| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Philippe Joly, Philippe Lacan, Martine Bererd, Caroline Garcia, Isabelle Zanella-Cleon, Michel Becchi, Martine Aubry, Nicole Couprie, Alain Francin. Description of two new alpha variants: Hb Canuts [alpha85(F6)Asp-->His (alpha1)] and Hb Ambroise Pare [alpha117(GH5)Phe-->Ile (alpha2)]; two new beta variants: Hb Beaujolais [beta84(EF8)Thr-->Asn] and Hb Monplaisir [beta147 (Tyr-Lys-Leu-Ala-Phe-Phe-Leu-Leu-Ser-Asn-Phe-Tyr-158-COOH)] and one new delta variant: Hb (A2)North Africa [delta59(E3)Lys-->Met]. Hemoglobin. vol 33. issue 3. 2010-02-09. PMID:19657833. |
description of two new alpha variants: hb canuts [alpha85(f6)asp-->his (alpha1)] and hb ambroise pare [alpha117(gh5)phe-->ile (alpha2)]; two new beta variants: hb beaujolais [beta84(ef8)thr-->asn] and hb monplaisir [beta147 (tyr-lys-leu-ala-phe-phe-leu-leu-ser-asn-phe-tyr-158-cooh)] and one new delta variant: hb (a2)north africa [delta59(e3)lys-->met]. |
2010-02-09 |
2023-08-12 |
Not clear |
| Valeh Hadavi, Maryam Jafroodi, Nima Hafezi-Nejad, Sousan Dehnadi Moghadam, Fatemeh Eskandari, Shahin Tarashohi, Hamideh Pourfahim, Christian Oberkanins, Hai-Yang Law, Hossein Najmabad. Alpha-thalassemia mutations in Gilan Province, North Iran. Hemoglobin. vol 33. issue 3. 2010-02-09. PMID:19657838. |
most prevalent of the 16 different alpha-thalassemia (alpha-thal) alleles was -alpha(3.7) (42.5%), followed by the polyadenylation signal (poly a2) (aataaa>aatgaa) (12.4%), hb constant spring [hb cs, alpha142, term-->gln (taa>caa in alpha2] (10.6%), --(med) (8.8%), ivs-i donor site [gag gtg agg>gag g-----, alpha(-5 nt) (-tgagg)] (7.1%), -alpha(4.2) (4.4%) and poly a1 (aataaa>aataag) (3.5%). |
2010-02-09 |
2023-08-12 |
Not clear |
| Corinne Vasseur, Elisa Domingues-Hamdi, Thomas Brillet, Michael C Marden, Véronique Baudin-Creuz. The alpha-hemoglobin stabilizing protein and expression of unstable alpha-Hb variants. Clinical biochemistry. vol 42. issue 18. 2010-02-03. PMID:19482015. |
the different abnormalities of the alpha chain were located either in the g helix: hb bronovo alpha103(g10)his-->leu, hb sallanches alpha104(g11)cys-->tyr, hb oegstgeest alpha104(g11)cys-->ser, hb bleuland alpha108(g15)thr-->asn, hb suan dok alpha109(g16)leu-->arg and as yet undescribed alpha109(g16)leu-->gln, in the gh corner: hb foggia alpha117(gh5)phe-->ser, or in the h helix: hb groene hart alpha119(h2)pro-->ser, hb diamant alpha119(h2)pro-->leu, hb utrecht alpha129(h12)leu-->pro. |
2010-02-03 |
2023-08-12 |
Not clear |
| Barbara Manconi, Irene Messana, Federica Maggiani, Alessandra Olianas, Mariagiuseppina Pellegrini, Roberto Crnjar, Massimo Castagnola, Bruno Giardina, Maria Teresa Sann. Structural and functional characterization of Delphinus delphis hemoglobin system. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. vol 179. issue 8. 2010-01-21. PMID:19554331. |
structural analysis of the hemoglobin (hb) system of delphinus delphis revealed a high globin multiplicity: hplc-electrospray ionization-mass spectrometry (esi-ms) analysis evidenced three major beta (beta1 16,022 da, beta2 16,036 da, beta3 16,036 da, labeled according to their progressive elution times) and two major alpha globins (alpha1 15,345 da, alpha2 15,329 da). |
2010-01-21 |
2023-08-12 |
human |
| Barbara Manconi, Irene Messana, Federica Maggiani, Alessandra Olianas, Mariagiuseppina Pellegrini, Roberto Crnjar, Massimo Castagnola, Bruno Giardina, Maria Teresa Sann. Structural and functional characterization of Delphinus delphis hemoglobin system. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. vol 179. issue 8. 2010-01-21. PMID:19554331. |
the alpha2 globin differs from the alpha1 for the substitution ser15 --> ala. anion-exchange chromatography allowed the separation of two hb fractions and hplc-esi-ms analysis revealed that the fraction with higher pi (hbi) contained beta1, beta2 and both the alpha globins, and the fraction with lower pi (hbii) contained beta3 and both the alpha globins. |
2010-01-21 |
2023-08-12 |
human |
