| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tao Hu, Dongxia Li, Belur N Manjula, Michael Brenowitz, Muthuchidambaram Prabhakaran, Seetharama A Achary. PEGylation of Val-1(alpha) destabilizes the tetrameric structure of hemoglobin. Biochemistry. vol 48. issue 3. 2009-02-04. PMID:19119852. |
in order to provide a biochemical insight into the tetramer-dimer dissociation of this pegylated hb, we prepared and characterized two pegylated hbs site-specifically modified at val-1(alpha) and at val-1(beta), respectively. |
2009-02-04 |
2023-08-12 |
Not clear |
| Tao Hu, Dongxia Li, Belur N Manjula, Michael Brenowitz, Muthuchidambaram Prabhakaran, Seetharama A Achary. PEGylation of Val-1(alpha) destabilizes the tetrameric structure of hemoglobin. Biochemistry. vol 48. issue 3. 2009-02-04. PMID:19119852. |
pegylation at val-1(alpha) and at val-1(beta) increase the tetramer-dimer dissociation constant (k(d)) of hb by 2 and 1 order of magnitude, respectively. |
2009-02-04 |
2023-08-12 |
Not clear |
| Tao Hu, Dongxia Li, Belur N Manjula, Michael Brenowitz, Muthuchidambaram Prabhakaran, Seetharama A Achary. PEGylation of Val-1(alpha) destabilizes the tetrameric structure of hemoglobin. Biochemistry. vol 48. issue 3. 2009-02-04. PMID:19119852. |
in order to determine the role of the polyethylene glycol (peg) chains on the tetramer stability of hb, we prepared a propylated hb site-specifically modified at val-1(alpha). |
2009-02-04 |
2023-08-12 |
Not clear |
| Tao Hu, Dongxia Li, Belur N Manjula, Michael Brenowitz, Muthuchidambaram Prabhakaran, Seetharama A Achary. PEGylation of Val-1(alpha) destabilizes the tetrameric structure of hemoglobin. Biochemistry. vol 48. issue 3. 2009-02-04. PMID:19119852. |
interestingly, site-specific propylation of hb at val-l(alpha) stabilizes the hb tetramer by 1 order of magnitude. |
2009-02-04 |
2023-08-12 |
Not clear |
| Tao Hu, Dongxia Li, Belur N Manjula, Michael Brenowitz, Muthuchidambaram Prabhakaran, Seetharama A Achary. PEGylation of Val-1(alpha) destabilizes the tetrameric structure of hemoglobin. Biochemistry. vol 48. issue 3. 2009-02-04. PMID:19119852. |
therefore, conjugation of the peg chains at val-1(alpha) can greatly destabilize the tetramer stability of hb. |
2009-02-04 |
2023-08-12 |
Not clear |
| Tao Hu, Dongxia Li, Belur N Manjula, Michael Brenowitz, Muthuchidambaram Prabhakaran, Seetharama A Achary. PEGylation of Val-1(alpha) destabilizes the tetrameric structure of hemoglobin. Biochemistry. vol 48. issue 3. 2009-02-04. PMID:19119852. |
on the structural aspects, the peg chains conjugated at va-1(alpha) unfavorably alter the heme environment and quaternary structure and destabilize the alpha1beta2 interface of hb. |
2009-02-04 |
2023-08-12 |
Not clear |
| Tao Hu, Dongxia Li, Belur N Manjula, Michael Brenowitz, Muthuchidambaram Prabhakaran, Seetharama A Achary. PEGylation of Val-1(alpha) destabilizes the tetrameric structure of hemoglobin. Biochemistry. vol 48. issue 3. 2009-02-04. PMID:19119852. |
on the functional aspects, the peg chains conjugated at val-1(alpha) decrease the hill coefficient, the bohr effect of hb and the sensitization to the presence of the allosteric effectors. |
2009-02-04 |
2023-08-12 |
Not clear |
| Varvara Douna, Ioannis Papassotiriou, Alexandra Stamoulakatou, Anna Metaxotou-Mavrommati, Emmanuel Kanavakis, Joanne Traeger-Synodino. Association of mild and severely unstable alpha chain variants: the first observation of a compound heterozygote with Hb Setif [alpha94(G1)Asp-->Tyr (alpha2)] and Hb Agrinio [alpha29(B10)Leu-->Pro (alpha2)] in a Greek family. Hemoglobin. vol 32. issue 6. 2009-02-02. PMID:19065338. |
