All Relations between hb and alpha

Publication Sentence Publish Date Extraction Date Species
Y Huang, T Yonetani, A Tsuneshige, B M Hoffman, G K Acker. Heterometallic hybrids of homometallic human hemoglobins. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 9. 1996-07-01. PMID:8633083. it was found that four of the metal-substituted hbs (mg2+ hb, mn2+ hb, ni2+ hb, and zn2+ hb) did not form detectable amounts of heterometallic hybrids with normal fe2+ hb even though (i) their homometallic parents formed tight tetrameric complexes with stabilities similar to that of fe2+ hb and (ii) hybrids with metal substitution at both alpha sites or both beta sites are known to form readily. 1996-07-01 2023-08-12 human
P Winichagoon, S Fucharoen, P Wilairat, Y Fukumak. Molecular mechanisms of thalassemia in southeast Asia. The Southeast Asian journal of tropical medicine and public health. vol 26 Suppl 1. 1996-06-26. PMID:8629113. hb constant spring (cs) occurs from the mutation at the termination codon of the alpha-globin gene resulting in an elongated polypeptide; alpha(cs)-globin mrna is also unstable and only small amounts of hb cs are produced. 1996-06-26 2023-08-12 Not clear
J Tan, J S Tay, Y C Wong, S K Kham, N Bte Abd Aziz, S H Teo, H B Won. Molecular analysis of Hb Q-H disease and Hb Q-Hb E in a Singaporean family. The Southeast Asian journal of tropical medicine and public health. vol 26 Suppl 1. 1996-06-26. PMID:8629117. hb q (alpha 74asp-his) results from a mutation in the alpha-gene such that abnormal alpha q-chains are synthesized. 1996-06-26 2023-08-12 Not clear
J Tan, J S Tay, Y C Wong, S K Kham, N Bte Abd Aziz, S H Teo, H B Won. Molecular analysis of Hb Q-H disease and Hb Q-Hb E in a Singaporean family. The Southeast Asian journal of tropical medicine and public health. vol 26 Suppl 1. 1996-06-26. PMID:8629117. the alpha q-chains combine with the normal beta a-chains to form abnormal hb alpha 2q beta 2a (hb q). 1996-06-26 2023-08-12 Not clear
J Tan, J S Tay, Y C Wong, S K Kham, N Bte Abd Aziz, S H Teo, H B Won. Molecular analysis of Hb Q-H disease and Hb Q-Hb E in a Singaporean family. The Southeast Asian journal of tropical medicine and public health. vol 26 Suppl 1. 1996-06-26. PMID:8629117. cellulose acetate electrophoresis showed hb h and hb q with the absence of hb a. globin chain biosynthesis was carried out and alpha q- and beta-chains were detected. 1996-06-26 2023-08-12 Not clear
J Tan, J S Tay, Y C Wong, S K Kham, N Bte Abd Aziz, S H Teo, H B Won. Molecular analysis of Hb Q-H disease and Hb Q-Hb E in a Singaporean family. The Southeast Asian journal of tropical medicine and public health. vol 26 Suppl 1. 1996-06-26. PMID:8629117. cellulose acetate electrophoresis of the father's blood showed the presence of hb a, f and e. molecular analysis of the father's dna confirmed an intact set of alpha-genes (alpha alpha/alpha alpha). 1996-06-26 2023-08-12 Not clear
K Torcharus, T Sriphaisal, T Krutvecho, C Suwanasophon, J Intarapakawon. Clinical phenotypes and genotypes diagnosis of thalassemia in children. The Southeast Asian journal of tropical medicine and public health. vol 26 Suppl 1. 1996-06-26. PMID:8629123. alpha and beta thalassemia, hemoglobin (hb) e, and hb constant spring (cs) are prevalent in thailand. 1996-06-26 2023-08-12 Not clear
N S Smetanina, J Y Leonova, N Levy, T H Huisma. The alpha / beta and alpha 2 / alpha 1-globin mRNA ratios in different forms of alpha-thalassemia. Biochimica et biophysica acta. vol 1315. issue 3. 1996-06-04. PMID:8611658. the father carried the 4.2 kb deletion on one chromosome and a taa --> caa mutation at the terminating codon of the alpha 2 gene (hb constant spring or cs) on the other chromosome. 1996-06-04 2023-08-12 Not clear
N S Smetanina, J Y Leonova, N Levy, T H Huisma. The alpha / beta and alpha 2 / alpha 1-globin mRNA ratios in different forms of alpha-thalassemia. Biochimica et biophysica acta. vol 1315. issue 3. 1996-06-04. PMID:8611658. the mother had the 3.7 kb deletion on one chromosome and a ta a --> tat mutation at the terminating codon of the alpha 2-globin gene (hb paksé) of the second chromosome. 1996-06-04 2023-08-12 Not clear
N S Smetanina, J Y Leonova, N Levy, T H Huisma. The alpha / beta and alpha 2 / alpha 1-globin mRNA ratios in different forms of alpha-thalassemia. Biochimica et biophysica acta. vol 1315. issue 3. 1996-06-04. PMID:8611658. the results confirm the importance of the alpha 2 alpha 1-mrna for the synthesis of alpha chains in alpha-thalassemia-2 homozygotes (-alpha/-alpha) and in patients with hb h disease due to the deletion of three alpha-globin genes (-alpha/--). 1996-06-04 2023-08-12 Not clear
