| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Adachi, P Konitzer, C G Paulraj, S Surre. Role of Leu-beta 88 in the hydrophobic acceptor pocket for Val-beta 6 during hemoglobin S polymerization. The Journal of biological chemistry. vol 269. issue 26. 1994-07-29. PMID:8021253. |
ala and phe substitutions at the beta 88 position in hb s were made using a yeast expression system in an effort to clarify the role of leu-beta 88 in creating a suitable acceptor site for val-beta 6 during polymerization of hb s. both ala- and phe-beta 88 substitutions in hb s inhibited polymerization compared with hb s. critical concentrations for polymerization of alpha 2 beta 2 val-6,ala-88 and alpha 2 beta 2val-6,phe-88 were 6- and 10-fold higher, respectively, than that of hb s (alpha 2 beta 2val-6,leu-88). |
1994-07-29 |
2023-08-12 |
Not clear |
| P E Keipert, C L Gomez, A Gonzales, V W MacDonald, J R Hess, R M Winslo. Diaspirin cross-linked hemoglobin: tissue distribution and long-term excretion after exchange transfusion. The Journal of laboratory and clinical medicine. vol 123. issue 5. 1994-06-29. PMID:8195676. |
this report describes the tissue distribution and long-term (14-day) excretion of hemoglobin cross-linked between the alpha-chains (alpha alpha hb) with carbon 14-labeled bis(3,5-dibromosalicyl)fumarate. |
1994-06-29 |
2023-08-12 |
rat |
| P E Keipert, C L Gomez, A Gonzales, V W MacDonald, J R Hess, R M Winslo. Diaspirin cross-linked hemoglobin: tissue distribution and long-term excretion after exchange transfusion. The Journal of laboratory and clinical medicine. vol 123. issue 5. 1994-06-29. PMID:8195676. |
fully conscious, chronically cannulated rats (n = 40) were treated with a 50% isovolemic exchange transfusion (et) with solutions of 14c-labeled alpha alpha hb (8.0 gm/dl) and were then monitored for as long as 14 days. |
1994-06-29 |
2023-08-12 |
rat |
| P E Keipert, C L Gomez, A Gonzales, V W MacDonald, J R Hess, R M Winslo. Diaspirin cross-linked hemoglobin: tissue distribution and long-term excretion after exchange transfusion. The Journal of laboratory and clinical medicine. vol 123. issue 5. 1994-06-29. PMID:8195676. |
the 14c-labeled alpha alpha hb did not appear to cross the blood-brain barrier, because radioactivity in the brain was barely detectable. |
1994-06-29 |
2023-08-12 |
rat |
| P E Keipert, C L Gomez, A Gonzales, V W MacDonald, J R Hess, R M Winslo. Diaspirin cross-linked hemoglobin: tissue distribution and long-term excretion after exchange transfusion. The Journal of laboratory and clinical medicine. vol 123. issue 5. 1994-06-29. PMID:8195676. |
the dose of 14c-labeled alpha alpha hb (2.4 gm hb/kg) produced an initial plasma hb level of 4.6 gm/dl, with a half-life in the plasma of 5.0 hours. |
1994-06-29 |
2023-08-12 |
rat |
| P E Keipert, C L Gomez, A Gonzales, V W MacDonald, J R Hess, R M Winslo. Diaspirin cross-linked hemoglobin: tissue distribution and long-term excretion after exchange transfusion. The Journal of laboratory and clinical medicine. vol 123. issue 5. 1994-06-29. PMID:8195676. |
the peak concentration in kidney, spleen, and liver occurred at 24 hours after et, when at least 92% of the 14c-labeled alpha alpha hb in plasma had been cleared. |
1994-06-29 |
2023-08-12 |
rat |
| P E Keipert, C L Gomez, A Gonzales, V W MacDonald, J R Hess, R M Winslo. Diaspirin cross-linked hemoglobin: tissue distribution and long-term excretion after exchange transfusion. The Journal of laboratory and clinical medicine. vol 123. issue 5. 1994-06-29. PMID:8195676. |
this study demonstrated that 2 weeks were required for the metabolic degradation and elimination of a large dose of alpha alpha hb in rats. |
1994-06-29 |
2023-08-12 |
rat |
| P C Giordano, C L Harteveld, H Streng, J C Oosterwijk, J G Heister, R Amons, L F Bernin. Hb Kurdistan [alpha 47(CE5)Asp-->Tyr], a new alpha chain variant in combination with beta (0)-thalassemia. Hemoglobin. vol 18. issue 1. 1994-06-27. PMID:8195005. |
hb kurdistan [alpha 47(ce5)asp-->tyr], a new alpha chain variant in combination with beta (0)-thalassemia. |
1994-06-27 |
2023-08-12 |
Not clear |
| J Bardakdjian, J Kister, H Wajcman, P Boulard, B Bohn, Y Blouquit, F Galactero. Hb Poitiers [alpha 45(CE3)His-->Asp]: a new hemoglobin variant with a two-fold increase in oxygen affinity. Hemoglobin. vol 18. issue 1. 1994-06-27. PMID:8195004. |
