| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alessandra Colombini, Cristina Ceriani, Giuseppe Banfi, Marco Brayda-Bruno, Matteo Morett. Fibrin in intervertebral disc tissue engineering. Tissue engineering. Part B, Reviews. vol 20. issue 6. 2015-07-21. PMID:24961887. |
it has been able to support disc cell survival, favor extracellular matrix production, and enhance the efficiency of cell transfer in the intervertebral disc (ivd). |
2015-07-21 |
2023-08-13 |
human |
| Fackson Mwale, Hong Tian Wang, Peter Roughley, John Antoniou, Lisbet Haglun. Link N and mesenchymal stem cells can induce regeneration of the early degenerate intervertebral disc. Tissue engineering. Part A. vol 20. issue 21-22. 2015-07-01. PMID:24786145. |
ivd repair can also potentially be enhanced by mesenchymal stem cell (msc) supplementation to maximize extracellular matrix (ecm) production. |
2015-07-01 |
2023-08-13 |
cattle |
| Jeremy Mercuri, Caroline Addington, Richard Pascal, Sanjitpal Gill, Dan Simionesc. Development and initial characterization of a chemically stabilized elastin-glycosaminoglycan-collagen composite shape-memory hydrogel for nucleus pulposus regeneration. Journal of biomedical materials research. Part A. vol 102. issue 12. 2015-06-29. PMID:24497431. |
destruction of the np extracellular matrix (ecm) is observed during the early stages of ivd degeneration. |
2015-06-29 |
2023-08-12 |
human |
| John Antoniou, Hong Tian Wang, Abdulrahman M Alaseem, Lisbet Haglund, Peter J Roughley, Fackson Mwal. The effect of Link N on differentiation of human bone marrow-derived mesenchymal stem cells. Arthritis research & therapy. vol 14. issue 6. 2015-05-12. PMID:23227926. |
we previously showed that link n can stimulate extracellular matrix biosynthesis by intervertebral disc (ivd) cells, both in vitro and in vivo, and is therefore a potential stimulator of ivd repair. |
2015-05-12 |
2023-08-12 |
human |
| Wilson C W Chan, Tiffany Y K Au, Vivian Tam, Kathryn S E Cheah, Danny Cha. Coming together is a beginning: the making of an intervertebral disc. Birth defects research. Part C, Embryo today : reviews. vol 102. issue 1. 2015-05-12. PMID:24677725. |
the characteristics of these cells are different, as they produce specific extracellular matrix (ecm) for tissue function and the niche in supporting the differentiation status of the cells in the ivd. |
2015-05-12 |
2023-08-12 |
Not clear |
| Yongxing Liu, Mohamed N Rahaman, B Sonny Ba. Modulating notochordal differentiation of human induced pluripotent stem cells using natural nucleus pulposus tissue matrix. PloS one. vol 9. issue 7. 2015-04-20. PMID:25054208. |
collectively, the present study confirmed the effectiveness and flexibility of using natural np tissue matrix to direct notochordal differentiation of hipscs, and the potential of using the generated nc-like cells for treating ivd degeneration. |
2015-04-20 |
2023-08-13 |
human |
| Jiang-Wei Chen, Bo Li, Yue-Hua Yang, Sheng-Dan Jiang, Lei-Sheng Jian. Significance of hypoxia in the physiological function of intervertebral disc cells. Critical reviews in eukaryotic gene expression. vol 24. issue 3. 2015-04-16. PMID:25072146. |
by reviewing the available literature about the effect of oxygen tension on regulating the phenotype, energy metabolism, matrix production, and survival of ivd cells, as well as on the expression and function of hypoxia-inducible factor in ivd cells, we conclude that hypoxia is essential in maintaining the physiological function of ivd cells. |
2015-04-16 |
2023-08-13 |
Not clear |
| B Alkhatib, D H Rosenzweig, E Krock, P J Roughley, L Beckman, T Steffen, M H Weber, J A Ouellet, L Haglun. Acute mechanical injury of the human intervertebral disc: link to degeneration and pain. European cells & materials. vol 28. 2015-04-02. PMID:25214017. |
this study investigates biochemical changes and extracellular matrix disruption in whole-organ human ivd cultures following acute mechanical injury. |
2015-04-02 |
2023-08-13 |
human |
| Sandra Spillekom, Lucas A Smolders, Guy C M Grinwis, Irene T M Arkesteijn, Keita Ito, Björn P Meij, Marianna A Tryfonido. Increased osmolarity and cell clustering preserve canine notochordal cell phenotype in culture. Tissue engineering. Part C, Methods. vol 20. issue 8. 2015-03-30. PMID:24304309. |
ncs are known to maintain extracellular matrix quality and stimulate the chondrocyte-like np cells, making ncs attractive for designing new tissue engineering approaches for ivd regeneration. |
2015-03-30 |
2023-08-12 |
Not clear |
| Anthony J Hayes, Mark A Gibson, Cindy Shu, James Melros. Confocal microscopy demonstrates association of LTBP-2 in fibrillin-1 microfibrils and colocalisation with perlecan in the disc cell pericellular matrix. Tissue & cell. vol 46. issue 3. 2015-02-26. PMID:24867584. |
ltbp-2 was a prominent pericellular component of annular fibrochondrocytes in the posterior annulus fibrosus (af), interstitial matrix adjacent to nucleus pulposus (np) cells and to fibrillar and cell associated material in the anterior af of the human foetal ivd and also displayed a pericellular localisation pattern in murine ivds. |
2015-02-26 |
2023-08-13 |
mouse |
| Antonio Cuesta, Miguel E Del Valle, Olivia García-Suárez, Eliseo Viña, Roberto Cabo, Gorka Vázquez, Juan L Cobo, Antonio Murcia, Marco Alvarez-Vega, José García-Cosamalón, José A Veg. Acid-sensing ion channels in healthy and degenerated human intervertebral disc. Connective tissue research. vol 55. issue 3. 2015-02-04. PMID:24432912. |