association of mild and severely unstable alpha chain variants: the first observation of a compound heterozygote with hb setif [alpha94(g1)asp-->tyr (alpha2)] and hb agrinio [alpha29(b10)leu-->pro (alpha2)] in a greek family. |
2009-02-02 |
2023-08-12 |
Not clear |
| J M López Góme. [Management of anemia in chronic kidney disease]. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia. vol 28 Suppl 3. 2009-01-07. PMID:19018741. |
resistance to esas: a hyporesponse to esas is considered to be present when an hb level of 11 g/dl is not achieved with a dose of epoetin > 300 iu/kg/week or a dose of darbepoetin alpha > 1.5 microg/kg/week (strength of recommendation b). |
2009-01-07 |
2023-08-12 |
Not clear |
| Gianna Panetta, Alessandro Arcovito, Veronica Morea, Andrea Bellelli, Adriana Erica Miel. Hb(alphaalpha,betabeta): a novel fusion construct for a dimeric, four-domain hemoglobin. Biochimica et biophysica acta. vol 1784. issue 10. 2008-12-31. PMID:18267132. |
in this paper we investigated a novel protein, hb(alphaalpha,betabeta) obtained as a combination of two homodimers alpha(2) and beta(2) both derived from a fusion gene containing two alfa chains or two beta chains, each respectively coupled via a specific linker. |
2008-12-31 |
2023-08-12 |
Not clear |
| Ami D Patel, Judith M Nocek, Brian M Hoffma. Kinetic-dynamic model for conformational control of an electron transfer photocycle: mixed-metal hemoglobin hybrids. The journal of physical chemistry. B. vol 112. issue 37. 2008-12-12. PMID:18717535. |
this model successfully describes the changes in the et photocycle within the "predocked" mixed-metal hemoglobin (hb) hybrid, [alpha(zn), beta(fe3+n 3 (-))], as conformational kinetics are modulated by variations in viscosity (eta = 1-15 cp; 20 degrees c). |
2008-12-12 |
2023-08-12 |
Not clear |
| Ami D Patel, Judith M Nocek, Brian M Hoffma. Kinetic-dynamic model for conformational control of an electron transfer photocycle: mixed-metal hemoglobin hybrids. The journal of physical chemistry. B. vol 112. issue 37. 2008-12-12. PMID:18717535. |
current ideas about hb function lead to the testable hypothesis that et in the hybrid may be coupled to allosteric fluctuations of the two [alpha 1, beta 2] dimers of hb. |
2008-12-12 |
2023-08-12 |
Not clear |
| Kanokwan Sanchaisuriya, Sunisa Chirakul, Hataichanok Srivorakun, Goonnapa Fucharoen, Supan Fucharoen, Yossombat Changtrakul, Pattara Sanchaisuriy. Effective screening for double heterozygosity of Hb E/alpha0-thalassemia. Annals of hematology. vol 87. issue 11. 2008-11-12. PMID:18575861. |
it is concluded that hb e level < 26%, mcv < 74 fl, and mch < 24 pg could be used for screening alpha(o)-thalassemia in heterozygous hb e. however, to improve specificity and ppv of the tests, a combination of hb e level < 26% with either mcv < 74 fl or mch < 24 pg is recommended. |
2008-11-12 |
2023-08-12 |
Not clear |
| Onekham Savongsy, Supan Fucharoen, Goonnapa Fucharoen, Kanokwan Sanchaisuriya, Nattaya Sae-Un. Thalassemia and hemoglobinopathies in pregnant Lao women: carrier screening, prevalence and molecular basis. Annals of hematology. vol 87. issue 8. 2008-10-30. PMID:18414862. |
three clinically important forms of thalassemia including alpha(o)-, beta-thalassemia, and hb e were identified in 39 (12.7%), 11 (3.6%), and 93 (30.2%) subjects, respectively. |
