| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Umile Giuseppe Longo, Stefano Petrillo, Edoardo Franceschetti, Nicola Maffulli, Vincenzo Denar. Growth factors and anticatabolic substances for prevention and management of intervertebral disc degeneration. Stem cells international. vol 2012. 2014-08-07. PMID:25098367. |
biological strategies aim to prevent and manage ivd degeneration, improving the function and anabolic and reparative capabilities of the nucleus pulposus and annulus fibrosus cells and inhibiting matrix degradation. |
2014-08-07 |
2023-08-13 |
Not clear |
| Jun Chen, Esther J Lee, Liufang Jing, Nicolas Christoforou, Kam W Leong, Lori A Setto. Differentiation of mouse induced pluripotent stem cells (iPSCs) into nucleus pulposus-like cells in vitro. PloS one. vol 8. issue 9. 2014-07-14. PMID:24086564. |
great interest exists in the use of autologous or allogeneic cells delivered to the degenerated ivd to promote matrix regeneration. |
2014-07-14 |
2023-08-12 |
mouse |
| Suat Canbay, Nesrin Turhan, Melih Bozkurt, Kemal Arda, Sukru Cagla. Correlation of matrix metalloproteinase-3 expression with patient age, magnetic resonance imaging and histopathological grade in lumbar disc degeneration. Turkish neurosurgery. vol 23. issue 4. 2014-05-16. PMID:24101259. |
the purpose of the present study is to analyze the expression of matrix metalloproteinase-3 (mmp-3), magnetic resonance imaging (mri) grading and histopathological alterations of the intervertebral disc (ivd) for correlations with each other and with the age, gender and low back pain duration of the patients who had undergone operations for lumbar disc herniation (ldh). |
2014-05-16 |
2023-08-12 |
Not clear |
| Hongsik Cho, Sangmin Lee, Sang-Hyug Park, Jinsong Huang, Karen A Hasty, Song-Ja Ki. Synergistic effect of combined growth factors in porcine intervertebral disc degeneration. Connective tissue research. vol 54. issue 3. 2014-03-21. PMID:23586390. |
several strategies using biological agents have been attempted to manage ivd degeneration, improving the function and anabolic capabilities of ivd cells and inhibiting matrix degradation. |
2014-03-21 |
2023-08-12 |
Not clear |
| Neena E Rajan, Ona Bloom, Robert Maidhof, Nathanial Stetson, Barbara Sherry, Mitchell Levine, Nadeen O Chahin. Toll-Like Receptor 4 (TLR4) expression and stimulation in a model of intervertebral disc inflammation and degeneration. Spine. vol 38. issue 16. 2014-02-10. PMID:22850250. |
we hypothesize that stimulation of the ivd with the tlr4 ligand lipopolysaccharide (lps) results in upregulation of a coordinated set of proinflammatory mediators and inhibition of matrix expression, both consistent with a molecular profile of degeneration. |
2014-02-10 |
2023-08-12 |
Not clear |
| Hao Li, Cheng Zhen Liang, Qi Xin Che. Regulatory role of hypoxia inducible factor in the biological behavior of nucleus pulposus cells. Yonsei medical journal. vol 54. issue 4. 2014-01-27. PMID:23709411. |
the alternated phenotypes, reduced cell survival, decreased metabolic activity, loss of matrix production and dystrophic mineralization of nucleus pulposus (np) cells may be key contributors to progressive ivd degeneration. |
2014-01-27 |
2023-08-12 |
Not clear |
| Fan Ding, Zeng-wu Shao, Li-ming Xion. Cell death in intervertebral disc degeneration. Apoptosis : an international journal on programmed cell death. vol 18. issue 7. 2013-12-23. PMID:23512131. |
