervertebral disc: basic and translational implications. Cell and tissue research. 2022-07-06. PMID:35792910. |
in healthy mature ivd tissues, extracellular matrix (ecm) complex possesses favorable biochemical and biomechanical properties, withstanding compression and torsion forces. |
2022-07-06 |
2023-08-14 |
Not clear |
| Ayshe Hajiesmailpoor, Omid Mohamadi, Payam Emami, Reza Farzanegan, Masoud Ghorban. Overview of Stem cell therapy in Intervertebral Disc Disease: Clinical perspectives. Current stem cell research & therapy. 2022-06-28. PMID:35762555. |
intervertebral disc degeneration [idd] is recognized as an aging process, important and most common pathological condition caused by an imbalance of anabolic and catabolic metabolisms in the intervertebral disc [ivd] and leads to changes in the extracellular matrix [ecm], impaired metabolic regulation of nucleus pulposus [np], and increased oxidative stress. |
2022-06-28 |
2023-08-14 |
Not clear |
| Cang-Yu Zhang, Xu-Chang Hu, Guang-Zhi Zhang, Ming-Qiang Liu, Hai-Wei Chen, Xue-Wen Kan. Role of Nrf2 and HO-1 in intervertebral disc degeneration. Connective tissue research. 2022-06-23. PMID:35736364. |
the pathogenesis of idd is mainly mediated by the death of intervertebral disc (ivd) cells and the imbalance of extracellular matrix (ecm) synthesis and degradation. |
2022-06-23 |
2023-08-14 |
Not clear |
| Alexander Eckersley, Matiss Ozols, Peikai Chen, Vivian Tam, Liam J Ward, Judith A Hoyland, Andrew Trafford, Xi-Ming Yuan, Herbert B Schiller, Danny Chan, Michael J Sherrat. Peptide location fingerprinting identifies species- and tissue-conserved structural remodelling of proteins as a consequence of ageing and disease. Matrix biology : journal of the International Society for Matrix Biology. 2022-05-26. PMID:35618217. |
extracellular matrix (ecm) in the intervertebral disc (ivd), lung and artery are thought to undergo the age-dependant accumulation of damage by chronic exposure to mechanisms such as reactive oxygen species, proteases and glycation. |
2022-05-26 |
2023-08-13 |
mouse |
| Cosimo Ligorio, Judith A Hoyland, Alberto Saian. Self-Assembling Peptide Hydrogels as Functional Tools to Tackle Intervertebral Disc Degeneration. Gels (Basel, Switzerland). vol 8. issue 4. 2022-04-21. PMID:35448112. |
during degeneration, the ivd is hit by a cell-driven cascade of events, which progressively lead to extracellular matrix (ecm) degradation, chronic inflammation, and pain. |
2022-04-21 |
2023-08-13 |
Not clear |
| Kunihiko Miyazaki, Shingo Miyazaki, Takashi Yurube, Yoshiki Takeoka, Yutaro Kanda, Zhongying Zhang, Yuji Kakiuchi, Ryu Tsujimoto, Hiroki Ohnishi, Tomoya Matsuo, Masao Ryu, Ryosuke Kuroda, Kenichiro Kakutan. Protective Effects of Growth Differentiation Factor-6 on the Intervertebral Disc: An In Vitro and In Vivo Study. Cells. vol 11. issue 7. 2022-04-12. PMID:35406739. |
growth differentiation factors (gdfs) regulate homeostasis by amplifying extracellular matrix anabolism and inhibiting pro-inflammatory cytokine production in the intervertebral disc (ivd). |
2022-04-12 |
2023-08-13 |
human |
| Marianne Lintz, Remy E Walk, Simon Y Tang, Lawrence J Bonassa. The degenerative impact of hyperglycemia on the structure and mechanics of developing murine intervertebral discs. JOR spine. vol 5. issue 1. 2022-04-07. PMID:35386755. |
diabetes has long been implicated as a major risk factor for intervertebral disc (ivd) degeneration, interfering with molecular signaling and matrix biochemistry, which ultimately aggravates the progression of the disease. |
2022-04-07 |
2023-08-13 |
Not clear |
