| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chencheng Feng, Huan Liu, Minghui Yang, Yang Zhang, Bo Huang, Yue Zho. Disc cell senescence in intervertebral disc degeneration: Causes and molecular pathways. Cell cycle (Georgetown, Tex.). vol 15. issue 13. 2017-06-05. PMID:27192096. |
moreover, the senescent disc cells were supposed to accelerate the process of idd via their aberrant paracrine effects by which senescent cells cause the senescence of neighboring cells and enhance the matrix catabolism and inflammation in ivd. |
2017-06-05 |
2023-08-13 |
Not clear |
| Yu-Ping Liu, Chong-Ming Yuan, Shuai-Gong Zhang, Qing-Hai Hao, Ming-Ming Wang, Zhong Zhang, Qian Meng, Ming Li, Yue-Dong Ha. TWEAK/Fn14 signaling: a promising target in intervertebral disc degeneration. Histology and histopathology. vol 31. issue 9. 2017-04-14. PMID:26907852. |
the interaction of tweak with fn14 is involved in physiological and pathological activities of ivd degeneration patients, which includes apoptosis of endplate chondrocytes, extracellular matrix degradation, reduction in proteoglycan synthesis and so on. |
2017-04-14 |
2023-08-13 |
Not clear |
| Zhixiao Yao, Lin Nie, Yunpeng Zhao, Yuanqiang Zhang, Yi Liu, Jingkun Li, Lei Chen. Salubrinal Suppresses IL-17-Induced Upregulation of MMP-13 and Extracellular Matrix Degradation Through the NF-kB Pathway in Human Nucleus Pulposus Cells. Inflammation. vol 39. issue 6. 2017-04-04. PMID:27590238. |
this study examined the effect of il-17 on the regulation of mmp-13 and the extracellular matrix (ecm) in the intervertebral disc (ivd). |
2017-04-04 |
2023-08-13 |
human |
| Cheng Wang, Xiaohua Yu, Yiguo Yan, Wei Yang, Shujun Zhang, Yongxiao Xiang, Jian Zhang, Wenjun Wan. Tumor necrosis factor-α: a key contributor to intervertebral disc degeneration. Acta biochimica et biophysica Sinica. vol 49. issue 1. 2017-01-30. PMID:27864283. |
tnf-α is highly expressed in degenerative ivd tissues, and it is deeply involved in multiple pathological processes of disc degeneration, including matrix destruction, inflammatory responses, apoptosis, autophagy, and cell proliferation. |
2017-01-30 |
2023-08-13 |
Not clear |
| Huanxin Xie, Yongbin Jing, Jingjun Xia, Xintao Wang, Changcheng You, Jinglong Ya. Aquaporin 3 protects against lumbar intervertebral disc degeneration via the Wnt/β-catenin pathway. International journal of molecular medicine. vol 37. issue 3. 2016-12-19. PMID:26820815. |
the objective of the present study was to investigate the effect of aqp3 on cell proliferation and extracellular matrix (ecm) degradation in human nucleus pulposus cells (hnpcs) using gain-of-function and loss-of-function experiments, and to determine whether wnt/β-catenin signaling is involved in the effect of aqp3 on ivd degeneration. |
2016-12-19 |
2023-08-13 |
human |
| A Yee, M P Y Lam, V Tam, W C W Chan, I K Chu, K S E Cheah, K M C Cheung, D Cha. Fibrotic-like changes in degenerate human intervertebral discs revealed by quantitative proteomic analysis. Osteoarthritis and cartilage. vol 24. issue 3. 2016-12-13. PMID:26463451. |
the purpose of this study is to understand the extracellular matrix (ecm) changes in disc biology through comparative proteomic analysis of degenerated and non-degenerated human intervertebral disc (ivd) tissues of different ages. |
2016-12-13 |
2023-08-13 |
human |
| Min Ho Hwang, Kyoung Soo Kim, Chang Min Yoo, Jae Hee Shin, Hyo Geun Nam, Jin Su Jeong, Joo Han Kim, Kwang Ho Lee, Hyuk Cho. Photobiomodulation on human annulus fibrosus cells during the intervertebral disk degeneration: extracellular matrix-modifying enzymes. Lasers in medical science. vol 31. issue 4. 2016-12-13. PMID:26987527. |
