| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T P Molchanova, D D Pobedimskaya, T H Huisma. The differences in quantities of alpha 2- and alpha 1-globin gene variants in heterozygotes. British journal of haematology. vol 88. issue 2. 1995-02-02. PMID:7803274. |
we have identified through sequencing of amplified dna the mutations in the alpha 2- and alpha 1-globin genes in 63 individuals with a heterozygosity for an alpha chain abnormal haemoglobin (hb). |
1995-02-02 |
2023-08-12 |
Not clear |
| T P Molchanova, D D Pobedimskaya, T H Huisma. The differences in quantities of alpha 2- and alpha 1-globin gene variants in heterozygotes. British journal of haematology. vol 88. issue 2. 1995-02-02. PMID:7803274. |
the average percentage of the abnormal hb in heterozygotes with alpha 2 mutations (23.5%) was slightly higher than that in heterozygotes with alpha 1 mutations (19.7%) (stable hbs only). |
1995-02-02 |
2023-08-12 |
Not clear |
| F Galacteros, E Girodon, A M'Rad, J Martin, M Goossens, L Jaber, I J Cohen, H Tamary, Y Goshen, R Zaizo. Hb Taybe (alpha 38 or 39 THR deleted): an alpha-globin defect, silent in the heterozygous state and producing severe hemolytic anemia in the homozygous. Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. vol 317. issue 5. 1995-01-19. PMID:7994622. |
hb taybe (alpha 38 or 39 thr deleted): an alpha-globin defect, silent in the heterozygous state and producing severe hemolytic anemia in the homozygous. |
1995-01-19 |
2023-08-12 |
Not clear |
| A G Tsai, B Friesenecker, R M Winslow, M Intagliett. Functional capillary density changes during blood substitution with alpha alpha Hb and dextran 70: influence on oxygen delivery. Artificial cells, blood substitutes, and immobilization biotechnology. vol 22. issue 3. 1995-01-17. PMID:7527725. |
functional capillary density changes during blood substitution with alpha alpha hb and dextran 70: influence on oxygen delivery. |
1995-01-17 |
2023-08-12 |
Not clear |
| A G Tsai, B Friesenecker, R M Winslow, M Intagliett. Functional capillary density changes during blood substitution with alpha alpha Hb and dextran 70: influence on oxygen delivery. Artificial cells, blood substitutes, and immobilization biotechnology. vol 22. issue 3. 1995-01-17. PMID:7527725. |
we use this rationale to analyze the effectiveness of isovolemic blood substitution with alpha alpha hb (3,5-bis(dibromosalicyl)fumarate) compared to isooncotic and isovolemic hemodilution with dextran 70. |
1995-01-17 |
2023-08-12 |
Not clear |
| A G Tsai, B Friesenecker, R M Winslow, M Intagliett. Functional capillary density changes during blood substitution with alpha alpha Hb and dextran 70: influence on oxygen delivery. Artificial cells, blood substitutes, and immobilization biotechnology. vol 22. issue 3. 1995-01-17. PMID:7527725. |
functional capillary density was maintained during moderate hemodilution with dextran 70, whereas alpha alpha hb exchange caused a gradual reduction in the number of flowing capillaries. |
1995-01-17 |
2023-08-12 |
Not clear |
| A G Tsai, B Friesenecker, R M Winslow, M Intagliett. Functional capillary density changes during blood substitution with alpha alpha Hb and dextran 70: influence on oxygen delivery. Artificial cells, blood substitutes, and immobilization biotechnology. vol 22. issue 3. 1995-01-17. PMID:7527725. |
our findings suggest that augmentation of the o2 content of blood with alpha alpha hb substitution produces similar results in terms of capillary o2 delivery and capacity as isovolemic and isooncotic hemodilution with dextran 70. |