| Tori Kroon, Neharika Bhadouria, Paul Niziolek, Daniel Edwards, Erica L Clinkenbeard, Alexander Robling, Nilsson Holgui. Suppression of sost/sclerostin and dikkopf-1 augment intervertebral disc structure in mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2022-03-12. PMID:35278242. |
intervertebral disc (ivd) degeneration is a leading cause of low back pain, characterized by accelerated extracellular matrix breakdown and ivd height loss but there is no approved pharmacological therapeutic. |
2022-03-12 |
2023-08-13 |
mouse |
| Weihang Li, Shilei Zhang, Dong Wang, Huan Zhang, Quan Shi, Yuyuan Zhang, Mo Wang, Ziyi Ding, Songjie Xu, Bo Gao, Ming Ya. Exosomes Immunity Strategy: A Novel Approach for Ameliorating Intervertebral Disc Degeneration. Frontiers in cell and developmental biology. vol 9. 2022-02-28. PMID:35223870. |
the pathology of idd is based on the impaired homeostasis of catabolism and anabolism in the extracellular matrix (ecm), uncontrolled activation of immunologic cascades, dysfunction, and loss of nucleus pulposus (np) cells in addition to dynamic cellular and biochemical alterations in the microenvironment of intervertebral disc (ivd). |
2022-02-28 |
2023-08-13 |
Not clear |
| Joo Han Kim, Chang Hwa Ham, Woo-Keun Kwo. Current Knowledge and Future Therapeutic Prospects in Symptomatic Intervertebral Disc Degeneration. Yonsei medical journal. vol 63. issue 3. 2022-02-20. PMID:35184422. |
in this article, we describe the molecular basis of symptomatic ivd degenerative disc diseases (ddds), emphasizing the role of degeneration, inflammation, angiogenesis, and extracellular matrix (ecm) regulation during this process. |
2022-02-20 |
2023-08-13 |
Not clear |
| Margaret M Smith, Anthony J Hayes, James Melros. Pentosan Polysulphate (PPS), a Semi-Synthetic Heparinoid DMOAD With Roles in Intervertebral Disc Repair Biology emulating The Stem Cell Instructive and Tissue Reparative Properties of Heparan Sulphate. Stem cells and development. 2022-02-01. PMID:35102748. |
the ivd contains small cell membrane hs-proteoglycans (hspgs) such as syndecan, and glypican and a large multifunctional hs/chondroitin sulphate (cs) hybrid proteoglycan (hspg2/perlecan) that have important matrix stabilising properties and sequester, control and present growth factors from the fgf, vegf, pdgf and bmp families to cellular receptors to promote cell proliferation, differentiation and matrix synthesis. |
2022-02-01 |
2023-08-13 |
Not clear |
| Shuo Zhang, Peng Wang, Binwu Hu, Weijian Liu, Xiao Lv, Songfeng Chen, Zengwu Sha. HSP90 Inhibitor 17-AAG Attenuates Nucleus Pulposus Inflammation and Catabolism Induced by M1-Polarized Macrophages. Frontiers in cell and developmental biology. vol 9. 2022-01-21. PMID:35059401. |
immunohistochemical staining of degenerated human ivd samples showed massive infiltration of macrophages, especially m1 phenotype, as well as elevated levels of interleukin (il)-1β, tumor necrosis factor (tnf)-α and matrix metalloproteinase (mmp)13. |
2022-01-21 |
2023-08-13 |
human |
| A L Castro, C Ribeiro-Machado, C M Oliveira, G Q Teixeira, C Neidlinger-Wilke, P Pereira, R Vaz, M A Barbosa, R M Gonçalve. Fibrotic alterations in human annulus fibrosus correlate with progression of intervertebral disc herniation. Arthritis research & therapy. vol 24. issue 1. 2022-01-18. PMID:35039075. |
ivd herniation involves cellular and extracellular matrix (ecm) alterations that have been associated with tissue fibrosis, although still poorly investigated. |
2022-01-18 |
2023-08-13 |
human |
| Ozge Uysal, Elif Arslan, Gulcihan Gulseren, Mustafa Cemil Kilinc, Ihsan Dogan, Hakan Ozalp, Yusuf Sukru Caglar, Mustafa O Guler, Ayse B Tekina. Collagen Peptide Presenting Nanofibrous Scaffold for Intervertebral Disc Regeneration. ACS applied bio materials. vol 2. issue 4. 2022-01-14. PMID:35026903. |
