| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| O Castro, W P Winter, T C Lee, V E Heading. Prevalence of alpha-chain variants at birth. American journal of clinical pathology. vol 75. issue 1. 1981-03-27. PMID:7457429. |
in some newborns, hb g (alpha 2 g beta 2) was also detectable, so that these cord bloods had four hemoglobin components: f, f/g, a, and g. the prevalence of hb g-philadelphia in this population sample is higher than that usually reported for black americans and may represent a founder effect. |
1981-03-27 |
2023-08-12 |
Not clear |
| G B Sancar, B Tatsis, M M Cedeno, R F Riede. Proportion of hemoglobin G Philadelphia (alpha 268 Asn leads to Lys beta 2) in heterozygotes is determined by alpha-globin gene deletions. Proceedings of the National Academy of Sciences of the United States of America. vol 77. issue 11. 1981-03-24. PMID:6935689. |
in addition to the alpha g gene, subjects who synthesized 33% hb g possessed two alpha a genes on the homologous chromosome and exhibited the mild form of alpha-thalassemia trait ("silent carrier"). |
1981-03-24 |
2023-08-12 |
human |
| G B Sancar, B Tatsis, M M Cedeno, R F Riede. Proportion of hemoglobin G Philadelphia (alpha 268 Asn leads to Lys beta 2) in heterozygotes is determined by alpha-globin gene deletions. Proceedings of the National Academy of Sciences of the United States of America. vol 77. issue 11. 1981-03-24. PMID:6935689. |
subjects who synthesized 50% hb g possessed a single alpha a gene trans to the alpha g locus and displayed the more pronounced form of alpha-thalassemia trait. |
1981-03-24 |
2023-08-12 |
human |
| G B Sancar, B Tatsis, M M Cedeno, R F Riede. Proportion of hemoglobin G Philadelphia (alpha 268 Asn leads to Lys beta 2) in heterozygotes is determined by alpha-globin gene deletions. Proceedings of the National Academy of Sciences of the United States of America. vol 77. issue 11. 1981-03-24. PMID:6935689. |
one subject, who synthesized 100% alpha g chains and had hb g-hb h disease, was found to have a single nonfunctional alpha gene trans to the alpha g gene. |
1981-03-24 |
2023-08-12 |
human |
| G B Sancar, B Tatsis, M M Cedeno, R F Riede. Proportion of hemoglobin G Philadelphia (alpha 268 Asn leads to Lys beta 2) in heterozygotes is determined by alpha-globin gene deletions. Proceedings of the National Academy of Sciences of the United States of America. vol 77. issue 11. 1981-03-24. PMID:6935689. |
thus the proportion of hb g synthesized by heterozygotes is determined by interaction with alpha-globin gene deletions cis and trans to the alpha g locus. |
1981-03-24 |
2023-08-12 |
human |
| D R Higgs, L Pressley, G R Serjeant, J B Clegg, D J Weatheral. The genetics and molecular basis of alpha thalassaemia in association with Hb S in Jamaican Negroes. British journal of haematology. vol 47. issue 1. 1981-02-26. PMID:7437345. |
the genetics and molecular basis of alpha thalassaemia in association with hb s in jamaican negroes. |
1981-02-26 |
2023-08-12 |
human |
| D R Higgs, L Pressley, G R Serjeant, J B Clegg, D J Weatheral. The genetics and molecular basis of alpha thalassaemia in association with Hb S in Jamaican Negroes. British journal of haematology. vol 47. issue 1. 1981-02-26. PMID:7437345. |
furthermore, since in each family alpha thalassaemia was present in association with the gene for the sickle cell mutation we have determined the proportion of hb s in the peripheral blood of individuals with the alpha alpha/alpha alpha, -alpha/alpha alpha and -alpha/-alpha genotype who are also heterozygous for the betas mutation. |
1981-02-26 |
2023-08-12 |
human |
| D Todd, V Chan, R G Schneider, A M Dozy, Y W Kan, T K Cha. Globin chain synthesis in haemoglobin New York (beta 113 replaced by glutamic acid). British journal of haematology. vol 46. issue 4. 1981-02-24. PMID:7437334. |
the presence of hb new york was confirmed in a chinese family in which affected members have occasional red cells with hb-h-like inclusions and a relative decrease in alpha chain synthesis, suggestive of a coexisting alpha thalassaemia trait. |
1981-02-24 |
2023-08-12 |
Not clear |
| D Todd, V Chan, R G Schneider, A M Dozy, Y W Kan, T K Cha. Globin chain synthesis in haemoglobin New York (beta 113 replaced by glutamic acid). British journal of haematology. vol 46. issue 4. 1981-02-24. PMID:7437334. |
chromatographic separation of hb ny and hb a before chain analysis revealed preferential binding of newly synthesized alpha chains to beta ny, with a four-fold increase in specific activity of the alpha hb ny chains. |
1981-02-24 |
2023-08-12 |
Not clear |
| T P Molchanova, L V Abaturov, V A Spivak, N V Ermakov, Iu N Tokare. [Hemoglobin M Saskatoon alpha 2 beta 2 63 (E7) His--Tyr. Structural identification, hemichrome formation and proteolytic degradation]. Molekuliarnaia biologiia. vol 14. issue 6. 1981-02-24. PMID:7442669. |
