| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Caihong Qiu, Emmanuel N Olivier, Michelle Velho, Eric E Bouhassir. Globin switches in yolk sac-like primitive and fetal-like definitive red blood cells produced from human embryonic stem cells. Blood. vol 111. issue 4. 2008-05-21. PMID:18024790. |
we show here that these primitive erythroblasts undergo a switch in hemoglobin (hb) composition during late terminal erythroid maturation with the basophilic erythroblasts expressing predominantly hb gower i (zeta(2)epsilon(2)) and the orthochromatic erythroblasts hemoglobin gower ii (alpha(2)epsilon(2)). |
2008-05-21 |
2023-08-12 |
human |
| Z M Younossi, F H Nader, C Bai, R Sjogren, J P Ong, R Collantes, M Sjogren, D Farmer, L Ramsey, K Terra, H Gujral, C Gurung, M Srishord, Y Fan. A phase II dose finding study of darbepoetin alpha and filgrastim for the management of anaemia and neutropenia in chronic hepatitis C treatment. Journal of viral hepatitis. vol 15. issue 5. 2008-05-06. PMID:18194172. |
patients with anaemia [haemoglobin (hb) alpha (3 mug/kg once every 2 weeks); the dose was titrated to achieve a hb level of 12.0 g/dl. |
2008-05-06 |
2023-08-12 |
Not clear |
| Z M Younossi, F H Nader, C Bai, R Sjogren, J P Ong, R Collantes, M Sjogren, D Farmer, L Ramsey, K Terra, H Gujral, C Gurung, M Srishord, Y Fan. A phase II dose finding study of darbepoetin alpha and filgrastim for the management of anaemia and neutropenia in chronic hepatitis C treatment. Journal of viral hepatitis. vol 15. issue 5. 2008-05-06. PMID:18194172. |
hb at the time of darbepoetin alpha initiation was 10.2 +/- 0.4 g/dl. |
2008-05-06 |
2023-08-12 |
Not clear |
| Giuseppina Lacerra, Clelia Scarano, Gennaro Musollino, Angela Flagiello, Piero Pucci, Clementina Caresti. Hb Foggia or alpha 117(GH5)Phe -> Ser: a new alpha 2 globin allele affecting the alpha Hb-AHSP interaction. Haematologica. vol 93. issue 1. 2008-04-23. PMID:18166800. |
hb foggia or alpha 117(gh5)phe -> ser: a new alpha 2 globin allele affecting the alpha hb-ahsp interaction. |
2008-04-23 |
2023-08-12 |
Not clear |
| Freya J I Fowkes, Stephen J Allen, Angela Allen, Michael P Alpers, David J Weatherall, Karen P Da. Increased microerythrocyte count in homozygous alpha(+)-thalassaemia contributes to protection against severe malarial anaemia. PLoS medicine. vol 5. issue 3. 2008-04-10. PMID:18351796. |
the heritable haemoglobinopathy alpha(+)-thalassaemia is caused by the reduced synthesis of alpha-globin chains that form part of normal adult haemoglobin (hb). |
2008-04-10 |
2023-08-12 |
Not clear |
| Freya J I Fowkes, Stephen J Allen, Angela Allen, Michael P Alpers, David J Weatherall, Karen P Da. Increased microerythrocyte count in homozygous alpha(+)-thalassaemia contributes to protection against severe malarial anaemia. PLoS medicine. vol 5. issue 3. 2008-04-10. PMID:18351796. |
alpha(+)-thalassaemia homozygosity confers considerable protection against severe malaria, including severe malarial anaemia (sma) (hb concentration < 50 g/l), but does not influence parasite count. |
2008-04-10 |
2023-08-12 |
Not clear |
| Masako Nagai, Yukifumi Nagai, Yayoi Aki, Kiyohiro Imai, Yoshinao Wada, Shigenori Nagatomo, Yasuhiko Yamamot. Effect of reversed heme orientation on circular dichroism and cooperative oxygen binding of human adult hemoglobin. Biochemistry. vol 47. issue 2. 2008-03-03. PMID:18085800. |
1h nmr revealed that sp-1 is identical with native hb a, while sp-2 and sp-3 largely contain the reversed heme isomer in both the alpha and beta subunits, with contents of approximately 50 and >80% in sp-2 and sp-3, respectively. |
