| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrew Tsz Hang Choy, Barbara Pui Cha. A Structurally and Functionally Biomimetic Biphasic Scaffold for Intervertebral Disc Tissue Engineering. PloS one. vol 10. issue 6. 2016-05-10. PMID:26115332. |
here, a biphasic scaffold was fabricated with collagen and glycosaminoglycans (gags), two of the most abundant extracellular matrix components in the ivd. |
2016-05-10 |
2023-08-13 |
Not clear |
| Wei Yang, Xiao-Hua Yu, Cheng Wang, Wen-Si He, Shu-Jun Zhang, Yi-Guo Yan, Jian Zhang, Yong-Xiao Xiang, Wen-Jun Wan. Interleukin-1β in intervertebral disk degeneration. Clinica chimica acta; international journal of clinical chemistry. vol 450. 2016-05-03. PMID:26341894. |
il-1β is highly expressed in degenerative intervertebral disk (ivd) tissues and cells, and it has been shown to be involved in multiple pathological processes during disk degeneration, including inflammatory responses, matrix destruction, angiogenesis and innervation, cellular apoptosis, oxidative stress and cellular senescence. |
2016-05-03 |
2023-08-13 |
Not clear |
| Cheng Wang, Wen-Jun Wang, Yi-Guo Yan, Yong-Xiao Xiang, Jian Zhang, Zhi-Han Tang, Zhi-Sheng Jian. MicroRNAs: New players in intervertebral disc degeneration. Clinica chimica acta; international journal of clinical chemistry. vol 450. 2016-05-03. PMID:26368266. |
chronic low back pain is generally attributed to intervertebral disc (ivd) degeneration (idd), which is closely associated with apoptosis, extracellular matrix (ecm) disruption, cell proliferation and inflammatory response. |
2016-05-03 |
2023-08-13 |
human |
| Nicole Willems, Frances C Bach, Saskia G M Plomp, Mattie H P van Rijen, Jeannette Wolfswinkel, Guy C M Grinwis, Clemens Bos, Gustav J Strijkers, Wouter J A Dhert, Björn P Meij, Laura B Creemers, Marianna A Tryfonido. Intradiscal application of rhBMP-7 does not induce regeneration in a canine model of spontaneous intervertebral disc degeneration. Arthritis research & therapy. vol 17. 2016-03-25. PMID:26013758. |
recombinant human bone morphogenetic protein 7 (rhbmp-7) has been shown to stimulate matrix production by ivd cells in vitro and in vivo in animal models of induced ivd degeneration. |
2016-03-25 |
2023-08-13 |
human |
| Yun-peng Zhao, Qing-yun Tian, Ben Liu, Jason Cuellar, Brendon Richbourgh, Tang-hong Jia, Chuan-ju Li. Progranulin knockout accelerates intervertebral disc degeneration in aging mice. Scientific reports. vol 5. 2016-02-24. PMID:25777988. |
moreover, pgrn knockout mice exhibited accelerated ivd matrix degeneration, abnormal bone formation and exaggerated bone resorption in vertebra with aging. |
2016-02-24 |
2023-08-13 |
mouse |
| Osamu Sakamoto, Natsuko Arai-Ichinoi, Hiroshi Mitsubuchi, Yasutsugu Chinen, Hidenori Haruna, Hidehiko Maruyama, Hidenori Sugawara, Shigeo Kur. Phenotypic Variability and Newly Identified Mutations of the IVD Gene in Japanese Patients with Isovaleric Acidemia. The Tohoku journal of experimental medicine. vol 236. issue 2. 2016-02-17. PMID:26018748. |
it is caused by a deficiency in isovaleryl-coa dehydrogenase (ivd), a mitochondrial matrix enzyme that catalyzes the oxidation of isovaleryl-coa to 3-methylcrotonyl-coa. |
2016-02-17 |
2023-08-13 |
human |
| Baoshan Xu, Haiwei Xu, Yaohong Wu, Xiulan Li, Yang Zhang, Xinlong Ma, Qiang Yan. Intervertebral Disc Tissue Engineering with Natural Extracellular Matrix-Derived Biphasic Composite Scaffolds. PloS one. vol 10. issue 4. 2016-02-09. PMID:25894203. |
in present study we developed a novel integrated biphasic ivd scaffold using a simple freeze-drying and cross-linking technique of pig bone matrix gelatin (bmg) for the outer annulus fibrosus (af) phase and pig acellular cartilage ecm (acecm) for the inner nucleus pulposus (np) phase. |
2016-02-09 |
2023-08-13 |
mouse |
