| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephen P Henry, Shoudan Liang, Kadir C Akdemir, Benoit de Crombruggh. The postnatal role of Sox9 in cartilage. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 27. issue 12. 2013-02-08. PMID:22777888. |
inactivation of sox9 in the ivd markedly reduced the expression of several genes encoding extracellular matrix proteins, as well as some of the enzymes responsible for their posttranslational modification. |
2013-02-08 |
2023-08-12 |
mouse |
| Zili Wang, Sung Soo Kim, William C Hutton, Sangwook Tim Yoo. E-cadherin upregulates expression of matrix macromolecules aggrecan and collagen II in the intervertebral disc cells through activation of the intracellular BMP-Smad1/5 pathway. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 30. issue 11. 2012-12-17. PMID:22615104. |
in this study, we investigated the effects of e-cadherin on ivd matrix synthesis using pharmacological and molecular biology methods. |
2012-12-17 |
2023-08-12 |
Not clear |
| Zili Wang, Sung Soo Kim, William C Hutton, Sangwook Tim Yoo. E-cadherin upregulates expression of matrix macromolecules aggrecan and collagen II in the intervertebral disc cells through activation of the intracellular BMP-Smad1/5 pathway. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 30. issue 11. 2012-12-17. PMID:22615104. |
our study indicates that the ectopic expression of e-cadherin can stimulate matrix anabolism of the ivd cells, which was evidenced by increased expression of the matrix macromolecules aggrecan and collagen ii. |
2012-12-17 |
2023-08-12 |
Not clear |
| Zili Wang, Sung Soo Kim, William C Hutton, Sangwook Tim Yoo. E-cadherin upregulates expression of matrix macromolecules aggrecan and collagen II in the intervertebral disc cells through activation of the intracellular BMP-Smad1/5 pathway. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 30. issue 11. 2012-12-17. PMID:22615104. |
together this study demonstrates that the e-cadherin stimulates the synthesis of ivd matrix macromolecules aggrecan and collagen ii through the induction of bmp genes and enhancement of the smad1/5 phosphorylation. |
2012-12-17 |
2023-08-12 |
Not clear |
| Khoi D Than, Shayan U Rahman, Monique J Vanaman, Anthony C Wang, Chia-Ying Lin, Huina Zhang, Frank La Marca, Paul Par. Bone morphogenetic proteins and degenerative disk disease. Neurosurgery. vol 70. issue 4. 2012-11-09. PMID:22426045. |
direct administration of bmp-2 to ivd cells results in increased production of components of the extracellular matrix. |
2012-11-09 |
2023-08-12 |
human |
| Hao Li, Chengzhen Liang, Yiqing Tao, Xiaopeng Zhou, Fangcai Li, Gang Chen, Qi-xin Che. Acidic pH conditions mimicking degenerative intervertebral discs impair the survival and biological behavior of human adipose-derived mesenchymal stem cells. Experimental biology and medicine (Maywood, N.J.). vol 237. issue 7. 2012-10-26. PMID:22829705. |
admscs harvested from young donors may be more suitable to be utilized for the implantation into degenerated ivd, and the implantations may be more effective at an early stage of ivd degeneration when the ph of matrix acidity is higher than 6.8. |
2012-10-26 |
2023-08-12 |
human |
| Fumiyuki Arai, Akihiko Hiyama, Daisuke Sakai, Katsuya Yokoyama, Joji Mochid. The expression and role of non-canonical (PKC) signaling in nucleus pulposus cell metabolism. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 30. issue 9. 2012-09-28. PMID:22389031. |
it is concluded that activation of pkc signaling might lead to an increase in matrix synthesis and cell proliferation, thereby inhibiting ivd degeneration. |
2012-09-28 |
2023-08-12 |
rat |
| Chengzhen Liang, Hao Li, Yiqing Tao, Xiaopeng Zhou, Fangcai Li, Gang Chen, Qixin Che. Responses of human adipose-derived mesenchymal stem cells to chemical microenvironment of the intervertebral disc. Journal of translational medicine. vol 10. 2012-08-07. PMID:22424131. |
this study aimed to investigate the viability, proliferation and the expression of main matrix proteins of admscs in the chemical microenvironment of ivd under normal and degeneration conditions. |
2012-08-07 |
2023-08-12 |
human |
| Samantha C W Chan, Stephen J Ferguson, Benjamin Gantenbein-Ritte. The effects of dynamic loading on the intervertebral disc. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. vol 20. issue 11. 2012-07-19. PMID:21541667. |
loading is important to maintain the balance of matrix turnover in the intervertebral disc (ivd). |
2012-07-19 |
2023-08-12 |
Not clear |
| Umile Giuseppe Longo, Nicola Papapietro, Stefano Petrillo, Edoardo Franceschetti, Nicola Maffulli, Vincenzo Denar. Mesenchymal stem cell for prevention and management of intervertebral disc degeneration. Stem cells international. vol 2012. 2012-07-13. PMID:22550520. |
the aim of biological strategies is to prevent and manage ivd degeneration, improve the function, the anabolic and reparative capabilities of the nucleus pulposus and annulus fibrosus cells, and inhibit matrix degradation. |
2012-07-13 |
2023-08-12 |
Not clear |
| Fackson Mwale, Koichi Masuda, Rajeswari Pichika, Laura M Epure, Tomoaki Yoshikawa, Aseem Hemmad, Peter J Roughley, John Antonio. The efficacy of Link N as a mediator of repair in a rabbit model of intervertebral disc degeneration. Arthritis research & therapy. vol 13. issue 4. 2012-03-29. PMID:21787415. |
