| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ming-Hsiao Hu, Li-Wei Hung, Shu-Hua Yang, Yuan-Hui Sun, Tiffany Ting-Fang Shih, Feng-Huei Li. Lovastatin promotes redifferentiation of human nucleus pulposus cells during expansion in monolayer culture. Artificial organs. vol 35. issue 4. 2011-08-15. PMID:20883448. |
to acquire the capacities for matrix production and preservation of an expanded volume within a damaged intervertebral disc (ivd), cells isolated from human nucleus pulposus (np) tissues must undergo several passages in monolayer culture. |
2011-08-15 |
2023-08-12 |
human |
| Alain Petit, Guoying Yao, Sora Al Rowas, Rahul Gawri, Laura Epure, John Antoniou, Fackson Mwal. Effect of synthetic link N peptide on the expression of type I and type II collagens in human intervertebral disc cells. Tissue engineering. Part A. vol 17. issue 7-8. 2011-08-03. PMID:21067464. |
intervertebral disc (ivd) degeneration is associated with proteolytic degradation of proteoglycan aggregates present within the extracellular matrix of the disc. |
2011-08-03 |
2023-08-12 |
human |
| Carla Loreto, Giuseppe Musumeci, Alessandro Castorina, Corrado Loreto, Giuseppa Martine. Degenerative disc disease of herniated intervertebral discs is associated with extracellular matrix remodeling, vimentin-positive cells and cell death. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. vol 193. issue 2. 2011-07-19. PMID:21330123. |
we studied patients with degenerative disc disease (ddd) to demonstrate that i) remodeling of the extracellular matrix (ecm) in the intervertebral disc (ivd), particularly the elastic fiber system, of subjects with herniated discs is dysregulated and that ii) it is accompanied by accelerated elastin degradation due to increased expression of matrix metalloprotease-9 (mmp-9). |
2011-07-19 |
2023-08-12 |
human |
| F Mwale, H T Wang, D J Zukor, O L Huk, A Petit, J Antonio. Effect of a Type II Collagen Fragment on the Expression of Genes of the Extracellular Matrix in Cells of the Intervertebral Disc. The open orthopaedics journal. vol 2. 2011-07-14. PMID:19461923. |
in the present study, we have investigated the effect of the cii (245-270) peptide on the expression of matrix molecules, proteinases, and interleukin genes in cells of the ivd. |
2011-07-14 |
2023-08-12 |
cattle |
| Y Zhuang, B Huang, C Q Li, L T Liu, Y Pan, W J Zheng, G Luo, Y Zho. Construction of tissue-engineered composite intervertebral disc and preliminary morphological and biochemical evaluation. Biochemical and biophysical research communications. vol 407. issue 2. 2011-06-03. PMID:21382343. |
the aim of this study was to construct tissue-engineered composite intervertebral disc (ivd) consisting of demineralized bone matrix gelatin (dbmg) and collagen ii/hyaluronate/chondroitin-6-sulfate (cii/hya-cs) scaffolds seeded with anulus fibrosus (af) and nucleus pulposus (np) cells, respectively. |
2011-06-03 |
2023-08-12 |
mouse |
| Chang-Qing Zhao, Yue-Hui Zhang, Sheng-Dan Jiang, Hai Li, Lei-Sheng Jiang, Li-Yang Da. ADAMTS-5 and intervertebral disc degeneration: the results of tissue immunohistochemistry and in vitro cell culture. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 29. issue 5. 2011-05-26. PMID:21437951. |
matrix metalloproteinases (mmps) are known to be involved in ivd degeneration by hydrolyzing the extracellular matrix (ecm), especially the collagens. |
2011-05-26 |
2023-08-12 |
human |
| Hamish T J Gilbert, Judith A Hoyland, Sarah J Millward-Sadle. The response of human anulus fibrosus cells to cyclic tensile strain is frequency-dependent and altered with disc degeneration. Arthritis and rheumatism. vol 62. issue 11. 2010-11-30. PMID:20617521. |
