| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Weidong Zheng, Yanhui Liu, Dong Chen, Kabin Rong, Yanfen Ge, Caiping Gong, Heping Che. Complex interaction of Hb Q-Thailand and Hb E with alpha(0)-thalassemia and hereditary persistence of fetal hemoglobin in a Chinese family. Annals of hematology. vol 89. issue 9. 2010-08-16. PMID:20333523. |
family study identified that her father was a double heterozygote for hb q-thailand and hb e, whereas her mother was a heterozygote for sea-hpfh with alpha(0)-thalassemia. |
2010-08-16 |
2023-08-12 |
Not clear |
| Shigenori Ito, Takashi Nakahari, Daisuke Yamamot. Relationship between impaired glycation and the N-terminal structure of the Hb Görwihl [beta5(A2)Pro-->Ala] variant. Hemoglobin. vol 34. issue 2. 2010-07-09. PMID:20353350. |
on the basis of the results, we predicted that the glycation site would have the following characteristics: 1) glycation of the beta-n-terminus of hb is probably accelerated by the neighboring histidine residue at beta2(na2), which acts as an acid-base catalyst via a phosphate-mediated proton transfer; and 2) the mutation beta5(a2)pro-->ala would bring about impaired glycation of the n-terminal residue by forming an electrostatic bond between the alpha amino group of beta1(na1)val and beta carboxyl group of beta79(ef3)asp. |
2010-07-09 |
2023-08-12 |
Not clear |
| Can Liao, Jian-Ying Zhou, Xing-Mei Xie, Jian Li, Ru Li, Dong-Zhi L. Detection of Hb Constant Spring by a capillary electrophoresis method. Hemoglobin. vol 34. issue 2. 2010-07-09. PMID:20353355. |
in conjunction with alpha(0)-thal, it can cause severe hb h (beta(4)) disease. |
2010-07-09 |
2023-08-12 |
Not clear |
| M E Roux, A Florin-Christensen, R M Arana, D Doniac. Paraproteins with antibody activity in acute viral hepatitis and chronic autoimmune liver diseases. Gut. vol 15. issue 5. 2010-06-28. PMID:18668850. |
six of these monoclonal immunoglobulins were shown to have antibody activity, directed to human gamma globulin, alpha(1)-fetoprotein, smooth muscle, and mitochondria.eight of the patients suffered from acute viral hepatitis, five of whom were hb ag positive; in all these cases the monoclonal spikes were transient and their antibody activities were directed against igg in two cases and alpha(1)-fetoprotein in one.seven of the patients had active chronic hepatitis and in these the paraproteinaemia persisted, though remaining quantitatively unchanged over several years. |
2010-06-28 |
2023-08-12 |
human |
| Hung-Chang Shih, Tze-Kiong Er, Tien-Jye Chang, Ya-Sian Chang, Ta-Chih Liu, Jan-Gowth Chan. Development of a high-resolution melting method for the detection of hemoglobin alpha variants. Clinical biochemistry. vol 43. issue 7-8. 2010-06-28. PMID:20144601. |
the present study was aimed at identifying hemoglobin (hb) alpha variants. |
2010-06-28 |
2023-08-12 |
Not clear |
| Magnus G Olsson, Magnus Centlow, Sigurbjörg Rutardóttir, Iréne Stenfors, Jörgen Larsson, Bahram Hosseini-Maaf, Martin L Olsson, Stefan R Hansson, Bo Akerströ. Increased levels of cell-free hemoglobin, oxidation markers, and the antioxidative heme scavenger alpha(1)-microglobulin in preeclampsia. Free radical biology & medicine. vol 48. issue 2. 2010-06-14. PMID:19879940. |
increased amounts of alpha(1)-microglobulin mrna and protein were found in placenta from preeclamptic women, and the levels of plasma and placenta alpha(1)-microglobulin correlated with the plasma hb concentrations. |
2010-06-14 |
2023-08-12 |
Not clear |
