| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M J Romero, M L Garrido, E Abril, F Garrido, J M de Pablo. Detection of Hb J-Camagüey [alpha 141(HC3)Arg-->Gly] in three Spanish families. Hemoglobin. vol 19. issue 5. 1996-02-05. PMID:8537233. |
detection of hb j-camagüey [alpha 141(hc3)arg-->gly] in three spanish families. |
1996-02-05 |
2023-08-12 |
Not clear |
| N S Smetanina, J Y Leonova, N Levy, T H Huisma. Identification of several alpha-globin gene variations in a small Laotian family. Acta haematologica. vol 94. issue 3. 1996-01-18. PMID:7502632. |
the father carried the 4.2-kb deletion on one chromosome and a taa-->caa mutation at the terminating codon of the alpha 2-gene (hb constant spring or cs) on the other chromosome. |
1996-01-18 |
2023-08-12 |
Not clear |
| N S Smetanina, J Y Leonova, N Levy, T H Huisma. Identification of several alpha-globin gene variations in a small Laotian family. Acta haematologica. vol 94. issue 3. 1996-01-18. PMID:7502632. |
moreover, the remaining alpha 1-globin gene on the chromosome with the 4.2-kb deletion was mutated at codon 74 (gac-->cac; asp-->his; hb q-thailand). |
1996-01-18 |
2023-08-12 |
Not clear |
| N S Smetanina, J Y Leonova, N Levy, T H Huisma. Identification of several alpha-globin gene variations in a small Laotian family. Acta haematologica. vol 94. issue 3. 1996-01-18. PMID:7502632. |
the mother had the 3.7-kb deletion on one chromosome and a taa-->tat mutation at the terminating codon of the alpha 2-globin gene (hb paksé) of the second chromosome. |
1996-01-18 |
2023-08-12 |
Not clear |
| J R Hes. Review of modified hemoglobin research at Letterman: attempts to delineate the toxicity of cell-free tetrameric hemoglobin. Artificial cells, blood substitutes, and immobilization biotechnology. vol 23. issue 3. 1996-01-11. PMID:7493049. |
human mononuclear cells release tnf alpha and il-8 when exposed to chromatographically purified human hb (hba0). |
1996-01-11 |
2023-08-12 |
mouse |
| J R Hes. Review of modified hemoglobin research at Letterman: attempts to delineate the toxicity of cell-free tetrameric hemoglobin. Artificial cells, blood substitutes, and immobilization biotechnology. vol 23. issue 3. 1996-01-11. PMID:7493049. |
in rabbits hba0 and human hb cross-linked with bis(3,5-dibromosalicyl) fumarate (alpha alpha hb) caused hypertension and pulmonary arteritis. |
1996-01-11 |
2023-08-12 |
mouse |
| J R Hes. Review of modified hemoglobin research at Letterman: attempts to delineate the toxicity of cell-free tetrameric hemoglobin. Artificial cells, blood substitutes, and immobilization biotechnology. vol 23. issue 3. 1996-01-11. PMID:7493049. |
in swine, hba0 and alpha alpha hb caused systemic and pulmonary hypertension and a doubling of the vascular resistance that was equivalent to that seen with inhibition of nitric oxide synthesis. |
1996-01-11 |
2023-08-12 |
mouse |
| J R Hes. Review of modified hemoglobin research at Letterman: attempts to delineate the toxicity of cell-free tetrameric hemoglobin. Artificial cells, blood substitutes, and immobilization biotechnology. vol 23. issue 3. 1996-01-11. PMID:7493049. |
acute renal failure seen after administration hba0, did not appear after alpha alpha hb. |
1996-01-11 |
2023-08-12 |
mouse |
| J R Hes. Review of modified hemoglobin research at Letterman: attempts to delineate the toxicity of cell-free tetrameric hemoglobin. Artificial cells, blood substitutes, and immobilization biotechnology. vol 23. issue 3. 1996-01-11. PMID:7493049. |
infusion of cyanomet-alpha alpha hb did not cause the increased vascular resistance seen after alpha alpha hb. |
1996-01-11 |
2023-08-12 |
mouse |
| J R Hes. Review of modified hemoglobin research at Letterman: attempts to delineate the toxicity of cell-free tetrameric hemoglobin. Artificial cells, blood substitutes, and immobilization biotechnology. vol 23. issue 3. 1996-01-11. PMID:7493049. |
the infusion of 1-arginine or nitroglycerine with alpha alpha hb did not prevent the increased vascular resistance and decreased cardiac output or allow the increased oxygen carrying capacity provided by hb in the plasma from translating into improved oxygen delivery or improved oxygen consumption. |
1996-01-11 |
2023-08-12 |
mouse |
| R Motterlini, R Foresti, K Vandegriff, R M Winslo. The autoxidation of alpha alpha cross-linked hemoglobin: a possible role in the oxidative stress to endothelium. Artificial cells, blood substitutes, and immobilization biotechnology. vol 23. issue 3. 1996-01-11. PMID:7493050. |
porcine aortic endothelial cells were incubated for six hours in the presence of 60 microm unmodified hemoglobin (hba0), hemoglobin cross-linked between the alpha chains with bis-(3,5-dibromosalicyl) fumarate (alpha alpha hb) or cyanomet-alpha alpha-hemoglobin (cnmet alpha alpha hb). |
