| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Musumeci, G Schilirò, G Pizzarelli, L Tentori, M Marinucci, P P Fontanarosa, G Russ. Hemoglobin G San José [beta 2 7 (A4) Glu to Gly alpha 2], beta thalassemia, and alpha thalassemia in a Sicilian family. Human genetics. vol 52. issue 2. 1980-02-28. PMID:511180. |
therefore, the possibility of coexistence of an alpha thalassemia trait with a beta thalassemia trait in the mother of the proposita and with hb g san josé heterozygosity in the two sisters who had lowered levels of abnormal hb is discussed. |
1980-02-28 |
2023-08-11 |
Not clear |
| H Sick, K Gersond. Co-binding studies on Hb M Iwate. Allostery of a T state haemoglobin. Biochimica et biophysica acta. vol 581. issue 1. 1980-02-15. PMID:41591. |
the mutant haemoglobin hb m iwate alpha 2mmet87his leads to tyr beta 2, is characterized by a stable t structure and a low ligand affinity. |
1980-02-15 |
2023-08-11 |
Not clear |
| R M Baine, J M Wright, R W Wilkinso. HB G Waimanalo (alpha 64 Asp replaced by Asn) in a child with homozygous beta-thalassemia. Hemoglobin. vol 3. issue 4. 1980-01-24. PMID:500373. |
hb g waimanalo (alpha 64 asp replaced by asn) in a child with homozygous beta-thalassemia. |
1980-01-24 |
2023-08-11 |
Not clear |
| M Marinucci, F Mavilio, P P Fontanarosa, L Tentori, C Brancat. Studies on a family with Hb J Calabria (alpha 2 beta 2 64 (E8) Gly replaced by Asp). Hemoglobin. vol 3. issue 5. 1980-01-24. PMID:500375. |
studies on a family with hb j calabria (alpha 2 beta 2 64 (e8) gly replaced by asp). |
1980-01-24 |
2023-08-11 |
human |
| S Musumeci, G Schiliro, G Pizzarelli, A D'Agata, A Fischer, G Russ. Alpha thalassaemia in Sicily: haematological and biosynthetic studies. British journal of haematology. vol 43. issue 3. 1980-01-19. PMID:497118. |
the standard haematological tests and the alpha/beta chain synthesis ratios showed significantly different results in the patients with hb h disease as compared with alpha thalassaemia carriers, except for hb a2 values. |
1980-01-19 |
2023-08-11 |
Not clear |
| S Musumeci, G Schiliro, G Pizzarelli, A D'Agata, A Fischer, G Russ. Alpha thalassaemia in Sicily: haematological and biosynthetic studies. British journal of haematology. vol 43. issue 3. 1980-01-19. PMID:497118. |
there was no significant difference in the mean rbc, mcv, hb a2, hb a1 and hb f of alpha thalassaemia carriers compared with normal controls. |
1980-01-19 |
2023-08-11 |
Not clear |
| S T Olson, V Massey, S Ghisla, C D Whitfiel. Suicide inactivation of the flavoenzyme D-lactate dehydrogenase by alpha-hydroxybutynoate. Biochemistry. vol 18. issue 21. 1980-01-19. PMID:497163. |
the acetylenic alpha-hydroxy acid 2-hydroxy-3-butynoate (alpha hb) is a substrate and an irreversible inactivator of the fad-containing flavoenzyme d-lactate dehydrogenase from megasphaera elsdenii. |
1980-01-19 |
2023-08-11 |
Not clear |
| S T Olson, V Massey, S Ghisla, C D Whitfiel. Suicide inactivation of the flavoenzyme D-lactate dehydrogenase by alpha-hydroxybutynoate. Biochemistry. vol 18. issue 21. 1980-01-19. PMID:497163. |
on the average, the enzyme undergoes five catalytic turnovers with alpha hb in air at ph 7.0 before being inactivated. |
1980-01-19 |
2023-08-11 |
Not clear |
| S T Olson, V Massey, S Ghisla, C D Whitfiel. Suicide inactivation of the flavoenzyme D-lactate dehydrogenase by alpha-hydroxybutynoate. Biochemistry. vol 18. issue 21. 1980-01-19. PMID:497163. |
experiments were conducted to test whether inactivation was initiated by an alpha hb allene carbanion or the dehydrogenation product of alpha hb. |
1980-01-19 |
2023-08-11 |
Not clear |
| S T Olson, V Massey, S Ghisla, C D Whitfiel. Suicide inactivation of the flavoenzyme D-lactate dehydrogenase by alpha-hydroxybutynoate. Biochemistry. vol 18. issue 21. 1980-01-19. PMID:497163. |
since the keto acid derived from the oxidation of this alpha-hydroxy acid is expected to be as reactive as 2-keto-3-butynoate, it is concluded that an allene carbanion produced by abstraction of the alpha-hydrogen of alpha hb is the reactive species which covalently adds to the flavin. |
1980-01-19 |
2023-08-11 |
Not clear |
| M Marinucci, F Mavilio, A Massa, M Gabbianelli, P P Fontanarosa, A Camagna, C Ignesti, L Tentor. A new abnormal human hemoglobin: Hb Prato (alpha 2 31 (B12) Arg leads to Ser beta 2). Biochimica et biophysica acta. vol 578. issue 2. 1979-12-18. PMID:486536. |