1995-01-17 |
2023-08-12 |
Not clear |
| S S Panter, K D Vandegriff, P O Yan, R F Rega. Assessment of hemoglobin-dependent neurotoxicity: alpha-alpha crosslinked hemoglobin. Artificial cells, blood substitutes, and immobilization biotechnology. vol 22. issue 3. 1995-01-17. PMID:7994364. |
adult human hemoglobin a0 (hba0) has been shown to be neurotoxic, and we wish to report on similar studies conducted using a modified hemoglobin, which has been crosslinked between the alpha subunits (alpha-alpha hb). |
1995-01-17 |
2023-08-12 |
mouse |
| K D Vandegriff, Y C Le Tellie. A comparison of rates of heme exchange: site-specifically cross-linked versus polymerized human hemoglobins. Artificial cells, blood substitutes, and immobilization biotechnology. vol 22. issue 3. 1995-01-17. PMID:7994367. |
the total fitted amplitudes of the reaction depended upon the specific modification: beta beta-cross-linked hbs < alpha alpha-cross-linked hb approximately glycolaldehyde polymerized hb < glutaraldehyde polymerized hb < hba0. |
1995-01-17 |
2023-08-12 |
human |
| M Samaja, R Motterlini, E Rovid. Enhanced oxidation of bis(3,5-dibromosalicyl) fumarate alpha-alpha cross linked hemoglobin by free radicals generated by xanthine/xanthine oxidase. Artificial cells, blood substitutes, and immobilization biotechnology. vol 22. issue 3. 1995-01-17. PMID:7994373. |
we monitored the kinetics of the oxidation of stripped hb (shb), purified hba0 and alpha-alpha cross-linked hb (hbxl99 alpha) at [hb] in the 5 to 150 microm (heme) range. |
1995-01-17 |
2023-08-12 |
human |
| M Samaja, R Motterlini, E Rovid. Enhanced oxidation of bis(3,5-dibromosalicyl) fumarate alpha-alpha cross linked hemoglobin by free radicals generated by xanthine/xanthine oxidase. Artificial cells, blood substitutes, and immobilization biotechnology. vol 22. issue 3. 1995-01-17. PMID:7994373. |
for increasing [hb], the oxidation halftime (t1/2) increased for all hbs, but t1/2 was always less for hbxl99 alpha than for hba0 and shb. |
1995-01-17 |
2023-08-12 |
human |
| M Samaja, R Motterlini, E Rovid. Enhanced oxidation of bis(3,5-dibromosalicyl) fumarate alpha-alpha cross linked hemoglobin by free radicals generated by xanthine/xanthine oxidase. Artificial cells, blood substitutes, and immobilization biotechnology. vol 22. issue 3. 1995-01-17. PMID:7994373. |
such feature was attributed to the lower affinity for o2 of hbxl99 alpha and may represent a serious problem for use of this hb as blood substitute. |
1995-01-17 |
2023-08-12 |
human |
| V W Macdonald, R Motterlin. Vasoconstrictor effects in isolated rabbit heart perfused with bis(3,5-dibromosalicyl)fumarate cross-linked hemoglobin (alpha alpha Hb). Artificial cells, blood substitutes, and immobilization biotechnology. vol 22. issue 3. 1995-01-17. PMID:7994376. |
vasoconstrictor effects in isolated rabbit heart perfused with bis(3,5-dibromosalicyl)fumarate cross-linked hemoglobin (alpha alpha hb). |
1995-01-17 |
2023-08-12 |
human |
| V W Macdonald, R Motterlin. Vasoconstrictor effects in isolated rabbit heart perfused with bis(3,5-dibromosalicyl)fumarate cross-linked hemoglobin (alpha alpha Hb). Artificial cells, blood substitutes, and immobilization biotechnology. vol 22. issue 3. 1995-01-17. PMID:7994376. |
to study the mechanism by which cell-free hemoglobin preparations may alter coronary vascular reactivity, we investigated the effect of human hemoglobin cross-linked between alpha chains with bis(3,5-dibromosalicyl)fumarate (alpha alpha hb) on the vasomotor response to acetylcholine (ach) in isolated perfused rabbit hearts. |
