| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T H Huisma. Hb E and alpha-thalassemia; variability in the assembly of beta E chain containing tetramers. Hemoglobin. vol 21. issue 3. 1997-07-24. PMID:9140719. |
a decrease in hb e level was observed which was directly related to the type of alpha-thalassemia that was present; the lowest percentage of hb e (and hb a2) was 10.2%, seen in two persons with hb constant spring (cs)-hb h disease (alpha cs alpha/--). |
1997-07-24 |
2023-08-12 |
human |
| T H Huisma. Hb E and alpha-thalassemia; variability in the assembly of beta E chain containing tetramers. Hemoglobin. vol 21. issue 3. 1997-07-24. PMID:9140719. |
moreover, this single observation suggests an equal synthesis of beta a and beta e chains, the low level of hb e in adult heterozygotes being primarily the result of a greatly decreased rate of assembly of alpha beta e dimers. |
1997-07-24 |
2023-08-12 |
human |
| J T de Araújo, L Bodemeier, B Schmidt, R C Affons. Four adult hemoglobin types in one mulatto family. Revista do Instituto de Medicina Tropical de Sao Paulo. vol 38. issue 3. 1997-07-24. PMID:9163985. |
the hybrid hb cg-phila is formed by the combination velocity of the subunits alpha 2g-phila beta 2; therefore the proportion of the hybrid hb cg-phila is lower than hb g-phila and hb c. the identification and molecular characterization of hb g-phila showed the position alpha 2(68) asn-->lys beta 2 and hb c showed alpha 2 beta 2(6) glu-->lys. |
1997-07-24 |
2023-08-12 |
Not clear |
| L F de Figueiredo, M Mathru, D Solanki, V W Macdonald, J Hess, G C Krame. Pulmonary hypertension and systemic vasoconstriction may offset the benefits of acellular hemoglobin blood substitutes. The Journal of trauma. vol 42. issue 5. 1997-07-10. PMID:9191666. |
we tested the hypothesis that the pharmacologic properties of a small volume of alpha alpha-cross-linked hemoglobin (alpha alpha hb) could effectively resuscitate pigs subjected to hemorrhage. |
1997-07-10 |
2023-08-12 |
Not clear |
| C Oner, A Gürgey, R Oner, H Balkan, F Gümrük, E Baysal, C Alta. The molecular basis of Hb H disease in Turkey. Hemoglobin. vol 21. issue 1. 1997-07-07. PMID:9028822. |
in two patients, homozygosity for the polyadenylation signal mutation [alpha (pa-2)alpha] was found to be responsible for hb h disease. |
1997-07-07 |
2023-08-12 |
Not clear |
| I Borg, M Valentino, A Fiorini, A E Felic. Hb Setif [alpha 94(G1)Asp-->Tyr] in Malta. Hemoglobin. vol 21. issue 1. 1997-07-07. PMID:9028826. |
hb setif [alpha 94(g1)asp-->tyr] in malta. |
1997-07-07 |
2023-08-12 |
Not clear |
| D P Sun, M Zou, N T Ho, C H. Contribution of surface histidyl residues in the alpha-chain to the Bohr effect of human normal adult hemoglobin: roles of global electrostatic effects. Biochemistry. vol 36. issue 22. 1997-07-03. PMID:9184146. |
we have applied site-directed mutagenesis to our escherichia coli hemoglobin expression plasmid and constructed five recombinant mutant hemoglobins (r hbs): r hb(alpha20his-->gln or alpha:h20q); r hb(alpha:h50q); r hb(alpha:h72q); r hb(alpha:h89q); and r hb(alpha:h112q). |
1997-07-03 |
2023-08-12 |
human |
| L F Poli de Figueiredo, G I Elgjo, M Mathru, M Rocha e Silva, G C Krame. Hypertonic acetate-alpha alpha hemoglobin for small volume resuscitation of hemorrhagic shock. Artificial cells, blood substitutes, and immobilization biotechnology. vol 25. issue 1-2. 1997-06-05. PMID:9083627. |
we hypothesized that the combination of alpha alpha-crosslinked human hemoglobin (alpha alpha hb), an oxygen carrier and vasoconstrictor, with hypertonic sodium acetate (hahb), a vasodilator, may be effective for small volume resuscitation of hemorrhagic shock. |
1997-06-05 |
2023-08-12 |
human |
| L F Poli de Figueiredo, G I Elgjo, M Mathru, M Rocha e Silva, G C Krame. Hypertonic acetate-alpha alpha hemoglobin for small volume resuscitation of hemorrhagic shock. Artificial cells, blood substitutes, and immobilization biotechnology. vol 25. issue 1-2. 1997-06-05. PMID:9083627. |
compared to our previous study, in which animals received 4 ml-kg-1 of alpha alpha hb alone, hahb produced higher cardiac output and a smaller increase in systemic and pulmonary vascular resistance. |
1997-06-05 |
2023-08-12 |
human |
| J S Olson, R F Eich, L P Smith, J J Warren, B C Knowle. Protein engineering strategies for designing more stable hemoglobin-based blood substitutes. Artificial cells, blood substitutes, and immobilization biotechnology. vol 25. issue 1-2. 1997-06-05. PMID:9083641. |
over the past five years our laboratory has been using rational, comparative, and random combinatorial mutagenesis strategies to optimize the alpha and beta subunits of recombinant human hemoglobin (hb) for efficient o2 transport, greater stability, and minimum interference with vascular activity. |
