| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei-Hong Chen, Wen-Cheng Lo, Jie-Jen Lee, Ching-Hua Su, Che-Tong Lin, Hen-Yu Liu, Tsou-Wen Lin, Wei-Chao Lin, Te-Yang Huang, Win-Ping Den. Tissue-engineered intervertebral disc and chondrogenesis using human nucleus pulposus regulated through TGF-beta1 in platelet-rich plasma. Journal of cellular physiology. vol 209. issue 3. 2007-02-07. PMID:16955489. |
human intervertebral disc (ivd) degeneration often initiated from the human nucleus pulposus (hnp) with aging leading to ivd destruction and extracellular matrix (ecm) depletion. |
2007-02-07 |
2023-08-12 |
human |
| Yoshimasa Ishii, Ashby O Thomas, X Edward Guo, Clark T Hung, Faye H Che. Localization and distribution of cartilage oligomeric matrix protein in the rat intervertebral disc. Spine. vol 31. issue 14. 2006-08-03. PMID:16778685. |
whole rat intervertebral disc (ivd), as well as the anulus fibrosus (af) and the nucleus pulposus (np) were studied using immunoblot, immunohistochemistry, and reverse-transcription followed by polymerase chain reaction (rt-pcr) methods to investigate the expression and distribution of cartilage oligomeric matrix protein (comp). |
2006-08-03 |
2023-08-12 |
rat |
| Christine Lyn Le Maitre, Anthony J Freemont, Judith Alison Hoylan. The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration. Arthritis research & therapy. vol 7. issue 4. 2006-04-06. PMID:15987475. |
in this study, we investigated the hypotheses that in human intervertebral disc (ivd) degeneration there is local production of the cytokine il-1, and that this locally produced cytokine can induce the cellular and matrix changes of ivd degeneration. |
2006-04-06 |
2023-08-12 |
human |
| Christine Lyn Le Maitre, Anthony J Freemont, Judith Alison Hoylan. The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration. Arthritis research & therapy. vol 7. issue 4. 2006-04-06. PMID:15987475. |
we have also shown that il-1 treatment of human ivd cells resulted in increased gene expression for the matrix-degrading enzymes (mmp 3 (matrix metalloproteinase 3), mmp 13 (matrix metalloproteinase 13), and adamts-4 (a disintegrin and metalloproteinase with thrombospondin motifs)) and a decrease in the gene expression for matrix genes (aggrecan, collagen ii, collagen i, and sox6). |
2006-04-06 |
2023-08-12 |
human |
| Peter Roughley, Caroline Hoemann, Eric DesRosiers, Fackson Mwale, John Antoniou, Mauro Alin. The potential of chitosan-based gels containing intervertebral disc cells for nucleus pulposus supplementation. Biomaterials. vol 27. issue 3. 2006-02-27. PMID:16125220. |
the suitability of chitosan-based hydrogels as scaffolds for the encapsulation of intervertebral disc (ivd) cells and the accumulation of a functional extracellular matrix mimicking that of the nucleus pulposus (np) was investigated. |
2006-02-27 |
2023-08-12 |
Not clear |
| Christine L Le Maitre, Stephen M A Richardson, Pauline Baird, Anthony J Freemont, Judith A Hoylan. Expression of receptors for putative anabolic growth factors in human intervertebral disc: implications for repair and regeneration of the disc. The Journal of pathology. vol 207. issue 4. 2006-01-13. PMID:16278806. |
current evidence implicates loss of intervertebral disc (ivd) matrix consequent upon 'degeneration' as a major cause of lbp. |
2006-01-13 |
2023-08-12 |
human |
| Christine L Le Maitre, Stephen M A Richardson, Pauline Baird, Anthony J Freemont, Judith A Hoylan. Expression of receptors for putative anabolic growth factors in human intervertebral disc: implications for repair and regeneration of the disc. The Journal of pathology. vol 207. issue 4. 2006-01-13. PMID:16278806. |
degeneration of the ivd involves increases in degradative enzymes and decreases in the extracellular matrix (ecm) component in a process that is controlled by a range of cytokines and growth factors. |
2006-01-13 |
2023-08-12 |
human |
| Christine L Le Maitre, Stephen M A Richardson, Pauline Baird, Anthony J Freemont, Judith A Hoylan. Expression of receptors for putative anabolic growth factors in human intervertebral disc: implications for repair and regeneration of the disc. The Journal of pathology. vol 207. issue 4. 2006-01-13. PMID:16278806. |
studies have suggested using anabolic growth factors to regenerate the normal matrix of the ivd, hence restoring disc height and reversing degenerative disc disease. |
2006-01-13 |
2023-08-12 |
human |
| Christine L Le Maitre, Stephen M A Richardson, Pauline Baird, Anthony J Freemont, Judith A Hoylan. Expression of receptors for putative anabolic growth factors in human intervertebral disc: implications for repair and regeneration of the disc. The Journal of pathology. vol 207. issue 4. 2006-01-13. PMID:16278806. |
in conclusion, this study has demonstrated the expression of the four growth factor receptors at similar levels in the chondrocyte-like cells of the np and iaf in both non-degenerate and degenerate discs, implicating a role in normal disc homeostasis and suggesting that the application of these growth factors to the degenerate human ivd would stimulate matrix production. |
2006-01-13 |
2023-08-12 |
human |
| Eric Steck, Helge Bertram, Rainer Abel, Bohua Chen, Anja Winter, Wiltrud Richte. Induction of intervertebral disc-like cells from adult mesenchymal stem cells. Stem cells (Dayton, Ohio). vol 23. issue 3. 2005-08-23. PMID:15749935. |
