| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Recep Basaran, Mehmet Senol, Seyma Ozkanli, Mustafa Efendioglu, Tuncay Kane. Correlation of matrix metalloproteinase (MMP)-1, -2, -3, and -9 expressions with demographic and radiological features in primary lumbar intervertebral disc disease. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 41. 2018-01-02. PMID:28343922. |
mmps are a family of proteolytic enzymes and involved in the degradation of the matrix components of the ivd. |
2018-01-02 |
2023-08-13 |
human |
| Norihiko Takegami, Koji Akeda, Junichi Yamada, Tomohiko Sano, Koichiro Murata, Jenny Huang, Koichi Masuda, Akihiro Sud. RANK/RANKL/OPG system in the intervertebral disc. Arthritis research & therapy. vol 19. issue 1. 2018-01-02. PMID:28576140. |
the purposes of this study were to examine the expression of the rank/rankl/opg system and to evaluate the function of rankl in the matrix metabolism of the rat ivd. |
2018-01-02 |
2023-08-13 |
rat |
| Xianfeng Lin, Xiangqian Fang, Qiang Wang, Zhijun Hu, Kai Chen, Zhi Shan, Shuai Chen, Jiying Wang, Jian Mo, Jianjun Ma, Wenbing Xu, An Qin, Shunwu Fa. Decellularized allogeneic intervertebral disc: natural biomaterials for regenerating disc degeneration. Oncotarget. vol 7. issue 11. 2017-12-14. PMID:26933821. |
this study established a modified protocol for intervertebral disc (ivd) decellularization and prepared its extracellular matrix (ecm). |
2017-12-14 |
2023-08-13 |
human |
| Akshay Srivastava, Isma Liza Mohd Isa, Peadar Rooney, Abhay Pandi. Bioengineered three-dimensional diseased intervertebral disc model revealed inflammatory crosstalk. Biomaterials. vol 123. 2017-12-13. PMID:28167391. |
the developed model has provided us with an understanding of the molecular changes that occur at genetic level which modulate the production of extracellular matrix components and key inflammatory pathways in the inflamed ivd. |
2017-12-13 |
2023-08-13 |
human |
| Shady Elmasry, Shihab Asfour, Juan Pablo de Rivero Vaccari, Francesco Travasci. A computational model for investigating the effects of changes in bioavailability of insulin-like growth factor-1 on the homeostasis of the intervertebral disc. Computers in biology and medicine. vol 78. 2017-12-08. PMID:27697672. |
insulin-like growth factor-1 (igf-1) is well-known for upregulating cell proliferation and biosynthesis of the extracellular matrix in the intervertebral disc (ivd). |
2017-12-08 |
2023-08-13 |
Not clear |
| Shady Elmasry, Shihab Asfour, Juan Pablo de Rivero Vaccari, Francesco Travasci. A computational model for investigating the effects of changes in bioavailability of insulin-like growth factor-1 on the homeostasis of the intervertebral disc. Computers in biology and medicine. vol 78. 2017-12-08. PMID:27697672. |
in this study, we developed a computational model for disc homeostasis specifically addressing the role of igf-1 in modulating both extracellular matrix biosynthesis and cellularity in the ivd. |
2017-12-08 |
2023-08-13 |
Not clear |
| Rahel D May, Adel Tekari, Daniela A Frauchiger, Anna Krismer, Lorin M Benneker, Benjamin Gantenbei. Efficient Nonviral Transfection of Primary Intervertebral Disc Cells by Electroporation for Tissue Engineering Application. Tissue engineering. Part C, Methods. vol 23. issue 1. 2017-11-16. PMID:27968705. |
cell-based therapy and tissue engineered ivd constructs supplemented with transfected disc cells that incorporate factors enhancing matrix synthesis represent an appealing approach to regenerate the ivd. |
2017-11-16 |
2023-08-13 |
human |
| ZhanJun Yan, YouDong Pan, ShiHui Wang, MaoHua Cheng, HongMei Kong, ChunGuang Sun, Kai Hu, TongLei Chen, QiRong Dong, JianFeng Che. Static Compression Induces ECM Remodeling and Integrin α2β1 Expression and Signaling in a Rat Tail Caudal Intervertebral Disc Degeneration Model. Spine. vol 42. issue 8. 2017-10-17. PMID:27548579. |
a three-level rat tail caudal intervertebral disc (ivd) degeneration (ivdd) model was established to study effects of static compression on extracellular matrix (ecm) remodeling and integrin signaling in ivds during ivdd. |
2017-10-17 |
2023-08-13 |
rat |
| Jianru Wang, Hehai Pan, Xiang Li, Kuibo Zhang, Zemin Li, Hua Wang, Zhaomin Zheng, Hui Li. Hypoxia suppresses serum deprivation-induced degradation of the nucleus pulposus cell extracellular matrix through the JNK and NF-κB pathways. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 35. issue 9. 2017-10-10. PMID:27869311. |
intervertebral disc (ivd) degeneration is associated with the imbalance between anabolism and catabolism of the nucleus pulposus (np) extracellular matrix (ecm). |
2017-10-10 |
2023-08-13 |
Not clear |
| Tao Gu, Zhiyuan Shi, Chaofeng Wang, Chun Chen, Jianhong Wu, Deli Wang, Cheng Xu, He Qing, Ruan Dik. Human bone morphogenetic protein 7 transfected nucleus pulposus cells delay the degeneration of intervertebral disc in dogs. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 35. issue 6. 2017-10-02. PMID:26218641. |
the main reason for intervertebral disc (ivd) degeneration is the decrease in the quantity and activity of ivd cells with subsequent reduction of the extracellular matrix (ecm). |
2017-10-02 |
2023-08-13 |
human |
