| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Adachi, C H Lai, P Konitzer, M Donahee, A Campbell, S Surre. Crystallization of recombinant hemoglobins with basic amino acid substitutions (Lys and Arg) at the beta 6 position. Blood. vol 84. issue 4. 1994-09-07. PMID:8049445. |
crystallization of native hb c and both rhbs was inhibited by hb f. these results suggest that alpha 2 beta gamma-heterohybrids that have basic amino acids at the beta 6 position behave similarly and are unable to crystallize like hb c. |
1994-09-07 |
2023-08-12 |
human |
| J S Waye, M Patterson, B Eng, D H Chui, G D Sher, N F Olivier. DNA diagnosis of Hb S and Hb Caribbean (alpha 2 beta 2 91 Leu-->Arg) in a Jamaican family. American journal of hematology. vol 47. issue 1. 1994-08-19. PMID:8042613. |
dna diagnosis of hb s and hb caribbean (alpha 2 beta 2 91 leu-->arg) in a jamaican family. |
1994-08-19 |
2023-08-12 |
Not clear |
| O Schaad, B Vallone, S J Edelstei. Critical residues responsible for self-association differences of hemoglobin alpha and beta chains: analysis by molecular modeling. Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. vol 316. issue 6. 1994-08-04. PMID:8019877. |
although the alpha and beta chains of adult human hemoglobin (hb a) are very similar, when isolated the individual chains display marked differences in the propensities to form homotetramers: alpha chains alone associate weakly into dimers, while beta chains form relatively stable tetramers. |
1994-08-04 |
2023-08-12 |
human |
| O Schaad, B Vallone, S J Edelstei. Critical residues responsible for self-association differences of hemoglobin alpha and beta chains: analysis by molecular modeling. Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. vol 316. issue 6. 1994-08-04. PMID:8019877. |
for the alpha 1-beta 1 interface (also designated as the x-interface) 19 alpha chain and 19 beta chain residues were identified that each contribute at least 1% to the energy of the contact in hb a. |
1994-08-04 |
2023-08-12 |
human |
| O Schaad, B Vallone, S J Edelstei. Critical residues responsible for self-association differences of hemoglobin alpha and beta chains: analysis by molecular modeling. Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. vol 316. issue 6. 1994-08-04. PMID:8019877. |
for the alpha 1-beta 2 interface (also designated as the z-interface) 10 alpha chain and 10 beta chain residues are identified as contributing at least 1% to the energy of the contact in hb a; about half of the contact residues are identical for corresponding positions of alpha and beta chains and most of these residues are retained at the interfaces in the two types of homotetramers, but with fewer alpha-alpha contacts. |
1994-08-04 |
2023-08-12 |
human |
| K Adachi, P Konitzer, C G Paulraj, S Surre. Role of Leu-beta 88 in the hydrophobic acceptor pocket for Val-beta 6 during hemoglobin S polymerization. The Journal of biological chemistry. vol 269. issue 26. 1994-07-29. PMID:8021253. |
ala and phe substitutions at the beta 88 position in hb s were made using a yeast expression system in an effort to clarify the role of leu-beta 88 in creating a suitable acceptor site for val-beta 6 during polymerization of hb s. both ala- and phe-beta 88 substitutions in hb s inhibited polymerization compared with hb s. critical concentrations for polymerization of alpha 2 beta 2 val-6,ala-88 and alpha 2 beta 2val-6,phe-88 were 6- and 10-fold higher, respectively, than that of hb s (alpha 2 beta 2val-6,leu-88). |
1994-07-29 |
2023-08-12 |
Not clear |
| P E Keipert, C L Gomez, A Gonzales, V W MacDonald, J R Hess, R M Winslo. Diaspirin cross-linked hemoglobin: tissue distribution and long-term excretion after exchange transfusion. The Journal of laboratory and clinical medicine. vol 123. issue 5. 1994-06-29. PMID:8195676. |
this report describes the tissue distribution and long-term (14-day) excretion of hemoglobin cross-linked between the alpha-chains (alpha alpha hb) with carbon 14-labeled bis(3,5-dibromosalicyl)fumarate. |
1994-06-29 |
2023-08-12 |
rat |
| P E Keipert, C L Gomez, A Gonzales, V W MacDonald, J R Hess, R M Winslo. Diaspirin cross-linked hemoglobin: tissue distribution and long-term excretion after exchange transfusion. The Journal of laboratory and clinical medicine. vol 123. issue 5. 1994-06-29. PMID:8195676. |
fully conscious, chronically cannulated rats (n = 40) were treated with a 50% isovolemic exchange transfusion (et) with solutions of 14c-labeled alpha alpha hb (8.0 gm/dl) and were then monitored for as long as 14 days. |
1994-06-29 |
2023-08-12 |
rat |