| Nanako Ogasawara, Takashi Oguro, Toshitsugu Sakabe, Miyoko Matsushima, Osamu Takikawa, Ken-ichi Isobe, Fumihiko Nagas. Hemoglobin induces the expression of indoleamine 2,3-dioxygenase in dendritic cells through the activation of PI3K, PKC, and NF-kappaB and the generation of reactive oxygen species. Journal of cellular biochemistry. vol 108. issue 3. 2009-11-24. PMID:19693771. |
hb induced the phosphorylation and degradation of i kappab alpha. |
2009-11-24 |
2023-08-12 |
Not clear |
| Russell H Cole, Ashok Malavalli, Kim D Vandegrif. Erythrocytic ATP release in the presence of modified cell-free hemoglobin. Biophysical chemistry. vol 144. issue 3. 2009-10-30. PMID:19709800. |
when an acellular human hb intramolecularly cross-linked between alpha subunits (alphaalphahb, p50 = 33 mmhg) was added to the red cell suspension, atp production was significantly less than that in the presence of a lower p50 hboc (hb cross-linked between beta subunits, betabetahb, p50 = 8 mmhg). |
2009-10-30 |
2023-08-12 |
human |
| Yen-Lin Lin, Kuang-Tse Huan. Comparison of nitric oxide-induced oxidation of recombinant oxyhemoglobin subunits using a competition experiment. Nitric oxide : biology and chemistry. vol 21. issue 1. 2009-10-22. PMID:19427391. |
for recombinant mutant hb alpha(l29f)beta the rates for alpha(l29f) and beta are approximately 15- and 1.6-fold smaller than for wild-type hb. |
2009-10-22 |
2023-08-12 |
Not clear |
| Fantao Meng, Belur N Manjula, Amy G Tsai, Pedro Cabrales, Marcos Intaglietta, Paul K Smith, Muthuchidambaram Prabhakaran, Seetharama A Achary. Hexa-thiocarbamoyl phenyl PEG5K Hb: vasoactivity and structure: influence of rigidity of the conjugation linkage on the PEGylation induced plasma expander-like solution properties of PEG-Hb adducts. The protein journal. vol 28. issue 5. 2009-10-20. PMID:19653083. |
of the six peg5k chains of (tcp-peg5k)(6)-hb, 4 are conjugated to the alpha-amino groups of hb, and the other 2 chains are distributed on epsilon-amino groups, identified as lys-40(alpha) (approximately 45%), lys-56(alpha) (approximately 25%), and lys-8(beta) (approximately 24%). |
2009-10-20 |
2023-08-12 |
Not clear |
| Rossarin Karnpean, Goonnapa Fucharoen, Supan Fucharoen, Nattaya Sae-ung, Kanokwan Sanchaisuriya, Thawalwong Ratanasir. Accurate prenatal diagnosis of Hb Bart's hydrops fetalis in daily practice with a double-check PCR system. Acta haematologica. vol 121. issue 4. 2009-08-25. PMID:19546525. |
hemoglobin (hb) bart's hydrops fetalis is a fatal condition associated with homozygous alpha(0)-thalassemia. |
2009-08-25 |
2023-08-12 |
Not clear |
| Rossarin Karnpean, Goonnapa Fucharoen, Supan Fucharoen, Nattaya Sae-ung, Kanokwan Sanchaisuriya, Thawalwong Ratanasir. Accurate prenatal diagnosis of Hb Bart's hydrops fetalis in daily practice with a double-check PCR system. Acta haematologica. vol 121. issue 4. 2009-08-25. PMID:19546525. |
the final diagnoses included 13 normal, 29 unaffected heterozygote and 22 homozygote alpha(0)-thalassemia fetuses.the two pcr assays disclosed no discordant result in the diagnosis of the hb bart's hydrops fetalis caused by alpha(0)-thalassemia.the combined pcr assay for gap-pcr, zeta(2) xbai and alpha(2) rsai fragments, described here, is simple, accurate and applicable in the prenatal diagnosis of hb bart's hydrops fetalis in a routine setting. |
2009-08-25 |
2023-08-12 |
Not clear |
| Gurusamy Balakrishnan, Mohammed Ibrahim, Piotr J Mak, Jessica Hata, James R Kincaid, Thomas G Spir. Linking conformation change to hemoglobin activation via chain-selective time-resolved resonance Raman spectroscopy of protoheme/mesoheme hybrids. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. vol 14. issue 5. 2009-08-24. PMID:19288145. |
time-resolved resonance raman (rr) spectra are reported for hemoglobin (hb) tetramers, in which the alpha and beta chains are selectively substituted with mesoheme. |
2009-08-24 |
2023-08-12 |
Not clear |
| Gurusamy Balakrishnan, Mohammed Ibrahim, Piotr J Mak, Jessica Hata, James R Kincaid, Thomas G Spir. Linking conformation change to hemoglobin activation via chain-selective time-resolved resonance Raman spectroscopy of protoheme/mesoheme hybrids. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. vol 14. issue 5. 2009-08-24. PMID:19288145. |