| Fubiao Ye, Hua Wang, Zhaomin Zheng, Peiheng He, Shilabant Sen Sribastav, Huafeng Wang, Jianru Wang, Hui Liu, Victor Y L Leun. Role of SHOX2 in the development of intervertebral disc degeneration. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 35. issue 5. 2017-09-26. PMID:26697824. |
first, we detected the expression of shox2 in different stages of human ivd degeneration; then explored the role of shox2 on nucleus pulposus (np) cells proliferation and apoptosis, finally we evaluated the effect of shox2 on the production of extracellular matrix in np cells. |
2017-09-26 |
2023-08-13 |
human |
| A J Hayes, C C Shu, M S Lord, C B Little, J M Whitelock, J Melros. Pericellular colocalisation and interactive properties of type VI collagen and perlecan in the intervertebral disc. European cells & materials. vol 32. 2017-09-11. PMID:27377666. |
pericellular colocalisation of perlecan and type vi collagen provides matrix stabilisation and cell-matrix communication which allows ivd cells to perceive and respond to perturbations in their biomechanical microenvironment. |
2017-09-11 |
2023-08-13 |
mouse |
| B A Walter, D Purmessur, A Moon, J Occhiogrosso, D M Laudier, A C Hecht, J C Iatridi. Reduced tissue osmolarity increases TRPV4 expression and pro-inflammatory cytokines in intervertebral disc cells. European cells & materials. vol 32. 2017-09-11. PMID:27434269. |
this osmotic environment is a biophysical signal that changes with disease and may contribute to the elevated matrix breakdown and altered biologic response to loading observed in ivd degeneration and osteoarthritis. |
2017-09-11 |
2023-08-13 |
human |
| Svenja Illien-Jünger, Dillon D Sedaghatpour, Damien M Laudier, Andrew C Hecht, Sheeraz A Qureshi, James C Iatridi. Development of a bovine decellularized extracellular matrix-biomaterial for nucleus pulposus regeneration. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 34. issue 5. 2017-09-05. PMID:26509556. |
there is a clinical need to develop injectable biomaterials capable of promoting ivd regeneration, yet many available biomaterials do not mimic the native extracellular matrix (ecm) or promote matrix production. |
2017-09-05 |
2023-08-13 |
human |
| Kang Li, Yan Li, Bo Xu, Lu Mao, Jie Zha. Sesamin inhibits lipopolysaccharide-induced inflammation and extracellular matrix catabolism in rat intervertebral disc. Connective tissue research. vol 57. issue 5. 2017-09-04. PMID:27128308. |
organ culture experiments demonstrate that sesamin protects the ivd from lps-induced depletion of the extracellular matrix ex vivo. |
2017-09-04 |
2023-08-13 |
rat |
| Kang Li, Yan Li, Bo Xu, Lu Mao, Jie Zha. Sesamin inhibits lipopolysaccharide-induced inflammation and extracellular matrix catabolism in rat intervertebral disc. Connective tissue research. vol 57. issue 5. 2017-09-04. PMID:27128308. |
in light of our results, sesamin protects the ivd from inflammation and extracellular matrix catabolism, presenting positive prospects in the treatment of ivd degenerative diseases. |
2017-09-04 |
2023-08-13 |
rat |
| Xinyan Tang, Liufang Jing, William J Richardson, Robert E Isaacs, Robert D Fitch, Christopher R Brown, Melissa M Erickson, Lori A Setton, Jun Che. Identifying molecular phenotype of nucleus pulposus cells in human intervertebral disc with aging and degeneration. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 34. issue 8. 2017-08-31. PMID:27018499. |
previous study claimed that disc degeneration may be preceded by structure and matrix changes in the intervertebral disc (ivd) which coincide with the loss of distinct notochordally derived nucleus pulposus (np) cells. |
2017-08-31 |
2023-08-13 |
human |
| Xinyan Tang, Liufang Jing, William J Richardson, Robert E Isaacs, Robert D Fitch, Christopher R Brown, Melissa M Erickson, Lori A Setton, Jun Che. Identifying molecular phenotype of nucleus pulposus cells in human intervertebral disc with aging and degeneration. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 34. issue 8. 2017-08-31. PMID:27018499. |
furthermore, the potential of phenotype juvenilization and matrix regeneration of ivd cells in a laminin-rich pseudo-3d culture system were evaluated at day 28 by immunostaining, safranin o, and type ii collagen staining. |
2017-08-31 |
2023-08-13 |
human |
| Wai Hon Chooi, Samantha Chun Wai Chan, Benjamin Gantenbein, Barbara Pui Cha. Loading-Induced Heat-Shock Response in Bovine Intervertebral Disc Organ Culture. PloS one. vol 11. issue 8. 2017-07-27. PMID:27580124. |
mechanical loading has been shown to affect cell viability and matrix maintenance in the intervertebral disc (ivd) but there is no investigation on how cells survive mechanical stress and whether the ivd cells perceive mechanical loading as stress and respond by expression of heat shock proteins. |
2017-07-27 |
2023-08-13 |
cattle |
| Joana C Antunes, Catarina Leite Pereira, Graciosa Q Teixeira, Ricardo V Silva, Joana Caldeira, Sibylle Grad, Raquel M Gonçalves, Mário A Barbos. Poly(γ-glutamic acid) and poly(γ-glutamic acid)-based nanocomplexes enhance type II collagen production in intervertebral disc. Journal of materials science. Materials in medicine. vol 28. issue 1. 2017-07-04. PMID:27885573. |
this study is a first proof of concept that γ-pga and γ-pga/ch ncs promote recovery of ivd native matrix, opening new perspectives on the development of alternative therapeutic approaches for ivd degeneration. |
2017-07-04 |
2023-08-13 |
cattle |