| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S H Orkin, J Old, H Lazarus, C Altay, A Gurgey, D J Weatherall, D G Natha. The molecular basis of alpha-thalassemias: frequent occurrence of dysfunctional alpha loci among non-Asians with Hb H disease. Cell. vol 17. issue 1. 1979-09-25. PMID:455460. |
restriction mapping of the 20 kb eco rl fragment found in asian and some non-asian hb h disease dnas demonstrated a striking similarity in the placement of restriction sites about the single alpha gene compared with sites about the two genes in the 22.5 kb eco rl fragment seen in normal dna. |
1979-09-25 |
2023-08-11 |
Not clear |
| S H Orkin, J Old, H Lazarus, C Altay, A Gurgey, D J Weatherall, D G Natha. The molecular basis of alpha-thalassemias: frequent occurrence of dysfunctional alpha loci among non-Asians with Hb H disease. Cell. vol 17. issue 1. 1979-09-25. PMID:455460. |
the molecular heterogeneity and frequent occurrence of defective alpha loci in non-asian hb h disease dnas described here may explain, in part, the clinical heterogeneity of alpha-thalassemias and the absence of the homozygous deletion state (hydrops fetalis) in non-asians. |
1979-09-25 |
2023-08-11 |
Not clear |
| G R Honig, R G Mason, L M Tremaine, L N Vid. Unbalanced globin chain synthesis by Hb Lincoln Park (anti-Lepore) reticulocytes. American journal of hematology. vol 5. issue 4. 1979-09-17. PMID:753103. |
incorporation of l-leucine-3h into the alpha and beta delta chains of hb lincoln park was substantially less than the incorporation into the corresponding globin chains of hb a, with the rate of synthesis of the beta delta chain being similar to that of the delta chain of hb a2. |
1979-09-17 |
2023-08-11 |
Not clear |
| A Maniatis, T Bousios, R L Nagel, T Balazs, Y Ueda, R M Bookchin, G M Maniati. Hemoglobin Crete (beta 129 ala leads to pro): a new high-affinity variant interacting with beta o -and delta beta o -thalassemia. Blood. vol 54. issue 1. 1979-08-16. PMID:36184. |
we postulate that the beta 129 proline substitution disrupts the h helix, perturbing nearby residues involved in alpha 1 beta 1 contact sites of the hb tetramer. |
1979-08-16 |
2023-08-11 |
Not clear |
| G Brittenham, B Lozoff, J W Harris, N V Nayudu, M Gravely, J B Wilson, H Lam, T H Huisma. Hemoglobin Hofu or alpha 2 beta 2 [126 (H4) Va1 leads to Glu] found in combination with hemoglobin S. Hemoglobin. vol 2. issue 6. 1979-07-28. PMID:750554. |
hemoglobin hofu or alpha 2 beta 2 [126 (h4) va1 leads to glu] found in combination with hemoglobin s. hb hofu, alpha 2 beta 2 [126 (h4) va1 leads to glu], was found in 10 members of 2 apparently unrelated valmiki families in central india. |
1979-07-28 |
2023-08-11 |
Not clear |
| I Iuchi, K Hidaka, S Ueda, S Shibata, F Hitomi, A Takesu. Hb Ube-4 (alpha 116 Glu leads to Ala): a second independent instance found in a Korean family of Japan. Hemoglobin. vol 2. issue 6. 1979-07-28. PMID:750557. |
hb ube-4 (alpha 116 glu leads to ala): a second independent instance found in a korean family of japan. |
1979-07-28 |
2023-08-11 |
Not clear |
| A Felice, E C Abraham, A Miller, M Stallings, T H Huisma. Is the trimodality of Hb Leslie (alpha 2 beta 2 131 Gln---O) in heterozygotes the result of a variable number of active alpha-chain genes? Evidence for posttranslational control of hemoglobin synthesis. American journal of hematology. vol 5. issue 1. 1979-05-23. PMID:747178. |
is the trimodality of hb leslie (alpha 2 beta 2 131 gln---o) in heterozygotes the result of a variable number of active alpha-chain genes? |
1979-05-23 |
2023-08-11 |
Not clear |
| N S Young, E J Benz, J A Kantor, P Kretschmer, A W Nienhui. Hemoglobin switching in sheep: only the gamma gene is in the active conformation in fetal liver but all the beta and gamma genes are in the active conformation in bone marrow. Proceedings of the National Academy of Sciences of the United States of America. vol 75. issue 12. 1979-03-13. PMID:282609. |
differential expression of the closely linked gamma, beta(a) (or beta(b)), and beta(c) globin genes in sheep results in the production of fetal hemoglobin (hb f, alpha(2)gamma(2)) during gestation and the adult hemoglobins (hb a, alpha(2)beta(2) (a), and hb b, alpha(2)beta(2) (b)) after birth. |
1979-03-13 |
2023-08-11 |
Not clear |
| N S Young, E J Benz, J A Kantor, P Kretschmer, A W Nienhui. Hemoglobin switching in sheep: only the gamma gene is in the active conformation in fetal liver but all the beta and gamma genes are in the active conformation in bone marrow. Proceedings of the National Academy of Sciences of the United States of America. vol 75. issue 12. 1979-03-13. PMID:282609. |
