| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kevin E Sanders, John Lo, Stephen G Sliga. Intersubunit circular permutation of human hemoglobin. Blood. vol 100. issue 1. 2002-07-26. PMID:12070040. |
by circularly permuting one alpha sequence, the second alpha chain in the hb tetramer can be linked with glycine residues to form 2 bridges across the central cavity. |
2002-07-26 |
2023-08-12 |
human |
| Fumio Shishikur. The primary structure of hemoglobin D from the Aldabra giant tortoise, Geochelone gigantea. Zoological science. vol 19. issue 2. 2002-07-24. PMID:12012783. |
the complete primary structures of alpha d-2- and beta-globin of hemoglobin d (hb d) from the aldabra giant tortoise, geochelone gigantea, have been constructed by amino acid sequencing analysis in assistance with nucleotide sequencing analysis of pcr fragments amplified using degenerate oligonucleotide primers. |
2002-07-24 |
2023-08-12 |
Not clear |
| Fumio Shishikur. The primary structure of hemoglobin D from the Aldabra giant tortoise, Geochelone gigantea. Zoological science. vol 19. issue 2. 2002-07-24. PMID:12012783. |
using computer-assisted sequence comparisons, the alpha d-2-globin shared a 92.0% sequence identity versus alpha d-globin of geochelone carbonaria, a 75.2% versus alpha d-globin of aves (rhea americana) and a 62.4% versus alpha a-globin of hb a expressed in adult red blood cells of geochelone gigantea. |
2002-07-24 |
2023-08-12 |
Not clear |
| Fumio Shishikur. The primary structure of hemoglobin D from the Aldabra giant tortoise, Geochelone gigantea. Zoological science. vol 19. issue 2. 2002-07-24. PMID:12012783. |
additionally, judging from their primary structures, an identical beta-globin was common to the two hemoglobin components, hb a and hb d. the alpha d-2- and beta-globin genes contained the three-exon and two-intron configurations and showed the characteristic of all functional vertebrate hemoglobin genes except an abnormal gc dinucleotide instead of the invariant gt at the 5' end of the second intron sequence. |
2002-07-24 |
2023-08-12 |
Not clear |
| Vip Viprakasit, Sarah Green, Sue Height, Helena Ayyub, Douglas R Higg. Hb H hydrops fetalis syndrome associated with the interaction of two common determinants of alpha thalassaemia (--MED/(alpha)TSaudi(alpha)). British journal of haematology. vol 117. issue 3. 2002-07-12. PMID:12028055. |
hb h hydrops fetalis syndrome associated with the interaction of two common determinants of alpha thalassaemia (--med/(alpha)tsaudi(alpha)). |
2002-07-12 |
2023-08-12 |
Not clear |
| Vip Viprakasit, Sarah Green, Sue Height, Helena Ayyub, Douglas R Higg. Hb H hydrops fetalis syndrome associated with the interaction of two common determinants of alpha thalassaemia (--MED/(alpha)TSaudi(alpha)). British journal of haematology. vol 117. issue 3. 2002-07-12. PMID:12028055. |
here we show for the first time that the interaction between two relatively common forms of alpha thalassaemia (--med/(alpha)tsaudi(alpha)) may be associated with a clinically severe form of alpha thalassaemia, hb h hydrops fetalis. |
2002-07-12 |
2023-08-12 |
Not clear |
| Vip Viprakasit, Parichat Pung-Amritt, Lerlugh Suwanthon, Kevin Clark, Vorvarn S Tanphaicht. Complex interactions of deltabeta hybrid haemoglobin (Hb Lepore-Hollandia) Hb E (beta(26G-->A)) and alpha+ thalassaemia in a Thai family. European journal of haematology. vol 68. issue 2. 2002-06-28. PMID:12038449. |
we describe a family from central thailand, in which this hb lepore-hollandia interacts with a common beta globin variant (beta(e) resulting from the codon 26, g-->a mutation) and alpha(+) thalassaemia (alpha(3.7)). |
2002-06-28 |
2023-08-12 |
Not clear |
| Chung-ke Chang, Virgil Simplaceanu, Chien H. Effects of amino acid substitutions at beta 131 on the structure and properties of hemoglobin: evidence for communication between alpha 1 beta 1- and alpha 1 beta 2-subunit interfaces. Biochemistry. vol 41. issue 17. 2002-05-29. PMID:11969426. |
proton exchange measurements also detect faster exchange rates for both alpha(1)beta(1)-interface histidine side chains of the mutant rhbs in 0.1 m sodium phosphate buffer at ph 7.0 than for those of hb a under the same conditions. |
2002-05-29 |
2023-08-12 |
human |
| Chung-ke Chang, Virgil Simplaceanu, Chien H. Effects of amino acid substitutions at beta 131 on the structure and properties of hemoglobin: evidence for communication between alpha 1 beta 1- and alpha 1 beta 2-subunit interfaces. Biochemistry. vol 41. issue 17. 2002-05-29. PMID:11969426. |
we have also conducted studies on the reactivity of the sh group of beta93cys (a residue located in the region of the alpha(1)beta(2)-subunit interface) toward p-mercuribenzoate, and our results show that low-oxygen-affinity rhbs have a more reactive beta93cys than hb a in the co form. |
2002-05-29 |
2023-08-12 |
human |
| Chung-ke Chang, Virgil Simplaceanu, Chien H. Effects of amino acid substitutions at beta 131 on the structure and properties of hemoglobin: evidence for communication between alpha 1 beta 1- and alpha 1 beta 2-subunit interfaces. Biochemistry. vol 41. issue 17. 2002-05-29. PMID:11969426. |
