| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christine Lyn Le Maitre, Jennie Frain, Andrew P Fotheringham, Anthony J Freemont, Judith Alison Hoylan. Human cells derived from degenerate intervertebral discs respond differently to those derived from non-degenerate intervertebral discs following application of dynamic hydrostatic pressure. Biorheology. vol 45. issue 5. 2009-01-07. PMID:19065005. |
physiological levels of hp have an anabolic effect on ivd matrix metabolism in cells derived from non-degenerate animal and herniated ivd while excessive hp has a catabolic effect. |
2009-01-07 |
2023-08-12 |
human |
| Michael B Ellman, Howard S An, Prasuna Muddasani, Hee-Jeong I. Biological impact of the fibroblast growth factor family on articular cartilage and intervertebral disc homeostasis. Gene. vol 420. issue 1. 2008-09-17. PMID:18565695. |
evidence suggests that bfgf selectively activates fgf receptor 1 (fgfr1) to exert degradative effects in both human articular chondrocytes and ivd tissue via upregulation of matrix-degrading enzyme activity, inhibition of matrix production, and increased cell proliferation resulting in clustering of cells seen in arthritic states. |
2008-09-17 |
2023-08-12 |
human |
| J A Hoyland, C Le Maitre, A J Freemon. Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc. Rheumatology (Oxford, England). vol 47. issue 6. 2008-06-26. PMID:18397957. |
to establish if il-1 or tnf regulates matrix degradation in the non-degenerate or degenerate intervertebral disc (ivd). |
2008-06-26 |
2023-08-12 |
Not clear |
| Min Cui, Yuqing Wan, D Greg Anderson, Francis H Shen, Brian M Leo, Cato T Laurencin, Gary Balian, Xudong L. Mouse growth and differentiation factor-5 protein and DNA therapy potentiates intervertebral disc cell aggregation and chondrogenic gene expression. The spine journal : official journal of the North American Spine Society. vol 8. issue 2. 2008-05-20. PMID:17974491. |
growth and differentiation factor-5 (gdf-5)-deficient mice showed abnormalities in intervertebral disc (ivd) structure and extracellular matrix. |
2008-05-20 |
2023-08-12 |
mouse |
| J P H J Rutges, J A Kummer, F C Oner, A J Verbout, R J M Castelein, H J A Roestenburg, W J A Dhert, L B Creemer. Increased MMP-2 activity during intervertebral disc degeneration is correlated to MMP-14 levels. The Journal of pathology. vol 214. issue 4. 2008-04-23. PMID:18200629. |
intervertebral disc (ivd) degeneration is associated with the increased expression of several matrix metalloproteinases (mmps), in particular mmp-2. |
2008-04-23 |
2023-08-12 |
human |
| Christine L Le Maitre, Judith A Hoyland, Anthony J Freemon. Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ zymographic and gene therapy study. Arthritis research & therapy. vol 9. issue 4. 2008-04-03. PMID:17760968. |
data implicate il-1 in the altered matrix biology that characterizes human intervertebral disc (ivd) degeneration. |
2008-04-03 |
2023-08-12 |
human |
| Christine L Le Maitre, Judith A Hoyland, Anthony J Freemon. Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ zymographic and gene therapy study. Arthritis research & therapy. vol 9. issue 4. 2008-04-03. PMID:17760968. |
in the current study we investigated the enzymic mechanism by which il-1 induces matrix degradation in degeneration of the human ivd, and whether the il-1 inhibitor il-1 receptor antagonist (il-1ra) will inhibit degradation. |
2008-04-03 |
2023-08-12 |
human |
| Christine L Le Maitre, Judith A Hoyland, Anthony J Freemon. Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ zymographic and gene therapy study. Arthritis research & therapy. vol 9. issue 4. 2008-04-03. PMID:17760968. |
the novel findings from this study are: il-1ra delivered directly onto explants of degenerate ivds eliminates matrix degradation as assessed by multi-substrate isz; there is a direct relationship between matrix degradation assessed by isz and mdp expression defined by immunohistochemistry; single injections of ivd cells engineered to over-express il-1ra significantly inhibit mdp expression for two weeks. |
2008-04-03 |
2023-08-12 |
human |
| Christine L Le Maitre, Judith A Hoyland, Anthony J Freemon. Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ zymographic and gene therapy study. Arthritis research & therapy. vol 9. issue 4. 2008-04-03. PMID:17760968. |
our findings show that il-1 is a key cytokine driving matrix degradation in the degenerate ivd. |
2008-04-03 |
2023-08-12 |
human |
| Christine L Le Maitre, Judith A Hoyland, Anthony J Freemon. Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ zymographic and gene therapy study. Arthritis research & therapy. vol 9. issue 4. 2008-04-03. PMID:17760968. |
furthermore, il-1ra delivered directly or by gene therapy inhibits ivd matrix degradation. |
2008-04-03 |
