| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H W Kim, T J Shen, D P Sun, N T Ho, M Madrid, M F Tam, M Zou, P F Cottam, C H. Restoring allosterism with compensatory mutations in hemoglobin. Proceedings of the National Academy of Sciences of the United States of America. vol 91. issue 24. 1994-12-27. PMID:7972099. |
we have determined the o2 binding properties of this recombinant double mutant hb, hb(asp-beta 99-->asn and tyr-alpha 42-->asp) and have used 1h nmr spectroscopy to investigate the tertiary structures around the heme groups and the quaternary structure in the alpha 1 beta 2 subunit interface. |
1994-12-27 |
2023-08-12 |
human |
| J S Waye, B Eng, M Patterson, D H Chui, L S Chang, B Cogionis, A O Poon, N F Olivier. Hb E/Hb LeporeHollandia in a family from Bangladesh. American journal of hematology. vol 47. issue 4. 1994-12-27. PMID:7977297. |
we describe a family from bangladesh in which three children are compound heterozygotes for hb e (alpha 2 beta 2, beta 26glu lys) and hb lepore (delta-beta fusion gene). |
1994-12-27 |
2023-08-12 |
Not clear |
| D D Pobedimskaya, T P Molchanova, S Streichman, T H Huisma. Compound heterozygosity for two alpha-globin gene defects, Hb Taybe (alpha 1; 38 or 39 minus Thr) and a poly A mutation (alpha 2; AATAAA-->AATAAG), results in a severe hemolytic anemia. American journal of hematology. vol 47. issue 3. 1994-11-18. PMID:7942784. |
compound heterozygosity for two alpha-globin gene defects, hb taybe (alpha 1; 38 or 39 minus thr) and a poly a mutation (alpha 2; aataaa-->aataag), results in a severe hemolytic anemia. |
1994-11-18 |
2023-08-12 |
Not clear |
| D D Pobedimskaya, T P Molchanova, S Streichman, T H Huisma. Compound heterozygosity for two alpha-globin gene defects, Hb Taybe (alpha 1; 38 or 39 minus Thr) and a poly A mutation (alpha 2; AATAAA-->AATAAG), results in a severe hemolytic anemia. American journal of hematology. vol 47. issue 3. 1994-11-18. PMID:7942784. |
this leads to the synthesis of an abnormal alpha chain with one instead of two threonine residues at positions 38-39 and to the formation of the unstable hb taybe. |
1994-11-18 |
2023-08-12 |
Not clear |
| D D Pobedimskaya, T P Molchanova, S Streichman, T H Huisma. Compound heterozygosity for two alpha-globin gene defects, Hb Taybe (alpha 1; 38 or 39 minus Thr) and a poly A mutation (alpha 2; AATAAA-->AATAAG), results in a severe hemolytic anemia. American journal of hematology. vol 47. issue 3. 1994-11-18. PMID:7942784. |
the hemolytic disease in this man, resembling hb h disease, is likely the result of a severe downregulation of both alpha-globin genes on the chromosome with the alpha 2 poly a mutation, and the instability of the alpha-taybe chain being the product of an alpha 1-globin gene; this leaves only one alpha 2-globin gene normally active. |
1994-11-18 |
2023-08-12 |
Not clear |
| S L McCune, M P Reilly, M J Chomo, T Asakura, T M Towne. Recombinant human hemoglobins designed for gene therapy of sickle cell disease. Proceedings of the National Academy of Sciences of the United States of America. vol 91. issue 21. 1994-11-10. PMID:7937904. |
two human hemoglobins designed to inhibit the polymerization of sickle hemoglobin (hb s; alpha 2 beta s2) have been produced. |
1994-11-10 |
2023-08-12 |
mouse |
| W Kaca, R I Roth, J Levi. Hemoglobin, a newly recognized lipopolysaccharide (LPS)-binding protein that enhances LPS biological activity. The Journal of biological chemistry. vol 269. issue 40. 1994-11-04. PMID:7929195. |
mixtures of each of three different hb preparations (cross-linked alpha alpha hb, cross-linked carbon monoxy-alpha alpha hbco, and non-cross-linked (native) hbao) and lps (escherichia coli o26:b6 or proteus mirabilis s1959) were examined by several independent methods for evidence of hb.lps complex formation. |
1994-11-04 |
2023-08-12 |
human |
| S Rahbar, T D Lee, M Davis, W F Novotny, H M Ranne. A second case of Hb Hanamaki [alpha 2 139(HC1)Lys->Glu beta 2] in an American family with erythrocytosis. Hemoglobin. vol 18. issue 3. 1994-10-28. PMID:7928378. |
a second case of hb hanamaki [alpha 2 139(hc1)lys->glu beta 2] in an american family with erythrocytosis. |
1994-10-28 |
2023-08-12 |
Not clear |
| M S Gonçalves, M F Sonati, M Kimura, V R Arruda, F F Costa, J F Nechtman, T A Stomin. Association of Hb Santa Ana [alpha 2 beta (2)88(F4)Leu- > Pro] and Hb Porto Alegre [alpha 2 beta (2)9(A6)Ser- > Cys] in a Brazilian female. Hemoglobin. vol 18. issue 3. 1994-10-28. PMID:7928381. |
association of hb santa ana [alpha 2 beta (2)88(f4)leu- > pro] and hb porto alegre [alpha 2 beta (2)9(a6)ser- > cys] in a brazilian female. |
1994-10-28 |
2023-08-12 |
Not clear |
| D Plaseska, B Cepreganova-Krstik, A Momirovska, G D Efremo. Hb F-Macedonia-I or alpha 2A gamma (2)2(NA2)His- > Gln. Hemoglobin. vol 18. issue 3. 1994-10-28. PMID:7928382. |
hb f-macedonia-i or alpha 2a gamma (2)2(na2)his- > gln. |
1994-10-28 |
2023-08-12 |
Not clear |
| M A Zago, F Costa, C Bottur. Beta-thalassemia in Brazil. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 14. issue 6. 1994-10-19. PMID:6086110. |