| Aiqun Wei, Bojiang Shen, Lisa Williams, Ashish Diwa. Mesenchymal stem cells: potential application in intervertebral disc regeneration. Translational pediatrics. vol 3. issue 2. 2016-02-02. PMID:26835326. |
degeneration of the intervertebral disc (ivd) is a major pathological process implicated in low back pain, which is characterized by cellular apoptosis and senescence with reduced synthesis of extracellular matrix (ecm). |
2016-02-02 |
2023-08-13 |
Not clear |
| Alessandra Colombini, Silvia Lopa, Cristina Ceriani, Arianna B Lovati, Samantha J Croiset, Alessia Di Giancamillo, Giovanni Lombardi, Giuseppe Banfi, Matteo Morett. In vitro characterization and in vivo behavior of human nucleus pulposus and annulus fibrosus cells in clinical-grade fibrin and collagen-enriched fibrin gels. Tissue engineering. Part A. vol 21. issue 3-4. 2015-11-16. PMID:25236589. |
fibrin-based scaffolds as cell carriers are promising candidates in ivd tissue engineering, thanks to their ability to be easily delivered into the defect and to adapt to the lesion shape, to support/retain the injected cells into the implantation site and to favor the production of a suitable extracellular matrix (ecm). |
2015-11-16 |
2023-08-13 |
mouse |
| Silvia Gonzales, Chong Wang, Howard Levene, Herman S Cheung, Chun-Yuh Charles Huan. ATP promotes extracellular matrix biosynthesis of intervertebral disc cells. Cell and tissue research. vol 359. issue 2. 2015-10-27. PMID:25407524. |
the objective of this study was therefore to investigate the effects of extracellular atp on the extracellular matrix (ecm) biosynthesis of porcine ivd cells isolated from two distinct anatomical regions: the annulus fibrosus (af) and nucleus pulposus (np). |
2015-10-27 |
2023-08-13 |
Not clear |
| Bin Han, Hai-chao Wang, Hao Li, Yi-qing Tao, Cheng-zhen Liang, Fang-cai Li, Gang Chen, Qi-xin Che. Nucleus pulposus mesenchymal stem cells in acidic conditions mimicking degenerative intervertebral discs give better performance than adipose tissue-derived mesenchymal stem cells. Cells, tissues, organs. vol 199. issue 5-6. 2015-10-05. PMID:25661884. |
the microenvironment of the intervertebral disc (ivd) is characterized by matrix acidity, hypoxia, hyperosmolarity and limited nutrition, which are major obstacles to stem cell-based regeneration. |
2015-10-05 |
2023-08-13 |
rat |
| Maria Molinos, Catarina R Almeida, Joana Caldeira, Carla Cunha, Raquel M Gonçalves, Mário A Barbos. Inflammation in intervertebral disc degeneration and regeneration. Journal of the Royal Society, Interface. vol 12. issue 104. 2015-09-30. PMID:25673296. |
deeper knowledge of the complex spatial and temporal orchestration of cellular interactions and extracellular matrix remodelling is critical to improve current ivd therapies, which have so far proved unsatisfactory. |
2015-09-30 |
2023-08-13 |
Not clear |
| K S Emanuel, P-P A Vergroesen, M Peeters, R M Holewijn, I Kingma, T H Smi. Poroelastic behaviour of the degenerating human intervertebral disc: a ten-day study in a loaded disc culture system. European cells & materials. vol 29. 2015-09-17. PMID:26091731. |
these properties were related to the nucleus glycosaminoglycan/hydroxyproline (gag/hyp) ratio, rather than gag content alone, indicating that remodelling of the extracellular matrix reduces poroelastic properties of the ivd. |
2015-09-17 |
2023-08-13 |
human |
| Catarina Leite Pereira, Raquel M Gonçalves, Marianna Peroglio, Girish Pattappa, Matteo D'Este, David Eglin, Mário A Barbosa, Mauro Alini, Sibylle Gra. The effect of hyaluronan-based delivery of stromal cell-derived factor-1 on the recruitment of MSCs in degenerating intervertebral discs. Biomaterials. vol 35. issue 28. 2015-09-14. PMID:24969636. |