2008-10-30 |
2023-08-12 |
human |
| Vineeta Sharma, Ved Prakash Choudhry, Renu Saxen. Association of HbE with Hb Lepore and alpha triplication in a Bengali family. Clinica chimica acta; international journal of clinical chemistry. vol 395. issue 1-2. 2008-10-20. PMID:18502204. |
association of hbe with hb lepore and alpha triplication in a bengali family. |
2008-10-20 |
2023-08-12 |
Not clear |
| Luigi Vitagliano, Alessandro Vergara, Giovanna Bonomi, Antonello Merlino, Cinzia Verde, Guido di Prisco, Barry D Howes, Giulietta Smulevich, Lelio Mazzarell. Spectroscopic and crystallographic characterization of a tetrameric hemoglobin oxidation reveals structural features of the functional intermediate relaxed/tense state. Journal of the American Chemical Society. vol 130. issue 32. 2008-10-06. PMID:18642904. |
here we report a spectroscopic characterization of the autoxidation process of the trematomus newnesi major hb component and the atomic resolution structure (1.25 a) of an intermediate form along the pathway characterized by a different binding and oxidation state of the alpha and beta chains. |
2008-10-06 |
2023-08-12 |
Not clear |
| Paul W Buehler, Florence Vallelian, Malgorzata G Mikolajczyk, Gabriele Schoedon, Thomas Schweizer, Abdu I Alayash, Dominik J Schae. Structural stabilization in tetrameric or polymeric hemoglobin determines its interaction with endogenous antioxidant scavenger pathways. Antioxidants & redox signaling. vol 10. issue 8. 2008-09-29. PMID:18522492. |
modified hb interaction with cd163 and cellular uptake demonstrated an inverse relation with molecular size, irrespective of alpha and beta cross-linking. |
2008-09-29 |
2023-08-12 |
Not clear |
| Henri Wajcman, Jan Traeger-Synodinos, Ioannis Papassotiriou, Piero C Giordano, Cornelis L Harteveld, Véronique Baudin-Creuza, John Ol. Unstable and thalassemic alpha chain hemoglobin variants: a cause of Hb H disease and thalassemia intermedia. Hemoglobin. vol 32. issue 4. 2008-09-22. PMID:18654884. |
unstable and thalassemic alpha chain hemoglobin variants: a cause of hb h disease and thalassemia intermedia. |
2008-09-22 |
2023-08-12 |
Not clear |
| Henri Wajcman, Jan Traeger-Synodinos, Ioannis Papassotiriou, Piero C Giordano, Cornelis L Harteveld, Véronique Baudin-Creuza, John Ol. Unstable and thalassemic alpha chain hemoglobin variants: a cause of Hb H disease and thalassemia intermedia. Hemoglobin. vol 32. issue 4. 2008-09-22. PMID:18654884. |
this is predicted to result in precipitation of the unstable alpha chains or hb variant, a concomitant decrease in the overall quantity of normal alpha-globin in the red cells and a potential degree of anemia and possibly, hemolysis. |
2008-09-22 |
2023-08-12 |
Not clear |
| Varvara Douna, Dimitra Liapi, Dimitrios Kampourakis, Zoe Repapinou, Ioannis Papassotiriou, Alexandra Stamoulakatou, Christos Poziopoulos, Emmanuel Kanavakis, Joanne Traeger-Synodino. First observation of Hb Taybe [Codons 38/39 (-Acc) Thr-->0 (alpha1)] in Greece: clinical and hematological findings in patients with co-inherited alpha+-thalassemia mutations. Hemoglobin. vol 32. issue 4. 2008-09-22. PMID:18654887. |
dna analysis identified the inheritance of common alpha(+)-thalassemia (alpha(+)-thal) mutations in trans to an in-frame 3 bp deletion at codons 38/39 (-acc) on the alpha1-globin gene, previously described as hb taybe. |
2008-09-22 |
2023-08-12 |
Not clear |