| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C C McIntyre, W M Gril. Sensitivity analysis of a model of mammalian neural membrane. Biological cybernetics. vol 79. issue 1. 1998-10-09. PMID:9742675. |
individual changes in six of the eleven parameters (alpha ma, alpha md, alpha ha, beta ma, beta mb, and beta hb) generated substantial changes in the rheobase current and chronaxie time (tch) of the model. |
1998-10-09 |
2023-08-12 |
Not clear |
| C C McIntyre, W M Gril. Sensitivity analysis of a model of mammalian neural membrane. Biological cybernetics. vol 79. issue 1. 1998-10-09. PMID:9742675. |
scaling a combination of five parameters (alpha ma, alpha mb, alpha ha, beta ma, and beta hb) by an equal amount produced a model that generated anode break excitation and increased tch, but also decreased the amplitude of the action potential. |
1998-10-09 |
2023-08-12 |
Not clear |
| T K Tran, U Kreutzer, T Ju. Observing the deoxy myoglobin and hemoglobin signals from rat myocardium in situ. FEBS letters. vol 434. issue 3. 1998-10-08. PMID:9742944. |
under 12% inspired o2, the erythrocyte hb is partially desaturated and yields the alpha and beta proximal histidyl ndeltah signals of deoxy hb. |
1998-10-08 |
2023-08-12 |
rat |
| W Sriroongrueng, M Pornpatkul, V Panich, S Fucharoe. Alpha-thalassemia incidence in southern Thailand by restriction endonuclease analysis of globin DNA from placental blood at Songklanagarind Hospital. The Southeast Asian journal of tropical medicine and public health. vol 28 Suppl 3. 1998-09-14. PMID:9640606. |
the incidence of hb cs trait was 5.8%, with the gene frequency of 0.0292 for alpha cs alpha/. |
1998-09-14 |
2023-08-12 |
Not clear |
| J Traeger-Synodinos, A Metaxotou-Mavromati, E Kanavakis, C Vrettou, I Papassotiriou, T Michael, C Kattami. An alpha-thalassemic hemoglobinopathy: homozygosity for the HB Agrinio alpha 2-globin chain variant. Hemoglobin. vol 22. issue 3. 1998-09-08. PMID:9629496. |
an alpha-thalassemic hemoglobinopathy: homozygosity for the hb agrinio alpha 2-globin chain variant. |
1998-09-08 |
2023-08-12 |
Not clear |
| J Traeger-Synodinos, A Metaxotou-Mavromati, E Kanavakis, C Vrettou, I Papassotiriou, T Michael, C Kattami. An alpha-thalassemic hemoglobinopathy: homozygosity for the HB Agrinio alpha 2-globin chain variant. Hemoglobin. vol 22. issue 3. 1998-09-08. PMID:9629496. |
this report describes the first case of homozygosity for the hb agrinio [alpha 29(b10)leu-->pro] alpha 2-globin gene variant (codon 29, ctg-->ccg) in a greek patient. |
1998-09-08 |
2023-08-12 |
Not clear |
| J Traeger-Synodinos, A Metaxotou-Mavromati, E Kanavakis, C Vrettou, I Papassotiriou, T Michael, C Kattami. An alpha-thalassemic hemoglobinopathy: homozygosity for the HB Agrinio alpha 2-globin chain variant. Hemoglobin. vol 22. issue 3. 1998-09-08. PMID:9629496. |
analysis of alpha- and beta-globin genotypes demonstrated that the patient was homozygous for the highly unstable hb agrinio variant, caused by a t-->c mutation in codon 29 of the alpha 2-globin gene. |
1998-09-08 |
2023-08-12 |
Not clear |
| C Oner, R Oner, H Balkan, F Gümrük, A Gürge. Coexistence of Hb Lepore-Boston-Washington (delta 87Gln-beta-IVS-II-8) with alpha-thalassemia [alpha(-5NT)alpha/alpha alpha]. Hemoglobin. vol 22. issue 3. 1998-09-08. PMID:9629502. |
coexistence of hb lepore-boston-washington (delta 87gln-beta-ivs-ii-8) with alpha-thalassemia [alpha(-5nt)alpha/alpha alpha]. |
1998-09-08 |
2023-08-12 |
Not clear |
| T Ikuta, G Atweh, V Boosalis, G L White, S Da Fonseca, M Boosalis, D V Faller, S P Perrin. Cellular and molecular effects of a pulse butyrate regimen and new inducers of globin gene expression and hematopoiesis. Annals of the New York Academy of Sciences. vol 850. 1998-08-12. PMID:9668531. |
following induction of gamma-globin mrna and protein synthesis, total hemoglobin increased in beta-thalassemia patients by more than 2 g/dl above baseline, and hb f increased above 20% in 5/8 sickle cell patients from baseline levels of 2% hb f. specific regulatory regions were identified in the gamma- and beta-globin gene promoters to which new binding of transcription factors, including alpha cp2 (an activator of gamma globin) occur during therapy solely in the butyrate-responsive patients. |
1998-08-12 |
2023-08-12 |
Not clear |
| D C Rees, L Styles, E P Vichinsky, J B Clegg, D J Weatheral. The hemoglobin E syndromes. Annals of the New York Academy of Sciences. vol 850. 1998-08-12. PMID:9668555. |
the beta thalassemia mutation, alpha thalassemia and the xmn 1 g gamma polymorphism do not explain this variability, but the relative and absolute amounts of hbf correlate significantly with total hb. |
1998-08-12 |
2023-08-12 |
Not clear |
