| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shuichi Mizuno, Gianluca Vadala, James D Kan. Biological Therapeutic Modalities for Intervertebral Disc Diseases:An Orthoregeneration Network (ON) Foundation Review. Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association. 2023-11-02. PMID:37918699. |
promising and established treatment modalities include repair of the annulus fibrosis; injection of expanded or non-expanded autologous or allogenic cells that are chondrogenic or from a stem cell lineage used to promote matrix tissue regeneration of the intervertebral disc (ivd), including nucleus pulpous cells and mesenchymal stem cells isolated from bone marrow, umbilical cord blood, or adipose tissue; and injection of platelet rich plasma, platelet rich fibrin, or fibrin sealant. |
2023-11-02 |
2023-11-08 |
Not clear |
| Shirley Tang, Connor Gantt, Ana Salazar Puerta, Lucy Bodine, Safdar Khan, Natalia Higuita-Castro, Devina Purmessu. Nonviral overexpression of Scleraxis or Mohawk drives reprogramming of degenerate human annulus fibrosus cells from a diseased to a healthy phenotype. JOR spine. vol 6. issue 3. 2023-10-02. PMID:37780832. |
the annulus fibrosus (af) plays a critical role in maintaining ivd structure/function and undergoes degenerative changes such as matrix catabolism and inflammation. |
2023-10-02 |
2023-10-07 |
human |
| Takashi Ohnishi, Kentaro Homan, Akira Fukushima, Daisuke Ukeba, Norimasa Iwasaki, Hideki Sud. A Review: Methodologies to Promote the Differentiation of Mesenchymal Stem Cells for the Regeneration of Intervertebral Disc Cells Following Intervertebral Disc Degeneration. Cells. vol 12. issue 17. 2023-09-08. PMID:37681893. |
hence, the ultimate goal of msc therapy is to recover ivd cells and consequently regenerate the extracellular matrix of degenerated ivds. |
2023-09-08 |
2023-10-07 |
Not clear |
| Kenichiro Kakutani, Takashi Yurube, Howard S An, Minoru Doita, Koichi Masud. Cytokine Inhibitors Upregulate Extracellular Matrix Anabolism of Human Intervertebral Discs under Alginate Beads and Alginate-Embedded Explant Cultures. International journal of molecular sciences. vol 24. issue 15. 2023-08-12. PMID:37569715. |
we investigated the effects of the cytokine inhibitors il-1 receptor antagonist (il-1ra) and soluble tumor necrosis factor receptor-1 (stnfr1) on the extracellular matrix metabolism of human intervertebral discs (ivds) and the roles of il-1β and tnf in the homeostasis of ivd cells. |
2023-08-12 |
2023-08-16 |
human |
| Tara C Schmitz, Bas van Genabeek, Maarten J Pouderoijen, Henk M Janssen, Marina van Doeselaar, João F Crispim, Marianna A Tryfonidou, Keita It. Semi-synthetic degradable notochordal cell-derived matrix hydrogel for use in degenerated intervertebral discs: Initial in vitro characterization. Journal of biomedical materials research. Part A. 2023-08-04. PMID:37539663. |
recently, we established a protocol for decellularization of notochordal cell derived matrix (ncm) and found that it can provide regenerative cues to nucleus pulposus cells of the ivd. |
2023-08-04 |
2023-08-14 |
Not clear |
| Evgeny A Idelevich, Betty Nedow, Marcus Vollmer, Karsten Becke. Evaluation of a Novel Benchtop Tool for Acceleration of Sample Preparation for MALDI-TOF Mass Spectrometry. Journal of clinical microbiology. 2023-07-26. PMID:37493547. |
this study evaluated the application of a multipurpose benchtop tool, mbt fast shuttle ivd, for accelerated drying of liquid assay components (matrix, formic acid, and/or sample) on a maldi target. |
2023-07-26 |
2023-08-14 |
Not clear |