intervertebral disc (ivd) degeneration is associated with proteolytic degradation of the extracellular matrix, and its repair requires both the production of extracellular matrix and the downregulation of proteinase activity. |
2012-03-29 |
2023-08-12 |
rabbit |
| Koji Fujita, Takashi Ando, Tetsuro Ohba, Masanori Wako, Nobutaka Sato, Yuki Nakamura, Yuko Ohnuma, Yasushi Hara, Ryohei Kato, Atsuhito Nakao, Hirotaka Har. Age-related expression of MCP-1 and MMP-3 in mouse intervertebral disc in relation to TWEAK and TNF-α stimulation. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 30. issue 4. 2012-03-27. PMID:21928379. |
this study was undertaken to investigate the age-related differences of monocyte chemotactic protein-1 (mcp-1) and matrix metalloproteinase-3 (mmp-3) expression in mouse intervertebral disc (ivd) and to determine whether mmp-3 plays a role in disc degeneration. |
2012-03-27 |
2023-08-12 |
mouse |
| Hongsik Cho, Aman Seth, Jenna Warmbold, James T Robertson, Karen A Hast. Aging affects response to cyclic tensile stretch: paradigm for intervertebral disc degeneration. European cells & materials. vol 22. 2012-02-17. PMID:21932191. |
to characterise the effect of mechanical stimulation on cells from older discs, an in vitro study of ivd cells harvested from different aged pigs was conducted to measure extracellular matrix (ecm) gene expression in response to cyclic tensile stress (cts). |
2012-02-17 |
2023-08-12 |
Not clear |
| Anthony J Hayes, Susan M Smith, Mark A Gibson, James Melros. Comparative immunolocalization of the elastin fiber-associated proteins fibrillin-1, LTBP-2, and MAGP-1 with components of the collagenous and proteoglycan matrix of the fetal human intervertebral disc. Spine. vol 36. issue 21. 2012-02-15. PMID:21540769. |
a comparative immunolocalization study of elastin-associated proteins and established intervertebral disc (ivd) extracellular matrix (ecm) components. |
2012-02-15 |
2023-08-12 |
human |
| Hamish T J Gilbert, Judith A Hoyland, Anthony J Freemont, Sarah J Millward-Sadle. The involvement of interleukin-1 and interleukin-4 in the response of human annulus fibrosus cells to cyclic tensile strain: an altered mechanotransduction pathway with degeneration. Arthritis research & therapy. vol 13. issue 1. 2012-02-10. PMID:21276216. |
recent evidence suggests that intervertebral disc (ivd) cells derived from degenerative tissue are unable to respond to physiologically relevant mechanical stimuli in the 'normal' anabolic manner, but instead respond by increasing matrix catabolism. |
2012-02-10 |
2023-08-12 |
human |
| Marina Klawitter, Lilian Quero, Alessando Bertolo, Marco Mehr, Jivko Stoyanov, Andreas G Nerlich, Juergen Klasen, Nikolaus Aebli, Norbert Boos, Karin Wuert. Human MMP28 expression is unresponsive to inflammatory stimuli and does not correlate to the grade of intervertebral disc degeneration. Journal of negative results in biomedicine. vol 10. 2012-01-27. PMID:21801383. |
mmp28 (epilysin) is a recently discovered member of the mmp (matrix metalloproteinase) family that is, amongst others, expressed in osteoarthritic cartilage and intervertebral disc (ivd) tissue. |
2012-01-27 |
2023-08-12 |
human |
| Feng Wang, Yue Zh. Aquaporin-1: a potential membrane channel for facilitating the adaptability of rabbit nucleus pulposus cells to an extracellular matrix environment. Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association. vol 16. issue 3. 2011-11-29. PMID:21451971. |
during the process of degenerative aging of the intervertebral disc (ivd), the extracellular matrix (ecm) environment changes, with osmolarity and oxygen (o(2)) concentration important components of such changes. |
2011-11-29 |
2023-08-12 |
rabbit |
| Hanan N Fernando, Jessica Czamanski, Tai-Yi Yuan, Weiyong Gu, Abdi Salahadin, Chun-Yuh Charles Huan. Mechanical loading affects the energy metabolism of intervertebral disc cells. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 29. issue 11. 2011-11-18. PMID:21484859. |
research has shown that mechanical loading affects matrix biosynthesis of intervertebral disc (ivd) cells; however, the pathway(s) to this effect is currently unknown. |
2011-11-18 |
2023-08-12 |
Not clear |
| Christopher K Kepler, D Greg Anderson, Chadi Tannoury, Ravi K Ponnappa. Intervertebral disk degeneration and emerging biologic treatments. The Journal of the American Academy of Orthopaedic Surgeons. vol 19. issue 9. 2011-11-02. PMID:21885700. |
acceleration of cellular senescence and apoptosis in degenerative ivds and the depletion of matrix proteins have prompted the development of treatments based on replacing ivd cells using various cell sources. |
2011-11-02 |
2023-08-12 |
Not clear |
| Robby D Bowles, Harry H Gebhard, Roger Härtl, Lawrence J Bonassa. Tissue-engineered intervertebral discs produce new matrix, maintain disc height, and restore biomechanical function to the rodent spine. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 32. 2011-10-18. PMID:21808048. |
when implanted into the rat caudal spine, tissue-engineered ivd maintained disc space height, produced de novo extracellular matrix, and integrated into the spine, yielding an intact motion segment with dynamic mechanical properties similar to that of native ivd. |
2011-10-18 |
2023-08-12 |
rat |