our results indicate that there is communication between the alpha(1)beta(1)- and alpha(1)beta(2)-subunit interfaces, and a possible communication pathway for the cooperative oxygenation of hb a that allows the alpha(1)beta(1)-subunit interface to modulate the functional properties in conjunction with the alpha(1)beta(2) interface is proposed. |
2002-05-29 |
2023-08-12 |
human |
| P Lacan, G Souillet, M Aubry, D Promé, S Richelme-David, J Kister, H Wajcman, A Francin. New alpha 2 globin chain variant with low oxygen affinity affecting the N-terminal residue and leading to N-acetylation [Hb Lyon-Bron alpha 1(NA1)Val --> Ac-Ala]. American journal of hematology. vol 69. issue 3. 2002-04-19. PMID:11891810. |
new alpha 2 globin chain variant with low oxygen affinity affecting the n-terminal residue and leading to n-acetylation [hb lyon-bron alpha 1(na1)val --> ac-ala]. |
2002-04-19 |
2023-08-12 |
Not clear |
| M A el-Hazmi, A S Wars. Pattern for alpha-thalassaemia in Yemeni sickle-cell-disease patients. Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit. vol 5. issue 6. 2002-04-17. PMID:11924105. |
in the scd patients the frequency of single alpha-gene deletion (-alpha/alpha alpha) was 0.346, compared to 0.263 in the hb aa group. |
2002-04-17 |
2023-08-12 |
Not clear |
| M A el-Hazmi, A S Wars. Pattern for alpha-thalassaemia in Yemeni sickle-cell-disease patients. Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit. vol 5. issue 6. 2002-04-17. PMID:11924105. |
in one hb aa case, a triple alpha-gene arrangement (alpha alpha alpha/alpha alpha) was found (frequency 0.053). |
2002-04-17 |
2023-08-12 |
Not clear |
| F Lorey, G Cunningham, E P Vichinsky, B H Lubin, H E Witkowska, A Matsunaga, M Azimi, J Sherwin, J Eastman, F Farina, J S Waye, D H Chu. Universal newborn screening for Hb H disease in California. Genetic testing. vol 5. issue 2. 2002-03-04. PMID:11551109. |
alpha-thalassemia is a common hemoglobin (hb) disorder, and causes hb h (beta4) disease, and usually fatal homozygous alpha(0)-thalassemia, also known as hb bart's (gamma4) hydrops fetalis syndrome. |
2002-03-04 |
2023-08-12 |
Not clear |
| F Lorey, G Cunningham, E P Vichinsky, B H Lubin, H E Witkowska, A Matsunaga, M Azimi, J Sherwin, J Eastman, F Farina, J S Waye, D H Chu. Universal newborn screening for Hb H disease in California. Genetic testing. vol 5. issue 2. 2002-03-04. PMID:11551109. |
the correct diagnosis would allow affected infants to be properly cared for, and would also raise awareness for the prevention of homozygous alpha(0)-thalassemia or hb bart's hydrops fetalis syndrome. |
2002-03-04 |
2023-08-12 |
Not clear |
| L Kiger, M C Marde. Electron transfer kinetics between hemoglobin subunits. The Journal of biological chemistry. vol 276. issue 51. 2002-01-31. PMID:11602592. |
with a time coefficient of a few hours at ph 7, 25 degrees c, the hb solution (0.1 mm heme) approaches a form with about 60% of beta chains reduced, indicating a faster transfer rate in the direction alpha to beta. |
2002-01-31 |
2023-08-12 |
Not clear |
| G J Cianciolo, J J Enghild, S V Pizz. Covalent complexes of antigen and alpha(2)-macroglobulin: evidence for dramatically-increased immunogenicity. Vaccine. vol 20. issue 3-4. 2002-01-30. PMID:11672922. |
our goal was to determine if incorporation of hb, the monomeric form of hepatitis b virus (hbv) surface antigen (hbsag), into alpha(2)m would result in increased immune reactivity. |
2002-01-30 |
2023-08-12 |
mouse |
| G J Cianciolo, J J Enghild, S V Pizz. Covalent complexes of antigen and alpha(2)-macroglobulin: evidence for dramatically-increased immunogenicity. Vaccine. vol 20. issue 3-4. 2002-01-30. PMID:11672922. |
using hb complexes prepared with alpha(2)m we now report dramatically-increased immunogenicity of hb in balb/c mice. |
2002-01-30 |
2023-08-12 |
mouse |
| D Pietraforte, A M Salzano, G Scorza, G Marino, M Minett. Mechanism of peroxynitrite interaction with ferric hemoglobin and identification of nitrated tyrosine residues. CO(2) inhibits heme-catalyzed scavenging and isomerization. Biochemistry. vol 40. issue 50. 2002-01-30. PMID:11735412. |
hb was nitrated by peroxynitrite/co(2) mainly in tyrosines beta 130, alpha 42, and alpha 140 and, to a lesser extent, alpha 24. |
2002-01-30 |
2023-08-12 |
human |
| A E Miele, F Draghi, A Arcovito, A Bellelli, M Brunori, C Travaglini-Allocatelli, B Vallon. Control of heme reactivity by diffusion: structural basis and functional characterization in hemoglobin mutants. Biochemistry. vol 40. issue 48. 2002-01-08. PMID:11724557. |
the mutations involve residues at topological position b10 and e7, i.e., leu (b10) to tyr and his (e7) to gln, on either the alpha chains alone (yielding the hybrid tetramer hbalpha(yq)), the beta chains alone (hybrid tetramer hbbeta(yq)), or both types of chains (hb(yq)). |
2002-01-08 |
2023-08-12 |
human |