a new abnormal human hemoglobin: hb prato (alpha 2 31 (b12) arg leads to ser beta 2). |
1979-12-18 |
2023-08-11 |
human |
| J Thillet, M L North, J Ros. Functional properties of Hb Stanleyville II alpha 78 (EF 7) asparagine replaced by lysine. Effect of sodium chloride. Hemoglobin. vol 3. issue 2-3. 1979-11-21. PMID:39047. |
functional properties of hb stanleyville ii alpha 78 (ef 7) asparagine replaced by lysine. |
1979-11-21 |
2023-08-11 |
Not clear |
| B Dingle, H Farguharson, D Williams, J B Wilson, T H Huisma. Hb Rainier or alpha 2 beta 2 (145 (HC2) Tyr replaced by Cys) observed in members of a Canadian family of Greek origin. Hemoglobin. vol 3. issue 2-3. 1979-11-21. PMID:478981. |
hb rainier or alpha 2 beta 2 (145 (hc2) tyr replaced by cys) observed in members of a canadian family of greek origin. |
1979-11-21 |
2023-08-11 |
Not clear |
| R E Benesch, S Kwong, R Edalji, R Benesc. alpha Chain mutations with opposite effects on the gelation of hemoglobin S. The Journal of biological chemistry. vol 254. issue 17. 1979-10-26. PMID:468817. |
by contrast, the introduction of a tyrosine at alpha 75 and an alanine at alpha 6 have the opposite effect and are the first examples of alpha chain mutations which potentiate the gelation of hb s. the molecular mechanisms responsible for the effects of the mutations on the self-association of hb s are discussed. |
1979-10-26 |
2023-08-11 |
Not clear |
| T H Huisma. Sickle cell anemia as a syndrome: a review of diagnostic features. American journal of hematology. vol 6. issue 2. 1979-10-24. PMID:382840. |
combinations of a hb s heterozygosity with a heterozygosity for a hb d-type of variant, for either one of two types of beta-thalassemia, two types of alpha beta- thalassemia, and five types of hpfh are discussed, and data are compared with those obtained for hb s homozygotes. |
1979-10-24 |
2023-08-11 |
Not clear |
| G Brittenham, B Lozoff, J W Harris, S M Mayson, A Miller, T H Huisma. Sickle cell anemia and trait in southern India: further studies. American journal of hematology. vol 6. issue 2. 1979-10-24. PMID:474571. |
chromatographic quantitation of the hemoglobin fractions in these heterozygotes showed a trimodal distribution of the proportion of hb sexplicable by a genetic model postulating the presence of genotypes with two (-alpha/-alpha), three (-alpha/alpha alpha) and four (alpha alpha/alpha alpha) active alpha-globin genes. |
1979-10-24 |
2023-08-11 |
Not clear |
| S H Orkin, J Old, H Lazarus, C Altay, A Gurgey, D J Weatherall, D G Natha. The molecular basis of alpha-thalassemias: frequent occurrence of dysfunctional alpha loci among non-Asians with Hb H disease. Cell. vol 17. issue 1. 1979-09-25. PMID:455460. |
the molecular basis of alpha-thalassemias: frequent occurrence of dysfunctional alpha loci among non-asians with hb h disease. |
1979-09-25 |
2023-08-11 |
Not clear |
| S H Orkin, J Old, H Lazarus, C Altay, A Gurgey, D J Weatherall, D G Natha. The molecular basis of alpha-thalassemias: frequent occurrence of dysfunctional alpha loci among non-Asians with Hb H disease. Cell. vol 17. issue 1. 1979-09-25. PMID:455460. |
study of asians has previously indicated that deletion of alpha-globin structural genes is the predominant lesion in alpha-thalassemias and that hb h disease occurs when three of four normal alpha loci per cell are deleted. |
1979-09-25 |
2023-08-11 |
Not clear |
| S H Orkin, J Old, H Lazarus, C Altay, A Gurgey, D J Weatherall, D G Natha. The molecular basis of alpha-thalassemias: frequent occurrence of dysfunctional alpha loci among non-Asians with Hb H disease. Cell. vol 17. issue 1. 1979-09-25. PMID:455460. |
whereas in normal dna, alpha sequences are present in a single eco rl fragment of cellular dna approximately 22.5 kb long, fragments of 22.5, 20 and 2.6 kb were found in various hb h disease dnas. |
1979-09-25 |
2023-08-11 |
Not clear |
| S H Orkin, J Old, H Lazarus, C Altay, A Gurgey, D J Weatherall, D G Natha. The molecular basis of alpha-thalassemias: frequent occurrence of dysfunctional alpha loci among non-Asians with Hb H disease. Cell. vol 17. issue 1. 1979-09-25. PMID:455460. |
non-asian hb h disease dnas contained one, two or three alpha loci per cell in contrast to the one locus predicted by the simple deletion model of alpha-thalassemia. |
1979-09-25 |
2023-08-11 |
Not clear |