based on these findings, we hypothesized that an injectable hydrogel that can enhance the number of migrated mscs in the ivd and provide a suitable matrix for their survival and differentiation would be ideal. |
2015-09-14 |
2023-08-13 |
human |
| Lilian Quero, Marina Klawitter, Anja Schmaus, Melanie Rothley, Jonathan Sleeman, André N Tiaden, Juergen Klasen, Norbert Boos, Michael O Hottiger, Karin Wuertz, Peter J Richard. Hyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of toll-like receptor 2 signalling pathways. Arthritis research & therapy. vol 15. issue 4. 2015-09-10. PMID:23968377. |
intervertebral disc (ivd) degeneration is characterized by extracellular matrix breakdown and is considered to be a primary cause of discogenic back pain. |
2015-09-10 |
2023-08-12 |
human |
| Lilian Quero, Marina Klawitter, Anja Schmaus, Melanie Rothley, Jonathan Sleeman, André N Tiaden, Juergen Klasen, Norbert Boos, Michael O Hottiger, Karin Wuertz, Peter J Richard. Hyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of toll-like receptor 2 signalling pathways. Arthritis research & therapy. vol 15. issue 4. 2015-09-10. PMID:23968377. |
as fragmentation of matrix components occurs during ivd degeneration, we assessed the potential involvement of hyaluronic acid fragments (fhas) in the induction of inflammatory and catabolic mediators. |
2015-09-10 |
2023-08-12 |
human |
| Chencheng Feng, Huan Liu, Yang Yang, Bo Huang, Yue Zho. Growth and differentiation factor-5 contributes to the structural and functional maintenance of the intervertebral disc. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 35. issue 1. 2015-09-10. PMID:25547527. |
growth factors stimulate the proliferation of and matrix synthesis by intervertebral disc (ivd) cells, leading to the regeneration of degenerative discs. |
2015-09-10 |
2023-08-13 |
mouse |
| Claire G Jeong, Aubrey T Francisco, Zhenbin Niu, Robert L Mancino, Stephen L Craig, Lori A Setto. Screening of hyaluronic acid-poly(ethylene glycol) composite hydrogels to support intervertebral disc cell biosynthesis using artificial neural network analysis. Acta biomaterialia. vol 10. issue 8. 2015-09-02. PMID:24859415. |
the objective of this study was to rapidly screen multiple ha-peg composite hydrogel formulations for an effect on matrix synthesis and behaviors of nucleus pulposus (np) and annulus fibrosus (af) cells of the intervertebral disc (ivd). |
2015-09-02 |
2023-08-13 |
Not clear |
| Giovanni Marfia, Rolando Campanella, Stefania Elena Navone, Ileana Zucca, Alessandro Scotti, Matteo Figini, Clara Di Vito, Giulio Alessandri, Laura Riboni, Eugenio Parat. Potential use of human adipose mesenchymal stromal cells for intervertebral disc regeneration: a preliminary study on biglycan-deficient murine model of chronic disc degeneration. Arthritis research & therapy. vol 16. issue 5. 2015-08-11. PMID:25293819. |
biglycan is an important proteoglycan of the extracellular matrix of intervertebral disc (ivd), and its decrease with aging has been correlated with ivd degeneration. |
2015-08-11 |
2023-08-13 |
mouse |
| Dominic W Pelle, Jacqueline D Peacock, Courtney L Schmidt, Kevin Kampfschulte, Donald J Scholten, Scott S Russo, Kenneth J Easton, Matthew R Steensm. Genetic and functional studies of the intervertebral disc: a novel murine intervertebral disc model. PloS one. vol 9. issue 12. 2015-08-10. PMID:25474689. |
we present a novel technique for isolation of murine ivd explants with demonstration of explant viability (cmfda/propidium iodide staining), disc anatomy (h&e), maintenance of extracellular matrix (ecm) (alcian blue staining), and native expression profile (qrt-pcr) as well as ex vivo genetic recombination (mt/mg reporter mice; adcre) following 14 days of culture in dmem media containing 10% fetal bovine serum, 1% l-glutamine, and 1% penicillin/streptomycin. |
2015-08-10 |
2023-08-13 |
mouse |