| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Philippe Lacan, Michel Becchi, Isabelle Zanella-Cleon, Martine Aubry, Martine Ffrench, Nicole Couprie, Alain Francin. Two new beta-chain variants: Hb Tripoli [beta26(B8)Glu-->Ala] and Hb Tizi-Ouzou [beta29(B11)Gly-->Ser]. Hemoglobin. vol 28. issue 3. 2005-02-16. PMID:15481887. |
the presence of microcytosis and hypochromia is explained by an additional homozygous 3.7 kb alpha(+) thalassemic deletion for the carrier of hb tizi-ouzou. |
2005-02-16 |
2023-08-12 |
Not clear |
| Angela L Williamson, Paolo Lecchi, Benjamin E Turk, Youngchool Choe, Peter J Hotez, James H McKerrow, Lewis C Cantley, Mohammed Sajid, Charles S Craik, Alex Louka. A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms. The Journal of biological chemistry. vol 279. issue 34. 2005-02-15. PMID:15199048. |
proteolytic cleavage sites within the hb alpha and beta chains were determined for the three enzymes, identifying a total of 131 cleavage sites. |
2005-02-15 |
2023-08-12 |
Not clear |
| Zhenning He, J Eric Russel. Effect of zeta-globin substitution on the O2-transport properties of Hb S in vitro and in vivo. Biochemical and biophysical research communications. vol 325. issue 4. 2005-01-18. PMID:15555579. |
hemoglobin zeta(2)beta(2)(s) is generated by substituting embryonic zeta-globin subunits for the normal alpha-globin components of hb s (alpha(2)beta(2)(s)). |
2005-01-18 |
2023-08-12 |
mouse |
| Chairat Turbpaiboon, Atchasai Siritantikorn, Wanna Thongnoppakhun, Duangkamon Bunditworapoom, Chanin Limwongse, Pa-thai Yenchitsomanus, Noppadol Siritanaratkul, Prapon Wilaira. Hemoglobin Pakse: presence on red blood cell membrane and detection by polymerase chain reaction-single-strand conformational polymorphism. International journal of hematology. vol 80. issue 2. 2004-12-07. PMID:15481441. |
the presence of alpha(pakse)-globin on membranes of hb pakse-containing red blood cells affords an explanation for the severity of anemia observed in such patients. |
2004-12-07 |
2023-08-12 |
Not clear |
| Cornelis L Harteveld, Pierre W Wijermans, Juliette E L M de Ree, Pauline Ter Hal, Peter Van Delft, Irene H Van Rooijen-Nijdam, Ellen Rasp, Peter J M J Kok, John H M Souverijn, Florens G A Versteegh, Piero C Giordan. A new Hb evanston allele [alpha14(A12)Trp --> Arg] found solely, and in the presence of common alpha-thalassemia deletions, in three independent Asian cases. Hemoglobin. vol 28. issue 1. 2004-10-07. PMID:15008259. |
hb evanston [alpha14(a12)trp --> arg] is considered to be a rare alpha chain mutant, and was originally observed in two black families in 1982, inducing a mild hb h disease phenotype in a homozygous state for the -alpha3.7 deletion ( -alpha(evanston)/ -alpha). |
2004-10-07 |
2023-08-12 |
Not clear |
| Philippe Lacan, Michel Becchi, Isabelle Zanella-Cleon, Martine Aubry, Philippe Renaudier, Alain Franci. Two new alpha chain variants: Hb Part-Dieu [alpha65(E14)Ala --> Thr (alpha2)] and Hb Decines-Charpieu [alpha69(E18)Ala --> Thr (alpha2)]. Hemoglobin. vol 28. issue 1. 2004-10-07. PMID:15008265. |
two new alpha chain variants: hb part-dieu [alpha65(e14)ala --> thr (alpha2)] and hb decines-charpieu [alpha69(e18)ala --> thr (alpha2)]. |
2004-10-07 |
2023-08-12 |
Not clear |
| Philippe Lacan, Martine Aubry, Nicole Couprie, Alain Francin. Two new alpha chain variants: Hb Die [alpha93(FG5)Val --> Ala (alpha1)] and Hb Beziers [alpha99(G6)Lys --> Asn (alpha1)]. Hemoglobin. vol 28. issue 1. 2004-10-07. PMID:15008266. |
two new alpha chain variants: hb die [alpha93(fg5)val --> ala (alpha1)] and hb beziers [alpha99(g6)lys --> asn (alpha1)]. |
2004-10-07 |
2023-08-12 |
Not clear |
| Masoud Garshasbi, Christian Oberkanins, Hai Yang Law, Maryam Neishabury, Roxana Kariminejad, Hossein Najmabad. alpha-globin gene deletion and point mutation analysis among in Iranian patients with microcytic hypochromic anemia. Haematologica. vol 88. issue 10. 2004-09-30. PMID:14555321. |