after tgf beta-mediated differentiation, msc spheroids turned positive for collagen type ii protein and expressed a large panel of genes characteristic for chondrocytes, including aggrecan, decorin, fibromodulin, and cartilage oligomeric matrix protein, although at levels closer to ivd tissue than to hyaline articular cartilage. |
2005-08-23 |
2023-08-12 |
human |
| Christine Lyn Le Maitre, Anthony J Freemont, Judith Alison Hoylan. Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc. The Journal of pathology. vol 204. issue 1. 2004-10-12. PMID:15307137. |
the histological and biochemical changes that occur in the extracellular matrix of the intervertebral disc (ivd) during ageing and degeneration have been investigated extensively. |
2004-10-12 |
2023-08-12 |
human |
| Christine Lyn Le Maitre, Anthony J Freemont, Judith Alison Hoylan. Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc. The Journal of pathology. vol 204. issue 1. 2004-10-12. PMID:15307137. |
a number of studies have suggested the involvement of matrix metalloproteinases (mmps) and adamts in ivd degeneration, but few have localized the site of production of these enzymes to the cells of the degenerate disc. |
2004-10-12 |
2023-08-12 |
human |
| Fackson Mwale, Caroline N Demers, Alain Petit, Peter Roughley, A Robin Poole, Thomas Steffen, Max Aebi, John Antonio. A synthetic peptide of link protein stimulates the biosynthesis of collagens II, IX and proteoglycan by cells of the intervertebral disc. Journal of cellular biochemistry. vol 88. issue 6. 2003-12-11. PMID:12647302. |
in the studies reported here, a serum-free pellet culture system has been used to examine whether link n can play a role in maintaining the integrity of disc matrix, specifically at the level of matrix assembly by cells of the ivd. |
2003-12-11 |
2023-08-12 |
human |
| S M Han, S Y Lee, M H Cho, J K Le. Disc hydration measured by magnetic resonance imaging in relation to its compressive stiffness in rat models. Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine. vol 215. issue 5. 2001-12-13. PMID:11726050. |
this study suggests that the dehydrated matrix of the ivd may be responsible for a stiffer disc that may lead to a less flexible spine. |
2001-12-13 |
2023-08-12 |
rat |
| K Däschner, I Couée, S Binde. The mitochondrial isovaleryl-coenzyme a dehydrogenase of arabidopsis oxidizes intermediates of leucine and valine catabolism. Plant physiology. vol 126. issue 2. 2001-10-11. PMID:11402190. |
expression of ativd:smgfp4 fusion proteins in tobacco (nicotiana tabacum) protoplasts and biochemical studies now demonstrate the in vivo import of the plant isovaleryl-coa dehydrogenase (ivd) into mitochondria and the enzyme in the matrix of these organelles. |
2001-10-11 |
2023-08-12 |
Not clear |
| S T Pattison, J Melrose, P Ghosh, T K Taylo. Regulation of gelatinase-A (MMP-2) production by ovine intervertebral disc nucleus pulposus cells grown in alginate bead culture by Transforming Growth Factor-beta(1)and insulin like growth factor-I. Cell biology international. vol 25. issue 7. 2001-10-04. PMID:11448107. |
limited degradation of the collagen matrix by matrix metalloproteases (mmps) may facilitate the loosening of cell-cell and cell-matrix interactions within the injured intervertebral disc (ivd) to favour the penetration of blood vessels and migration of fibroblasts into the defect to promote repair processes. |
2001-10-04 |
2023-08-12 |
Not clear |
| T Reinard, V Janke, J Willard, F Buck, H J Jacobsen, J Vockle. Cloning of a gene for an acyl-CoA dehydrogenase from Pisum sativum L. and purification and characterization of its product as an isovaleryl-CoA dehydrogenase. The Journal of biological chemistry. vol 275. issue 43. 2000-11-24. PMID:10913142. |
in this report we describe the identification and characterization of an ivd from pea, purification of the enzyme using a novel and rapid auxin affinity chromatography matrix, and cloning of the corresponding gene. |
2000-11-24 |
2023-08-12 |
human |
| Y T Konttinen, P Kemppinen, T F Li, E Waris, H Pihlajamäki, T Sorsa, M Takagi, S Santavirta, G S Schultz, M G Humphreys-Behe. Transforming and epidermal growth factors in degenerated intervertebral discs. The Journal of bone and joint surgery. British volume. vol 81. issue 6. 2000-01-13. PMID:10615986. |
we conclude that the nucleus pulposus of the herniated ivd is vulnerable to proteolytic degradation and depletion of proteoglycans due to the lack and/or low production of anabolic growth factors/receptors which could increase the local synthesis of the extracellular matrix. |
2000-01-13 |
2023-08-12 |
human |
| J Melrose, P Ghosh, T K Taylor, J L Andrew. The serine proteinase inhibitory proteins of the human intervertebral disc: their isolation, characterization and variation with ageing and degeneration. Matrix (Stuttgart, Germany). vol 12. issue 6. 1993-03-15. PMID:1287414. |
a depletion of total spi levels was evident overall in degenerate discs suggesting a functional role for these inhibitory proteins in the maintenance of ivd matrix homeostasis. |
1993-03-15 |
2023-08-11 |
human |
| J Vockley, B Parimoo, K Tanak. Molecular characterization of four different classes of mutations in the isovaleryl-CoA dehydrogenase gene responsible for isovaleric acidemia. American journal of human genetics. vol 49. issue 1. 1991-08-02. PMID:2063866. |
isovaleric acidemia (iva) is an inborn error of leucine metabolism and is caused by a genetically determined deficiency of isovaleryl-coa dehydrogenase (ivd), a mitochondrial matrix enzyme. |
1991-08-02 |
2023-08-11 |
Not clear |