| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fackson Mwale, Koichi Masuda, Michael P Grant, Laura M Epure, Kenji Kato, Shingo Miyazaki, Kevin Cheng, Junichi Yamada, Won C Bae, Carol Muehleman, Peter J Roughley, John Antonio. Short Link N promotes disc repair in a rabbit model of disc degeneration. Arthritis research & therapy. vol 20. issue 1. 2019-04-15. PMID:30157962. |
the degeneration of the intervertebral disc (ivd) is characterized by proteolytic degradation of the extracellular matrix, and its repair requires the production of an extracellular matrix with a high proteoglycan-to-collagen ratio characteristic of a nucleus pulposus (np)-like phenotype in vivo. |
2019-04-15 |
2023-08-13 |
rabbit |
| Paolo E Palacio-Mancheno, Thomas W Evashwick-Rogler, Damien M Laudier, Devina Purmessur, James C Iatridi. Hyperosmolarity induces notochordal cell differentiation with aquaporin3 upregulation and reduced N-cadherin expression. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 36. issue 2. 2019-03-19. PMID:28853179. |
a mouse ivd organ culture model was used to test the hypotheses that hyperosmotic overloading will induce np maturation with transition of ncs to snpcs while also increasing matrix accumulation and altering osmoregulatory and mechanotransductive proteins. |
2019-03-19 |
2023-08-13 |
mouse |
| Lilong Du, Qiang Yang, Jiamin Zhang, Meifeng Zhu, Xinlong Ma, Yang Zhang, Lianyong Wang, Baoshan X. Engineering a biomimetic integrated scaffold for intervertebral disc replacement. Materials science & engineering. C, Materials for biological applications. vol 96. 2019-03-13. PMID:30606562. |
however, simulating the cellular and matrix structures and function of the complex structure of ivd is still a critical challenge. |
2019-03-13 |
2023-08-13 |
mouse |
| Lilong Du, Qiang Yang, Jiamin Zhang, Meifeng Zhu, Xinlong Ma, Yang Zhang, Lianyong Wang, Baoshan X. Engineering a biomimetic integrated scaffold for intervertebral disc replacement. Materials science & engineering. C, Materials for biological applications. vol 96. 2019-03-13. PMID:30606562. |
engineered ivd implants showed progressive tissue formation over time after subcutaneous implantation in nude mice, which were indicated by deposition and organization of extracellular matrix and enhanced mechanical properties. |
2019-03-13 |
2023-08-13 |
mouse |
| Ying Zhang, Chi Xiong, Mateusz Kudelko, Yan Li, Cheng Wang, Yuk Lun Wong, Vivian Tam, Muhammad Farooq Rai, James Cheverud, Heather A Lawson, Linda Sandell, Wilson C W Chan, Kathryn S E Cheah, Pak C Sham, Danny Cha. Early onset of disc degeneration in SM/J mice is associated with changes in ion transport systems and fibrotic events. Matrix biology : journal of the International Society for Matrix Biology. vol 70. 2019-02-25. PMID:29649547. |
further, the extracellular matrix changes in the np are consistent with ivd degeneration. |
2019-02-25 |
2023-08-13 |
mouse |
| Hua Wang, Peiheng He, Hehai Pan, Jun Long, Jianru Wang, Zemin Li, Hui Liu, Weiying Jiang, Zhaomin Zhen. Circular RNA circ-4099 is induced by TNF-α and regulates ECM synthesis by blocking miR-616-5p inhibition of Sox9 in intervertebral disc degeneration. Experimental & molecular medicine. vol 50. issue 4. 2019-02-11. PMID:29651107. |
circ-4099 may play a role in a protective mechanism and be part of a compensatory response that maintains the synthesis and secretion of the extracellular matrix in np cells and might be a protective factor in ivd degeneration as well as restore np cell function. |
2019-02-11 |
2023-08-13 |
human |
| Ruhang Tang, Liufang Jing, Vincent P Willard, Chia-Lung Wu, Farshid Guilak, Jun Chen, Lori A Setto. Differentiation of human induced pluripotent stem cells into nucleus pulposus-like cells. Stem cell research & therapy. vol 9. issue 1. 2019-01-28. PMID:29523190. |