five different mutations (-alpha(3.7), -alpha(4.2), --med, -(alpha)20.5, hb constant spring) were identified in a total of 43 cases |
2004-09-30 |
2023-08-12 |
Not clear |
| Maria Cristina Pignataro Emerenciano de Araújo, Edvis Santos Soares Serafim, Wivel Antonio Pereira de Castro, Tereza Maria Dantas de Medeiro. [Prevalence of abnormal hemoglobins in newborns in Natal, Rio Grande do Norte, Brazil]. Cadernos de saude publica. vol 20. issue 1. 2004-09-16. PMID:15029312. |
some 37 (1.91%) of the newborns presented hemoglobinopathies, as follows: 29 (1.50%) sickle cell trait (hb fas), 6 (0.31%) heterozygous hb c (hb fac), one (0.05%) homozygous hb s (hb fs), and one (0.05%) hb barts suggestive of alpha thalassemia. |
2004-09-16 |
2023-08-12 |
Not clear |
| Yayoi Jin, Masako Nagai, Yukifumi Nagai, Shigenori Nagatomo, Teizo Kitagaw. Heme structures of five variants of hemoglobin M probed by resonance Raman spectroscopy. Biochemistry. vol 43. issue 26. 2004-09-03. PMID:15222763. |
below 900 cm(-1), hb m iwate [alpha(f8)his --> tyr] exhibited a distinct spectral pattern for nu(15), gamma(11), delta(c(beta)c(a)c(b))(2,4), and delta(c(beta)c(c)c(d))(6,7) compared to that of hb m boston [alpha(e7)his --> tyr], although both heme irons are coordinated by tyr. |
2004-09-03 |
2023-08-12 |
Not clear |
| Vip Viprakasit, Worrawut Chinchang, Parichat Pung-Amritt, Voravarn S Tanphaichit. Identification of Hb Q-India (alpha64 Asp-->His) in Thailand. Hematology (Amsterdam, Netherlands). vol 9. issue 2. 2004-08-24. PMID:15203872. |
in addition to these, here we report, for the first time, the identification of hb q-india, an innocuous alpha globin variant, in a thai family with indian ancestry. |
2004-08-24 |
2023-08-12 |
human |
| Yayoi Jin, Hiroshi Sakurai, Yukifumi Nagai, Masako Naga. Changes of near-UV CD spectrum of human hemoglobin upon oxygen binding: a study of mutants at alpha 42, alpha 140, beta 145 tyrosine or beta 37 tryptophan. Biopolymers. vol 74. issue 1-2. 2004-07-20. PMID:15137095. |
to evaluate the contributions of the aromatic residues at the alpha(1)beta(2) contact and the penultimate tyrosine residues of the alpha and beta subunits (alpha 140 and beta 145) to the negative cd band, three recombinant (r) hbs (rhb ser-alpha 42, rhb his-beta 37, and rhb thr-beta 145) were produced in escherichia coli, and we compared the near-uv cd spectra of these three rhbs and hb rouen (tyr-alpha 140-->his) with the spectra of hb a under the condition in which all mutant hbs were able to undergo the t-->r transition (hill's n > 2.0). |
2004-07-20 |
2023-08-12 |
human |
| M S Sulkowski, R Wasserman, L Brooks, L Ball, R Gis. Changes in haemoglobin during interferon alpha-2b plus ribavirin combination therapy for chronic hepatitis C virus infection. Journal of viral hepatitis. vol 11. issue 3. 2004-07-02. PMID:15117326. |
interferon alpha and ribavirin (rbv) combination therapy is associated with decreases in haemoglobin (hb) concentrations and anaemia. |
2004-07-02 |
2023-08-12 |
Not clear |
| Atsuko Yatani, Song-Jung Kim, Raymond K Kudej, Qian Wang, Christophe Depre, Keiichi Irie, Evangelia G Kranias, Stephen F Vatner, Dorothy E Vatne. Insights into cardioprotection obtained from study of cellular Ca2+ handling in myocardium of true hibernating mammals. American journal of physiology. Heart and circulatory physiology. vol 286. issue 6. 2004-06-28. PMID:14962828. |
