| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R F Rieder, G W Jame. Translation of human globin mRNA: globin synthesis in cells containing Hb Leiden. Blood. vol 47. issue 3. 1976-06-02. PMID:1252618. |
in reticulocytes of subjects with hb leiden (beta 6 or 7 glu leads to 0) there is greater production of alpha than beta globin in vitro (beta/alpha = 0.67), and slightly more beta a is synthesized than beta leiden (beta a/beta leiden = 1.28). |
1976-06-02 |
2023-08-11 |
human |
| C Politis-Tsegos, A Lang, R Stathopoulou, H Lehman. Is haemoglobin G alpha Philadelphia linked to alpha-thalassaemia? Human genetics. vol 31. issue 1. 1976-04-30. PMID:1248825. |
the question, "is hb g alpha philadelphia linked to alpha-thalassaemia?" |
1976-04-30 |
2023-08-11 |
Not clear |
| G Trabuchet, M Dahmane, J Pagnier, D Labie, M Benabadj. Hb J Mexico in Algeria: arguments for an heterogenous distribution of alpha genes. FEBS letters. vol 61. issue 2. 1976-04-19. PMID:1248618. |
hb j mexico in algeria: arguments for an heterogenous distribution of alpha genes. |
1976-04-19 |
2023-08-11 |
Not clear |
| M H Steinber. Haemoglobin C/alpha thalassaemia: haematological and biosynthetic studies. British journal of haematology. vol 30. issue 3. 1976-03-01. PMID:1201216. |
a family with genes for haemoglobin c (hb c) and alpha thalassaemia was studied. |
1976-03-01 |
2023-08-11 |
Not clear |
| M H Steinber. Haemoglobin C/alpha thalassaemia: haematological and biosynthetic studies. British journal of haematology. vol 30. issue 3. 1976-03-01. PMID:1201216. |
the coexistence of alpha thalassaemia influences the level of mutant haemoglobin in haemoglobinopathies in which hb c is present, in a fashion similar to that observed in sickle-cell trait. |
1976-03-01 |
2023-08-11 |
Not clear |
| M E Pembrey, D J Weatherall, J B Clegg, C Bunch, R P Perrin. Haemoglobin Bart's in Saudi Arabia. British journal of haematology. vol 29. issue 2. 1976-02-27. PMID:1238097. |
these findings indicate that elevated levels of hb bart's in this population are due to the presence of alpha thalassaemia. |
1976-02-27 |
2023-08-11 |
Not clear |
| M H Steinberg, J G Adams, B J Dreilin. Alpha thalassaemia in adults with sickle-cell trait. British journal of haematology. vol 30. issue 1. 1976-02-26. PMID:1191571. |
these findings are consistent with the presence of alpha thalassaemia in patients with sickle-cell trait who have lower than usual levels of hb s and microcytosis. |
1976-02-26 |
2023-08-11 |
Not clear |
| J Bonaventura, C Bonaventura, B Sullivan, G Godett. Hemoglobin Deer Lodge (beta 2 His replaced by Arg). Consequences of altering the 2,3-diphosphoglycerate binding site. The Journal of biological chemistry. vol 250. issue 24. 1976-02-09. PMID:393. |
we suggest that functional differences between the alpha and beta chains are enhanced in hb deer lodge. |
1976-02-09 |
2023-08-11 |
human |
| H T Gaud, S J Gill, B G Barisas, K Gersond. Heats of carbon monoxide binding by hemoglobin M Iwate. Biochemistry. vol 14. issue 21. 1976-01-29. PMID:241384. |
a large than normal heat of reaction (-21.6 +/- 0.5 kcal/mol of co) is attributed to the abnormal alpha chains in hb m iwate. |
1976-01-29 |
2023-08-11 |
Not clear |
| D Weil, N Van Cong, R Rebourcet, J Fréza. [Genetic study of GM2 gangliosidosis (Tay-Sachs and Sandhoff) by the study of the hexosaminidases of the Sandhoff-rodents hybrids (mouse and hamster)]. Annales de genetique. vol 18. issue 3. 1975-12-23. PMID:810067. |
it is suggested that "hex a fast" and "hex a like" are human-rodent hybrid hexosaminidases: "hex a fast" = (alpha beta')n; "hex a like" = (alpha beta's)n with the assumption that hamster hb' = (beta' beta')n and mouse hex b's = (beta's beta's)n. the specific anti hex a = anti (alpha beta); the non-specific anti hex a = anti hex b = anti (beta); the anti (alpha) would be absent or weak. |
1975-12-23 |
2023-08-11 |
mouse |
| K Nishikura, Y Sugita, M Nagai, Y Yoneyam. Ethylisocyanide equilibria of hemoglobins M Iwate, M Boston, M Hyde Park, M Saskatoon, and M Milwaukee-I in half-ferric and fully reduced states. The Journal of biological chemistry. vol 250. issue 17. 1975-12-04. PMID:1158877. |