the group included 8 beta zero-thalassemia homozygotes, 7 carriers of at least one beta + gene, one delta beta zero/beta zero-thalassemia double heterozygote and one beta zero homozygote also carrying the alpha-chain variant hb hasharon (alpha 2(47) his beta 2). |
1994-10-19 |
2023-08-12 |
Not clear |
| K Sudhakar, S Loe, T Yonetani, J M Vanderkoo. Fluorescent derivatives of human hemoglobin. Differences in interaction of the porphyrin with the protein between the alpha and beta subunits. The Journal of biological chemistry. vol 269. issue 37. 1994-10-11. PMID:8083211. |
the fluorescence properties of porphyrin were compared in protoporphyrin-protoheme hybrid hemoglobins (hb) in which the protohemes (fe) in either the alpha or beta subunits were substituted with protoporphyrin ix, alpha (p)2 beta (fe)2-hb and alpha (fe)2 beta(p)2-hb, respectively. |
1994-10-11 |
2023-08-12 |
human |
| V Brabec, K Indrák, H Fortová, J Suttnar, B Blazek, J Cermák, V Divoký, L Vepreková, J Zema. Hb Nottingham or alpha 2 beta 2 98 (FG5) Val-->Gly in a Czech child. Annals of hematology. vol 69. issue 2. 1994-10-10. PMID:8080886. |
hb nottingham or alpha 2 beta 2 98 (fg5) val-->gly in a czech child. |
1994-10-10 |
2023-08-12 |
Not clear |
| V Brabec, K Indrák, H Fortová, J Suttnar, B Blazek, J Cermák, V Divoký, L Vepreková, J Zema. Hb Nottingham or alpha 2 beta 2 98 (FG5) Val-->Gly in a Czech child. Annals of hematology. vol 69. issue 2. 1994-10-10. PMID:8080886. |
we report a fourth case of hb nottingham [alpha 2 beta 2 98 (fg5) val-->gly] observed in an 8-year-old girl in the czech republic with clinical and laboratory symptoms of severe hemolytic anemia. |
1994-10-10 |
2023-08-12 |
Not clear |
| K Adachi, C H Lai, P Konitzer, M Donahee, A Campbell, S Surre. Crystallization of recombinant hemoglobins with basic amino acid substitutions (Lys and Arg) at the beta 6 position. Blood. vol 84. issue 4. 1994-09-07. PMID:8049445. |
we have produced recombinant hemoglobins (rhbs) alpha 2 beta 2(6glu-->lys) (rhb beta e6k) and alpha 2 beta 2(6glu-->arg) (rhb beta e6r) using a yeast expression system coupled with a polymerase chain reaction (pcr)-based mutagenesis strategy for studies focused on defining determinants that facilitate crystallization of hb c (alpha 2 beta 2(6lys)). |
1994-09-07 |
2023-08-12 |
human |
| K Adachi, C H Lai, P Konitzer, M Donahee, A Campbell, S Surre. Crystallization of recombinant hemoglobins with basic amino acid substitutions (Lys and Arg) at the beta 6 position. Blood. vol 84. issue 4. 1994-09-07. PMID:8049445. |
crystallization of native hb c and both rhbs was inhibited by hb f. these results suggest that alpha 2 beta gamma-heterohybrids that have basic amino acids at the beta 6 position behave similarly and are unable to crystallize like hb c. |
1994-09-07 |
2023-08-12 |
human |
| J S Waye, M Patterson, B Eng, D H Chui, G D Sher, N F Olivier. DNA diagnosis of Hb S and Hb Caribbean (alpha 2 beta 2 91 Leu-->Arg) in a Jamaican family. American journal of hematology. vol 47. issue 1. 1994-08-19. PMID:8042613. |
dna diagnosis of hb s and hb caribbean (alpha 2 beta 2 91 leu-->arg) in a jamaican family. |
1994-08-19 |
2023-08-12 |
Not clear |
| O Schaad, B Vallone, S J Edelstei. Critical residues responsible for self-association differences of hemoglobin alpha and beta chains: analysis by molecular modeling. Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. vol 316. issue 6. 1994-08-04. PMID:8019877. |
although the alpha and beta chains of adult human hemoglobin (hb a) are very similar, when isolated the individual chains display marked differences in the propensities to form homotetramers: alpha chains alone associate weakly into dimers, while beta chains form relatively stable tetramers. |
1994-08-04 |
2023-08-12 |
human |
| O Schaad, B Vallone, S J Edelstei. Critical residues responsible for self-association differences of hemoglobin alpha and beta chains: analysis by molecular modeling. Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. vol 316. issue 6. 1994-08-04. PMID:8019877. |
for the alpha 1-beta 1 interface (also designated as the x-interface) 19 alpha chain and 19 beta chain residues were identified that each contribute at least 1% to the energy of the contact in hb a. |
1994-08-04 |
2023-08-12 |
human |
| O Schaad, B Vallone, S J Edelstei. Critical residues responsible for self-association differences of hemoglobin alpha and beta chains: analysis by molecular modeling. Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. vol 316. issue 6. 1994-08-04. PMID:8019877. |
for the alpha 1-beta 2 interface (also designated as the z-interface) 10 alpha chain and 10 beta chain residues are identified as contributing at least 1% to the energy of the contact in hb a; about half of the contact residues are identical for corresponding positions of alpha and beta chains and most of these residues are retained at the interfaces in the two types of homotetramers, but with fewer alpha-alpha contacts. |
1994-08-04 |
2023-08-12 |
human |