| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R I Rot. Hemoglobin enhances the production of tissue factor by endothelial cells in response to bacterial endotoxin. Blood. vol 83. issue 10. 1994-06-14. PMID:8180381. |
cell-free hb (10 mg/ml), either purified native (hbao) or chemically cross-linked (alpha alpha hb), was incubated with lps (0.1 microgram/ml), and the mixtures then were added to huvec in culture. |
1994-06-14 |
2023-08-12 |
human |
| R I Rot. Hemoglobin enhances the production of tissue factor by endothelial cells in response to bacterial endotoxin. Blood. vol 83. issue 10. 1994-06-14. PMID:8180381. |
cross-linked alpha alpha hb also greatly enhanced the production of tf protein compared with tf protein generated by lps alone (12-fold greater v 3.5-fold greater than huvec alone, respectively). |
1994-06-14 |
2023-08-12 |
human |
| T P Molchanova, D D Pobedimskaya, Z Ye, T H Huisma. Two different mutations in codon 68 are observed in Hb G-Philadelphia heterozygotes. American journal of hematology. vol 45. issue 4. 1994-06-03. PMID:8178806. |
through sequencing of amplified dna containing the appropriate alpha-globin genes we have identified the base substitution leading to the formation of hb g-philadelphia [alpha 68(e17)asn lys]. |
1994-06-03 |
2023-08-12 |
human |
| T P Molchanova, D D Pobedimskaya, Z Ye, T H Huisma. Two different mutations in codon 68 are observed in Hb G-Philadelphia heterozygotes. American journal of hematology. vol 45. issue 4. 1994-06-03. PMID:8178806. |
three subjects (approximately 25% hb g) had an acc aaa change at codon 68 of the alpha 2-globin gene; the chromosome with this mutation carried two alpha genes (alpha alpha). |
1994-06-03 |
2023-08-12 |
human |
| T P Molchanova, D D Pobedimskaya, Z Ye, T H Huisma. Two different mutations in codon 68 are observed in Hb G-Philadelphia heterozygotes. American journal of hematology. vol 45. issue 4. 1994-06-03. PMID:8178806. |
six subjects (approximately 33% hb g) had an aac aag change at the same codon of the alpha 2 alpha 1 hybrid gene on a chromosome with the 3.7 kb deletion (-alpha 3.7). |
1994-06-03 |
2023-08-12 |
human |
| H Tan, J B Whitne. Genomic rearrangement of the alpha-globin gene complex during mammalian evolution. Biochemical genetics. vol 31. issue 11-12. 1994-05-20. PMID:8166621. |
in man, the gene for hydroxyacyl glutathione hydrolase (hagh; glyoxalase ii) is closely linked to the alpha-globin locus (hb alpha) on chromosome 16. |
1994-05-20 |
2023-08-12 |
mouse |
| L Zhang, Y Wan. [The study on clinical characteristics of the development of primary hepatocyte carcinoma induced by hepatitis B]. Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi. vol 14. issue 6. 1994-05-18. PMID:7512449. |
during the phase of hb, 21.0% of these patients had elevated alpha fp (mean titer 80.0 ng/ml). |
1994-05-18 |
2023-08-12 |
Not clear |
| H Wajcman, J Kister, A M'Rad, A M Soummer, F Galactero. Hb Cemenelum [alpha 92 (FG4) Arg-->Trp]: a hemoglobin variant of the alpha 1/beta 2 interface that displays a moderate increase in oxygen affinity. Annals of hematology. vol 68. issue 2. 1994-05-10. PMID:8148419. |
hb cemenelum [alpha 92 (fg4) arg-->trp]: a hemoglobin variant of the alpha 1/beta 2 interface that displays a moderate increase in oxygen affinity. |
1994-05-10 |
2023-08-12 |
Not clear |
| H Wajcman, J Kister, A M'Rad, A M Soummer, F Galactero. Hb Cemenelum [alpha 92 (FG4) Arg-->Trp]: a hemoglobin variant of the alpha 1/beta 2 interface that displays a moderate increase in oxygen affinity. Annals of hematology. vol 68. issue 2. 1994-05-10. PMID:8148419. |
hb cemenelum [alpha 92 (fg4) arg-->trp] carries a structural modification at the same position as hb chesapeake, a very high oxygen affinity variant. |
1994-05-10 |
2023-08-12 |
Not clear |
| H Wajcman, J Kister, A M'Rad, A M Soummer, F Galactero. Hb Cemenelum [alpha 92 (FG4) Arg-->Trp]: a hemoglobin variant of the alpha 1/beta 2 interface that displays a moderate increase in oxygen affinity. Annals of hematology. vol 68. issue 2. 1994-05-10. PMID:8148419. |
the purified abnormal hemoglobin, like hb j cape town, another variant of position alpha 92(fg4), displayed only a 1.5- to 2-fold increased oxygen affinity and a reduced cooperativity. |
1994-05-10 |
2023-08-12 |
Not clear |
| K Adachi, P Konitzer, S Surre. Role of gamma 87 Gln in the inhibition of hemoglobin S polymerization by hemoglobin F. The Journal of biological chemistry. vol 269. issue 13. 1994-05-05. PMID:7511590. |
role of gamma 87 gln in the inhibition of hemoglobin s polymerization by hemoglobin f. previous studies suggested that gamma 87 gln in hemoglobin (hb) f is an important site for promoting inhibition of hb s (alpha 2 beta 2(6 glu-->val) polymerization by hb f. we engineered and isolated the double mutant (hb alpha 2 beta 2(6 glu-->val,87 thr-->gln) using a yeast expression system and characterized polymerization properties of this modified tetramer in an effort to clarify the role of gln at position 87 in inhibiting hb s polymerization. |
