| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V W Macdonald, R Motterlin. Vasoconstrictor effects in isolated rabbit heart perfused with bis(3,5-dibromosalicyl)fumarate cross-linked hemoglobin (alpha alpha Hb). Artificial cells, blood substitutes, and immobilization biotechnology. vol 22. issue 3. 1995-01-17. PMID:7994376. |
we found that the sensitivity to ach-induced vasoconstriction was significantly potentiated in the presence of alpha alpha hb and l-name. |
1995-01-17 |
2023-08-12 |
human |
| V W Macdonald, R Motterlin. Vasoconstrictor effects in isolated rabbit heart perfused with bis(3,5-dibromosalicyl)fumarate cross-linked hemoglobin (alpha alpha Hb). Artificial cells, blood substitutes, and immobilization biotechnology. vol 22. issue 3. 1995-01-17. PMID:7994376. |
in addition, this response was only partially reversed after removal of alpha alpha hb, except when dfo was simultaneously infused with the alpha alpha hb solution. |
1995-01-17 |
2023-08-12 |
human |
| A Dumoulin, V Baudin, L Kiger, S J Edelstein, M Marden, C Poyart, J Pagnie. Chimeric hemoglobin subunits: functional properties of a recombinant beta/alpha hemoglobin. Artificial cells, blood substitutes, and immobilization biotechnology. vol 22. issue 3. 1995-01-17. PMID:7994395. |
molecular building indicated that this construction could result in hb homotetramers possessing the alpha 1 beta 2 interface, responsible for the heme-heme interaction in hb heterotetramers. |
1995-01-17 |
2023-08-12 |
human |
| J Simoni, G Simoni, C D Lox, M Feol. Reaction of human endothelial cells to bovine hemoglobin solutions and tumor necrosis factor. Artificial cells, blood substitutes, and immobilization biotechnology. vol 22. issue 3. 1995-01-17. PMID:7994400. |
human umbilical vein endothelial cells (huvec) were incubated for 24 hours with 0.1 mm or 0.3 mm of: [a] unmodified (u) hb-feiio2; [b] uhb-feiii; [c] uhb-feiv-oh; [d] polymerized low molecular weight hb (< 400 kda); [e] polymerized high molecular weight hb (< 1,020 kda); [f] polymerized low molecular weight hb + endotoxin (2.5 eu/ml); [g] rtnf alpha 100 pg/ml; [h] rtnf alpha 400 pg/ml; [i] rtnf alpha 800 pg/ml. |
1995-01-17 |
2023-08-12 |
human |
| H W Kim, T J Shen, D P Sun, N T Ho, M Madrid, M F Tam, M Zou, P F Cottam, C H. Restoring allosterism with compensatory mutations in hemoglobin. Proceedings of the National Academy of Sciences of the United States of America. vol 91. issue 24. 1994-12-27. PMID:7972099. |
abnormal human hemoglobins (hbs) with amino acid substitutions in the alpha 1 beta 2 interface have very high oxygen affinity and greatly reduced cooperativity in o2 binding compared to normal human hb. |
1994-12-27 |
2023-08-12 |
human |
| H W Kim, T J Shen, D P Sun, N T Ho, M Madrid, M F Tam, M Zou, P F Cottam, C H. Restoring allosterism with compensatory mutations in hemoglobin. Proceedings of the National Academy of Sciences of the United States of America. vol 91. issue 24. 1994-12-27. PMID:7972099. |
we have determined the o2 binding properties of this recombinant double mutant hb, hb(asp-beta 99-->asn and tyr-alpha 42-->asp) and have used 1h nmr spectroscopy to investigate the tertiary structures around the heme groups and the quaternary structure in the alpha 1 beta 2 subunit interface. |
1994-12-27 |
2023-08-12 |
human |