N S Smetanina, J Y Leonova, N Levy, T H Huisma. The alpha / beta and alpha 2 / alpha 1-globin mRNA ratios in different forms of alpha-thalassemia. Biochimica et biophysica acta. vol 1315. issue 3. 1996-06-04. PMID:8611658. furthermore, the mrna production of the alpha 1-globin gene on the chromosome with the alpha cs mutation (alpha cs alpha) is only one-half of that by the alpha 2 alpha 1-globin gene of a chromosome with a 3.7 or 4.2 kb deletion, explaining the greater severity of, and higher hb h level in hb h patients with the alpha cs alpha condition (alpha cs alpha/--) as compared to those with the three gene deletion (-alpha/--). 1996-06-04 2023-08-12 Not clear
K Adachi, J Pang, P Konitzer, S Surre. Polymerization of recombinant hemoglobin F gamma E6V and hemoglobin F gamma E6V, gamma Q87T alone, and in mixtures with hemoglobin S. Blood. vol 87. issue 4. 1996-05-29. PMID:8608256. these results suggest that gin-gamma 87 is a critical amino acid for exclusion of fs hybrids (alpha 2 beta s gamma) from nuclei formation with hb s. our findings also show that val-gamma 6 in hybrids that form in mixtures of the hb f variants with either hb s or hb a interacts with the hydrophobic acceptor pocket on the ef helix of an adjacent tetramer containing thr-beta 87. 1996-05-29 2023-08-12 Not clear
E Kanavakis, J Traeger-Synodinos, I Papasotiriou, C Vrettou, A Metaxotou-Mavromati, A Stamoulakatou, E Lagona, C Kattami. The interaction of alpha zero thalassaemia with Hb Icaria: three unusual cases of haemoglobinopathy H. British journal of haematology. vol 92. issue 2. 1996-05-15. PMID:8602995. the interaction of alpha zero thalassaemia with hb icaria: three unusual cases of haemoglobinopathy h. the clinical, haematological, biosynthetic and molecular data of three greek haemoglobin h (hbh) disease patients with a distinctive clinical phenotype are described. 1996-05-15 2023-08-12 Not clear
E Kanavakis, J Traeger-Synodinos, I Papasotiriou, C Vrettou, A Metaxotou-Mavromati, A Stamoulakatou, E Lagona, C Kattami. The interaction of alpha zero thalassaemia with Hb Icaria: three unusual cases of haemoglobinopathy H. British journal of haematology. vol 92. issue 2. 1996-05-15. PMID:8602995. this observation should be considered carefully when giving genetic counselling to families carrying the rare hb icaria mutation and an alpha zero thalassaemia mutation. 1996-05-15 2023-08-12 Not clear
A Takats. [Sudden unexpected natural death from a viewpoint of forensic pathology]. Nihon hoigaku zasshi = The Japanese journal of legal medicine. vol 49. issue 6. 1996-03-15. PMID:8583687. parameters included in the last type, which is a useful tool for speculation of antemortem pathophysiology were t-bil, ttt, ztt, bun, cre, ua, alpha 1- and beta 2-microglobin, t-chol, gha1c, tp, a/g, hb and hct. 1996-03-15 2023-08-12 Not clear
H Kosaka, A Seiyam. Physiological role of nitric oxide as an enhancer of oxygen transfer from erythrocytes to tissues. Biochemical and biophysical research communications. vol 218. issue 3. 1996-03-12. PMID:8579585. the present study revealed the physiological role of no as an enhancer of oxygen release from erythrocytes to peripheral tissue by breaking or stretching the heme iron-proximal histidine bond in the alpha subunit of hemoglobin (hb), while maintaining oxygen binding capacity by restoring the bond in the lungs. 1996-03-12 2023-08-12 Not clear
H Kosaka, A Seiyam. Physiological role of nitric oxide as an enhancer of oxygen transfer from erythrocytes to tissues. Biochemical and biophysical research communications. vol 218. issue 3. 1996-03-12. PMID:8579585. oxygen affinity was significantly decreased in blood containing no-bound hb alpha. 1996-03-12 2023-08-12 Not clear
B Landin, S Berglund, K Wallma. Two different mutations in codon 97 of the beta-globin gene cause Hb Malmö in Sweden. American journal of hematology. vol 51. issue 1. 1996-03-04. PMID:8571935. an abnormal hemoglobin with increased oxygen affinity, hb malmö [alpha 2 beta 297(fg4)his-->gln], was found to cause erythrocytosis in two apparently unrelated swedish families. 1996-03-04 2023-08-12 Not clear
S Fucharoen, N Siritanaratkul, P Winichagoon, J Chowthaworn, W Siriboon, W Muangsup, S Chaicharoen, N Poolsup, B Chindavijak, P Pootrakul, A Piankijagum, A N Schechter, G P Rodger. Hydroxyurea increases hemoglobin F levels and improves the effectiveness of erythropoiesis in beta-thalassemia/hemoglobin E disease. Blood. vol 87. issue 3. 1996-03-01. PMID:8562958. complete blood counts including reticulocyte counts, amounts of hb e and hb f, g gamma:a gamma and alpha:non-alpha globin biosynthetic ratios were evaluated before and during treatment. 1996-03-01 2023-08-12 Not clear
S Fucharoen, N Siritanaratkul, P Winichagoon, J Chowthaworn, W Siriboon, W Muangsup, S Chaicharoen, N Poolsup, B Chindavijak, P Pootrakul, A Piankijagum, A N Schechter, G P Rodger. Hydroxyurea increases hemoglobin F levels and improves the effectiveness of erythropoiesis in beta-thalassemia/hemoglobin E disease. Blood. vol 87. issue 3. 1996-03-01. PMID:8562958. we conclude that increased hb f production in beta-thalassemia/hb e patients, with an improvement in the alpha:non-alpha globin ratios and, probably, the effectiveness of erythropoiesis, can be achieved using hu. 1996-03-01 2023-08-12 Not clear