1994-05-05 |
2023-08-12 |
Not clear |
| D D Pobedimskaya, T P Molchanova, R Amernick, M S Druskin, B B Webber, J B Wilson, T H Huisma. Hb Sinai-Baltimore or alpha 2 beta (2)18(A15)Val->Gly, a silent, mildly unstable beta chain variant detected by isoelectrofocusing and high performance liquid chromatography. Hemoglobin. vol 17. issue 6. 1994-05-04. PMID:8144351. |
hb sinai-baltimore or alpha 2 beta (2)18(a15)val->gly, a silent, mildly unstable beta chain variant detected by isoelectrofocusing and high performance liquid chromatography. |
1994-05-04 |
2023-08-12 |
Not clear |
| M C Owen, P A Ockelford, R M Well. Hb Howick [beta 37(C3)Trp-->Gly]: a new high oxygen affinity variant of the alpha 1 beta 2 contact. Hemoglobin. vol 17. issue 6. 1994-05-04. PMID:8144352. |
hb howick [beta 37(c3)trp-->gly]: a new high oxygen affinity variant of the alpha 1 beta 2 contact. |
1994-05-04 |
2023-08-12 |
Not clear |
| D D Pobedimskaya, T P Molchanova, T H Huisman, S R Harding, R Bakane. Hb F-Saskatoon or alpha 2G gamma (2)21(B3)Glu-->Lys observed in a North American Indian newborn. Hemoglobin. vol 17. issue 6. 1994-05-04. PMID:8144355. |
hb f-saskatoon or alpha 2g gamma (2)21(b3)glu-->lys observed in a north american indian newborn. |
1994-05-04 |
2023-08-12 |
Not clear |
| H Ueno, A M Popowicz, J M Mannin. Random chemical modification of the oxygen-linked chloride-binding sites of hemoglobin: those in the central dyad axis may influence the transition between deoxy- and oxy-hemoglobin. Journal of protein chemistry. vol 12. issue 5. 1994-05-02. PMID:8141998. |
after removal of unmodified hb chains, the mixture of randomly modified acetylated alpha or beta chains was subjected to tandem treatment with trypsin and chymotrypsin. |
1994-05-02 |
2023-08-12 |
cattle |
| H Ueno, A M Popowicz, J M Mannin. Random chemical modification of the oxygen-linked chloride-binding sites of hemoglobin: those in the central dyad axis may influence the transition between deoxy- and oxy-hemoglobin. Journal of protein chemistry. vol 12. issue 5. 1994-05-02. PMID:8141998. |
two other chloride-binding sites, lys-99(alpha) and lys-103(beta), align the sides of the central dyad axis connecting the two well-known major chloride-binding sites of bovine hb. |
1994-05-02 |
2023-08-12 |
cattle |
| I Malavé, Y Perdomo, E Escalona, E Rodriguez, M Anchustegui, H Malavé, T Arend. Levels of tumor necrosis factor alpha/cachectin (TNF alpha) in sera from patients with sickle cell disease. Acta haematologica. vol 90. issue 4. 1994-04-28. PMID:8140855. |
an inverse correlation was observed between the percentages of hb f and the levels of tnf alpha found in the sera from the patients. |
1994-04-28 |
2023-08-12 |
Not clear |
| R E Weber, T H Jessen, H Malte, J Tam. Mutant hemoglobins (alpha 119-Ala and beta 55-Ser): functions related to high-altitude respiration in geese. Journal of applied physiology (Bethesda, Md. : 1985). vol 75. issue 6. 1994-04-11. PMID:8125885. |
the amino acid residues alpha-119 and beta-55, which form an alpha 1 beta 1 contact in human hemoglobin (hb), are altered in bar-headed and andean geese, respectively, which suggests that loss of this contact increases o2 affinity. |
1994-04-11 |
2023-08-12 |
human |
| K Ishimori, M Hashimoto, K Imai, K Fushitani, G Miyazaki, H Morimoto, Y Wada, I Morishim. Site-directed mutagenesis in hemoglobin: functional and structural role of the penultimate tyrosine in the alpha subunit. Biochemistry. vol 33. issue 9. 1994-04-07. PMID:8117715. |
to elucidate the functional and structural role of the penultimate residue in the alpha-subunit, we prepared new artificial mutants; hb y140 alpha q, in which tyr-140 alpha is replaced by a nonaromatic residue, gln, and hb y140 alpha f, which loses its hydrogen bond to val-93 alpha by the substitution of phe for tyr. |
1994-04-07 |
2023-08-12 |
Not clear |
| K Ishimori, M Hashimoto, K Imai, K Fushitani, G Miyazaki, H Morimoto, Y Wada, I Morishim. Site-directed mutagenesis in hemoglobin: functional and structural role of the penultimate tyrosine in the alpha subunit. Biochemistry. vol 33. issue 9. 1994-04-07. PMID:8117715. |
hb y140 alpha q exhibited a markedly increased oxygen affinity and almost completely diminished cooperativity, whereas hb y140 alpha f showed similar but less extensively impaired function, indicating that the aromatic residue at the penultimate position in the alpha-subunit contributes to the stabilization of the t-quaternary structure as does the corresponding residue in the beta-subunit. |
1994-04-07 |
2023-08-12 |
Not clear |