| J S Waye, B Eng, M Patterson, D H Chui, L S Chang, B Cogionis, A O Poon, N F Olivier. Hb E/Hb LeporeHollandia in a family from Bangladesh. American journal of hematology. vol 47. issue 4. 1994-12-27. PMID:7977297. |
we describe a family from bangladesh in which three children are compound heterozygotes for hb e (alpha 2 beta 2, beta 26glu lys) and hb lepore (delta-beta fusion gene). |
1994-12-27 |
2023-08-12 |
Not clear |
| D D Pobedimskaya, T P Molchanova, S Streichman, T H Huisma. Compound heterozygosity for two alpha-globin gene defects, Hb Taybe (alpha 1; 38 or 39 minus Thr) and a poly A mutation (alpha 2; AATAAA-->AATAAG), results in a severe hemolytic anemia. American journal of hematology. vol 47. issue 3. 1994-11-18. PMID:7942784. |
compound heterozygosity for two alpha-globin gene defects, hb taybe (alpha 1; 38 or 39 minus thr) and a poly a mutation (alpha 2; aataaa-->aataag), results in a severe hemolytic anemia. |
1994-11-18 |
2023-08-12 |
Not clear |
| D D Pobedimskaya, T P Molchanova, S Streichman, T H Huisma. Compound heterozygosity for two alpha-globin gene defects, Hb Taybe (alpha 1; 38 or 39 minus Thr) and a poly A mutation (alpha 2; AATAAA-->AATAAG), results in a severe hemolytic anemia. American journal of hematology. vol 47. issue 3. 1994-11-18. PMID:7942784. |
this leads to the synthesis of an abnormal alpha chain with one instead of two threonine residues at positions 38-39 and to the formation of the unstable hb taybe. |
1994-11-18 |
2023-08-12 |
Not clear |
| D D Pobedimskaya, T P Molchanova, S Streichman, T H Huisma. Compound heterozygosity for two alpha-globin gene defects, Hb Taybe (alpha 1; 38 or 39 minus Thr) and a poly A mutation (alpha 2; AATAAA-->AATAAG), results in a severe hemolytic anemia. American journal of hematology. vol 47. issue 3. 1994-11-18. PMID:7942784. |
the hemolytic disease in this man, resembling hb h disease, is likely the result of a severe downregulation of both alpha-globin genes on the chromosome with the alpha 2 poly a mutation, and the instability of the alpha-taybe chain being the product of an alpha 1-globin gene; this leaves only one alpha 2-globin gene normally active. |
1994-11-18 |
2023-08-12 |
Not clear |
| S L McCune, M P Reilly, M J Chomo, T Asakura, T M Towne. Recombinant human hemoglobins designed for gene therapy of sickle cell disease. Proceedings of the National Academy of Sciences of the United States of America. vol 91. issue 21. 1994-11-10. PMID:7937904. |
two human hemoglobins designed to inhibit the polymerization of sickle hemoglobin (hb s; alpha 2 beta s2) have been produced. |
1994-11-10 |
2023-08-12 |
mouse |
| W Kaca, R I Roth, J Levi. Hemoglobin, a newly recognized lipopolysaccharide (LPS)-binding protein that enhances LPS biological activity. The Journal of biological chemistry. vol 269. issue 40. 1994-11-04. PMID:7929195. |
mixtures of each of three different hb preparations (cross-linked alpha alpha hb, cross-linked carbon monoxy-alpha alpha hbco, and non-cross-linked (native) hbao) and lps (escherichia coli o26:b6 or proteus mirabilis s1959) were examined by several independent methods for evidence of hb.lps complex formation. |
1994-11-04 |
2023-08-12 |
human |
| S Rahbar, T D Lee, M Davis, W F Novotny, H M Ranne. A second case of Hb Hanamaki [alpha 2 139(HC1)Lys->Glu beta 2] in an American family with erythrocytosis. Hemoglobin. vol 18. issue 3. 1994-10-28. PMID:7928378. |