here, we demonstrate a collagen peptide presenting nanofiber scaffold to mimic the structure and function of the natural extracellular matrix of the tissue for ivd regeneration. |
2022-01-14 |
2023-08-13 |
rabbit |
| Ajay Matta, William Mark Erwi. Current Status of the Instructional Cues Provided by Notochordal Cells in Novel Disc Repair Strategies. International journal of molecular sciences. vol 23. issue 1. 2022-01-11. PMID:35008853. |
further, notochordal cell-rich ivd nps maintain a stable, healthy extracellular matrix whereas notochordal cell-deficient ivds result in a biomechanically and extracellular matrix defective phenotype. |
2022-01-11 |
2023-08-13 |
human |
| Wei Guo, Luzia Douma, Ming Hsien Hu, David Eglin, Mauro Alini, Amra Šećerović, Sibylle Grad, Xinsheng Peng, Xuenong Zou, Matteo D'Este, Marianna Perogli. Hyaluronic acid-based interpenetrating network hydrogel as a cell carrier for nucleus pulposus repair. Carbohydrate polymers. vol 277. 2021-12-11. PMID:34893245. |
when implanted in an ex vivo ivd organ culture model, the ipn supported cell viability, phenotype expression of encapsulated np cells and ivd matrix production over four weeks under physiological loading. |
2021-12-11 |
2023-08-13 |
Not clear |
| An-Gi Kim, Tae-Won Kim, Woo-Keun Kwon, Kwang-Ho Lee, Sehoon Jeong, Min-Ho Hwang, Hyuk Cho. Microfluidic Chip with Low Constant-Current Stimulation (LCCS) Platform: Human Nucleus Pulposus Degeneration In Vitro Model for Symptomatic Intervertebral Disc. Micromachines. vol 12. issue 11. 2021-11-30. PMID:34832700. |
this phenomenon is caused by several processes, including matrix degradation in ivd tissues, which is mediated by matrix metalloproteinases (mmps) and inflammatory responses, which can be mediated by interactions among immune cells, such as macrophages and ivd cells. |
2021-11-30 |
2023-08-13 |
human |
| Vera Francisco, Jesús Pino, Miguel Ángel González-Gay, Francisca Lago, Jaro Karppinen, Osmo Tervonen, Ali Mobasheri, Oreste Gualill. A new immunometabolic perspective of intervertebral disc degeneration. Nature reviews. Rheumatology. 2021-11-30. PMID:34845360. |
ivd degeneration, like osteoarthritis, is a common comorbidity in patients with obesity and type 2 diabetes mellitus, two metabolic syndrome pathological conditions in which adipokines are important promoters of low-grade inflammation, extracellular matrix degradation and fibrosis. |
2021-11-30 |
2023-08-13 |
Not clear |
| Jiaxin Chen, Haifeng Zhu, Yutao Zhu, Chenchen Zhao, Shengyu Wang, Yixin Zheng, Ziang Xie, Yang Jin, Honghai Song, Linjun Yang, Jin Zhang, Jiayong Dai, Zhijun Hu, Huaiyu Wan. Injectable self-healing hydrogel with siRNA delivery property for sustained STING silencing and enhanced therapy of intervertebral disc degeneration. Bioactive materials. vol 9. 2021-11-26. PMID:34820553. |
inflammatory responses of nucleus pulposus (np) can induce imbalanced anabolism and catabolism of extracellular matrix, and the cytosolic dsdna accumulation and sting-nf-κb pathway activation found in np inflammation are considered as fairly important cause of intervertebral disc (ivd) degeneration. |
2021-11-26 |
2023-08-13 |
Not clear |
| Devante A Horne, Peter D Jones, Matthew S Adams, Jeffrey C Lotz, Chris J Diederic. LIPUS far-field exposimetry system for uniform stimulation of tissues in-vitro: development and validation with bovine intervertebral disc cells. Biomedical physics & engineering express. vol 6. issue 3. 2021-11-15. PMID:33438678. |
therapeutic low-intensity pulsed ultrasound (lipus) has been applied clinically for bone fracture healing and has been shown to stimulate extracellular matrix (ecm) metabolism in numerous soft tissues including intervertebral disc (ivd). |
2021-11-15 |
2023-08-13 |
cattle |