mechanical loads are important for homeostasis of the intervertebral disc (ivd) cell matrix, with physiologic and nonphysiologic loads leading to matrix anabolism and catabolism, respectively. |
2010-11-30 |
2023-08-12 |
human |
| B Scholz, C Kinzelmann, K Benz, J Mollenhauer, H Wurst, B Schlosshaue. Suppression of adverse angiogenesis in an albumin-based hydrogel for articular cartilage and intervertebral disc regeneration. European cells & materials. vol 20. 2010-10-27. PMID:20628970. |
in summary, aiming at articular cartilage and ivd regeneration the albumin gel promises to be a beneficial implant matrix for chondrocytes simultaneously exhibiting non-permissive properties for adverse endothelial cells. |
2010-10-27 |
2023-08-12 |
mouse |
| Helena Brisby, Ai Qun Wei, Tim Molloy, Sylvia A Chung, George A Murrell, Ashish D Diwa. The effect of running exercise on intervertebral disc extracellular matrix production in a rat model. Spine. vol 35. issue 15. 2010-09-27. PMID:20592578. |
using a running rat model, the effects of physical exercise on cellular function and intervertebral disc (ivd) extracellular matrix were studied. |
2010-09-27 |
2023-08-12 |
rat |
| Qian-Qian Liang, Zhi-Jie Xi, Qin Bian, Xue-Jun Cui, Chen-Guang Li, Wei Hou, Qi Shi, Yong-Jun Wan. Herb formula "Fufangqishe-Pill" prevents upright posture-induced intervertebral disc degeneration at the lumbar in rats. Journal of pharmacological sciences. vol 113. issue 1. 2010-09-13. PMID:20472983. |
pretreatment of ffqsp for one month prevented the histological changes indicating ivd disorganization; increased type ii-collagen level, decreased type x-collagen protein level, and increased col2alpha1 mrna expression at all time points; and decreased col10alpha1, matrix metalloproteinase (mmp)-3, mmp13, and interleukin (il)-1beta mrna expression induced by upright posture for 7 and 9 months. |
2010-09-13 |
2023-08-12 |
rat |
| Aurelie Quintin, Constantin Schizas, Corinne Scaletta, Sandra Jaccoud, Stefan Gerber, Maria-Chiara Osterheld, Lucienne Juillerat, Lee Ann Applegate, Dominique P Piolett. Isolation and in vitro chondrogenic potential of human foetal spine cells. Journal of cellular and molecular medicine. vol 13. issue 8B. 2010-07-19. PMID:19413893. |
histology and immunohistochemistry of foetal tissues showed that the structure and the matrix composition (aggrecan, type i and ii collagen) of foetal intervertebral disc (ivd) were similar to adult ivd. |
2010-07-19 |
2023-08-12 |
human |
| J P Little, M J Pearcy, G Tevelen, J H Evans, G Pettet, C J Ada. The mechanical response of the ovine lumbar anulus fibrosus to uniaxial, biaxial and shear loads. Journal of the mechanical behavior of biomedical materials. vol 3. issue 2. 2010-04-21. PMID:20129414. |
there is a paucity of detailed mechanical data describing the material response of the reinforced-ground matrix in the anulus fibrosus of the ivd. |
2010-04-21 |
2023-08-12 |
human |
| Christine L Le Maitre, Anthony J Freemont, Judith A Hoylan. Expression of cartilage-derived morphogenetic protein in human intervertebral discs and its effect on matrix synthesis in degenerate human nucleus pulposus cells. Arthritis research & therapy. vol 11. issue 5. 2010-02-03. PMID:19754961. |
loss of intervertebral disc (ivd) matrix and ultimately disc height as a result of 'degeneration' has been implicated as a major cause of low back pain (lbp). |
2010-02-03 |
2023-08-12 |
human |
| Christine L Le Maitre, Anthony J Freemont, Judith A Hoylan. Expression of cartilage-derived morphogenetic protein in human intervertebral discs and its effect on matrix synthesis in degenerate human nucleus pulposus cells. Arthritis research & therapy. vol 11. issue 5. 2010-02-03. PMID:19754961. |