degeneration of intervertebral disc (ivd) is mainly a chronic process of excessive destruction of the extracellular matrix (ecm), and also is thought to be the primary cause of low back pain. |
2013-12-23 |
2023-08-12 |
Not clear |
| B Li, X-F Zheng, B-B Ni, Y-H Yang, S-D Jiang, H Lu, L-S Jian. Reduced expression of insulin-like growth factor 1 receptor leads to accelerated intervertebral disc degeneration in mice. International journal of immunopathology and pharmacology. vol 26. issue 2. 2013-12-03. PMID:23755749. |
insulin-like growth factor 1 (igf-1) and its receptor (insulin-like growth factor 1 receptor, igf1r) can regulate the extracellular matrix synthesis and play a crucial role in maintaining the normal functions of the intervertebral disc (ivd). |
2013-12-03 |
2023-08-12 |
mouse |
| Chong Wang, Silvia Gonzales, Howard Levene, Weiyong Gu, Chun-Yuh Charles Huan. Energy metabolism of intervertebral disc under mechanical loading. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 31. issue 11. 2013-12-02. PMID:23843186. |
intervertebral disc (ivd) degeneration is closely associated with low back pain (lbp), which is a major health concern in the u.s. cellular biosynthesis of extracellular matrix (ecm), which is important for maintaining tissue integrity and preventing tissue degeneration, is an energy demanding process. |
2013-12-02 |
2023-08-12 |
Not clear |
| Kate Louise Eve Phillips, Nikki Jordan-Mahy, Martin J H Nicklin, Christine Lyn Le Maitr. Interleukin-1 receptor antagonist deficient mice provide insights into pathogenesis of human intervertebral disc degeneration. Annals of the rheumatic diseases. vol 72. issue 11. 2013-11-26. PMID:23396662. |
interleukin 1 (il-1) is potentially important in the pathogenesis of intervertebral disc (ivd) degeneration; increasing production of matrix degradation enzymes and inhibiting matrix synthesis. |
2013-11-26 |
2023-08-12 |
mouse |
| P Madiraju, R Gawri, H Wang, J Antoniou, F Mwal. Mechanism of parathyroid hormone-mediated suppression of calcification markers in human intervertebral disc cells. European cells & materials. vol 25. 2013-11-15. PMID:23636951. |
the present study demonstrates that pth can potentially retard ivd degeneration by stimulating matrix synthesis and suppressing markers of calcification potential in degenerated disc cells via both mapk and pka signalling pathways. |
2013-11-15 |
2023-08-12 |
human |
| Xiaofei Cheng, Bin Ni, Zhaohuan Zhang, Qi Liu, Liping Wang, Yu Ding, Ying H. Polyol pathway mediates enhanced degradation of extracellular matrix via p38 MAPK activation in intervertebral disc of diabetic rats. Connective tissue research. vol 54. issue 2. 2013-09-27. PMID:23215968. |
the aim of this study was to determine the significance of diabetes on degradation of intervertebral disc (ivd) extracellular matrix. |
2013-09-27 |
2023-08-12 |
rat |
| Xiaofei Cheng, Bin Ni, Zhaohuan Zhang, Qi Liu, Liping Wang, Yu Ding, Ying H. Polyol pathway mediates enhanced degradation of extracellular matrix via p38 MAPK activation in intervertebral disc of diabetic rats. Connective tissue research. vol 54. issue 2. 2013-09-27. PMID:23215968. |
diabetes might contribute to enhanced matrix degradation in the ivd and the polyol pathway might mediate this process via p38 activation. |
2013-09-27 |
2023-08-12 |
rat |
| M B Ellman, D Yan, K Ahmadinia, D Chen, H S An, H J I. Fibroblast growth factor control of cartilage homeostasis. Journal of cellular biochemistry. vol 114. issue 4. 2013-09-25. PMID:23060229. |