| Y A Puius, M Zou, N T Ho, C Ho, S C Alm. Novel water-mediated hydrogen bonds as the structural basis for the low oxygen affinity of the blood substitute candidate rHb(alpha 96Val-->Trp). Biochemistry. vol 37. issue 26. 1998-07-23. PMID:9649306. |
we describe here two crystal structures of one such potential blood substitute, recombinant (r) hb(alpha 96val-->trp), refined to 1.9 a resolution in an alpha-aquomet, beta-deoxy t-state, and to 2.5 a resolution in a carbonmonoxy r-state. |
1998-07-23 |
2023-08-12 |
human |
| Y A Puius, M Zou, N T Ho, C Ho, S C Alm. Novel water-mediated hydrogen bonds as the structural basis for the low oxygen affinity of the blood substitute candidate rHb(alpha 96Val-->Trp). Biochemistry. vol 37. issue 26. 1998-07-23. PMID:9649306. |
we propose that these water-mediated hydrogen bonds are the structural basis for the lowered oxygen affinity of rhb(alpha 96val-->trp), and discuss the implications of these findings for future molecular dynamics studies and the design of hb mutants. |
1998-07-23 |
2023-08-12 |
human |
| X Hu, L A Dick, T G Spir. Fourier transform infrared evidence against Asp beta 99 protonation in hemoglobin: nature of the Tyr alpha 42-Asp beta 99 quaternary H-bond. Biochemistry. vol 37. issue 26. 1998-07-23. PMID:9649327. |
the tyr alpha 42-asp beta 99 intersubunit h-bond stabilizes the t quaternary structure in hemoglobin (hb) tetramers. |
1998-07-23 |
2023-08-12 |
Not clear |
| T Yamaguchi, J Pang, K S Reddy, S Surrey, K Adach. Role of beta112 Cys (G14) in homo- (beta4) and hetero- (alpha2 beta2) tetramer hemoglobin formation. The Journal of biological chemistry. vol 273. issue 23. 1998-07-16. PMID:9603919. |
hb beta112d can form tetrameric hemoglobin, but this beta112 change promotes dissociation into alpha and beta chains instead of alpha beta dimer formation upon dilution. |
1998-07-16 |
2023-08-12 |
Not clear |
| H Wajcman, D Promé, C Préhu, C Déon, J Riou, J C Bouanga, I Papassotiriou, A Lahary, F Galactéro. HB Les Andelys [alpha83(F4)LEU-->PRO]: a new moderately unstable variant. Hemoglobin. vol 22. issue 2. 1998-07-08. PMID:9576330. |
in this hemoglobin molecule the affected site, in the alpha chain, and the amino acid substitution are identical to those of hb santa ana, an unstable beta chain variant. |
1998-07-08 |
2023-08-12 |
Not clear |
| L Kiger, A Dumoulin, S J Edelstein, D J Abraham, D Promé, C Poyart, M C Marden, J Pagnie. Chimeric beta-EF3-alpha hemoglobin (Psi): energetics of subunit interaction and ligand binding. Biochemistry. vol 37. issue 20. 1998-06-22. PMID:9585547. |
in the cyanomethb species, the formation of the dimer-tetramer interface is 2 kcal/mol less favorable (delta g = -7 kcal/mol) than that of hb a (delta g = -9 kcal/mol), whereas the dimer-monomer interface is tightly assembled (< -10 kcal/mol) as for the hb a alpha 1 beta 1 interface. |
1998-06-22 |
2023-08-12 |
human |
| L Kiger, A L Klinger, L D Kwiatkowski, A De Young, M L Doyle, J M Holt, R W Noble, G K Acker. Thermodynamic studies on the equilibrium properties of a series of recombinant betaW37 hemoglobin mutants. Biochemistry. vol 37. issue 13. 1998-04-23. PMID:9521754. |
in human hemoglobin (hb) the beta37 tryptophan residue (betaw37), located at the hinge region of the alpha1beta2 interface, forms many contacts with alpha subunit residues of the opposite dimer, in both the t and r quaternary structures. |
1998-04-23 |
2023-08-12 |
human |
| H Wajcman, J Kister, J Riou, F Galactéros, R Girot, M Maier-Redelsperger, N V Nayudu, P C Giordan. Hb Godavari [alpha 95(G2)Pro-->Thr]: a neutral amino acid substitution in the alpha 1 beta 2 interface that modifies the electrophoretic mobility of hemoglobin. Hemoglobin. vol 22. issue 1. 1998-04-16. PMID:9494044. |
hb godavari [alpha 95(g2)pro-->thr]: a neutral amino acid substitution in the alpha 1 beta 2 interface that modifies the electrophoretic mobility of hemoglobin. |
1998-04-16 |
2023-08-12 |
Not clear |
| H Wajcman, J Kister, J Riou, F Galactéros, R Girot, M Maier-Redelsperger, N V Nayudu, P C Giordan. Hb Godavari [alpha 95(G2)Pro-->Thr]: a neutral amino acid substitution in the alpha 1 beta 2 interface that modifies the electrophoretic mobility of hemoglobin. Hemoglobin. vol 22. issue 1. 1998-04-16. PMID:9494044. |
hb godavari [alpha 95(g2)pro-->thr] was characterized independently in two families of different ethnic origin. |
1998-04-16 |
2023-08-12 |
Not clear |
| H Wajcman, J Kister, J Riou, F Galactéros, R Girot, M Maier-Redelsperger, N V Nayudu, P C Giordan. Hb Godavari [alpha 95(G2)Pro-->Thr]: a neutral amino acid substitution in the alpha 1 beta 2 interface that modifies the electrophoretic mobility of hemoglobin. Hemoglobin. vol 22. issue 1. 1998-04-16. PMID:9494044. |
hb godavari is the fourth example of a substitution involving neutral residues at position alpha 95(g2). |
1998-04-16 |
2023-08-12 |
Not clear |