intervertebral disc (ivd) degeneration is characterized by an early decrease in cellularity of the nucleus pulposus (np) region, and associated extracellular matrix changes, reduced hydration, and progressive degeneration. |
2019-01-28 |
2023-08-13 |
human |
| A Sadowska, T Kameda, O Krupkova, K Wuertz-Koza. Osmosensing, osmosignalling and inflammation: how intervertebral disc cells respond to altered osmolarity. European cells & materials. vol 36. 2019-01-14. PMID:30452080. |
age- and degeneration-induced degradation of the ivd's extracellular matrix causes osmotic imbalance, which, together with an altered function of cellular receptors and signalling pathways, instigates local osmotic stress. |
2019-01-14 |
2023-08-13 |
Not clear |
| Kalliopi Alpantaki, Alexandros Zafiropoulos, Melpomeni Tseliou, Eirini Vasarmidi, George Sourvino. Herpes simplex virus type-1 infection affects the expression of extracellular matrix components in human nucleus pulposus cells. Virus research. vol 259. 2019-01-10. PMID:30339788. |
intervertebral disc (ivd) degeneration has a complex multifactorial origin and it is tightly associated with changes in the secretion of proteoglycans and collagen of the nucleus pulposus (np) extracellular matrix. |
2019-01-10 |
2023-08-13 |
human |
| Stephen M Richardson, Francesca E Ludwinski, Kanna K Gnanalingham, Ross A Atkinson, Anthony J Freemont, Judith A Hoylan. Notochordal and nucleus pulposus marker expression is maintained by sub-populations of adult human nucleus pulposus cells through aging and degeneration. Scientific reports. vol 7. issue 1. 2018-12-17. PMID:28473691. |
the nucleus pulposus (np) of the intervertebral disc (ivd) demonstrates substantial changes in cell and matrix composition with both ageing and degeneration. |
2018-12-17 |
2023-08-13 |
human |
| Jian-Feng Zhang, Gang-Liang Wang, Zhi-Jie Zhou, Xiang-Qian Fang, Shuai Chen, Shun-Wu Fa. Expression of Matrix Metalloproteinases, Tissue Inhibitors of Metalloproteinases, and Interleukins in Vertebral Cartilage Endplate. Orthopaedic surgery. vol 10. issue 4. 2018-12-17. PMID:30474324. |
however, the expression pattern of pro-inflammatory factors, matrix metalloproteinases (mmp), and tissue inhibitors of metalloproteinases (timp) in the cartilage endplates (cep) of intervertebral discs (ivd) is not understood. |
2018-12-17 |
2023-08-13 |
Not clear |
| Xiaobin Wang, Bing Wang, Mingxiang Zou, Jing Li, Guohua Lü, Qianshi Zhang, Fubin Liu, Chang L. CircSEMA4B targets miR-431 modulating IL-1β-induced degradative changes in nucleus pulposus cells in intervertebral disc degeneration via Wnt pathway. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 11. 2018-12-11. PMID:30251693. |
intervertebral disc (ivd) degeneration (idd), characterized by elevated levels of proinflammatory mediators, increased aggrecan and collagen degradation, and increased degradation of extracellular matrix (ecm), has been widely regarded as a significant contributor to low back pain. |
2018-12-11 |
2023-08-13 |
Not clear |
| Qiang Zhang, Yiping Weng, Yuqing Jiang, Shujie Zhao, Dong Zhou, Nanwei X. Overexpression of miR-140-5p inhibits lipopolysaccharide-induced human intervertebral disc inflammation and degeneration by downregulating toll-like receptor 4. Oncology reports. vol 40. issue 2. 2018-10-17. PMID:29901170. |
it has been reported that tlr4 activation resulted in the upregulation of a coordinated set of proinflammatory mediators and inhibition of matrix expression in the intervertebral disc (ivd). |
2018-10-17 |
2023-08-13 |
human |
| Rahel D May, Daniela A Frauchiger, Christoph E Albers, Lorin M Benneker, Sandro Kohl, Benjamin Gantenbei. Inhibitory Effects of Human Primary Intervertebral Disc Cells on Human Primary Osteoblasts in a Co-Culture System. International journal of molecular sciences. vol 19. issue 4. 2018-09-11. PMID:29652862. |