erythropoietic stress in certain animals leads to production of hb c (alpha(2)beta(2) (c)). |
1979-03-13 |
2023-08-11 |
Not clear |
| R G Schneider, R C Barwic. Measuring relative electrophoretic mobilities of mutant hemoglobins and globin chains. Hemoglobin. vol 2. issue 5. 1979-02-21. PMID:721610. |
in electrophoresis on cellulose acetate, teb buffer, ph 8.5, mobilities are calculated as ratios of the mobility of simultaneously analyzed hb c. in electrophoresis on citrate agar, ph 6.0, anodic mobilities are also related to hb c, cathodic ones to hb f. in globin electrophoresis in urea 2-mercaptoethanol buffers, ph 6.0 and 8.9, mobilities of the mutant globin chains are calculated in relation to the mobilities of normal alpha and beta chains. |
1979-02-21 |
2023-08-11 |
Not clear |
| F Bossa, D Barra, R Petruzzelli, F Martini, M Brunor. Primary structure of hemoglobin from trout (Salmo irideus). Amino acid sequence of alpha chain of Hb trout I. Biochimica et biophysica acta. vol 536. issue 1. 1979-01-15. PMID:708770. |
amino acid sequence of alpha chain of hb trout i. |
1979-01-15 |
2023-08-11 |
human |
| F Bossa, D Barra, R Petruzzelli, F Martini, M Brunor. Primary structure of hemoglobin from trout (Salmo irideus). Amino acid sequence of alpha chain of Hb trout I. Biochimica et biophysica acta. vol 536. issue 1. 1979-01-15. PMID:708770. |
alignment of the peptides with the structure of human as well as carp and catostomus clarkii alpha chains shows that hb trout i alpha chain differs from the corresponding human protein by 43% amino acid substitutions and from the two other fish by 34.5% and 33.1%, respectively. |
1979-01-15 |
2023-08-11 |
human |
| T H Huisman, M E Gravely, J Henson, A Felice, J B Wilson, E C Abraham, F Vella, M W Littl. Variability in the interaction of beta-thalassemia with the alpha-chain variants Hb G-Philadelphia and Hb Rampa. The Journal of laboratory and clinical medicine. vol 92. issue 2. 1978-10-25. PMID:681817. |
data from in vitro recombination experiments with isolated alpha x, alpha a, and beta a chains, with heme attached, indicated a preferential formation of hb a over hb rampa but not over hb g-philadelphia in conditions of relative beta-chain deficiency. |
1978-10-25 |
2023-08-11 |
Not clear |
| G Trabuchet, M Benabadji, D Labi. Genetic and biosynthetic studies of families carrying hemoglobin J alpha Mexico: association of alpha-thalassemia with HbJ. Human genetics. vol 42. issue 2. 1978-09-15. PMID:669703. |
the elevated expression of alphaj chains in heterozygotes with 38% hb j may be due to an alpha thalassemia gene trans to the alphaj locus. |
1978-09-15 |
2023-08-11 |
human |
| A Felice, E C Abraham, A Miller, N Cope, M Gravely, T H Huisma. Post-translational control of human hemoglobin synthesis; the number of alpha chain genes and the synthesis of HB S. Progress in clinical and biological research. vol 21. 1978-08-28. PMID:662889. |
post-translational control of human hemoglobin synthesis; the number of alpha chain genes and the synthesis of hb s. |
1978-08-28 |
2023-08-11 |
human |
| Y Ohba, T Miyaji, M Matsuoka, M Morito, I Iuch. Characterization of Hb Ube-4: alpha 116 (GH4) Glu yield Ala. Hemoglobin. vol 2. issue 2. 1978-06-28. PMID:640856. |
characterization of hb ube-4: alpha 116 (gh4) glu yield ala. |
1978-06-28 |
2023-08-11 |
Not clear |
| G Martinez, F Lima, C Residenti, B Colomb. Hb J Camaguey alpha 2 141(HC3) Arg replaced by Gly beta 2: a new abnormal human hemoglobin. Hemoglobin. vol 2. issue 1. 1978-06-17. PMID:640841. |
hb j camaguey alpha 2 141(hc3) arg replaced by gly beta 2: a new abnormal human hemoglobin. |
1978-06-17 |
2023-08-11 |
human |
| M Marinucci, F Mavilio, L Tentori, R Albert. HB O Indonesia (alpha 2 116(GH4) Glu replaced by Lys beta 2) in association with beta thalassemia. Hemoglobin. vol 2. issue 1. 1978-06-17. PMID:640843. |
hb o indonesia (alpha 2 116(gh4) glu replaced by lys beta 2) in association with beta thalassemia. |
1978-06-17 |
2023-08-11 |
Not clear |
| T Kagimoto, Y Morino, S Kishimot. A new hemoglobin variant. HB Yatsushiro alpha 2 A beta 2 60 Val replaced by Leu. Biochimica et biophysica acta. vol 532. issue 1. 1978-03-29. PMID:620052. |
hb yatsushiro alpha 2 a beta 2 60 val replaced by leu. |
1978-03-29 |
2023-08-11 |
Not clear |
| P Pich, G Saglio, C Camaschella, O David, M A Vasino, G Ricco, U Mazz. Interaction between Hb Hasharon and alpha-thalassemia: an approach to the problem of the number of human alpha loci. Blood. vol 51. issue 2. 1978-03-21. PMID:620088. |
interaction between hb hasharon and alpha-thalassemia: an approach to the problem of the number of human alpha loci. |
1978-03-21 |
2023-08-11 |
human |