| Michal Dudek, Honor Morris, Natalie Rogers, Dharshika Rj Pathiranage, Sujitha Saba Raj, Danny Chan, Karl E Kadler, Judith Hoyland, Qing-Jun Men. The clock transcription factor BMAL1 is a key regulator of extracellular matrix homeostasis and cell fate in the intervertebral disc. Matrix biology : journal of the International Society for Matrix Biology. 2023-07-26. PMID:37495193. |
the intervertebral disc (ivd) in the spine contains circadian clocks which control ∼6% of the transcriptome in a rhythmic manner, including key genes involved in extracellular matrix (ecm) homeostasis. |
2023-07-26 |
2023-08-14 |
mouse |
| Weifeng Li, Pinghui Zhou, Bomin Yan, Meiyao Qi, Yedan Chen, Lijun Shang, Jianzhong Guan, Li Zhang, Yingji Ma. Disc regeneration by injectable fucoidan-methacrylated dextran hydrogels through mechanical transduction and macrophage immunomodulation. Journal of tissue engineering. vol 14. 2023-07-10. PMID:37427012. |
additionally, activation of the caveolin1-yes-associated protein (cav1-yap) mechanotransduction axis promoted extracellular matrix (ecm) metabolism and thus jointly promoted ivd regeneration. |
2023-07-10 |
2023-08-14 |
rat |
| Joshua D Stover, Matthew A R Trone, Jacob Weston, Christian Lewis, Hunter Levis, Matthew Philippi, Michelle Zeidan, Brandon Lawrence, Robby D Bowle. Therapeutic TNF-alpha Delivery After CRISPR Receptor Modulation in the Intervertebral Disc. bioRxiv : the preprint server for biology. 2023-07-03. PMID:37398456. |
disc degeneration, a leading contributor to lbp, can be characterized by the breakdown of the extracellular matrix of the intervertebral disc (ivd), disc height loss, and inflammation. |
2023-07-03 |
2023-08-14 |
Not clear |
| Xiaosong Zou, Xingmin Zhang, Song Han, Lin Wei, Zhi Zheng, Yongjie Wang, Jingguo Xin, Shaokun Zhan. Pathogenesis and therapeutic implications of matrix metalloproteinases in intervertebral disc degeneration: A comprehensive review. Biochimie. 2023-06-02. PMID:37268183. |
the extracellular matrix (ecm) is the structural foundation of the biomechanical properties of ivd, and its degradation is the main pathological characteristic of idd. |
2023-06-02 |
2023-08-14 |
Not clear |
| Zehao Chen, Zhendong Lv, Yaping Zhuang, Qimanguli Saiding, Wu Yang, Wei Xiong, Zhen Zhang, Hao Chen, Wenguo Cui, Yuhui Zhan. Mechanical Signal-Tailored Hydrogel Microspheres Recruit and Train Stem Cells for Precise Differentiation. Advanced materials (Deerfield Beach, Fla.). 2023-05-25. PMID:37230467. |
the combination of the soft matrix (2kpa) and low ligand density (2 μg/ml) could support the nucleus pulposus (np)-like differentiation of intervertebral disc (ivd) progenitor/stem cells by translocating yes-associated protein (yap), without the addition of inducible biochemical factors. |
2023-05-25 |
2023-08-14 |
Not clear |
| Ryan M Jarrah, Maria D Astudillo Potes, Xheneta Vitija, Sulaman Durrani, Abdul Karim Ghaith, William Mualem, Cameron Zamanian, Archis R Bhandarkar, Mohamad Bydo. Alginate hydrogels: A potential tissue engineering intervention for intervertebral disc degeneration. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 113. 2023-05-09. PMID:37159956. |
alginate hydrogels are an example of such a biomaterial that is biocompatible and can be tailored to mimic the native extracellular matrix of the ivd. |
2023-05-09 |
2023-08-14 |
Not clear |
| Feng Wang, Kai Guo, Liping Nan, Shuguang Wang, Jiawei Lu, Qiang Wang, Zhaoyu Ba, Yufeng Huang, Desheng W. Kartogenin-loaded hydrogel promotes intervertebral disc repair via protecting MSCs against reactive oxygen species microenvironment by Nrf2/TXNIP/NLRP3 axis. Free radical biology & medicine. 2023-05-06. PMID:37149010. |
furthermore, the composite hydrogel combined with adscs attenuated the in vivo degeneration of rat ivds, maintained ivd tissue integrity and accelerated the synthesis of np-like extracellular matrix. |
