| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R M Baine, D L Rucknagel, P A Dublin, J G Adam. Trimodality in the proportion of hemoglobin G Philadelphia in heterozygotes: evidence for heterogeneity in the number of human alpha chain loci. Proceedings of the National Academy of Sciences of the United States of America. vol 73. issue 10. 1976-12-30. PMID:1068476. |
biosynthetic studies of blood from 15 subjects revealed balanced synthesis of alpha and beta globin chains in heterozygotes from all three classes, strongly supporting variable gene dosage rather than alpha-thalassemia as the mechanism underlying the observed trimodality in the proportion of hb g. incompatibilities between out results and current concepts of alpha-thalassemia are discussed in the context of differences between black compared with oriental and italian forms of hb h disease. |
1976-12-30 |
2023-08-11 |
human |
| J Lampe, K Pommerenin. [Oxygen binding of hemoglobin following covalent fixation in the deoxy- and oxy- conformation]. Acta biologica et medica Germanica. vol 34?710. 1976-11-21. PMID:9763. |
as a reason for the varying oxygen-binding properties for the two hb derivatives it is assumed that the amino group of valin alpha 1 is involved in the hbo2 fixation. |
1976-11-21 |
2023-08-11 |
Not clear |
| R M Burton, K S Landreth, G H Barrows, D D Jarrett, C L Songste. Appearance, properties, and origin of altered human hemoglobin in feces. Laboratory investigation; a journal of technical methods and pathology. vol 35. issue 2. 1976-10-20. PMID:60507. |
instead, no change, or production of alpha and beta chains, or gradual but complete elimination of the hb antigen was seen. |
1976-10-20 |
2023-08-11 |
human |
| C C Winterbourn, B M McGrath, R W Carrel. Reactions involving superoxide and normal and unstable haemoglobins. The Biochemical journal. vol 155. issue 3. 1976-10-01. PMID:182128. |
superoxide was released on autoxidation of three unstable haemoglobins and isolated alpha and beta chains, at rates faster than with hb a. |
1976-10-01 |
2023-08-11 |
Not clear |
| T H Huisman, A Mille. Hb Grady and alpha thalassemia: a contribution to the problem of the number of Hb alpha structural loci in man. American journal of human genetics. vol 28. issue 4. 1976-09-25. PMID:941904. |
hb grady and alpha thalassemia: a contribution to the problem of the number of hb alpha structural loci in man. |
1976-09-25 |
2023-08-11 |
Not clear |
| T H Huisman, A Mille. Hb Grady and alpha thalassemia: a contribution to the problem of the number of Hb alpha structural loci in man. American journal of human genetics. vol 28. issue 4. 1976-09-25. PMID:941904. |
hematological evaluation and data from chain synthesis analyses in six members of the family with two members having hb grady (i.e., and alpha chain variant with elongated chains due to an insertion of three amino acid residues [1]) indicate the presence of multiple nonallelic hb alpha structural loci in the single hb grady heterozygote. |
1976-09-25 |
2023-08-11 |
Not clear |
| T H Huisman, A Mille. Hb Grady and alpha thalassemia: a contribution to the problem of the number of Hb alpha structural loci in man. American journal of human genetics. vol 28. issue 4. 1976-09-25. PMID:941904. |
the data support the earlier stated hypothesis that the hb alpha grady locus resulted from a crossing over between chromosomes of two tandemly repeated hb alpha loci. |
1976-09-25 |
2023-08-11 |
Not clear |
| T H Huisman, A Mille. Hb Grady and alpha thalassemia: a contribution to the problem of the number of Hb alpha structural loci in man. American journal of human genetics. vol 28. issue 4. 1976-09-25. PMID:941904. |
the presence of an alpha thalassemia condition in one of the two hb grady heterozygotes increases the relative production of the alpha grady chain by a factor of two. |
1976-09-25 |
2023-08-11 |
Not clear |
| D Beksedić, T Rajevsk. Hb Serbia (alpha 112 (G19) His leads to Arg), a new haemoglobin variant from Yugoslavia. FEBS letters. vol 58. issue 1. 1976-08-02. PMID:1225585. |
hb serbia (alpha 112 (g19) his leads to arg), a new haemoglobin variant from yugoslavia. |
1976-08-02 |
2023-08-11 |
Not clear |
| I Sumid. Studies of abnormal hemoglobins in western Japan. Frequency of visible hemoglobin variants, and chemical characterization of hemoglobin Sawara (alpha 26Alabeta2) and hemoglobin Mugino (Hb L Ferrara; alpha247Glybeta2). Jinrui idengaku zasshi. The Japanese journal of human genetics. vol 19. issue 4. 1976-08-02. PMID:1241593. |
