| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Motterlini, R Foresti, K Vandegriff, M Intaglietta, R M Winslo. Oxidative-stress response in vascular endothelial cells exposed to acellular hemoglobin solutions. The American journal of physiology. vol 269. issue 2 Pt 2. 1995-09-22. PMID:7653629. |
endothelial heme content and lactate dehydrogenase (ldh) release, an index of cell injury, were also higher in alpha alpha hb compared with hba0 and cnmet alpha alpha hb groups (p < 0.05). |
1995-09-22 |
2023-08-12 |
Not clear |
| R Motterlini, R Foresti, K Vandegriff, M Intaglietta, R M Winslo. Oxidative-stress response in vascular endothelial cells exposed to acellular hemoglobin solutions. The American journal of physiology. vol 269. issue 2 Pt 2. 1995-09-22. PMID:7653629. |
deferoxamine but not catalase markedly reduced the release of ldh induced by alpha alpha hb, whereas dimethylthiourea provided only a partial cytoprotection. |
1995-09-22 |
2023-08-12 |
Not clear |
| R Motterlini, R Foresti, K Vandegriff, M Intaglietta, R M Winslo. Oxidative-stress response in vascular endothelial cells exposed to acellular hemoglobin solutions. The American journal of physiology. vol 269. issue 2 Pt 2. 1995-09-22. PMID:7653629. |
these studies suggest that 1) the higher rate of oxidation of alpha alpha hb contributes to the augmented endothelial ho activity, and 2) both heme release and iron-mediated oxygen radical formation are major contributors to endothelial oxidative stress and cytotoxicity generated by the cross-linked hemoglobin. |
1995-09-22 |
2023-08-12 |
Not clear |
| E G Kazanetz, J Y Leonova, J B Wilson, S K McMillan, M Walbrecht, J M de Pablos Gallego, T H Huisma. Hb Anamosa or alpha 2(111)(G18)Ala-->Val beta 2 (alpha 2 mutation) and Hb Mulhacen or alpha 2(123)(H6)Ala-->Ser beta 2 (alpha 1 mutation) are two silent, stable variants detected by sequencing of amplified DNA. Hemoglobin. vol 19. issue 1-2. 1995-08-24. PMID:7615398. |
hb anamosa or alpha 2(111)(g18)ala-->val beta 2 (alpha 2 mutation) and hb mulhacen or alpha 2(123)(h6)ala-->ser beta 2 (alpha 1 mutation) are two silent, stable variants detected by sequencing of amplified dna. |
1995-08-24 |
2023-08-12 |
Not clear |
| E G Kazanetz, J Y Leonova, J B Wilson, S K McMillan, M Walbrecht, J M de Pablos Gallego, T H Huisma. Hb Anamosa or alpha 2(111)(G18)Ala-->Val beta 2 (alpha 2 mutation) and Hb Mulhacen or alpha 2(123)(H6)Ala-->Ser beta 2 (alpha 1 mutation) are two silent, stable variants detected by sequencing of amplified DNA. Hemoglobin. vol 19. issue 1-2. 1995-08-24. PMID:7615398. |
both involve an alanine residue in the core peptide, namely ala-->val at position 111 (codon change in the alpha 2 gene; gcc->gtc; hb anamosa) and ala-->ser at position 123 (codon change in the alpha 1 gene; gcc-->tcc; hb mulhacen). |
1995-08-24 |
2023-08-12 |
Not clear |
| N Koibuchi, S Yamaoka, M Suzuk. In situ hybridization histochemistry of c-erbA alpha 2 mRNA in the hypothalamus and its surrounding structures in the adult male rat. Endocrine journal. vol 42. issue 1. 1995-08-07. PMID:7599698. |
these results not only confirm previous findings in the pvn, hb, pvt and hipp, but also extend the finding to the vmn, arc and am, in which cells expressing c-erba alpha 2 primary transcript were concentrated. |
1995-08-07 |
2023-08-12 |
rat |