the beta chain mutants, hb m hyde park and hb m saskatoon, have almost normal affinity for ethylisocyanide and a normal bohr effect, whereas the alpha chain mutants, hb m iwate and hb m boston, have abnormally low affinity and almost no bohr effect. |
1975-12-04 |
2023-08-11 |
Not clear |
| W W De Jong, P Meera Khan, L F Bernin. Hemoglobin Koya Dora: high frequency of a chain termination mutant. American journal of human genetics. vol 27. issue 1. 1975-11-06. PMID:1155453. |
approximately 10% of the members of the koya dora tribe from andhra pradesh (india) carry an alpha chain hemoglobin variant, hb koya dora (hb kd), usually in amounts of 0.5%-2% of total hemoglobin. |
1975-11-06 |
2023-08-11 |
Not clear |
| W W De Jong, P Meera Khan, L F Bernin. Hemoglobin Koya Dora: high frequency of a chain termination mutant. American journal of human genetics. vol 27. issue 1. 1975-11-06. PMID:1155453. |
the alpha chain of hb kd was found to be elongated by at least 16 residues, possibly as a result of a mutation of the normal alpha chain termination codon uaa to uca, coding for serine. |
1975-11-06 |
2023-08-11 |
Not clear |
| W W De Jong, P Meera Khan, L F Bernin. Hemoglobin Koya Dora: high frequency of a chain termination mutant. American journal of human genetics. vol 27. issue 1. 1975-11-06. PMID:1155453. |
a pedigree in which two individuals possess hb kd as well as the alpha chain variant hb rampa and normal hb a proves the existence of two alpha chain loci in this population. |
1975-11-06 |
2023-08-11 |
Not clear |
| W W De Jong, P Meera Khan, L F Bernin. Hemoglobin Koya Dora: high frequency of a chain termination mutant. American journal of human genetics. vol 27. issue 1. 1975-11-06. PMID:1155453. |
hb dk resembles the previously described hb constant spring [6, 7] in many aspects, probably also in its alpha thalassemia-like expression. |
1975-11-06 |
2023-08-11 |
Not clear |
| D L Rucknagel, J A Risin. A heterozygote for Hb S beta, Hb C beta and Hb G Philadelphia beta in a family presenting evidence for heterogeneity of hemoglobin alpha chain loci. The American journal of medicine. vol 59. issue 1. 1975-09-09. PMID:1138551. |
a heterozygote for hb s beta, hb c beta and hb g philadelphia beta in a family presenting evidence for heterogeneity of hemoglobin alpha chain loci. |
1975-09-09 |
2023-08-11 |
Not clear |
| D L Rucknagel, J A Risin. A heterozygote for Hb S beta, Hb C beta and Hb G Philadelphia beta in a family presenting evidence for heterogeneity of hemoglobin alpha chain loci. The American journal of medicine. vol 59. issue 1. 1975-09-09. PMID:1138551. |
seven relatives were heterozygous for hb g beta and hb s beta and five were heterozygous only for hb g alpha. |
1975-09-09 |
2023-08-11 |
Not clear |
| D L Rucknagel, J A Risin. A heterozygote for Hb S beta, Hb C beta and Hb G Philadelphia beta in a family presenting evidence for heterogeneity of hemoglobin alpha chain loci. The American journal of medicine. vol 59. issue 1. 1975-09-09. PMID:1138551. |
among the latter, three had approximately 30 per cent and two had 40 per cent of hb g. these proportions are consistent with the hypothesis that the american negro genome contains two types of chromosomes bearing structural loci for alpha chains, some possessing one hb alpha locus, others having two loci. |
1975-09-09 |
2023-08-11 |
Not clear |
| E C Abraham, J F Taylo. Oxidation-reduction potentials of human fetal hemoglobin and gamma chains. Effects of blocking sulfhydryl groups. The Journal of biological chemistry. vol 250. issue 10. 1975-07-24. PMID:236306. |
the oxidation-reduction equilibrium of the gamma chains of human fetal hemoglobin (hb f) has been studied and compared with that of the alpha and beta chains of human adult hemoglobin (hb a). |
1975-07-24 |
2023-08-11 |
human |
| E Trittelvitz, K Gersonde, K H Winterhalte. Electron-spin resonance of nitrosyl haemoglobins: normal alpha and beta chains and mutants Hb M Iwate and Hb Zürich. European journal of biochemistry. vol 51. issue 1. 1975-07-07. PMID:235432. |
electron-spin resonance of nitrosyl haemoglobins: normal alpha and beta chains and mutants hb m iwate and hb zürich. |
1975-07-07 |
2023-08-11 |
Not clear |