2023-08-12 |
human |
| Christine Lyn Le Maitre, Anthony John Freemont, Judith Alison Hoylan. Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration. Arthritis research & therapy. vol 9. issue 3. 2008-01-31. PMID:17498290. |
we hypothesised that this is due to accelerated cellular senescence, which causes fundamental changes in the ability of disc cells to maintain the intervertebral disc (ivd) matrix, thus leading to ivd degeneration. |
2008-01-31 |
2023-08-12 |
human |
| James Melrose, Susan M Smith, Emily S Fuller, Allan A Young, Peter J Roughley, Andrew Dart, Christopher B Littl. Biglycan and fibromodulin fragmentation correlates with temporal and spatial annular remodelling in experimentally injured ovine intervertebral discs. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. vol 16. issue 12. 2008-01-29. PMID:17899219. |
remodeling of the ivd matrix in the lesion and sham discs was assessed histochemically at 3, 6,12 and 26 month post operation (po). |
2008-01-29 |
2023-08-12 |
Not clear |
| Christoph-E Heyde, Sven K Tschoeke, Markus Hellmuth, Arwed Hostmann, Wolfgang Ertel, Andreas Oberholze. Trauma induces apoptosis in human thoracolumbar intervertebral discs. BMC clinical pathology. vol 6. 2007-07-02. PMID:16719914. |
in this regard, apoptosis of ivd cells has been suggested to be involved in the critical changes of the extracellular matrix. |
2007-07-02 |
2023-08-12 |
human |
| Christopher L Gilchrist, Jun Chen, William J Richardson, Richard F Loeser, Lori A Setto. Functional integrin subunits regulating cell-matrix interactions in the intervertebral disc. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 25. issue 6. 2007-06-27. PMID:17318895. |
much is known about the extracellular matrix proteins in the intervertebral disc (ivd) and their variations with region, age, or degenerative state of the tissue. |
2007-06-27 |
2023-08-12 |
Not clear |
| Christopher L Gilchrist, Jun Chen, William J Richardson, Richard F Loeser, Lori A Setto. Functional integrin subunits regulating cell-matrix interactions in the intervertebral disc. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 25. issue 6. 2007-06-27. PMID:17318895. |
in contrast, little is known of the integrin cell surface receptors that directly bind to and interact with these matrix proteins in the ivd. |
2007-06-27 |
2023-08-12 |
Not clear |
| Cornelia Neidlinger-Wilke, Karin Würtz, Jill P G Urban, Wolfgang Börm, Markus Arand, Anita Ignatius, Hans-Joachim Wilke, Lutz E Clae. Regulation of gene expression in intervertebral disc cells by low and high hydrostatic pressure. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. vol 15 Suppl 3. 2007-04-05. PMID:16680448. |
we hypothesize that these different loading magnitudes influence the intervertebral disc (ivd) by alteration of disc matrix turnover depending on their magnitudes. |
2007-04-05 |
2023-08-12 |
human |
| Cornelia Neidlinger-Wilke, Karin Würtz, Jill P G Urban, Wolfgang Börm, Markus Arand, Anita Ignatius, Hans-Joachim Wilke, Lutz E Clae. Regulation of gene expression in intervertebral disc cells by low and high hydrostatic pressure. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. vol 15 Suppl 3. 2007-04-05. PMID:16680448. |
cells were harvested 24 h after the end of stimulation and changes in the expression of genes known to influence ivd matrix turnover (collagen-i, collagen-ii, aggrecan, mmp1, mmp2, mmp3, mmp13) were analyzed by real-time rt-pcr. |
2007-04-05 |
2023-08-12 |
human |
| Cornelia Neidlinger-Wilke, Karin Würtz, Jill P G Urban, Wolfgang Börm, Markus Arand, Anita Ignatius, Hans-Joachim Wilke, Lutz E Clae. Regulation of gene expression in intervertebral disc cells by low and high hydrostatic pressure. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. vol 15 Suppl 3. 2007-04-05. PMID:16680448. |
these results suggest that hydrostatic pressure as one of the physiological stimuli of the ivd may influence matrix turnover in a magnitude dependent way. |
2007-04-05 |
2023-08-12 |
human |
| C L Le Maitre, A J Freemont, J A Hoylan. Human disc degeneration is associated with increased MMP 7 expression. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 81. issue 4-6. 2007-03-16. PMID:17129995. |
during intervertebral disc (ivd) degeneration, normal matrix synthesis decreases and degradation of disc matrix increases. |
2007-03-16 |
2023-08-12 |
human |
| C L Le Maitre, A J Freemont, J A Hoylan. Human disc degeneration is associated with increased MMP 7 expression. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 81. issue 4-6. 2007-03-16. PMID:17129995. |
matrix metalloproteinase 7 (mmp 7) (matrilysin, pump-1) is known to cleave the major matrix molecules found within the ivd, i.e., the proteoglycan aggrecan and collagen type ii. |
2007-03-16 |
2023-08-12 |
human |