the use of anabolic growth factors as therapies to regenerate ivd matrix, hence restoring disc height and thus reversing degenerative disc disease, has been suggested. |
2010-02-03 |
2023-08-12 |
human |
| Jun Chen, Liufang Jing, Christopher L Gilchrist, William J Richardson, Robert D Fitch, Lori A Setto. Expression of laminin isoforms, receptors, and binding proteins unique to nucleus pulposus cells of immature intervertebral disc. Connective tissue research. vol 50. issue 5. 2010-01-26. PMID:19863388. |
intervertebral disc (ivd) disorders are believed to be related to aging-related cell loss and phenotypic changes, as well as biochemical and structural changes in the extracellular matrix of the nucleus pulposus (np) region. |
2010-01-26 |
2023-08-12 |
human |
| Stephen M Richardson, Paul Doyle, Ben M Minogue, Kanna Gnanalingham, Judith A Hoylan. Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc. Arthritis research & therapy. vol 11. issue 4. 2009-12-16. PMID:19695094. |
matrix metalloproteinases (mmps) are known to be involved in the degradation of the nucleus pulposus (np) during intervertebral disc (ivd) degeneration. |
2009-12-16 |
2023-08-12 |
Not clear |
| Christine L Le Maitre, Pauline Baird, Anthony J Freemont, Judith A Hoylan. An in vitro study investigating the survival and phenotype of mesenchymal stem cells following injection into nucleus pulposus tissue. Arthritis research & therapy. vol 11. issue 1. 2009-09-09. PMID:19210770. |
the decreased disc height characteristic of intervertebral disc (ivd) degeneration has often been linked to low back pain, and thus regeneration strategies aimed at restoring the disc extracellular matrix and ultimately disc height have been proposed as potential treatments for ivd degeneration. |
2009-09-09 |
2023-08-12 |
human |
| Christine L Le Maitre, Pauline Baird, Anthony J Freemont, Judith A Hoylan. An in vitro study investigating the survival and phenotype of mesenchymal stem cells following injection into nucleus pulposus tissue. Arthritis research & therapy. vol 11. issue 1. 2009-09-09. PMID:19210770. |
one such therapy under investigation by a number of groups worldwide is the use of autologous mesenchymal stem cells (mscs) to aid in the regeneration of the ivd extracellular matrix. |
2009-09-09 |
2023-08-12 |
human |
| Kern Singh, Koichi Masuda, Eugene J-M A Thonar, Howard S An, Gabriella Cs-Szab. Age-related changes in the extracellular matrix of nucleus pulposus and anulus fibrosus of human intervertebral disc. Spine. vol 34. issue 1. 2009-03-09. PMID:19127156. |
to characterize age-related changes in the matrix of human intervertebral disc (ivd) specimens, human specimens from the third to the eighth decade of life were collected and analyzed for collagen and proteoglycan (pg) composition. |
2009-03-09 |
2023-08-12 |
human |
| S A Abbah, W W Lu, S L Peng, D M K Aladin, Z Y Li, W K Tam, K M C Cheung, K D K Luk, G Q Zho. Extracellular matrix stability of primary mammalian chondrocytes and intervertebral disc cells cultured in alginate-based microbead hydrogels. Cell transplantation. vol 17. issue 10-11. 2009-02-23. PMID:19181212. |
in the present study, we evaluated the chondrogenic matrix stability of primary rat chondrocytes and intervertebral disc (ivd) cells cultured in three different alginate-based microbead matrices to determine the influence of microenvironment on the cellular and metabolic behaviors of chondrogenic cells confined in alginate microbeads. |
2009-02-23 |
2023-08-12 |
rat |