hb poitiers [alpha 45(ce3)his-->asp]: a new hemoglobin variant with a two-fold increase in oxygen affinity. |
1994-06-27 |
2023-08-12 |
Not clear |
| J Bardakdjian, J Kister, H Wajcman, P Boulard, B Bohn, Y Blouquit, F Galactero. Hb Poitiers [alpha 45(CE3)His-->Asp]: a new hemoglobin variant with a two-fold increase in oxygen affinity. Hemoglobin. vol 18. issue 1. 1994-06-27. PMID:8195004. |
hb poitiers or alpha 45(ce3)his-->asp was found in a 9-year-old french caucasian boy. |
1994-06-27 |
2023-08-12 |
Not clear |
| M C Owen, J G Hend. Hb Footscray or alpha 133(H16) Ser-->Arg: a new hemoglobin variant. Hemoglobin. vol 18. issue 1. 1994-06-27. PMID:8195006. |
hb footscray or alpha 133(h16) ser-->arg: a new hemoglobin variant. |
1994-06-27 |
2023-08-12 |
Not clear |
| M C Owen, J G Hend. Hb Footscray or alpha 133(H16) Ser-->Arg: a new hemoglobin variant. Hemoglobin. vol 18. issue 1. 1994-06-27. PMID:8195006. |
hb footscray, alpha 133(h16) ser-->arg, is a newly described hemoglobin variant found in an adult male of polish-hungarian descent. |
1994-06-27 |
2023-08-12 |
Not clear |
| L Manca, B Masala, M Manca, P Ferranti, P Pucc. Hb G-Waimanalo [alpha 64(E13)Asp-->Asn] observed in a Caucasian family. Hemoglobin. vol 18. issue 1. 1994-06-27. PMID:8195008. |
hb g-waimanalo [alpha 64(e13)asp-->asn] observed in a caucasian family. |
1994-06-27 |
2023-08-12 |
Not clear |
| G Dinçol, K Dinçol, S Erdem, D D Pobedimskaya, T P Molchanova, Z Ye, B B Webber, J B Wilson, T H Huisma. Hb Capa or alpha (2)94(G1)Asp-->Gly beta 2, a mildly unstable variant with an A-->G (GAC-->GGC) mutation in codon 94 of the alpha 1-globin gene. Hemoglobin. vol 18. issue 1. 1994-06-27. PMID:8195009. |
hb capa or alpha (2)94(g1)asp-->gly beta 2, a mildly unstable variant with an a-->g (gac-->ggc) mutation in codon 94 of the alpha 1-globin gene. |
1994-06-27 |
2023-08-12 |
Not clear |
| B Landin, P Ber. Alpha 2-globin gene mutation Hb G-Waimanalo: occurrence in combination with alpha-thalassemia-1. Hemoglobin. vol 18. issue 1. 1994-06-27. PMID:8195011. |
alpha 2-globin gene mutation hb g-waimanalo: occurrence in combination with alpha-thalassemia-1. |
1994-06-27 |
2023-08-12 |
Not clear |
| R I Rot. Hemoglobin enhances the production of tissue factor by endothelial cells in response to bacterial endotoxin. Blood. vol 83. issue 10. 1994-06-14. PMID:8180381. |
cell-free hb (10 mg/ml), either purified native (hbao) or chemically cross-linked (alpha alpha hb), was incubated with lps (0.1 microgram/ml), and the mixtures then were added to huvec in culture. |
1994-06-14 |
2023-08-12 |
human |
| R I Rot. Hemoglobin enhances the production of tissue factor by endothelial cells in response to bacterial endotoxin. Blood. vol 83. issue 10. 1994-06-14. PMID:8180381. |
cross-linked alpha alpha hb also greatly enhanced the production of tf protein compared with tf protein generated by lps alone (12-fold greater v 3.5-fold greater than huvec alone, respectively). |
1994-06-14 |
2023-08-12 |
human |
| T P Molchanova, D D Pobedimskaya, Z Ye, T H Huisma. Two different mutations in codon 68 are observed in Hb G-Philadelphia heterozygotes. American journal of hematology. vol 45. issue 4. 1994-06-03. PMID:8178806. |
through sequencing of amplified dna containing the appropriate alpha-globin genes we have identified the base substitution leading to the formation of hb g-philadelphia [alpha 68(e17)asn lys]. |
1994-06-03 |
2023-08-12 |
human |
| T P Molchanova, D D Pobedimskaya, Z Ye, T H Huisma. Two different mutations in codon 68 are observed in Hb G-Philadelphia heterozygotes. American journal of hematology. vol 45. issue 4. 1994-06-03. PMID:8178806. |
three subjects (approximately 25% hb g) had an acc aaa change at codon 68 of the alpha 2-globin gene; the chromosome with this mutation carried two alpha genes (alpha alpha). |
1994-06-03 |
2023-08-12 |
human |
| T P Molchanova, D D Pobedimskaya, Z Ye, T H Huisma. Two different mutations in codon 68 are observed in Hb G-Philadelphia heterozygotes. American journal of hematology. vol 45. issue 4. 1994-06-03. PMID:8178806. |
six subjects (approximately 33% hb g) had an aac aag change at the same codon of the alpha 2 alpha 1 hybrid gene on a chromosome with the 3.7 kb deletion (-alpha 3.7). |
1994-06-03 |
2023-08-12 |
human |