the primary structure determination allowed to identify the variant as hb m saskatoon with alpha 2 beta 2 63 (e7) his leads to tyr substitution, that is the first known case of hb m saskatoon bearing in the soviet union. |
1981-02-24 |
2023-08-12 |
Not clear |
| B Giglioni, P Comi, R Taramelli, S Ottolenghi, M A Ciocca-Vasino, C Anè, M D Cappellini, A M Giann. Organization of alpha-globin genes in Hb Hasharon (alpha 47 asp replaced by his) carriers. Blood. vol 56. issue 6. 1981-02-19. PMID:6254584. |
organization of alpha-globin genes in hb hasharon (alpha 47 asp replaced by his) carriers. |
1981-02-19 |
2023-08-12 |
Not clear |
| B Giglioni, P Comi, R Taramelli, S Ottolenghi, M A Ciocca-Vasino, C Anè, M D Cappellini, A M Giann. Organization of alpha-globin genes in Hb Hasharon (alpha 47 asp replaced by his) carriers. Blood. vol 56. issue 6. 1981-02-19. PMID:6254584. |
restriction enzymes analysis of the dna from two unrelated italian families with hb hasharon, a variant hb (alpha 47asp replaced by his) frequently occurring in the polesine area in italy, indicates that this variant is associated to an alpha globin gene deletion. |
1981-02-19 |
2023-08-12 |
Not clear |
| R Vestri, C Crema, M Marinucci, P C Giordano, L F Bernin. Possible duplication of the hemoglobin alpha chain locus in sheep. Biochimica et biophysica acta. vol 625. issue 2. 1981-02-19. PMID:7437468. |
a variant (hb d) of the alpha chain, characterized by a substitution glycine leads to aspartic acid at position 15, has been described in yugoslavian sheep. |
1981-02-19 |
2023-08-12 |
Not clear |
| C N Ong, W R Le. High affinity of lead for fetal haemoglobin. British journal of industrial medicine. vol 37. issue 3. 1981-01-26. PMID:6158989. |
for the haemolysate from adults, lead was present in both hb a (alpha 2 beta 2) and hb a2 (alpha 2 delta 2), whereas, in the haemolysate from new-born infants, the haemoglobin of fetal origin, hb f (alpha 2 gamma 2) showed a much greater affinity for 203pb than the adult haemoglobin hb a (alpha 2 beta 2), obtained from maternal blood. |
1981-01-26 |
2023-08-12 |
human |
| S Surrey, K Ohene-Frempong, E Rappaport, J Atwater, E Schwart. Linkage of alpha G-Philadelphia to alpha-thalassemia in African-Americans . Proceedings of the National Academy of Sciences of the United States of America. vol 77. issue 8. 1981-01-26. PMID:6933536. |
we have studied the inheritance of the alpha-chain hemoglobin variant hb g-philadelphia (alpha 2(68 asn leads to lys)beta 2) in two african-american families. |
1981-01-26 |
2023-08-12 |
Not clear |
| W G Wood, M E Pembrey, G R Serjeant, R P Perrine, D J Weatheral. Hb F synthesis in sickle cell anaemia: a comparison of Saudi Arab cases with those of African origin. British journal of haematology. vol 45. issue 3. 1981-01-16. PMID:6158984. |
a high proportion of the cases in both groups were carriers of alpha thalassaemia in addition to ss, but no effect of alpha thalassaemia on hb f production was observed. |
1981-01-16 |
2023-08-12 |
Not clear |
| D R Higgs, L Pressley, J B Clegg, D J Weatherall, S Higgs, P Carey, G R Serjean. Detection of alpha thalassaemia in Negro infants. British journal of haematology. vol 46. issue 1. 1981-01-16. PMID:7426451. |
the results indicate that the genotypes alpha alpha/alpha alpha, -- alpha/alpha alpha and -- alpha/ -- alpha are associated with 0%, 0.1-2%, and greater than 2% hb bart's respectively. |
1981-01-16 |
2023-08-12 |
Not clear |
| D R Higgs, L Pressley, J B Clegg, D J Weatherall, S Higgs, P Carey, G R Serjean. Detection of alpha thalassaemia in Negro infants. British journal of haematology. vol 46. issue 1. 1981-01-16. PMID:7426451. |
although trace amounts of hb bart's may be associated with the genotype -- alpha/alpha alpha this is not always the case and therefore haemoglobin analysis in the neonatal period cannot be used to diagnose this genotype with any certainty. |
1981-01-16 |
2023-08-12 |
Not clear |
| A Hayashi, T Fujita, M Fujimura, K Titan. A new abnormal fetal hemoglobin, Hb FM-Osaka (alpha 2 gamma 2 63His replaced by Tyr). Hemoglobin. vol 4. issue 3-4. 1980-12-18. PMID:6158500. |
a new abnormal fetal hemoglobin, hb fm-osaka (alpha 2 gamma 2 63his replaced by tyr). |
1980-12-18 |
2023-08-12 |
Not clear |
| C Poyart, E Bursaux, A Arnone, J Bonaventura, C Bonaventur. Structural and functional studies of hemoglobin Suresnes (arg 141 alpha 2 replaced by His beta 2). Consequences of disrupting an oxygen-linked anion-binding site. The Journal of biological chemistry. vol 255. issue 19. 1980-11-24. PMID:7410435. |
hb suresnes is a human hemoglobin variant in which histidine replaces arginine at the cooh terminus of the alpha chains. |
1980-11-24 |
2023-08-12 |
human |