| P E Keipert, C L Gomez, A Gonzales, V W MacDonald, J R Hess, R M Winslo. Diaspirin cross-linked hemoglobin: tissue distribution and long-term excretion after exchange transfusion. The Journal of laboratory and clinical medicine. vol 123. issue 5. 1994-06-29. PMID:8195676. |
the 14c-labeled alpha alpha hb did not appear to cross the blood-brain barrier, because radioactivity in the brain was barely detectable. |
1994-06-29 |
2023-08-12 |
rat |
| P E Keipert, C L Gomez, A Gonzales, V W MacDonald, J R Hess, R M Winslo. Diaspirin cross-linked hemoglobin: tissue distribution and long-term excretion after exchange transfusion. The Journal of laboratory and clinical medicine. vol 123. issue 5. 1994-06-29. PMID:8195676. |
the dose of 14c-labeled alpha alpha hb (2.4 gm hb/kg) produced an initial plasma hb level of 4.6 gm/dl, with a half-life in the plasma of 5.0 hours. |
1994-06-29 |
2023-08-12 |
rat |
| P E Keipert, C L Gomez, A Gonzales, V W MacDonald, J R Hess, R M Winslo. Diaspirin cross-linked hemoglobin: tissue distribution and long-term excretion after exchange transfusion. The Journal of laboratory and clinical medicine. vol 123. issue 5. 1994-06-29. PMID:8195676. |
the peak concentration in kidney, spleen, and liver occurred at 24 hours after et, when at least 92% of the 14c-labeled alpha alpha hb in plasma had been cleared. |
1994-06-29 |
2023-08-12 |
rat |
| P E Keipert, C L Gomez, A Gonzales, V W MacDonald, J R Hess, R M Winslo. Diaspirin cross-linked hemoglobin: tissue distribution and long-term excretion after exchange transfusion. The Journal of laboratory and clinical medicine. vol 123. issue 5. 1994-06-29. PMID:8195676. |
this study demonstrated that 2 weeks were required for the metabolic degradation and elimination of a large dose of alpha alpha hb in rats. |
1994-06-29 |
2023-08-12 |
rat |
| P C Giordano, C L Harteveld, H Streng, J C Oosterwijk, J G Heister, R Amons, L F Bernin. Hb Kurdistan [alpha 47(CE5)Asp-->Tyr], a new alpha chain variant in combination with beta (0)-thalassemia. Hemoglobin. vol 18. issue 1. 1994-06-27. PMID:8195005. |
hb kurdistan [alpha 47(ce5)asp-->tyr], a new alpha chain variant in combination with beta (0)-thalassemia. |
1994-06-27 |
2023-08-12 |
Not clear |
| J Bardakdjian, J Kister, H Wajcman, P Boulard, B Bohn, Y Blouquit, F Galactero. Hb Poitiers [alpha 45(CE3)His-->Asp]: a new hemoglobin variant with a two-fold increase in oxygen affinity. Hemoglobin. vol 18. issue 1. 1994-06-27. PMID:8195004. |
hb poitiers [alpha 45(ce3)his-->asp]: a new hemoglobin variant with a two-fold increase in oxygen affinity. |
1994-06-27 |
2023-08-12 |
Not clear |
| J Bardakdjian, J Kister, H Wajcman, P Boulard, B Bohn, Y Blouquit, F Galactero. Hb Poitiers [alpha 45(CE3)His-->Asp]: a new hemoglobin variant with a two-fold increase in oxygen affinity. Hemoglobin. vol 18. issue 1. 1994-06-27. PMID:8195004. |
hb poitiers or alpha 45(ce3)his-->asp was found in a 9-year-old french caucasian boy. |
1994-06-27 |
2023-08-12 |
Not clear |
| M C Owen, J G Hend. Hb Footscray or alpha 133(H16) Ser-->Arg: a new hemoglobin variant. Hemoglobin. vol 18. issue 1. 1994-06-27. PMID:8195006. |
hb footscray or alpha 133(h16) ser-->arg: a new hemoglobin variant. |
1994-06-27 |
2023-08-12 |
Not clear |
| M C Owen, J G Hend. Hb Footscray or alpha 133(H16) Ser-->Arg: a new hemoglobin variant. Hemoglobin. vol 18. issue 1. 1994-06-27. PMID:8195006. |
hb footscray, alpha 133(h16) ser-->arg, is a newly described hemoglobin variant found in an adult male of polish-hungarian descent. |
1994-06-27 |
2023-08-12 |
Not clear |
| L Manca, B Masala, M Manca, P Ferranti, P Pucc. Hb G-Waimanalo [alpha 64(E13)Asp-->Asn] observed in a Caucasian family. Hemoglobin. vol 18. issue 1. 1994-06-27. PMID:8195008. |
hb g-waimanalo [alpha 64(e13)asp-->asn] observed in a caucasian family. |
1994-06-27 |
2023-08-12 |
Not clear |
| G Dinçol, K Dinçol, S Erdem, D D Pobedimskaya, T P Molchanova, Z Ye, B B Webber, J B Wilson, T H Huisma. Hb Capa or alpha (2)94(G1)Asp-->Gly beta 2, a mildly unstable variant with an A-->G (GAC-->GGC) mutation in codon 94 of the alpha 1-globin gene. Hemoglobin. vol 18. issue 1. 1994-06-27. PMID:8195009. |
hb capa or alpha (2)94(g1)asp-->gly beta 2, a mildly unstable variant with an a-->g (gac-->ggc) mutation in codon 94 of the alpha 1-globin gene. |
1994-06-27 |
2023-08-12 |
Not clear |
| B Landin, P Ber. Alpha 2-globin gene mutation Hb G-Waimanalo: occurrence in combination with alpha-thalassemia-1. Hemoglobin. vol 18. issue 1. 1994-06-27. PMID:8195011. |
alpha 2-globin gene mutation hb g-waimanalo: occurrence in combination with alpha-thalassemia-1. |
1994-06-27 |
2023-08-12 |
Not clear |