2023-05-06 |
2023-08-14 |
rat |
| Marta Empere, Xujia Wang, Carina Prein, Anders Aspberg, Markus Moser, Toshitaka Oohashi, Hauke Clausen-Schaumann, Attila Aszodi, Paolo Alberto. Aggrecan governs intervertebral discs development by providing critical mechanical cues of the extracellular matrix. Frontiers in bioengineering and biotechnology. vol 11. 2023-03-20. PMID:36937743. |
the extracellular matrix (ecm) of the ivd undergoes degenerative changes during aging, misuse or trauma, which inevitably alter the biochemical and biomechanical properties of the tissue. |
2023-03-20 |
2023-08-14 |
mouse |
| Fengfeng Wang, Chi Wai Cheung, Stanley Sau Ching Won. Regenerative medicine for the treatment of chronic low back pain: a narrative review. The Journal of international medical research. vol 51. issue 2. 2023-02-21. PMID:36802994. |
growth factors may stimulate the synthesis of extracellular matrix and attenuate or reverse the degenerative process in ivd, while platelet-rich plasma, which contains multiple growth factors, is thought to be a promising alternative therapy for ivd degeneration. |
2023-02-21 |
2023-08-14 |
Not clear |
| Liang Shang, Hui Ma, Xiao Zhang, Runze Mao, Cunyou Ma, Zhi Rua. Docosahexaenoic acid alleviates the excessive degradation of extracellular matrix in the nucleus pulposus by reducing the content of lncRNA NEAT1 to prevent the progression of intervertebral disc degeneration. Clinical and experimental pharmacology & physiology. 2023-02-03. PMID:36732892. |
however, damage to the stress-bearing system in the intervertebral disc (ivd) mediated by the excessive decomposition of extracellular matrix (ecm) in nucleus pulposus (np) cells caused by local stimulation is widely considered the core pathological process underlying ivdd. |
2023-02-03 |
2023-08-14 |
human |
| Sebastian Höflsauer, Florian Christof Bonnaire, Charlotte Emma Bamberger, Marina Danalache, Martina Feierabend, Ulf Krister Hofman. Changes in stiffness of the extracellular and pericellular matrix in the anulus fibrosus of lumbar intervertebral discs over the course of degeneration. Frontiers in bioengineering and biotechnology. vol 10. 2023-01-09. PMID:36619385. |
while a progressive structural and functional degradation of the extracellular (ecm) and pericellular (pcm) matrix occurs in osteoarthritic cartilage, these processes have not yet been biomechanically elucidated in the ivd. |
2023-01-09 |
2023-08-14 |
human |
| Changli Zhang, Katherine M Joseph, Nazir M Khan, Martha Elena Diaz-Hernandez, Hicham Drissi, Svenja Illien-Junge. PHLPP1 deficiency protects against age-related intervertebral disc degeneration. JOR spine. vol 5. issue 4. 2023-01-05. PMID:36601379. |
hallmarks of ivd degeneration include cell loss and extracellular matrix degradation. |
2023-01-05 |
2023-08-14 |
Not clear |
| Philip Poillot, Joseph W Snuggs, Christine L Le Maitre, Jacques M Huygh. L-type Voltage-Gated calcium channels partly mediate Mechanotransduction in the intervertebral disc. JOR spine. vol 5. issue 4. 2023-01-05. PMID:36601377. |
this evidence implicates a similar important role for vgics in ivd matrix turnover. |
2023-01-05 |
2023-08-14 |
Not clear |
| Hu Qian, Li He, Zhimin Ye, Zairong Wei, Jun A. Decellularized matrix for repairing intervertebral disc degeneration: Fabrication methods, applications and animal models. Materials today. Bio. vol 18. 2023-01-02. PMID:36590980. |
by contrast, the extracellular matrix (ecm), including collagen and glycosaminoglycans, which are well retained, have been extensively studied in ivd regeneration. |
2023-01-02 |
2023-08-14 |
Not clear |