| R P Roy, P Nacharaju, R L Nagel, A S Achary. Symmetric interspecies hybrids of mouse and human hemoglobin: molecular basis of their abnormal oxygen affinity. Journal of protein chemistry. vol 14. issue 2. 1995-07-27. PMID:7786409. |
interspecies hybrids of hba and hb from mouse c57bl/10 [alpha 2m beta 2h and alpha 2h beta 2m (h = human, m = mouse)], representing 19 and 27 sequence differences per alpha beta dimers (as compared with human alpha beta dimer) have been generated in vitro. |
1995-07-27 |
2023-08-12 |
mouse |
| R P Roy, P Nacharaju, R L Nagel, A S Achary. Symmetric interspecies hybrids of mouse and human hemoglobin: molecular basis of their abnormal oxygen affinity. Journal of protein chemistry. vol 14. issue 2. 1995-07-27. PMID:7786409. |
interestingly, the interspecies hybrid alpha 2m beta 2h has high o2 affinity (compared to either human or mouse hb), while the interspecies hybrid alpha 2h beta 2m exhibits a very low o2 affinity. |
1995-07-27 |
2023-08-12 |
mouse |
| R Darbellay, S Mach-Pascual, K Rose, J Graf, P Beri. Haemoglobin Tunis-Bizerte: a new alpha 1 globin 129 Leu-->Pro unstable variant with thalassaemic phenotype. British journal of haematology. vol 90. issue 1. 1995-07-27. PMID:7786798. |
a search for the abnormal hb and for the abnormal alpha globin chain by isoelectric focusing, carboxymethyl cellulose chromatography and electrospray ionization mass spectrometry was negative. |
1995-07-27 |
2023-08-12 |
Not clear |
| R Darbellay, S Mach-Pascual, K Rose, J Graf, P Beri. Haemoglobin Tunis-Bizerte: a new alpha 1 globin 129 Leu-->Pro unstable variant with thalassaemic phenotype. British journal of haematology. vol 90. issue 1. 1995-07-27. PMID:7786798. |
in the heterozygous state, the alpha 1(129)(h12) leu-->pro variant is manifested by microcytosis (mcv approximately 73 fl), whereas in the homozygous state there is moderate anaemia with marked microcytosis (hb 11.6 g/dl, mcv 65 fl). |
1995-07-27 |
2023-08-12 |
Not clear |
| H Bard, J A Widness, E E Ziegler, C Gagnon, K G Per. The proportions of G gamma- and A gamma-globins in the fetal hemoglobin synthesized in preterm and term infants. Pediatric research. vol 37. issue 3. 1995-07-20. PMID:7540282. |
the change in g gamma to a gamma ratio in relation to the switchover of fetal hb (hbf) to adult hb (alpha 2 beta 2) synthesis has not been well defined. |
1995-07-20 |
2023-08-12 |
Not clear |
| R E Benesch, S Kwon. Coupled reactions in hemoglobin. Heme-globin and dimer-dimer association. The Journal of biological chemistry. vol 270. issue 23. 1995-07-10. PMID:7775434. |
five different human hemoglobins were used to test the postulate that dissociation of hemoglobin (hb) tetramers into alpha beta dimers and dissociation of heme from globin are linked reactions. |
1995-07-10 |
2023-08-12 |
human |
| H C Lee, J Peisach, A Tsuneshige, T Yonetan. Electron spin echo envelope modulation study of oxygenated iron-cobalt hybrid hemoglobins reveals molecular features analogous to those of the oxy ferrous protein. Biochemistry. vol 34. issue 20. 1995-06-26. PMID:7756320. |
(1994) biochemistry 33, 7609], which correlates with the higher o2 affinity found for (alpha co beta fe-o2)2 hb than for (alpha fe-o2 beta co)2 hb [imai et al. |
1995-06-26 |
2023-08-12 |
Not clear |
| M Nagai, K Mawatari, Y Nagai, S Horita, Y Yoneyama, H Hor. Studies of the oxidation states of hemoglobin M Boston and hemoglobin M Saskatoon in blood by EPR spectroscopy. Biochemical and biophysical research communications. vol 210. issue 2. 1995-06-21. PMID:7755625. |