1995-01-17 |
2023-08-12 |
human |
| V W Macdonald, R Motterlin. Vasoconstrictor effects in isolated rabbit heart perfused with bis(3,5-dibromosalicyl)fumarate cross-linked hemoglobin (alpha alpha Hb). Artificial cells, blood substitutes, and immobilization biotechnology. vol 22. issue 3. 1995-01-17. PMID:7994376. |
dose-response curves were generated by monitoring the increase in coronary pressure during serial addition of 0.2-10 microm ach before, during and after 20 min infusion of three test solutions: a) 0.1 g/dl alpha alpha hb (62 microm heme); b) 0.1 g/dl alpha alpha hb plus 60 microm deferoxamine (dfo); c) 50 microm ng-nitro-l-arginine methyl ester (l-name), a specific inhibitor of nitric oxide (no) synthase. |
1995-01-17 |
2023-08-12 |
human |
| V W Macdonald, R Motterlin. Vasoconstrictor effects in isolated rabbit heart perfused with bis(3,5-dibromosalicyl)fumarate cross-linked hemoglobin (alpha alpha Hb). Artificial cells, blood substitutes, and immobilization biotechnology. vol 22. issue 3. 1995-01-17. PMID:7994376. |
we found that the sensitivity to ach-induced vasoconstriction was significantly potentiated in the presence of alpha alpha hb and l-name. |
1995-01-17 |
2023-08-12 |
human |
| V W Macdonald, R Motterlin. Vasoconstrictor effects in isolated rabbit heart perfused with bis(3,5-dibromosalicyl)fumarate cross-linked hemoglobin (alpha alpha Hb). Artificial cells, blood substitutes, and immobilization biotechnology. vol 22. issue 3. 1995-01-17. PMID:7994376. |
in addition, this response was only partially reversed after removal of alpha alpha hb, except when dfo was simultaneously infused with the alpha alpha hb solution. |
1995-01-17 |
2023-08-12 |
human |
| A Dumoulin, V Baudin, L Kiger, S J Edelstein, M Marden, C Poyart, J Pagnie. Chimeric hemoglobin subunits: functional properties of a recombinant beta/alpha hemoglobin. Artificial cells, blood substitutes, and immobilization biotechnology. vol 22. issue 3. 1995-01-17. PMID:7994395. |
molecular building indicated that this construction could result in hb homotetramers possessing the alpha 1 beta 2 interface, responsible for the heme-heme interaction in hb heterotetramers. |
1995-01-17 |
2023-08-12 |
human |
| J Simoni, G Simoni, C D Lox, M Feol. Reaction of human endothelial cells to bovine hemoglobin solutions and tumor necrosis factor. Artificial cells, blood substitutes, and immobilization biotechnology. vol 22. issue 3. 1995-01-17. PMID:7994400. |
human umbilical vein endothelial cells (huvec) were incubated for 24 hours with 0.1 mm or 0.3 mm of: [a] unmodified (u) hb-feiio2; [b] uhb-feiii; [c] uhb-feiv-oh; [d] polymerized low molecular weight hb (< 400 kda); [e] polymerized high molecular weight hb (< 1,020 kda); [f] polymerized low molecular weight hb + endotoxin (2.5 eu/ml); [g] rtnf alpha 100 pg/ml; [h] rtnf alpha 400 pg/ml; [i] rtnf alpha 800 pg/ml. |
1995-01-17 |
2023-08-12 |
human |
| H W Kim, T J Shen, D P Sun, N T Ho, M Madrid, M F Tam, M Zou, P F Cottam, C H. Restoring allosterism with compensatory mutations in hemoglobin. Proceedings of the National Academy of Sciences of the United States of America. vol 91. issue 24. 1994-12-27. PMID:7972099. |
abnormal human hemoglobins (hbs) with amino acid substitutions in the alpha 1 beta 2 interface have very high oxygen affinity and greatly reduced cooperativity in o2 binding compared to normal human hb. |
1994-12-27 |
2023-08-12 |
human |