| Shahper Nazeer Khan, Asad Ullah Kha. An in silico approach to map the binding site of doxorubicin on hemoglobin. Bioinformation. vol 2. issue 9. 2010-06-09. PMID:18795113. |
the alpha subunit of hb has been assigned to posses the binding site for dox with a binding affinity (ka) = 16.98 x10(3) mol(-1). |
2010-06-09 |
2023-08-12 |
Not clear |
| Attawut Chaibunruang, Sontong Pornphannukool, Nattaya Sae-Ung, Goonnapa Fucharoen, Kanokwan Sanchaisuriya, Supan Fucharoe. Improvement of alpha(0)-thalassemia screening using combined osmotic fragility, dichlorophenolindophenol and Hb H inclusion tests. Clinical laboratory. vol 56. issue 3-4. 2010-06-03. PMID:20476642. |
improvement of alpha(0)-thalassemia screening using combined osmotic fragility, dichlorophenolindophenol and hb h inclusion tests. |
2010-06-03 |
2023-08-12 |
Not clear |
| Attawut Chaibunruang, Hataichanok Srivorakun, Supan Fucharoen, Goonnapa Fucharoen, Nattaya Sae-ung, Kanokwan Sanchaisuriy. Interactions of hemoglobin Lepore (deltabeta hybrid hemoglobin) with various hemoglobinopathies: A molecular and hematological characteristics and differential diagnosis. Blood cells, molecules & diseases. vol 44. issue 3. 2010-05-28. PMID:20022270. |
using a combination of hb-hplc, hb-capillary electrophoresis and dna analyses, we have identified 14 patients with hb lepore-hollandia including eight heterozygotes, two double heterozygotes with alpha(+)-thalassemia, two compound heterozygotes with hb e (initially diagnosed as hb e-beta-thalassemia) and two previously undescribed conditions of double heterozygote for hb lepore/hb constant spring and hb lepore/alpha(0)-thalassemia, both associated with higher levels of hb f and lower levels of hb lepore. |
2010-05-28 |
2023-08-12 |
Not clear |
| P J A Zamaro, C R Bonini-Domingo. Abnormal hemoglobin phenotypes in carriers of mild anemia in Latin America. Genetics and molecular research : GMR. vol 9. issue 1. 2010-05-19. PMID:20309827. |
hb hasharon, an alpha globin chain mutant, was the most frequently found variant hemoglobin; it accounted for 14.3% of the abnormal dna samples. |
2010-05-19 |
2023-08-12 |
Not clear |
| Ivan Birukou, Rachel L Schweers, John S Olso. Distal histidine stabilizes bound O2 and acts as a gate for ligand entry in both subunits of adult human hemoglobin. The Journal of biological chemistry. vol 285. issue 12. 2010-04-12. PMID:20080971. |
replacing his(e7) with gly, ala, leu, or phe causes 20-500-fold increases in the rates of o(2) dissociation from either hb subunit, demonstrating unambiguously that the native his(e7) imidazole side chain forms a strong hydrogen bond with bound o(2) in both the alpha and beta chains (deltag(his(e7)h-bond) approximately -8 kj/mol). |
2010-04-12 |
2023-08-12 |
human |
| Yayoi Aki, Masako Nagai, Yukifumi Nagai, Kiyohiro Imai, Michihiko Aki, Akira Sato, Minoru Kubo, Shigenori Nagatomo, Teizo Kitagaw. Differences in coordination states of substituted tyrosine residues and quaternary structures among hemoglobin M probed by resonance Raman spectroscopy. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. vol 15. issue 2. 2010-03-24. PMID:19701784. |
among the four types of hemoglobin (hb) m with a substitution of a tyrosine (tyr) for either the proximal (f8) or distal (e7) histidine in the alpha or beta subunits, only hb m saskatoon (betae7tyr) assumes a hexacoordinate structure and its abnormal subunits can be reduced readily by methemoglobin (methb) reductase. |
2010-03-24 |
2023-08-12 |
Not clear |
| Suthat Fucharoen, Vip Viprakasi. Hb H disease: clinical course and disease modifiers. Hematology. American Society of Hematology. Education Program. 2010-03-15. PMID:20008179. |