the major findings of this study were the following: 1) the action potential duration in hb myocytes was significantly shorter than in nhb myocytes, but the amplitude of peak contraction was unchanged; 2) hb myocytes had a 33% decreased l-type ca2+ current (i(ca)) density and twofold faster i(ca) inactivation but no change in the current-voltage relationship; 3) there were no changes in the density of inward rectifier k+ current, transient outward k+ current, or na+/ca2+ exchange current, but hb myocytes had increased sarcoplasmic reticulum ca2+ content as estimated from caffeine-induced na+/ca2+ exchange current values; 4) expression of the l-type ca2+ channel alpha(1c)-subunit was decreased by 30% in hb hearts; and 5) mrna and protein levels of sarco(endo)plasmic reticulum ca2+-atpase 2a (serca2a), phospholamban, and the na+/ca2+ exchanger showed a pattern that is consistent with functional measurements: serca2a was increased and phospholamban was decreased in hb relative to nhb hearts with no change in the na+/ca2+ exchanger. |
2004-06-28 |
2023-08-12 |
Not clear |
| Frank P Mockenhaupt, Stephan Ehrhardt, Rowland Otchwemah, Teunis A Eggelte, Sylvester D Anemana, Klaus Stark, Ulrich Bienzle, Elisabeth Kohn. Limited influence of haemoglobin variants on Plasmodium falciparum msp1 and msp2 alleles in symptomatic malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene. vol 98. issue 5. 2004-06-24. PMID:15109555. |
haemoglobin (hb) s, hbc, and alpha(+)-thalassaemia confer protection from malaria. |
2004-06-24 |
2023-08-12 |
Not clear |
| B Masala, L Musino, M Pirastru, L Manc. The C-->G transition in the alpha 2-globin gene of a normal alpha alpha-chromosome is responsible for the Hb G-Philadelphia variant in Sardinians. European journal of haematology. vol 72. issue 6. 2004-06-15. PMID:15128423. |
the c-->g transition in the alpha 2-globin gene of a normal alpha alpha-chromosome is responsible for the hb g-philadelphia variant in sardinians. |
2004-06-15 |
2023-08-12 |
Not clear |
| B Masala, L Musino, M Pirastru, L Manc. The C-->G transition in the alpha 2-globin gene of a normal alpha alpha-chromosome is responsible for the Hb G-Philadelphia variant in Sardinians. European journal of haematology. vol 72. issue 6. 2004-06-15. PMID:15128423. |
sequencing of alpha-globin genes of 18 sardinian heterozygotes for the hb g-philadelphia [alpha 68(e17)asn-->lys] variant, with four active alpha genes and circulating level of the variant of about 27%, showed the aac-->aag change at codon 68 of the alpha 2-globin gene (alpha(g)alpha/alpha alpha). |
2004-06-15 |
2023-08-12 |
Not clear |
| X C Fu, G P Wang, Y F Wang, W Q Liang, Q S Yu, M S S Cho. Limitation of Potts and Guy's model and a predictive algorithm for skin permeability including the effects of hydrogen-bond on diffusivity. Die Pharmazie. vol 59. issue 4. 2004-06-03. PMID:15125573. |
a predictive algorithm for skin permeability including the effects of hydrogen-bond on diffusivity is proposed: log p = alpha log k - beta mv - gamma hb + delta where hb is the descriptor of hydrogen-bonding capacity of penetrants and gamma is a constant. |
2004-06-03 |
2023-08-12 |
human |
| Simon D Roger, Lawrence P McMahon, Anthony Clarkson, Alex Disney, David Harris, Carmel Hawley, Helen Healy, Peter Kerr, Kelvin Lynn, Alan Parnham, Roess Pascoe, David Voss, Robert Walker, Adeera Levi. Effects of early and late intervention with epoetin alpha on left ventricular mass among patients with chronic kidney disease (stage 3 or 4): results of a randomized clinical trial. Journal of the American Society of Nephrology : JASN. vol 15. issue 1. 2004-05-19. PMID:14694167. |
patients were monitored for 2 yr or until they required dialysis; the patients were randomized to receive epoetin alpha as necessary to maintain [hb] between 120 and 130 g/l (group a) or between 90 and 100 g/l (group b). |
2004-05-19 |
2023-08-12 |
Not clear |
| C Préhu, P Groff, G Kalmes, B Golinska, J Riou, D Prome, S Richelme-David, L Kiger, R Ducrocq, H Wajcma. Short insertion in a hemoglobin chain: Hb Esch, an unstable alpha1 variant with duplication of the sequence Ala65-Leu-Thr-Asn68. Blood cells, molecules & diseases. vol 31. issue 2. 2004-05-05. PMID:12972031. |
similar to other alpha chain variants due to short insertion (or deletion), hb esch probably results from a slipped mispairing mechanism. |
2004-05-05 |
2023-08-12 |
Not clear |