although we could see a trend in lower matrix mineralization in ob co-cultured with ivd cells, results of alkaline phosphatase (alp) activity and gene expression of major bone genes were inconclusive. |
2018-09-11 |
2023-08-13 |
human |
| Chencheng Feng, Minghui Yang, Yang Zhang, Minghong Lan, Bo Huang, Huan Liu, Yue Zho. Cyclic mechanical tension reinforces DNA damage and activates the p53-p21-Rb pathway to induce premature senescence of nucleus pulposus cells. International journal of molecular medicine. vol 41. issue 6. 2018-09-10. PMID:29512682. |
notably, the pathological process of idd is mediated by the phenotypic shift of ivd cells from an extracellular matrix anabolic phenotype to a catabolic and pro-inflammatory phenotype. |
2018-09-10 |
2023-08-13 |
Not clear |
| Andrea Friedmann, Felix Goehre, Christopher Ludtka, Thomas Mendel, Hans-Joerg Meisel, Andreas Heilmann, Stefan Schwa. Microstructure analysis method for evaluating degenerated intervertebral disc tissue. Micron (Oxford, England : 1993). vol 92. 2018-09-04. PMID:27871028. |
in this work, sequestered ivd tissue was successfully characterized using histology, light microscopy, and scanning electron microscopy (sem) to quantitatively evaluate parameters of interest for intervertebral disc degeneration (idd) such as delamination of the collagenous matrix, cell density, cell size, and extra cellular matrix (ecm) thickness. |
2018-09-04 |
2023-08-13 |
Not clear |
| Andrea Friedmann, Felix Goehre, Christopher Ludtka, Thomas Mendel, Hans-Joerg Meisel, Andreas Heilmann, Stefan Schwa. Microstructure analysis method for evaluating degenerated intervertebral disc tissue. Micron (Oxford, England : 1993). vol 92. 2018-09-04. PMID:27871028. |
additional qualitative parameters investigated included matrix fibration and irregularity, neovascularization of the ivd, granular inclusions in the matrix, and cell cluster formation. |
2018-09-04 |
2023-08-13 |
Not clear |
| Yu-Fu Wang, Howard B Levene, Weiyong Gu, C -Y Charles Huan. Enhancement of Energy Production of the Intervertebral Disc by the Implantation of Polyurethane Mass Transfer Devices. Annals of biomedical engineering. vol 45. issue 9. 2018-07-10. PMID:28612187. |
most cellular activities in the ivd (e.g., cell proliferation and extracellular matrix production) are mainly driven by adenosine-5'-triphosphate (atp) which is the main energy currency. |
2018-07-10 |
2023-08-13 |
Not clear |
| Sotiris-Spyros Vamvakas, Eleni Mavrogonatou, Dimitris Kletsa. Human nucleus pulposus intervertebral disc cells becoming senescent using different treatments exhibit a similar transcriptional profile of catabolic and inflammatory genes. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. vol 26. issue 8. 2018-03-21. PMID:28646455. |
chronic low back pain has been associated with intervertebral disc (ivd) degeneration, which is characterized by the accumulation of extracellular matrix (ecm)-degrading proteases and inflammatory molecules in the degenerate tissue. |
2018-03-21 |
2023-08-13 |
human |
| Masoud Ghorbani, Jafar Ai, Mohammad Reza Nourani, Mahmoud Azami, Batool Hashemi Beni, Shiva Asadpour, Sima Bordba. Injectable natural polymer compound for tissue engineering of intervertebral disc: In vitro study. Materials science & engineering. C, Materials for biological applications. vol 80. 2018-02-27. PMID:28866193. |
injectable hydrogel is one of the great interests for tissue engineering and cell encapsulation specially for intervertebral (ivd) affecting rate of regeneration success, in this study we assessed viscoelastic properties of a chitosan-β glycerophosphate-hyaluronic acid, chondroitin-6-sulfate, type 2 of collagen, gelatin, fibroin silk (ch-β-gp-ha-cs-col-ge-fs) hydrogel which was named as np hydrogel that is natural extracellular matrix of ivd. |
2018-02-27 |
2023-08-13 |
Not clear |