in the majority of cases, hb h disease results from double heterozygosity for alpha(0)-thalassemia due to deletions that remove both linked alpha-globin genes on chromosome 16, and deletional alpha(+)-thalassemia from single alpha-globin gene deletions (--/-alpha). |
2010-03-15 |
2023-08-12 |
Not clear |
| Suthat Fucharoen, Vip Viprakasi. Hb H disease: clinical course and disease modifiers. Hematology. American Society of Hematology. Education Program. 2010-03-15. PMID:20008179. |
however, hb h disease may occur from interactions between alpha(0)-thalassemia with non-deletional mutations (alpha(t)alpha or alpha(t)) or with abnormal hemoglobins such as hb constant spring, hb paksé, hb quong sze, and hb pak num po. |
2010-03-15 |
2023-08-12 |
Not clear |
| Anita H Nadkarni, Sona B Nair, Khushnooma Y Italia, Prashant Warang, Madhura Dalvi, Kanjaksha Ghosh, Roshan B Cola. Molecular diversity of hemoglobin H disease in India. American journal of clinical pathology. vol 133. issue 3. 2010-03-15. PMID:20154289. |
for the study, alpha genotyping was done in 8 patients with hb h disease using multiplex polymerase chain reaction and dna sequencing. |
2010-03-15 |
2023-08-12 |
Not clear |
| Anita H Nadkarni, Sona B Nair, Khushnooma Y Italia, Prashant Warang, Madhura Dalvi, Kanjaksha Ghosh, Roshan B Cola. Molecular diversity of hemoglobin H disease in India. American journal of clinical pathology. vol 133. issue 3. 2010-03-15. PMID:20154289. |
the nondeletional mutation hb sallanches (alpha 2 codon 104 g --> a) was seen in 3 cases. |
2010-03-15 |
2023-08-12 |
Not clear |
| Anna Babb, Susannah Solaiman, Brian N Green, Debbie Mantio, Ketan Pate. HB Hillingdon [alpha46(CE4)Phe-->Val (alpha1 Or alpha2)]: a new alpha chain hemoglobin variant. Hemoglobin. vol 33. issue 6. 2010-03-12. PMID:19958197. |
hb hillingdon [alpha46(ce4)phe-->val (alpha1 or alpha2)]: a new alpha chain hemoglobin variant. |
2010-03-12 |
2023-08-12 |
Not clear |
| Anna Babb, Susannah Solaiman, Brian N Green, Debbie Mantio, Ketan Pate. HB Hillingdon [alpha46(CE4)Phe-->Val (alpha1 Or alpha2)]: a new alpha chain hemoglobin variant. Hemoglobin. vol 33. issue 6. 2010-03-12. PMID:19958197. |
routine antenatal hemoglobinopathy screening detected a new alpha chain variant that eluted with hb a(2) on cation exchange high performance liquid chromatography (hplc) in a lady of sri lankan origin who had normal hematological indices. |
2010-03-12 |
2023-08-12 |
Not clear |
| Rob van Zwieten, Judith O Kaufmann, Herma Vuil, Jan Kouwenberg, Arthur J Verhoeven, Kea Fogelberg, Cornelis L Harteveld, Piero C Giordan. Hb Nile[A1] and Hb Nile[A2]: novel identical [alpha77(EF6)Pro-->Ser] variants found in either the alpha1- or alpha2-globin genes. Hemoglobin. vol 33. issue 3. 2010-02-09. PMID:19657832. |
we describe a novel hemoglobin (hb) variant, caused by a ccc > tcc transition at codon 77 on the alpha gene. |
2010-02-09 |
2023-08-12 |
Not clear |
| Rob van Zwieten, Judith O Kaufmann, Herma Vuil, Jan Kouwenberg, Arthur J Verhoeven, Kea Fogelberg, Cornelis L Harteveld, Piero C Giordan. Hb Nile[A1] and Hb Nile[A2]: novel identical [alpha77(EF6)Pro-->Ser] variants found in either the alpha1- or alpha2-globin genes. Hemoglobin. vol 33. issue 3. 2010-02-09. PMID:19657832. |
reversed phase hplc separation of the globin chains revealed the normal and abnormal alpha chains with an expression of about 20% for hb nile[a1], indicative of normal expression and stability of the mutant protein. |
2010-02-09 |
2023-08-12 |
Not clear |