since the transition from fast- to slow-rebinding hb also occurs at 20 micros, the drop in the alpha chain nu (fe-his) supports the localization of ligation restraint to tension in the fe-his bond, at least in the alpha chains. |
2009-08-24 |
2023-08-12 |
Not clear |
| Asude Alpman Durmaz, Haluk Akin, Aslihan Yilmaz Ekmekci, Huseyin Onay, Burak Durmaz, Ozgur Cogulu, Yesim Aydinok, Ferda Ozkina. A severe alpha thalassemia case compound heterozygous for Hb Adana in alpha1 gene and 20.5 kb double gene deletion. Journal of pediatric hematology/oncology. vol 31. issue 8. 2009-08-18. PMID:19636270. |
a severe alpha thalassemia case compound heterozygous for hb adana in alpha1 gene and 20.5 kb double gene deletion. |
2009-08-18 |
2023-08-12 |
Not clear |
| Asude Alpman Durmaz, Haluk Akin, Aslihan Yilmaz Ekmekci, Huseyin Onay, Burak Durmaz, Ozgur Cogulu, Yesim Aydinok, Ferda Ozkina. A severe alpha thalassemia case compound heterozygous for Hb Adana in alpha1 gene and 20.5 kb double gene deletion. Journal of pediatric hematology/oncology. vol 31. issue 8. 2009-08-18. PMID:19636270. |
mutation analysis using strip assay capable of detecting 22 mutations within the alpha genes was performed for the proband and the parents which revealed that the case was compound heterozygous for hb adana in alpha1 gene and 20.5 kb double gene deletion. |
2009-08-18 |
2023-08-12 |
Not clear |
| L M Storti-Melo, P H Mangonaro, C R Valencio, C Traina Junior, C R B Domingo. Three-dimensional visualization of human hemoglobin phenotypes with HPLC. Genetics and molecular research : GMR. vol 8. issue 1. 2009-08-05. PMID:19440971. |
it allowed separation of the samples with normal hb from those with alpha thalassemia, based on a significant difference (p < 0.05) between the mean values of the "fast" and "a" peaks, demonstrating the need for better evaluation of chromatograms; this method could be used to help diagnose alpha thalassemia in newborns. |
2009-08-05 |
2023-08-12 |
human |
| Ne-Win, Keiko Harano, Teruo Harano, Kyaw-Shwe, Aye-Aye-Myint, Khin-Thander-Aye, Shigeru Okad. Hb Constant Spring [alpha 142, Term-->Gln (TAA>CAA in alpha2)] in the alpha-thalassemia of anemic patients in Myanmar. Hemoglobin. vol 32. issue 5. 2009-07-10. PMID:18932070. |
hb constant spring [alpha 142, term-->gln (taa>caa in alpha2)] in the alpha-thalassemia of anemic patients in myanmar. |
2009-07-10 |
2023-08-12 |
Not clear |
| Ne-Win, Keiko Harano, Teruo Harano, Kyaw-Shwe, Aye-Aye-Myint, Khin-Thander-Aye, Shigeru Okad. Hb Constant Spring [alpha 142, Term-->Gln (TAA>CAA in alpha2)] in the alpha-thalassemia of anemic patients in Myanmar. Hemoglobin. vol 32. issue 5. 2009-07-10. PMID:18932070. |
hb constant spring (hb cs), the gene (alpha(cs)) of which arises from a point mutation in the termination codon of the alpha2-globin gene, is the most prevalent variety of nondeletional alpha-thalassemia (alpha-thal) in asian populations. |
2009-07-10 |
2023-08-12 |
Not clear |
| Ne-Win, Keiko Harano, Teruo Harano, Kyaw-Shwe, Aye-Aye-Myint, Khin-Thander-Aye, Shigeru Okad. Hb Constant Spring [alpha 142, Term-->Gln (TAA>CAA in alpha2)] in the alpha-thalassemia of anemic patients in Myanmar. Hemoglobin. vol 32. issue 5. 2009-07-10. PMID:18932070. |
it is a major cause of hb h disease in compound heterozygotes who have hb cs combined with a duplicated alpha gene deletion (--/alpha(cs)alpha), and it tends to be more severe than hb h disease which is caused by a triple alpha gene deletion (--/-alpha). |
2009-07-10 |
2023-08-12 |
Not clear |
| Ne-Win, Keiko Harano, Teruo Harano, Kyaw-Shwe, Aye-Aye-Myint, Khin-Thander-Aye, Shigeru Okad. Hb Constant Spring [alpha 142, Term-->Gln (TAA>CAA in alpha2)] in the alpha-thalassemia of anemic patients in Myanmar. Hemoglobin. vol 32. issue 5. 2009-07-10. PMID:18932070. |
detection of the alpha(cs) gene for the carriers of alpha-thal-1 and hb h disease was done by the mismatched pcr-rflp (restriction fragment length polymorphism) method and the alpha(cs) gene was found in the homozygous state in an alpha-thal-1 patient and a single gene form in two hb h disease patients. |
2009-07-10 |
2023-08-12 |
Not clear |