| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stefano Rivella, Chad May, Amy Chadburn, Isabelle Rivière, Michel Sadelai. A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human beta-globin gene transfer. Blood. vol 101. issue 8. 2003-06-18. PMID:12480689. |
long-term chimeras with an average 1.0-2.4 copies of the tns9 vector in their hematopoietic and blood cells stably produced up to 12 g/dl chimeric hb consisting of mu alpha(2):hu beta(2) tetramers. |
2003-06-18 |
2023-08-12 |
mouse |
| Kazuhiko Adachi, Min Ding, Suzanne Wehrli, Konda S Reddy, Saul Surrey, Kazumi Horiuch. Effects of different beta73 amino acids on formation of 14-stranded fibers of Hb S versus double-stranded crystals of Hb C-Harlem. Biochemistry. vol 42. issue 15. 2003-05-14. PMID:12693943. |
hb s (alpha(2)beta(2)(6glu-->val)) forms polymers, while hb c-harlem (alpha(2)beta(2)(6glu-->val,73asp-->asn)) forms crystals upon oversaturation. |
2003-05-14 |
2023-08-12 |
Not clear |
| Stephen O Brennan, Campbell Sheen, Stephen Johnso. Hb Manawatu [alpha 37(C2)Pro-->Leu]: a new mildly unstable mutation at an invariant proline residue. Hemoglobin. vol 26. issue 4. 2003-05-12. PMID:12484634. |
hb manawatu [alpha 37(c2)pro-->leu]: a new mildly unstable mutation at an invariant proline residue. |
2003-05-12 |
2023-08-12 |
Not clear |
| James D Hoyer, Eric Rachut, Kathleen S Kubik, Richard T Jones, George R Honig, Loyda N Vida, Virgil F Fairban. Hb Rampa [alpha 95(G2)pro-->Ser (alpha 2)] in a family of European ancestry: DNA analysis confirms the CCG-->TCG mutation at codon 95 of the alpha 2-globin gene; clinical and laboratory features. Hemoglobin. vol 26. issue 4. 2003-05-12. PMID:12484636. |
hb rampa [alpha 95(g2)pro-->ser (alpha 2)] in a family of european ancestry: dna analysis confirms the ccg-->tcg mutation at codon 95 of the alpha 2-globin gene; clinical and laboratory features. |
2003-05-12 |
2023-08-12 |
Not clear |
| P Lacan, M Aubry, N Couprie, A Francin. Hb Gerland [alpha55(E4)Val-->Ala (alpha2)]: a new neutral alpha chain variant involving the alpha2 gene. Hemoglobin. vol 25. issue 4. 2003-04-14. PMID:11791875. |
hb gerland [alpha55(e4)val-->ala (alpha2)]: a new neutral alpha chain variant involving the alpha2 gene. |
2003-04-14 |
2023-08-12 |
Not clear |
| Laura J Juszczak, Christophe Fablet, Veronique Baudin-Creuza, Sophie Lesecq-Le Gall, Rhoda Elison Hirsch, Ronald L Nagel, Joel M Friedman, Josee Pagnie. Conformational changes in hemoglobin S (betaE6V) imposed by mutation of the beta Glu7-beta Lys132 salt bridge and detected by UV resonance Raman spectroscopy. The Journal of biological chemistry. vol 278. issue 9. 2003-04-08. PMID:12488314. |
the results for the hb a betaglu(7)-betalys(132) salt bridge mutants demonstrate that attaining the t state conformation at the hinge region of the alpha(1)beta(2) dimer interface can be achieved through different intraglobin pathways; these pathways are subject to subtle mutagenic manipulation at sites well removed from the dimer interface. |
2003-04-08 |
2023-08-12 |
human |
| M Toussaint-Hacquard, Y Devaux, D Longrois, B Faivre-Fiorina, S Muller, J F Stoltz, C Vigneron, P Men. Biological response of human aortic endothelial cells exposed to acellular hemoglobin solutions developed as potential blood substitutes. Life sciences. vol 72. issue 10. 2003-02-05. PMID:12505545. |
cultured human aortic endothelial cells (haec) were incubated for 3 hours with purified cell-free hb, dex-btc-hb or alpha alpha-hb (16 g/l). |
2003-02-05 |
2023-08-12 |
human |
| A Tsuneshige, T Yonetan. Oxygenation properties of human erythrocytes containing exclusively alpha-nitrosyl hemoglobin: a promising blood transfusant candidate. Artificial cells, blood substitutes, and immobilization biotechnology. vol 29. issue 5. 2002-12-13. PMID:11708658. |
we have prepared human erythrocytes that contain exclusively alpha-nitrosyl hemoglobin (hb), i.e., alpha(fe-no)2beta(fe-o2)2, by incorporating nitric oxide (no) into erythrocytes in a well-controlled nitrosylation process. |
2002-12-13 |
2023-08-12 |
human |
| A Tsuneshige, T Yonetan. Oxygenation properties of human erythrocytes containing exclusively alpha-nitrosyl hemoglobin: a promising blood transfusant candidate. Artificial cells, blood substitutes, and immobilization biotechnology. vol 29. issue 5. 2002-12-13. PMID:11708658. |
the amount of alpha(fe-no) corresponding to 50% of the total heme content of the erythrocytes and exclusive binding of no to alpha-subunits of intraerythrocytic hb were confirmed by epr. |
2002-12-13 |
2023-08-12 |
human |
| H W Kim, J Tai, A G Greenbur. Alpha adrenergic activation and hemoglobin mediated contraction in the isolated rat thoracic aorta. Artificial cells, blood substitutes, and immobilization biotechnology. vol 29. issue 5. 2002-12-13. PMID:11708660. |
the present study investigated a possible role of the alpha adrenergic activation in the hb mediated contraction. |
2002-12-13 |