2008-03-03 |
2023-08-12 |
human |
| Katia Marino, Loredana Boschetto, Donatella de Pascale, Ennio Cocc. Organisation of the Hb 1 genes of the Antarctic skate Bathyraja eatonii: new insights into the evolution of globin genes. Gene. vol 406. issue 1-2. 2008-02-28. PMID:17997234. |
then, a genomic fragment of 6.2 kb was isolated where the hb 1 alpha and beta genes are linked in a tail-to-head (3' to 5') orientation. |
2008-02-28 |
2023-08-12 |
Not clear |
| Mitra S Rana, James E Knapp, Robert A B Holland, Austen F Rigg. Component D of chicken hemoglobin and the hemoglobin of the embryonic Tammar wallaby (Macropus eugenii) self-associate upon deoxygenation: Effect on oxygen binding. Proteins. vol 70. issue 2. 2008-01-16. PMID:17972287. |
we have reexamined this possibility of "super-cooperativity" with chicken hb components a (alpha(a) (2)beta(2)) and d (alpha(d) (2)beta(2)). |
2008-01-16 |
2023-08-12 |
chicken |
| Can Liao, Qiuming Li, Jiaxue Wei, Qiong Feng, Jian Li, Yining Huang, Dongzhi L. Prenatal control of Hb Bart's disease in southern China. Hemoglobin. vol 31. issue 4. 2008-01-09. PMID:17994381. |
fetuses with homozygous alpha(0)-thal, known as hb bart's (gamma(4)) disease, usually die during the last trimester of gestation, and the affected pregnancies are frequently associated with serious maternal morbidity and mortality. |
2008-01-09 |
2023-08-12 |
Not clear |
| Thanyachai Sura, Objoon Trachoo, Vip Viprakasit, Prin Vathesatogkit, Atchara Tunteeratum, Manisa Busabaratana, Raewadee Wisedpanichkij, Parttraporn Isarangkur. Hemoglobin H disease induced by the common SEA deletion and the rare hemoglobin Quong Sze in a Thai female: longitudinal clinical course, molecular characterization, and development of a PCR/RFLP-based detection method. Annals of hematology. vol 86. issue 9. 2007-12-26. PMID:17503046. |
recently, we identified hb quong sze (hb qs), a highly unstable globin gene mutation affecting codon 125 (ctg-->ccg) of alpha(2) globin gene in trans with the commonest alpha(0) thalassemia (-(sea)) in the patient. |
2007-12-26 |
2023-08-12 |
Not clear |
| Sanita Singsanan, Goonnapa Fucharoen, Onekham Savongsy, Kanokwan Sanchaisuriya, Supan Fucharoe. Molecular characterization and origins of Hb Constant Spring and Hb Paksé in Southeast Asian populations. Annals of hematology. vol 86. issue 9. 2007-12-26. PMID:17589844. |
the appearance of hb cs peak by high-performance liquid chromatography analysis indicates the ability to form a tetrameric hb molecule between the alpha(cs) and beta(e) chains, leading to a novel derivative with similar characteristics to hb cs. |
2007-12-26 |
2023-08-12 |
Not clear |
| Thanyachai Sura, Manisa Busabaratana, Supak Youngcharoen, Raewadee Wisedpanichkij, Vip Viprakasit, Objoon Tracho. Haemoglobin Hope in a northern Thai family: first identification of homozygous haemoglobin Hope associated with haemoglobin H disease. European journal of haematology. vol 79. issue 3. 2007-11-30. PMID:17655700. |
furthermore, we could identify that her brother carried the mutation of homozygous hb hope without abnormal alpha globin chain involvement, and another family member had heterozygous hb hope in association with -alpha(3.7) mutation, and both of them were clinically silent. |
2007-11-30 |
2023-08-12 |
Not clear |
| Maria Cristina De Rosa, Cristiana Carelli Alinovi, Maria Eugenia Schininà, Maria Elisabetta Clementi, Antonio Amato, Maria Pia Cappabianca, Michela Pezzotti, Bruno Giardin. Hb Santa Clara (beta 97His-->Asn), a human haemoglobin variant: functional characterization and structure modelling. Biochimica et biophysica acta. vol 1774. issue 10. 2007-11-27. PMID:17881306. |