frequency of visible hemoglobin variants, and chemical characterization of hemoglobin sawara (alpha 26alabeta2) and hemoglobin mugino (hb l ferrara; alpha247glybeta2). |
1976-08-02 |
2023-08-11 |
Not clear |
| H Colson-Guastalla, C Aymard, J P Chambon, F Miche. Studies on free or haptoglobin-bound hemoglobin and derivatives (semihemoglobins and porphyrinated semihemoglobins). Some aspects of their peroxidatic activity. Biochimie. vol 57. issue 9. 1976-07-06. PMID:1222141. |
the peroxidatic activity of free and hp-bound alpha and beta chains of hb were studied. |
1976-07-06 |
2023-08-11 |
human |
| H Colson-Guastalla, C Aymard, J P Chambon, F Miche. Studies on free or haptoglobin-bound hemoglobin and derivatives (semihemoglobins and porphyrinated semihemoglobins). Some aspects of their peroxidatic activity. Biochimie. vol 57. issue 9. 1976-07-06. PMID:1222141. |
the alpha chains of hb combine with hp whereas the beta chains fail to do so. |
1976-07-06 |
2023-08-11 |
human |
| P E Nute, W G Wood, G Stamatoyannopoulos, C Olweny, P J Failko. The Kenya form of hereditary persistence of fetal haemoglobin: structural studies and evidence for homogeneous distribution of haemoglobin F using fluorescent anti-haemoglobin F antibodies. British journal of haematology. vol 32. issue 1. 1976-07-06. PMID:1259926. |
the individuals had also 5-8% hb f, consisting solely of alpha and ggamma chains. |
1976-07-06 |
2023-08-11 |
human |
| M Seid-Akhavan, W P Winter, R K Abramson, D L Rucknage. Hemoglobin Wayne: a frameshift mutation detected in human hemoglobin alpha chains. Proceedings of the National Academy of Sciences of the United States of America. vol 73. issue 3. 1976-06-02. PMID:1062801. |
hemoglobin wayne is an alpha chain variant which manifests itself as two minor hemoglobin (hb) components that migrate more rapidly than hb a on electrophoresis at ph 8.6. |
1976-06-02 |
2023-08-11 |
human |
| M Seid-Akhavan, W P Winter, R K Abramson, D L Rucknage. Hemoglobin Wayne: a frameshift mutation detected in human hemoglobin alpha chains. Proceedings of the National Academy of Sciences of the United States of America. vol 73. issue 3. 1976-06-02. PMID:1062801. |
comparison of the alpha wayne sequences with the amino-acid sequences of alpha a and alpha constant spring leads to the conclusion that hb wayne i is the result of a -1 frameshift mutation in the alpha chain and that hb wayne ii is formed secondarily by spontaneous deamidation of the new asparagine residue. |
1976-06-02 |
2023-08-11 |
human |
| R F Rieder, G W Jame. Translation of human globin mRNA: globin synthesis in cells containing Hb Leiden. Blood. vol 47. issue 3. 1976-06-02. PMID:1252618. |
in reticulocytes of subjects with hb leiden (beta 6 or 7 glu leads to 0) there is greater production of alpha than beta globin in vitro (beta/alpha = 0.67), and slightly more beta a is synthesized than beta leiden (beta a/beta leiden = 1.28). |
1976-06-02 |
2023-08-11 |
human |
| C Politis-Tsegos, A Lang, R Stathopoulou, H Lehman. Is haemoglobin G alpha Philadelphia linked to alpha-thalassaemia? Human genetics. vol 31. issue 1. 1976-04-30. PMID:1248825. |
the question, "is hb g alpha philadelphia linked to alpha-thalassaemia?" |
1976-04-30 |
2023-08-11 |
Not clear |
| G Trabuchet, M Dahmane, J Pagnier, D Labie, M Benabadj. Hb J Mexico in Algeria: arguments for an heterogenous distribution of alpha genes. FEBS letters. vol 61. issue 2. 1976-04-19. PMID:1248618. |
hb j mexico in algeria: arguments for an heterogenous distribution of alpha genes. |
1976-04-19 |
2023-08-11 |
Not clear |
| M H Steinber. Haemoglobin C/alpha thalassaemia: haematological and biosynthetic studies. British journal of haematology. vol 30. issue 3. 1976-03-01. PMID:1201216. |
a family with genes for haemoglobin c (hb c) and alpha thalassaemia was studied. |
1976-03-01 |
2023-08-11 |
Not clear |
| M H Steinber. Haemoglobin C/alpha thalassaemia: haematological and biosynthetic studies. British journal of haematology. vol 30. issue 3. 1976-03-01. PMID:1201216. |
the coexistence of alpha thalassaemia influences the level of mutant haemoglobin in haemoglobinopathies in which hb c is present, in a fashion similar to that observed in sickle-cell trait. |
1976-03-01 |
2023-08-11 |
Not clear |