2023-08-12 |
rat |
| H W Kim, J Tai, A G Greenbur. Alpha adrenergic activation and hemoglobin mediated contraction in the isolated rat thoracic aorta. Artificial cells, blood substitutes, and immobilization biotechnology. vol 29. issue 5. 2002-12-13. PMID:11708660. |
in conclusion, alpha adrenergic activation is not a requisite for the hb mediated contraction in isolated rat aortic rings. |
2002-12-13 |
2023-08-12 |
rat |
| M R S C Wenning, C L Harteveld, P C Giordano, E M Kimura, S T O Saad, F F Costa, M F Sonat. Hemoglobin H disease resulting from the association of the - alpha 3.7 rightward deletion and the (alpha alpha)MM deletion in a Brazilian patient. European journal of haematology. vol 69. issue 3. 2002-12-04. PMID:12406012. |
a patient with hb h disease resulting from the association of the - alpha 3.7 rightward deletion with the rare (alpha alpha)mm deletion, which removes the entire alpha-major regulatory element (mre), is reported. |
2002-12-04 |
2023-08-12 |
Not clear |
| Cinzia Verde, Vito Carratore, Antonio Riccio, Maurizio Tamburrini, Elio Parisi, Guido Di Prisc. The functionally distinct hemoglobins of the Arctic spotted wolffish Anarhichas minor. The Journal of biological chemistry. vol 277. issue 39. 2002-11-13. PMID:12118003. |
hb 1 has the beta (beta(1)) chain in common with hb 2; hb 3 and hb 2 share the alpha (alpha(2)) chain. |
2002-11-13 |
2023-08-12 |
Not clear |
| O David, G Ivaldi, E Rabino-Massa, G Ricc. Functional studies on nine different haemoglobins with high oxygen affinity. Acta haematologica. vol 108. issue 3. 2002-11-06. PMID:12373084. |
however, a high hb a level is commonly believed to be the main compensatory factor of these subjects, but many indications suggest that often they have at least three, and not only two, main haemoglobin species: hb a, hb x plus hybrids of the type alpha(2)beta(a)beta(x). |
2002-11-06 |
2023-08-12 |
human |
| Shigenori Nagatomo, Yayoi Jin, Masako Nagai, Hiroshi Hori, Teizo Kitagaw. Changes in the abnormal alpha-subunit upon CO-binding to the normal beta-subunit of Hb M Boston: resonance Raman, EPR and CD study. Biophysical chemistry. vol 98. issue 1-2. 2002-10-22. PMID:12128200. |
heme-heme interaction in hb m boston (his alpha 58-->tyr) was investigated with visible and uv resonance raman (rr), epr, and cd spectroscopies. |
2002-10-22 |
2023-08-12 |
Not clear |
| YuCai Li, Jan-Olof Jeppsson, Magnus Jörntén-Karlsson, Eva Linné Larsson, Hans Jungvid, Igor Yu Galaev, Bo Mattiasso. Application of shielding boronate affinity chromatography in the study of the glycation pattern of haemoglobin. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 776. issue 2. 2002-10-11. PMID:12137996. |
several bands were observed on isoelectric focusing gel, which showed the same migration positions as hb adducts, such as hba(0), which is major hb component containing two alpha chains and two beta chains; hba(1c), which is post-translational glycation on the n-terminus of the beta chains of hba(0); foetal hb (hbf), consisting of two alpha chains and two gamma chains; and glutathione hb (also called hbssg), which is the result from thiol-disulphide interchain exchange during oxidation of the thiol groups of hb. |
2002-10-11 |
2023-08-12 |
human |
| A Villegas, P Ropero, F A González, E Anguita, D Espinó. The thalassemia syndromes: molecular characterization in the Spanish population. Hemoglobin. vol 25. issue 3. 2002-10-01. PMID:11570720. |
one hundred patients presented with heterozygous alpha(0)-thalassemia (18 of whom were progenitors of patients with hb h disease). |
2002-10-01 |
2023-08-12 |
human |
| A Villegas, P Ropero, F A González, E Anguita, D Espinó. The thalassemia syndromes: molecular characterization in the Spanish population. Hemoglobin. vol 25. issue 3. 2002-10-01. PMID:11570720. |
the alpha(0) determinant was found in 20 patients with hb h disease associated with -alpha(-3.7). |
2002-10-01 |
2023-08-12 |
human |
| Giuseppina Lacerra, Mirella Fiorito, Leonilde Pagano, Rosario Testa, Giovanni Li Volti, Carmelo Magnano, Emilia Medulla, Clementina Carest. Hb G-San Josè variant levels correlate with alpha-thalassemia genotypes. Hemoglobin. vol 26. issue 1. 2002-09-20. PMID:11939513. |
these data show that the reduced synthesis of alpha chains causes drastic reduction of probability to form hb g-san josè in favor of the formation of hb a. |
2002-09-20 |
2023-08-12 |
Not clear |
| Chairat Turbpaiboon, Saovaros Svasti, Phannee Sawangareetakul, Pranee Winichagoon, Chantragan Srisomsap, Noppadol Siritanaratkul, Suthat Fucharoen, Prapon Wilairat, Jisnuson Svast. Hb Siam [alpha15(A13)Gly-->Arg (alpha1) (GGT-->CGT)] is a typical alpha chain hemoglobinopathy without an alpha-thalassemic effect. Hemoglobin. vol 26. issue 1. 2002-09-20. PMID:11939517. |
hb siam [alpha15(a13)gly-->arg (alpha1) (ggt-->cgt)] is a typical alpha chain hemoglobinopathy without an alpha-thalassemic effect. |
2002-09-20 |
2023-08-12 |
Not clear |