| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I Papassotiriou, J Traeger-Synodinos, C Vlachou, M Karagiorga, A Metaxotou, E Kanavakis, A Stamoulakato. Rapid and accurate quantitation of Hb Bart's and Hb H using weak cation exchange high performance liquid chromatography: correlation with the alpha-thalassemia genotype. Hemoglobin. vol 23. issue 3. 1999-12-20. PMID:10490132. |
patients with nondeletional mutations (or association of alpha(0) deletion and nondeletional mutations) had notably higher hb bart's and hb h levels when compared to patients with deletional genotypes. |
1999-12-20 |
2023-08-12 |
Not clear |
| N Jassim, S Al-Arrayed, N Gerard, H Al-Mukharraq, A Al-Ajami, R Ramasawmy, R Krishnamoorth. A mismatched-primer polymerase chain reaction-restriction fragment length polymorphism strategy for rapid screening of the polyadenylation signal mutation alpha(T-Saudi) (AATAAA-->AATAAG) in the alpha2-globin gene. Hemoglobin. vol 23. issue 3. 1999-12-20. PMID:10490133. |
the most common nondeletional alpha-thalassemia allele, namely alpha(t-saudi) (aataaa-->aataag), in the arabian peninsula and neighboring countries is responsible for a number of cases of hb h disease. |
1999-12-20 |
2023-08-12 |
Not clear |
| A Koç, R Oner, C Oner, D Aktas, M Sözen, E Tunçbilek, C Alta. Myelodysplastic syndrome (MDS) associated with increased hemoglobin F and trisomy 8: presentation of a patient. Hematology and cell therapy. vol 41. issue 4. 1999-11-19. PMID:10543376. |
the study indicated that increased transcription of alpha and gamma genes are partly responsible for the elevation of hb f in mds. |
1999-11-19 |
2023-08-12 |
human |
| A Ameri, V F Fairbanks, G A Yanik, F Mahdi, S N Thibodeau, D J McCormick, L A Boxer, K T McDonag. Identification of the molecular genetic defect of patients with methemoglobin M-Kankakee (M-Iwate), alpha87 (F8) His --> Tyr: evidence for an electrostatic model of alphaM hemoglobin assembly. Blood. vol 94. issue 5. 1999-09-29. PMID:10477710. |
our evidence suggests that the greater-than-expected proportion of hb m-kankakee results from preferential association of the electronegative beta-globin chains with the alpha(m)-globin chains that are more electropositive than normal alpha-globin chains. |
1999-09-29 |
2023-08-12 |
Not clear |
| T Haran. [Hemoglobinopathy in Japan: detection and analysis]. Rinsho byori. The Japanese journal of clinical pathology. vol 47. issue 3. 1999-08-31. PMID:10228386. |
the alpha-thals had genotypes of -alpha 3.7/alpha alpha for alpha-thal-2, -sea/alpha alpha for alpha-thal-1 and -sea/-alpha 3.7 for hb h disease. |
1999-08-31 |
2023-08-12 |
human |
| C H Tsai, T J Shen, N T Ho, C H. Effects of substitutions of lysine and aspartic acid for asparagine at beta 108 and of tryptophan for valine at alpha 96 on the structural and functional properties of human normal adult hemoglobin: roles of alpha 1 beta 1 and alpha 1 beta 2 subunit interfaces in the cooperative oxygenation process. Biochemistry. vol 38. issue 27. 1999-08-02. PMID:10393550. |
using our escherichia coli expression system, we have produced five mutant recombinant (r) hemoglobins (hbs): r hb (alpha v96 w), r hb presbyterian (beta n108k), r hb yoshizuka (beta n108d), r hb (alpha v96w, beta n108k), and r hb (alpha v96w, beta n108d). |
1999-08-02 |
2023-08-12 |
human |
| C H Tsai, T J Shen, N T Ho, C H. Effects of substitutions of lysine and aspartic acid for asparagine at beta 108 and of tryptophan for valine at alpha 96 on the structural and functional properties of human normal adult hemoglobin: roles of alpha 1 beta 1 and alpha 1 beta 2 subunit interfaces in the cooperative oxygenation process. Biochemistry. vol 38. issue 27. 1999-08-02. PMID:10393550. |