recent evidence suggests that fgf-2 selectively activates fgf receptor 1 (fgfr1) to exert catabolic effects in human articular chondrocytes and ivd tissue via upregulation of matrix-degrading enzyme production, inhibition of extracellular matrix (ecm) accumulation and proteoglycan synthesis, and clustering of cells characteristic of arthritic states. |
2013-09-25 |
2023-08-12 |
human |
| Nam V Vo, Robert A Hartman, Takashi Yurube, Lloydine J Jacobs, Gwendolyn A Sowa, James D Kan. Expression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degeneration. The spine journal : official journal of the North American Spine Society. vol 13. issue 3. 2013-09-20. PMID:23369495. |
matrix metalloproteinases (mmps), and disintegrins and metalloproteinases with thrombospondin motifs (adamtss) are believed to be the major proteolytic enzymes responsible for ecm degradation in the intervertebral disc (ivd). |
2013-09-20 |
2023-08-12 |
Not clear |
| Michael B Ellman, Jaesung Kim, Howard S An, Di Chen, Ranjan Kc, Xin Li, Guozhi Xiao, Dongyao Yan, Joon Suh, Andre J van Wijnen, James H-C Wang, Su-Gwan Kim, Hee-Jeong I. Lactoferricin enhances BMP7-stimulated anabolic pathways in intervertebral disc cells. Gene. vol 524. issue 2. 2013-08-05. PMID:23644135. |
bone-morphogenetic protein-7 (bmp7) is a well-known anabolic and anti-catabolic growth factor on intervertebral disc (ivd) matrix and cell homeostasis. |
2013-08-05 |
2023-08-12 |
cattle |
| Young-Joon Kwon, Je-Wook Lee, Eun-Joung Moon, Yeon Gu Chung, Ok-Soon Kim, Hae-Jin Ki. Anabolic effects of Peniel 2000, a peptide that regulates TGF-β1 signaling on intervertebral disc degeneration. Spine. vol 38. issue 2. 2013-07-01. PMID:23124260. |
an in vitro study with bovine intervertebral disc (ivd) cells and an in vivo study with a rabbit disc degeneration model on the extracellular matrix metabolism by a biglycan-derived peptide (peniel 2000; p2k). |
2013-07-01 |
2023-08-12 |
rabbit |
| D Greg Anderson, Dessislava Markova, Howard S An, Ana Chee, Motomi Enomoto-Iwamoto, Vladimir Markov, Biagio Saitta, Peng Shi, Chander Gupta, Yejia Zhan. Human umbilical cord blood-derived mesenchymal stem cells in the cultured rabbit intervertebral disc: a novel cell source for disc repair. American journal of physical medicine & rehabilitation. vol 92. issue 5. 2013-06-19. PMID:23598901. |
repopulating the ivd with cells that could produce and maintain extracellular matrix would be an alternative therapy to surgery. |
2013-06-19 |
2023-08-12 |
human |
| Olivier Lucas, Olivier Hamel, Anne Blanchais, Julie Lesoeur, Jérôme Abadie, Borhane Hakim Fellah, Marion Fusellier, Olivier Gauthier, Eric Bord, Gaël Grimandi, Claire Vinatier, Jérôme Guicheux, Johann Cloue. Laser-treated Nucleus pulposus as an innovative model of intervertebral disc degeneration. Experimental biology and medicine (Maywood, N.J.). vol 237. issue 11. 2013-05-06. PMID:23239447. |
this innovative approach is based on the induction of extracellular matrix disorders in the intervertebral disc (ivd) using a diode laser. |
2013-05-06 |
2023-08-12 |
Not clear |
| Girish Pattappa, Zhen Li, Marianna Peroglio, Nadine Wismer, Mauro Alini, Sibylle Gra. Diversity of intervertebral disc cells: phenotype and function. Journal of anatomy. vol 221. issue 6. 2013-03-25. PMID:22686699. |
although the healthy ivd is able to balance the slow matrix turnover of synthesis and degradation, this balance is often disturbed, leading to degenerative disorders. |
2013-03-25 |
2023-08-12 |
human |