destruction of extracellular matrix (ecm) leads to degeneration of the intervertebral disk (ivd), which is a major contributor to many spine disorders. |
2016-12-13 |
2023-08-13 |
human |
| Hongsik Cho, David C Holt, Richard Smith, Song-Ja Kim, Raymond J Gardocki, Karen A Hast. The Effects of Platelet-Rich Plasma on Halting the Progression in Porcine Intervertebral Disc Degeneration. Artificial organs. vol 40. issue 2. 2016-10-21. PMID:26147759. |
disc degeneration and the subsequent herniation and/or rupture of the intervertebral disc (ivd) are due to a failure of the extracellular matrix of the annulus to contain the contents of the nucleus. |
2016-10-21 |
2023-08-13 |
Not clear |
| D H Rosenzweig, R Gawri, J Moir, L Beckman, D Eglin, T Steffen, P J Roughley, J A Ouellet, L Haglun. Dynamic loading, matrix maintenance and cell injection therapy of human intervertebral discs cultured in a bioreactor. European cells & materials. vol 31. 2016-10-19. PMID:26728497. |
long-term culture of intact ivds is necessary to develop ex vivo models of human ivd degeneration and repair, where the relationship between mechanobiology, disc matrix composition and metabolism can be better understood. |
2016-10-19 |
2023-08-13 |
human |
| Po-Hsin Chou, Shih-Tien Wang, Meng-Hua Yen, Chien-Lin Liu, Ming-Chau Chang, Oscar Kuang-Sheng Le. Fluid-induced, shear stress-regulated extracellular matrix and matrix metalloproteinase genes expression on human annulus fibrosus cells. Stem cell research & therapy. vol 7. 2016-10-11. PMID:26921206. |
mechanical loading plays an important role in the regulation of extracellular matrix (ecm) homeostasis as well as pathogenesis of intervertebral disc (ivd) degeneration. |
2016-10-11 |
2023-08-13 |
human |
| H Barreto Henriksson, N Papadimitriou, S Tschernitz, E Svala, E Skioldebrand, S Windahl, K Junevik, H Brisb. Indications of that migration of stem cells is influenced by the extra cellular matrix architecture in the mammalian intervertebral disk region. Tissue & cell. vol 47. issue 5. 2016-09-13. PMID:26337726. |
the aim of the study was to examine migration of mesenchymal stem cells (mscs), extracellular matrix (ecm) architecture in a potential cellular migration route (cmr; area located between the niche and ivd) and in the ivd in non-degenerated lapine- and in human degenerated ivd tissues. |
2016-09-13 |
2023-08-13 |
human |
| Young-Mi Kang, Seong-Hwan Hong, Jae-Ho Yang, Jin-Cheol Oh, Jin-Oh Park, Byung Ho Lee, Sang-Yoon Lee, Hak-Sun Kim, Hwan-Mo Lee, Seong-Hwan Moo. Pamidronate Down-regulates Tumor Necrosis Factor-alpha Induced Matrix Metalloproteinases Expression in Human Intervertebral Disc Cells. Journal of bone metabolism. vol 23. issue 3. 2016-09-13. PMID:27622181. |
the aim of this study is to demonstrate the effect of pamidronate, second generation nitrogen-containing bps and to elucidate matrix metallo-proteinases (mmps) mrna expression under serum starvation and/or tumor necrosis factor alpha (tnf-α) stimulation on metabolism of intervertebral disc (ivd) cells in vitro. |
2016-09-13 |
2023-08-13 |
human |
| Nicole Willems, Anna R Tellegen, Niklas Bergknut, Laura B Creemers, Jeannette Wolfswinkel, Christian Freudigmann, Karin Benz, Guy C M Grinwis, Marianna A Tryfonidou, Björn P Mei. Inflammatory profiles in canine intervertebral disc degeneration. BMC veterinary research. vol 12. 2016-09-07. PMID:26757881. |
therefore, in this study, we determined the levels of prostaglandin e2 (pge2), cytokines, chemokines, and matrix components in ivds from chondrodystrophic (cd) and non-chondrodystrophic (ncd) dogs with and without clinical signs of ivd disease, and correlated these to degeneration grade (according to pfirrmann), or herniation type (according to hansen). |