changes in the ph and osmolarity determine the viability of ivd cells and the composition of the extracellular matrix, and both are the basis of ivd degeneration. |
2015-02-04 |
2023-08-12 |
human |
| Demissew S Mern, Johann Fontana, Anja Beierfuß, Claudius Thomé, Aldemar A Hegewal. A combinatorial relative mass value evaluation of endogenous bioactive proteins in three-dimensional cultured nucleus pulposus cells of herniated intervertebral discs: identification of potential target proteins for gene therapeutic approaches. PloS one. vol 8. issue 11. 2015-01-02. PMID:24278441. |
nucleus pulposus (np) cells play a central role in intervertebral disc (ivd) maintenance by orchestrating catabolic, anabolic and inflammatory factors that affect the extracellular matrix. |
2015-01-02 |
2023-08-12 |
Not clear |
| Ting-Hsien Kao, Yi-Jen Peng, Hsi-Kai Tsou, Donald M Salter, Herng-Sheng Le. Nerve growth factor promotes expression of novel genes in intervertebral disc cells that regulate tissue degradation: Laboratory investigation. Journal of neurosurgery. Spine. vol 21. issue 4. 2014-12-03. PMID:25062286. |
the aim of the study was to assess if nerve growth factor (ngf) might alter gene expression of ivd cells and contribute to disc degeneration by enhancing expression or activity of factors that cause breakdown of ivd matrix. |
2014-12-03 |
2023-08-13 |
Not clear |
| Lisa A Williams, Aiqun Wei, Divya Bhargav, Ashish D Diwa. Cartilage derived morphogenetic protein 2 - a potential therapy for intervertebral disc regeneration? Biologicals : journal of the International Association of Biological Standardization. vol 42. issue 2. 2014-11-24. PMID:24457196. |
ivd degeneration involves the progressive deterioration of the highly organized disc tissue extracellular matrix, losing its elasticity and hence its' cushioning ability for the spine. |
2014-11-24 |
2023-08-12 |
xenopus_laevis |
| Lisa A Williams, Aiqun Wei, Divya Bhargav, Ashish D Diwa. Cartilage derived morphogenetic protein 2 - a potential therapy for intervertebral disc regeneration? Biologicals : journal of the International Association of Biological Standardization. vol 42. issue 2. 2014-11-24. PMID:24457196. |
the unique qualities of cdmp2 in ivd tissue formation, delineating discal matrix from vertebral bone, may prove adaptable in therapeutic applications to early discal degeneration. |
2014-11-24 |
2023-08-12 |
xenopus_laevis |
| Frances C Bach, Nicole Willems, Louis C Penning, Keita Ito, Björn P Meij, Marianna A Tryfonido. Potential regenerative treatment strategies for intervertebral disc degeneration in dogs. BMC veterinary research. vol 10. 2014-09-22. PMID:24387033. |
for this reason, there is interest in new regenerative therapies that can repair the degenerated disc matrix, resulting in restoration of the biomechanical function of the ivd. |
2014-09-22 |
2023-08-12 |
human |
| Ingrid Sitte, Anton Kathrein, Miranda Klosterhuber, Richard Andreas Lindtner, Sabrina Barbara Neururer, Stefan Rauch, Volker Kuhn, Werner Schmoel. Morphological similarities after compression trauma of bovine and human intervertebral discs: Do disc cells have a chance of surviving? Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 32. issue 9. 2014-09-16. PMID:24888549. |
to study the behavior of bovine disc cells and changes in disc matrix following in vitro compression tests; to compare the findings to investigations on human intervertebral discs (ivd) after burst fracture of the cervical spine. |
2014-09-16 |
2023-08-13 |
human |
| Brian H Chon, Esther J Lee, Liufang Jing, Lori A Setton, Jun Che. Human umbilical cord mesenchymal stromal cells exhibit immature nucleus pulposus cell phenotype in a laminin-rich pseudo-three-dimensional culture system. Stem cell research & therapy. vol 4. issue 5. 2014-09-11. PMID:24405888. |
however, no studies have demonstrated that mscs can regenerate matrix with unique characteristics matching that of immature nucleus pulposus (np) tissues of the ivd. |
2014-09-11 |
2023-08-12 |
human |
| Makarand V Risbud, Irving M Shapir. Role of cytokines in intervertebral disc degeneration: pain and disc content. Nature reviews. Rheumatology. vol 10. issue 1. 2014-08-15. PMID:24166242. |
ivd degeneration is characterized by increases in levels of the proinflammatory cytokines tnf, il-1α, il-1β, il-6 and il-17 secreted by the ivd cells; these cytokines promote extracellular matrix degradation, chemokine production and changes in ivd cell phenotype. |
2014-08-15 |
2023-08-12 |
Not clear |
| Shu-Hua Yang, Ming-Hsiao Hu, Yuan-Hui Sun, Feng-Huei Li. Differential phenotypic behaviors of human degenerative nucleus pulposus cells under normoxic and hypoxic conditions: influence of oxygen concentration during isolation, expansion, and cultivation. The spine journal : official journal of the North American Spine Society. vol 13. issue 11. 2014-08-11. PMID:23800820. |
although it has been demonstrated that a low oxygen concentration could promote synthesis of the extracellular matrix by ivd cells in the in vitro culture, isolation, expansion, and cultivation of ivd cells under classical tissue culture o2 saturation could still be detrimental. |
2014-08-11 |
2023-08-12 |
human |