the extent of the oxidation of hemoglobin (hb) m saskatoon (beta 63his-->tyr) and hb m boston (alpha 58his-->tyr) in the patient's blood was determined by measurement of the intensity of epr signals at g perpendicular = 6.0 for the normal subunits, g1 = 6.7 for the mutant subunits of hb m saskatoon and g1 = 6.3 for those of hb m boston, respectively. |
1995-06-21 |
2023-08-12 |
Not clear |
| H W Kim, T J Shen, D P Sun, N T Ho, M Madrid, C H. A novel low oxygen affinity recombinant hemoglobin (alpha96val--> Trp): switching quaternary structure without changing the ligation state. Journal of molecular biology. vol 248. issue 4. 1995-06-20. PMID:7752247. |
we have determined the oxygen-binding properties of this recombinant hemoglobin, r hb (alpha 96val-->trp), and have used proton nuclear magnetic resonance spectroscopy to investigate its tertiary structure around the heme group and the quaternary structure in the alpha 1 beta 2 subunit interface. |
1995-06-20 |
2023-08-12 |
human |
| H W Kim, T J Shen, D P Sun, N T Ho, M Madrid, C H. A novel low oxygen affinity recombinant hemoglobin (alpha96val--> Trp): switching quaternary structure without changing the ligation state. Journal of molecular biology. vol 248. issue 4. 1995-06-20. PMID:7752247. |
molecular dynamics simulations suggest that the unique oxygen-binding property of r hb (alpha 96val-->trp) may be due to an extra hydrogen bond between alpha 96trp and beta 99asp in the alpha 1 beta 2 subunit interface in the deoxy form. |
1995-06-20 |
2023-08-12 |
human |
| M Orisaka, T Sasaki, J Kato, K Harano, T Haran. [Hb M-Iwate [alpha 87 (F8) His-->Tyr]: analysis of the genomic DNA and biosynthesis]. Rinsho byori. The Japanese journal of clinical pathology. vol 43. issue 3. 1995-06-09. PMID:7745837. |
[hb m-iwate [alpha 87 (f8) his-->tyr]: analysis of the genomic dna and biosynthesis]. |
1995-06-09 |
2023-08-12 |
Not clear |
| M Orisaka, T Sasaki, J Kato, K Harano, T Haran. [Hb M-Iwate [alpha 87 (F8) His-->Tyr]: analysis of the genomic DNA and biosynthesis]. Rinsho byori. The Japanese journal of clinical pathology. vol 43. issue 3. 1995-06-09. PMID:7745837. |
hb m-iwate [alpha 87 (f8) his-->tyr] was identified as the cause of cyanosis in a 21-year-old japanese female. |
1995-06-09 |
2023-08-12 |
Not clear |
| E Baysal, M Kleanthous, G Bozkurt, A Kyrri, E Kalogirou, M Angastiniotis, P Ioannou, T H Huisma. alpha-Thalassaemia in the population of Cyprus. British journal of haematology. vol 89. issue 3. 1995-06-02. PMID:7734346. |
the phenotypes were comparable except for great variations in the level of hb h which was highest (average approximately 22%) in the 12 patients with the alpha 5nt alpha/--med-i combination. |
1995-06-02 |
2023-08-12 |
Not clear |
| V Jayaraman, T G Spir. Structure of a third cooperativity state of hemoglobin: ultraviolet resonance Raman spectroscopy of cyanomethemoglobin ligation microstates. Biochemistry. vol 34. issue 14. 1995-05-23. PMID:7718552. |
relative to fully ligated tetramers, hb(cn)4, the monoligated hybrids and deoxyhb all show fully developed t/r difference uvrr bands which are associated with t state quaternary contacts across the alpha 1 beta 2 interface, involving the trp beta 37 and tyr alpha 42 residues. |
1995-05-23 |
2023-08-12 |
Not clear |