these r hbs allow us to investigate the effect on the structure-function relationship of hb of replacing beta 108asn by either a positively charged lys or a negatively charged asp as well as the effect of replacing alpha 96val by a bulky, nonpolar trp. |
1999-08-02 |
2023-08-12 |
human |
| C H Tsai, T J Shen, N T Ho, C H. Effects of substitutions of lysine and aspartic acid for asparagine at beta 108 and of tryptophan for valine at alpha 96 on the structural and functional properties of human normal adult hemoglobin: roles of alpha 1 beta 1 and alpha 1 beta 2 subunit interfaces in the cooperative oxygenation process. Biochemistry. vol 38. issue 27. 1999-08-02. PMID:10393550. |
r hb presbyterian has the largest bohr effect, followed by hb a, r hb (alpha v96w), and r hb yoshizuka. |
1999-08-02 |
2023-08-12 |
human |
| C H Tsai, T J Shen, N T Ho, C H. Effects of substitutions of lysine and aspartic acid for asparagine at beta 108 and of tryptophan for valine at alpha 96 on the structural and functional properties of human normal adult hemoglobin: roles of alpha 1 beta 1 and alpha 1 beta 2 subunit interfaces in the cooperative oxygenation process. Biochemistry. vol 38. issue 27. 1999-08-02. PMID:10393550. |
r hb (alpha v96w, beta n108k), which has the lowest oxygen affinity among the hemoglobins studied, has the greatest tendency to switch to the t quaternary structure. |
1999-08-02 |
2023-08-12 |
human |
| S Deutsch, R Darbellay, R Offord, A Frutiger, J Kister, H Wajcman, P Beri. Hb Iraq-Halabja beta10 (A7) Ala-->Val (GCC-->GTC): a new beta-chain silent variant in a family with multiple Hb disorders. American journal of hematology. vol 61. issue 3. 1999-07-26. PMID:10398311. |
sequencing of the beta-globin gene and alpha cluster mapping in the propositus and his brother showed a previously undescribed beta-globin variant:hb iraq-halabja, beta10(a7) ala-->val (gcc-->gtc), associated with beta0-thalassemia ivs-2 nt1 g-->a and either alpha-thal-2-3.7 kb deletion (brother), or alpha-globin gene triplication anti-3.7 kb type (propositus). |
1999-07-26 |
2023-08-12 |
Not clear |
| N Thatcher, E S De Campos, D R Bell, W P Steward, G Varghese, R Morant, J F Vansteenkiste, R Rosso, S B Ewers, E Sundal, E Schatzmann, H Stocke. Epoetin alpha prevents anaemia and reduces transfusion requirements in patients undergoing primarily platinum-based chemotherapy for small cell lung cancer. British journal of cancer. vol 80. issue 3-4. 1999-07-15. PMID:10408844. |
this multicentre study was designed to evaluate the efficacy and safety of epoetin alpha in preventing the decline in haemoglobin (hb) level, and to determine whether the transfusion requirement could be reduced, in patients receiving 4-6 cycles of primarily platinum-based combination cyclic chemotherapy for small cell lung cancer (sclc). |
1999-07-15 |
2023-08-12 |
Not clear |
| N Thatcher, E S De Campos, D R Bell, W P Steward, G Varghese, R Morant, J F Vansteenkiste, R Rosso, S B Ewers, E Sundal, E Schatzmann, H Stocke. Epoetin alpha prevents anaemia and reduces transfusion requirements in patients undergoing primarily platinum-based chemotherapy for small cell lung cancer. British journal of cancer. vol 80. issue 3-4. 1999-07-15. PMID:10408844. |
reductions in epoetin alpha dosage were made during the study if hb level increased to >15 g dl(-1). |
1999-07-15 |
2023-08-12 |
Not clear |
| N Thatcher, E S De Campos, D R Bell, W P Steward, G Varghese, R Morant, J F Vansteenkiste, R Rosso, S B Ewers, E Sundal, E Schatzmann, H Stocke. Epoetin alpha prevents anaemia and reduces transfusion requirements in patients undergoing primarily platinum-based chemotherapy for small cell lung cancer. British journal of cancer. vol 80. issue 3-4. 1999-07-15. PMID:10408844. |