1997-06-05 |
2023-08-12 |
human |
| B C Israel, R A Blouin, W McIntyre, S I Shedlofsk. Effects of interferon-alpha monotherapy on hepatic drug metabolism in cancer patients. British journal of clinical pharmacology. vol 36. issue 3. 1997-05-01. PMID:9114909. |
the influence of interferon-alpha (ifn alpha) on the clearances of theophylline (th), antipyrine (ap) and hexobarbitone (hb) was studied in seven cancer patients given ifn alpha as their only treatment. |
1997-05-01 |
2023-08-12 |
Not clear |
| B C Israel, R A Blouin, W McIntyre, S I Shedlofsk. Effects of interferon-alpha monotherapy on hepatic drug metabolism in cancer patients. British journal of clinical pharmacology. vol 36. issue 3. 1997-05-01. PMID:9114909. |
ifn alpha caused minimal changes in hb clearance. |
1997-05-01 |
2023-08-12 |
Not clear |
| E George, A B Mokhtar, Z A Azman, K Hasnida, S Saripah, C M Hwan. Prenatal diagnosis of Hb Bart's hydrops fetalis in West Malaysia: the identification of the alpha thal 1 defect by PCR based strategies. Singapore medical journal. vol 37. issue 5. 1997-04-04. PMID:9046203. |
prenatal diagnosis of hb bart's hydrops fetalis in west malaysia: the identification of the alpha thal 1 defect by pcr based strategies. |
1997-04-04 |
2023-08-12 |
Not clear |
| L Kiger, V Baudin, A Desbois, J Pagnier, J Kister, N Griffon, Y Henry, C Poyart, M C Marde. Recombinant [Phe(beta)63]hemoglobin shows rapid oxidation of the beta chains and low-affinity, non-cooperative oxygen binding to the alpha subunits. European journal of biochemistry. vol 243. issue 1-2. 1997-03-20. PMID:9030761. |
the mutant hb exhibits non-cooperative binding of two oxygens with an affinity about fivefold lower than those of hba valency hybrids (alpha met beta)2. |
1997-03-20 |
2023-08-12 |
Not clear |
| E G Kazanetz, J Y Leonova, T H Huisman, F P van der Dijs, J W Smi. Hb Nunobiki or alpha 2 141 (HC3)Arg-->Cys beta 2 in a Belgian female results from a CGT-->TGT mutation in the alpha 2-globin gene. Hemoglobin. vol 20. issue 4. 1997-03-05. PMID:8936471. |
hb nunobiki or alpha 2 141 (hc3)arg-->cys beta 2 in a belgian female results from a cgt-->tgt mutation in the alpha 2-globin gene. |
1997-03-05 |
2023-08-12 |
Not clear |
| M J Rao, B N Manjula, R Kumar, A S Achary. Chimeric hemoglobins--hybrids of human and swine hemoglobin: assembly and stability of interspecies hybrids. Protein science : a publication of the Protein Society. vol 5. issue 5. 1997-02-21. PMID:8732767. |
the swine alpha human beta chimeric hb undergoes subunit exchange reaction with human alpha-chain in the presence of 0.9 m mgcl2, at ph 7.0. |
1997-02-21 |
2023-08-12 |
human |
| M J Rao, B N Manjula, R Kumar, A S Achary. Chimeric hemoglobins--hybrids of human and swine hemoglobin: assembly and stability of interspecies hybrids. Protein science : a publication of the Protein Society. vol 5. issue 5. 1997-02-21. PMID:8732767. |
a synergistic coupling of the intra- and interdimeric interactions of the swine alpha and human beta chain heterodimer is essential for the thermodynamic stability of the chimeric hb under the physiological conditions. |
1997-02-21 |
2023-08-12 |
human |
| P C Giordano, C L Harteveld, P J Kok, A Geenen, D Batelaan, R Amons, L F Bemin. HB Gouda [alpha 72(EF1)His-->Gln], a new silent alpha chain variant. Hemoglobin. vol 20. issue 1. 1997-02-19. PMID:8745429. |
hb gouda [alpha 72(ef1)his-->gln], a new silent alpha chain variant. |
1997-02-19 |
2023-08-12 |
Not clear |
| T P Molchanova, T H Huisma. The importance of the 3' untranslated region for the expression of the alpha-globin genes. Hemoglobin. vol 20. issue 1. 1997-02-19. PMID:8745431. |
data obtained for an hb g-philadelphia heterozygote (alpha alpha/-alpha g) show that the alpha 2 alpha 1 hybrid gene produces approximately 30% less mrna than an alpha 1-globin gene on a normal chromosome, which may be caused by loss of some sequences 3' to the alpha 2 gene. |
1997-02-19 |
2023-08-12 |
human |
| L Kéclard, V Ollendorf, C Berchel, H Loret, G Méraul. beta S haplotypes, alpha-globin gene status, and hematological data of sickle cell disease patients in Guadeloupe (F.W.I.). Hemoglobin. vol 20. issue 1. 1997-02-19. PMID:8745433. |
the beta gene cluster haplotypes, alpha gene status, hb f level and hematological parameters have been characterized in 154 unrelated guadeloupe patients with sickle cell disease: 112 with sickle cell anemia, 26 with sc disease, 15 with hb s-beta-thalassemia, and one patient with hb s in association with the hereditary persistence of fetal hemoglobin. |
1997-02-19 |
2023-08-12 |
Not clear |