a second case of hb hanamaki [alpha 2 139(hc1)lys->glu beta 2] in an american family with erythrocytosis. |
1994-10-28 |
2023-08-12 |
Not clear |
| M S Gonçalves, M F Sonati, M Kimura, V R Arruda, F F Costa, J F Nechtman, T A Stomin. Association of Hb Santa Ana [alpha 2 beta (2)88(F4)Leu- > Pro] and Hb Porto Alegre [alpha 2 beta (2)9(A6)Ser- > Cys] in a Brazilian female. Hemoglobin. vol 18. issue 3. 1994-10-28. PMID:7928381. |
association of hb santa ana [alpha 2 beta (2)88(f4)leu- > pro] and hb porto alegre [alpha 2 beta (2)9(a6)ser- > cys] in a brazilian female. |
1994-10-28 |
2023-08-12 |
Not clear |
| D Plaseska, B Cepreganova-Krstik, A Momirovska, G D Efremo. Hb F-Macedonia-I or alpha 2A gamma (2)2(NA2)His- > Gln. Hemoglobin. vol 18. issue 3. 1994-10-28. PMID:7928382. |
hb f-macedonia-i or alpha 2a gamma (2)2(na2)his- > gln. |
1994-10-28 |
2023-08-12 |
Not clear |
| M A Zago, F Costa, C Bottur. Beta-thalassemia in Brazil. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 14. issue 6. 1994-10-19. PMID:6086110. |
the group included 8 beta zero-thalassemia homozygotes, 7 carriers of at least one beta + gene, one delta beta zero/beta zero-thalassemia double heterozygote and one beta zero homozygote also carrying the alpha-chain variant hb hasharon (alpha 2(47) his beta 2). |
1994-10-19 |
2023-08-12 |
Not clear |
| K Sudhakar, S Loe, T Yonetani, J M Vanderkoo. Fluorescent derivatives of human hemoglobin. Differences in interaction of the porphyrin with the protein between the alpha and beta subunits. The Journal of biological chemistry. vol 269. issue 37. 1994-10-11. PMID:8083211. |
the fluorescence properties of porphyrin were compared in protoporphyrin-protoheme hybrid hemoglobins (hb) in which the protohemes (fe) in either the alpha or beta subunits were substituted with protoporphyrin ix, alpha (p)2 beta (fe)2-hb and alpha (fe)2 beta(p)2-hb, respectively. |
1994-10-11 |
2023-08-12 |
human |
| V Brabec, K Indrák, H Fortová, J Suttnar, B Blazek, J Cermák, V Divoký, L Vepreková, J Zema. Hb Nottingham or alpha 2 beta 2 98 (FG5) Val-->Gly in a Czech child. Annals of hematology. vol 69. issue 2. 1994-10-10. PMID:8080886. |
hb nottingham or alpha 2 beta 2 98 (fg5) val-->gly in a czech child. |
1994-10-10 |
2023-08-12 |
Not clear |
| V Brabec, K Indrák, H Fortová, J Suttnar, B Blazek, J Cermák, V Divoký, L Vepreková, J Zema. Hb Nottingham or alpha 2 beta 2 98 (FG5) Val-->Gly in a Czech child. Annals of hematology. vol 69. issue 2. 1994-10-10. PMID:8080886. |
we report a fourth case of hb nottingham [alpha 2 beta 2 98 (fg5) val-->gly] observed in an 8-year-old girl in the czech republic with clinical and laboratory symptoms of severe hemolytic anemia. |
1994-10-10 |
2023-08-12 |
Not clear |
| K Adachi, C H Lai, P Konitzer, M Donahee, A Campbell, S Surre. Crystallization of recombinant hemoglobins with basic amino acid substitutions (Lys and Arg) at the beta 6 position. Blood. vol 84. issue 4. 1994-09-07. PMID:8049445. |
we have produced recombinant hemoglobins (rhbs) alpha 2 beta 2(6glu-->lys) (rhb beta e6k) and alpha 2 beta 2(6glu-->arg) (rhb beta e6r) using a yeast expression system coupled with a polymerase chain reaction (pcr)-based mutagenesis strategy for studies focused on defining determinants that facilitate crystallization of hb c (alpha 2 beta 2(6lys)). |
1994-09-07 |
2023-08-12 |
human |