2016-09-07 |
2023-08-13 |
Not clear |
| Harris Pratsinis, Dimitris Kletsa. Organotypic Cultures of Intervertebral Disc Cells: Responses to Growth Factors and Signaling Pathways Involved. BioMed research international. vol 2015. 2016-08-31. PMID:26583105. |
accordingly, aim of this work was the study of ivd cell responses to mitogenic growth factors in a three-dimensional (3d) organotypic milieu, comprising characteristic molecules of ivd's extracellular matrix. |
2016-08-31 |
2023-08-13 |
Not clear |
| Syeda M Naqvi, Conor T Buckle. Extracellular matrix production by nucleus pulposus and bone marrow stem cells in response to altered oxygen and glucose microenvironments. Journal of anatomy. vol 227. issue 6. 2016-08-22. PMID:25913845. |
this study investigated the viability and production of key matrix proteins by nucleus pulposus (np) and bm stem cells cultured in the typical biochemical microenvironment of the ivd consisting of altered oxygen and glucose concentrations. |
2016-08-22 |
2023-08-13 |
Not clear |
| Hidenobu Ishibashi, Hitoshi Tonomura, Takumi Ikeda, Masateru Nagae, Munehiro Sakata, Hiroyoshi Fujiwara, Takashi Tanida, Ken-Ichi Mastuda, Mitsuhiro Kawata, Toshikazu Kub. Hepatocyte growth factor/c-met promotes proliferation, suppresses apoptosis, and improves matrix metabolism in rabbit nucleus pulposus cells in vitro. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 34. issue 4. 2016-08-15. PMID:26440443. |
the etiology of intervertebral disc (ivd) degeneration is closely related to apoptosis and extracellular matrix degradation in nucleus pulposus (np) cells. |
2016-08-15 |
2023-08-13 |
rabbit |
| Samantha C W Chan, Jochen Walser, Stephen J Ferguson, Benjamin Gantenbei. Duration-dependent influence of dynamic torsion on the intervertebral disc: an intact disc organ culture study. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. vol 24. issue 11. 2016-06-22. PMID:26215177. |
studies have demonstrated the role of compression in altering the cellular metabolism, anabolic and catabolic events of the disc, but little is known how complex loading such as torsion-compression affects the ivd cell metabolism and matrix homeostasis. |
2016-06-22 |
2023-08-13 |
Not clear |
| Yan Li, Kang Li, Lu Mao, Xiuguo Han, Kai Zhang, Changqing Zhao, Jie Zha. Cordycepin inhibits LPS-induced inflammatory and matrix degradation in the intervertebral disc. PeerJ. vol 4. 2016-05-18. PMID:27190710. |
in our study, we used a rat np cell culture and an intervertebral disc (ivd) organ culture model to examine the inhibitory effects of cordycepin on lipopolysaccharide (lps)-induced gene expression and the production of matrix degradation enzymes (mmp-3, mmp-13, adamts-4, and adamts-5) and oxidative stress-associated factors (nitric oxide and pge2). |
2016-05-18 |
2023-08-13 |
rat |
| Gianluca Fontana, Eugene See, Abhay Pandi. Current trends in biologics delivery to restore intervertebral disc anabolism. Advanced drug delivery reviews. vol 84. 2016-05-16. PMID:25174310. |
disc degeneration is characterized by a limited ability of ivd cells to produce functional matrix while producing abnormal amounts of matrix-degrading enzymes. |
2016-05-16 |
2023-08-13 |
Not clear |
| S B G Blanquer, D W Grijpma, A A Poo. Delivery systems for the treatment of degenerated intervertebral discs. Advanced drug delivery reviews. vol 84. 2016-05-16. PMID:25451138. |
during ivd degeneration, the balance between anabolic and catabolic processes in the disc is deregulated, amongst others leading to alteration of extracellular matrix production, abnormal enzyme activities and production of pro-inflammatory substances like cytokines. |
2016-05-16 |
2023-08-13 |
Not clear |