this study examines the functional and structural effects of amino acid substitution at alpha(1)beta(2) interface of hb santa clara (beta 97his-->asn). |
2007-11-27 |
2023-08-12 |
human |
| Yang Yingzhong, Cao Yue, Jin Guoen, Bai Zhenzhong, Ma Lan, Yun Haixia, Ge Ril. Molecular cloning and characterization of hemoglobin alpha and beta chains from plateau pika (Ochotona curzoniae) living at high altitude. Gene. vol 403. issue 1-2. 2007-11-27. PMID:17900824. |
to investigate the possible mechanisms of plateau pika hb in adaptation to high altitude, the complete cdna and amino acid sequences of plateau pika hemoglobin alpha and beta chains have been described. |
2007-11-27 |
2023-08-12 |
human |
| Maria Teresa Sanna, Barbara Manconi, Gabriella Podda, Alessandra Olianas, Mariagiuseppina Pellegrini, Massimo Castagnola, Irene Messana, Bruno Giardin. Alkaline Bohr effect of bird hemoglobins: the case of the flamingo. Biological chemistry. vol 388. issue 8. 2007-11-05. PMID:17655497. |
indeed, in spite of the close phylogenetic relationship between the two flamingo species, structural analysis based on tandem mass spectrometry of the alpha(a) chain of p. ruber roseus hb showed that a gln residue is present at position alpha89. |
2007-11-05 |
2023-08-12 |
Not clear |
| Lois R Manning, J Eric Russell, Julio C Padovan, Brian T Chait, Anthony Popowicz, Robert S Manning, James M Mannin. Human embryonic, fetal, and adult hemoglobins have different subunit interface strengths. Correlation with lifespan in the red cell. Protein science : a publication of the Protein Society. vol 16. issue 8. 2007-10-29. PMID:17656582. |
the dimer strengths increase in the order hb portland-2 (zeta(2)beta(2)) < hb portland-1 (zeta(2)gamma(2)) approximately equal hb gower-1 (zeta(2)epsilon(2)) < hb gower-2 (alpha(2)epsilon(2)) < hbf(1) < hbf (alpha(2)gamma(2)) < hba(2) (alpha(2)delta(2)), i.e., from embryonic to fetal to adult types, representing maturation from weaker to stronger monomer-monomer subunit contacts. |
2007-10-29 |
2023-08-12 |
human |
| Cornelis L Harteveld, Willem C H van Helden, George L Boxma, Peter van Delft, Margaretha Bakker-Verweij, Henri Wajcman, Isabelle Zanella-Cleon, Michel Becchi, Piero C Giordan. Hb Zoetermeer: a new mutation on the alpha2 gene inducing an Ala-->Ser substitution at codon 21 is possibly associated with a mild thalassemic phenotype. Hemoglobin. vol 31. issue 3. 2007-10-05. PMID:17654069. |
the hemoglobin (hb) pattern was normal and breakpoint polymerase chain reaction (pcr) excluded the six common deletion defects of the alpha gene cluster. |
2007-10-05 |
2023-08-12 |
Not clear |
| J S Waye, D H K Chu. Hb Evora [alpha 2-35, Ser-->Pro], a novel hemoglobin variant associated with an alpha-thalassemia phenotype. Haematologica. vol 92. issue 5. 2007-09-24. PMID:17562600. |
hb evora [alpha 2-35, ser-->pro], a novel hemoglobin variant associated with an alpha-thalassemia phenotype. |
2007-09-24 |
2023-08-12 |
Not clear |
| Xing-Can Shen, Xin-Yan Liou, Li-Ping Ye, Hong Liang, Zuo-Yuan Wan. Spectroscopic studies on the interaction between human hemoglobin and CdS quantum dots. Journal of colloid and interface science. vol 311. issue 2. 2007-09-21. PMID:17433354. |
the red shift of synchronous fluorescence spectra revealed that the microenvironments of tryptophan and tyrosine residues at the alpha(1)beta(2) interface of hb are disturbed by cds qds, which are induced from hydrophobic cavities to a more exposed or hydrophilic surrounding. |
2007-09-21 |
2023-08-12 |
human |