1996-01-11 |
2023-08-12 |
Not clear |
| R Motterlini, R Foresti, K Vandegriff, R M Winslo. The autoxidation of alpha alpha cross-linked hemoglobin: a possible role in the oxidative stress to endothelium. Artificial cells, blood substitutes, and immobilization biotechnology. vol 23. issue 3. 1996-01-11. PMID:7493050. |
microsomal ho content increased 4.1-fold in the presence of alpha alpha hb, 2.7-fold with hba0 and 1.8-fold with cnmet alpha alpha hb over the control value. |
1996-01-11 |
2023-08-12 |
Not clear |
| R Motterlini, R Foresti, K Vandegriff, R M Winslo. The autoxidation of alpha alpha cross-linked hemoglobin: a possible role in the oxidative stress to endothelium. Artificial cells, blood substitutes, and immobilization biotechnology. vol 23. issue 3. 1996-01-11. PMID:7493050. |
the rates of methemoglobin formation exhibited a linear relationship over the time of incubation (r = 0.94) and the apparent rate constant was 1.8-fold higher for alpha alpha hb (0.023 h-1) than hba0 (0.013 h-1). |
1996-01-11 |
2023-08-12 |
Not clear |
| R Motterlini, R Foresti, K Vandegriff, R M Winslo. The autoxidation of alpha alpha cross-linked hemoglobin: a possible role in the oxidative stress to endothelium. Artificial cells, blood substitutes, and immobilization biotechnology. vol 23. issue 3. 1996-01-11. PMID:7493050. |
when cells were incubated with 100% methemoglobin, ho activity increased 5.0-fold and 4.7-fold for hba0 and alpha alpha hb, respectively. |
1996-01-11 |
2023-08-12 |
Not clear |
| R Motterlini, R Foresti, K Vandegriff, R M Winslo. The autoxidation of alpha alpha cross-linked hemoglobin: a possible role in the oxidative stress to endothelium. Artificial cells, blood substitutes, and immobilization biotechnology. vol 23. issue 3. 1996-01-11. PMID:7493050. |
intracellular heme concentration, measured after 24 hours of incubation, was also significantly greater in the presence of alpha alpha hb (52.6% over baseline) compared to hba0 (10.8%) and cnmet alpha alpha hb (15.3%) groups (p < 0.05). |
1996-01-11 |
2023-08-12 |
Not clear |
| R Motterlini, R Foresti, K Vandegriff, R M Winslo. The autoxidation of alpha alpha cross-linked hemoglobin: a possible role in the oxidative stress to endothelium. Artificial cells, blood substitutes, and immobilization biotechnology. vol 23. issue 3. 1996-01-11. PMID:7493050. |
however, lactate dehydrogenase (ldh) release, measured as an index of endothelial cell injury, increased in all the hemoglobins examined: alpha alpha hb, 33.8 +/- 1.1 u/l; hba0, 38.5 +/- 3.5 u/l; cnmet alpha alpha hb, 41.9 +/- 4.0 u/l; (control group, 19.4 +/- 2.8 u/l). |
1996-01-11 |
2023-08-12 |
Not clear |
| R Motterlini, R Foresti, K Vandegriff, R M Winslo. The autoxidation of alpha alpha cross-linked hemoglobin: a possible role in the oxidative stress to endothelium. Artificial cells, blood substitutes, and immobilization biotechnology. vol 23. issue 3. 1996-01-11. PMID:7493050. |
we conclude that: 1) the higher rate of oxidation of alpha alpha hb renders the molecule more susceptible to induce endothelial oxidative stress (ho induction); 2) the accelerated methemoglobin formation is directly correlated to intracellular ho content and endothelial heme uptake; 3) persistent cell injury suggests that other factors besides heme release may contribute to the hemoglobin-mediated cytotoxicity. |
1996-01-11 |
2023-08-12 |
Not clear |
| L C Chan, J C So, D H Chu. Comparison of haemoglobin H inclusion bodies with embryonic zeta globin in screening for alpha thalassaemia. Journal of clinical pathology. vol 48. issue 9. 1996-01-04. PMID:7490322. |
to compare the haemoglobin (hb) h inclusion test with immunocytochemical detection of embryonic zeta chains in screening for alpha thalassaemia. |
1996-01-04 |
2023-08-12 |
Not clear |
| K Adachi, P Sabnekar, M Adachi, L R Reddy, J Pang, K S Reddy, S Surre. Polymerization of recombinant Hb S-Kempsey (deoxy-R state) and Hb S-Kansas (oxy-T state). The Journal of biological chemistry. vol 270. issue 45. 1995-12-26. PMID:7592928. |
in order to investigate the role of the r (relaxed) to t (tense) structural transition in facilitating polymerization of deoxy-hb s, we have engineered and expressed two hb s variants which destabilize either t state (hb s-kempsey, alpha 2 beta 2 val-6,asn-99) or r state structures (hb s-kansas, alpha 2 beta 2 val-6, thr-102). |
1995-12-26 |
2023-08-12 |
Not clear |
| R A Hernan, S G Sliga. Tetrameric hemoglobin expressed in Escherichia coli. Evidence of heterogeneous subunit assembly. The Journal of biological chemistry. vol 270. issue 44. 1995-12-21. PMID:7592833. |
recombinant alpha 2 beta 2 tetrameric hb expressed and assembled in escherichia coli has been characterized extensively. |
1995-12-21 |
2023-08-12 |
human |