in summary, epoetin alpha is effective and well-tolerated in maintaining hb level and reducing transfusion requirement in patients undergoing cyclic chemotherapy for sclc. |
1999-07-15 |
2023-08-12 |
Not clear |
| R G Shorr, S Kwong, C Gilbert, R E Benesc. Changes in the functional properties of bovine hemoglobin induced by covalent modification with polyethylene glycol. Artificial cells, blood substitutes, and immobilization biotechnology. vol 27. issue 3. 1999-07-01. PMID:10226683. |
the rate of heme transfer from hb to serum albumin at ph 9.0 was greatly increased by pegylation, suggesting destabilization of the heme-globin linkage and of the bonds between alpha beta dimers. |
1999-07-01 |
2023-08-12 |
human |
| L A Dick, G Heibel, E G Moore, T G Spir. UV resonance Raman spectra reveal a structural basis for diminished proton and CO2 binding to alpha,alpha-cross-linked hemoglobin. Biochemistry. vol 38. issue 20. 1999-06-09. PMID:10350458. |
these h-bonds are unaffected by bis(3,5-dibromosalicyl) fumarate cross-linking at the lys alpha 99 residues, which prevents dissociation of hb tetramers to dimers. |
1999-06-09 |
2023-08-12 |
Not clear |
| J M Goff, M R Jackson, M Taher, M A Cutting, B M Alving, C Krishnamurt. Physiologic responses of cross-linked hemoglobin in endotoxin-treated rats. Artificial cells, blood substitutes, and immobilization biotechnology. vol 27. issue 1. 1999-05-26. PMID:10063435. |
purified human cross-linked hemoglobin (alpha alpha hb) as well as recombinant human hemoglobin is undergoing clinical trials in the setting of acute blood loss and perioperative hemodilution. |
1999-05-26 |
2023-08-12 |
human |
| J M Goff, M R Jackson, M Taher, M A Cutting, B M Alving, C Krishnamurt. Physiologic responses of cross-linked hemoglobin in endotoxin-treated rats. Artificial cells, blood substitutes, and immobilization biotechnology. vol 27. issue 1. 1999-05-26. PMID:10063435. |
we have previously demonstrated that in rabbits with circulating plasma hb, such as alpha alpha hb, infusion of endotoxin (lps) impairs myocardial contractility which results in hypotension, tissue hypoperfusion and increased mortality. |
1999-05-26 |
2023-08-12 |
human |
| J M Goff, M R Jackson, M Taher, M A Cutting, B M Alving, C Krishnamurt. Physiologic responses of cross-linked hemoglobin in endotoxin-treated rats. Artificial cells, blood substitutes, and immobilization biotechnology. vol 27. issue 1. 1999-05-26. PMID:10063435. |
the untoward cardiovascular effects occurring after the combined infusion of lps and alpha alpha hb in this model are similar to those reported for other agents that inhibit nitric oxide (no) availability. |
1999-05-26 |
2023-08-12 |
human |
| J M Goff, M R Jackson, M Taher, M A Cutting, B M Alving, C Krishnamurt. Physiologic responses of cross-linked hemoglobin in endotoxin-treated rats. Artificial cells, blood substitutes, and immobilization biotechnology. vol 27. issue 1. 1999-05-26. PMID:10063435. |
to determine if the deleterious effects of alpha alpha hb and lps were species specific, we performed similar studies in rats. |
1999-05-26 |
2023-08-12 |
human |
| J M Goff, M R Jackson, M Taher, M A Cutting, B M Alving, C Krishnamurt. Physiologic responses of cross-linked hemoglobin in endotoxin-treated rats. Artificial cells, blood substitutes, and immobilization biotechnology. vol 27. issue 1. 1999-05-26. PMID:10063435. |
anesthetized sprague-dawley rats received lps (4 mg/kg or 40 mg/kg) alone or in combination with alpha alpha hb (0.7 g/kg). |
1999-05-26 |
2023-08-12 |
human |