| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jong-Whan Choi, Jong Hyuk Lee, Kwang Ho Lee, Hyean-Woo Lee, Joon Hyung Sohn, Joon Ho Yoon, Byung-Il Yeh, Seung Kyu Park, Kyu Jae Lee, Hyun-Won Ki. Characteristic of aromatic amino acid substitution at alpha 96 of hemoglobin. Journal of biochemistry and molecular biology. vol 38. issue 1. 2005-07-07. PMID:15715956. |
the second mutation, alpha96val -->trp, may compensate the functional defects of r hb (alpha42tyr --> phe), if the stability due to the introduction of trypophan at the alpha 96 position is strong enough to overcome the defect of r hb (alpha42tyr --> phe). |
2005-07-07 |
2023-08-12 |
Not clear |
| Jong-Whan Choi, Jong Hyuk Lee, Kwang Ho Lee, Hyean-Woo Lee, Joon Hyung Sohn, Joon Ho Yoon, Byung-Il Yeh, Seung Kyu Park, Kyu Jae Lee, Hyun-Won Ki. Characteristic of aromatic amino acid substitution at alpha 96 of hemoglobin. Journal of biochemistry and molecular biology. vol 38. issue 1. 2005-07-07. PMID:15715956. |
the present investigation has demonstrated that the presence of the crucible hydrogen bond between alpha 42tyr and beta 99asp is essential for the novel oxygen binding properties of deoxy hb (alpha96val --> trp) . |
2005-07-07 |
2023-08-12 |
Not clear |
| Meiling Lu, Hailin Wang, Xing-Fang Li, Xiufen Lu, William R Cullen, Lora L Arnold, Samuel M Cohen, X Chris L. Evidence of hemoglobin binding to arsenic as a basis for the accumulation of arsenic in rat blood. Chemical research in toxicology. vol 17. issue 12. 2005-06-14. PMID:15606151. |
the binding stoichiometry was consistent with the number of reactive cysteine residues in the alpha and beta chains of hb. |
2005-06-14 |
2023-08-12 |
human |
| Meiling Lu, Hailin Wang, Xing-Fang Li, Xiufen Lu, William R Cullen, Lora L Arnold, Samuel M Cohen, X Chris L. Evidence of hemoglobin binding to arsenic as a basis for the accumulation of arsenic in rat blood. Chemical research in toxicology. vol 17. issue 12. 2005-06-14. PMID:15606151. |
further characterization by nanoelectrospray mass spectrometry of the arsenic species in the rbc of these rats confirmed that most arsenic was bound to the alpha chain of hb. |
2005-06-14 |
2023-08-12 |
human |
| Pedro Cabrales, Amy G Tsai, Robert M Winslow, Marcos Intagliett. Effects of extreme hemodilution with hemoglobin-based O2 carriers on microvascular pressure. American journal of physiology. Heart and circulatory physiology. vol 288. issue 5. 2005-05-31. PMID:15637119. |
a surface-modified polyethylene glycol-conjugated human hemoglobin (mp4) and alpha alpha-cross-linked human hemoglobin (alpha alpha hb) were used to restore oxygen carrying capacity in conditions of extreme hemodilution (hematocrit 11%) in the hamster window model preparation. |
2005-05-31 |
2023-08-12 |
human |
| Pedro Cabrales, Amy G Tsai, Robert M Winslow, Marcos Intagliett. Effects of extreme hemodilution with hemoglobin-based O2 carriers on microvascular pressure. American journal of physiology. Heart and circulatory physiology. vol 288. issue 5. 2005-05-31. PMID:15637119. |
alpha alpha hb caused a greater recovery in map to 94.4 +/- 6.2 mmhg and lowered fcd to 62 +/- 8%. |
2005-05-31 |
2023-08-12 |
human |
| Pedro Cabrales, Amy G Tsai, Robert M Winslow, Marcos Intagliett. Effects of extreme hemodilution with hemoglobin-based O2 carriers on microvascular pressure. American journal of physiology. Heart and circulatory physiology. vol 288. issue 5. 2005-05-31. PMID:15637119. |
however, differences between alpha alpha hb and mp4 in fcd were not statistically significant. |
2005-05-31 |
2023-08-12 |
human |
| Pedro Cabrales, Amy G Tsai, Robert M Winslow, Marcos Intagliett. Effects of extreme hemodilution with hemoglobin-based O2 carriers on microvascular pressure. American journal of physiology. Heart and circulatory physiology. vol 288. issue 5. 2005-05-31. PMID:15637119. |
capillary pressures were in the ranges of 17-21 mmhg for mp4 and 15-19 mmhg for alpha alpha hb, with both significantly lower than baseline (p < 0.05). |
2005-05-31 |
2023-08-12 |
human |
| Pedro Cabrales, Amy G Tsai, Robert M Winslow, Marcos Intagliett. Effects of extreme hemodilution with hemoglobin-based O2 carriers on microvascular pressure. American journal of physiology. Heart and circulatory physiology. vol 288. issue 5. 2005-05-31. PMID:15637119. |
pressure in 80-microm-diameter arterioles was significantly increased with alpha alpha hb relative to mp4 (p < 0.05). |
2005-05-31 |
2023-08-12 |
human |
| Pedro Cabrales, Amy G Tsai, Robert M Winslow, Marcos Intagliett. Effects of extreme hemodilution with hemoglobin-based O2 carriers on microvascular pressure. American journal of physiology. Heart and circulatory physiology. vol 288. issue 5. 2005-05-31. PMID:15637119. |
measurement of changes in arteriolar diameter, microvascular blood flow, and fcd show that there was no statistical difference between using alpha alpha hb and mp4 in extreme hemodilution. |
2005-05-31 |
2023-08-12 |
human |
| Pedro Cabrales, Amy G Tsai, Robert M Winslow, Marcos Intagliett. Effects of extreme hemodilution with hemoglobin-based O2 carriers on microvascular pressure. American journal of physiology. Heart and circulatory physiology. vol 288. issue 5. 2005-05-31. PMID:15637119. |
microvascular resistance in arterioles with a diameter range of 70-80 microm showed an increase relative to control with alpha alpha hb, whereas mp4 caused a decrease. |
2005-05-31 |
2023-08-12 |
human |
| Vip Viprakasit, Gavivann Veerakul, Kleebsabai Sanpakit, Bunchoo Pongtanakul, Worrawut Chinchang, Voravarn S Tanphaichit. Acute haemolytic crisis in a Thai patient with homozygous haemoglobin Constant Spring (Hb CS/CS): a case report. Annals of tropical paediatrics. vol 24. issue 4. 2005-05-31. PMID:15720889. |
it has been shown previously that patients with homozygous hb cs had mild haemolytic anaemia secondary to an accumulation of alpha(cs) chains, which are toxic to red blood cell membrane cytoskeletons. |
2005-05-31 |
2023-08-12 |
Not clear |
| Ren Cai, Jingzhong Liu, Lirong Wang, Xin Liang, Bai Xiao, Liu Su, Yan Zhou, Lizhen Pa. Study on molecular epidemiology of the alpha-thalassemias in Liuzhou City, Guangxi Autonomous Region, China. Hemoglobin. vol 28. issue 4. 2005-05-11. PMID:15658188. |
the severity of the hb h diseases could be classified in the following order: alphacsalpha/--sea (alphaconstant (spring)alpha/--southeast asia); alpha(-4.2)/--sea; alpha(-3.7)/--sea. |
2005-05-11 |
2023-08-12 |
Not clear |
| Fabrizio Dutly, Jörg Fehr, Jeroen Simon Goede, Markus Morf, Heinz Troxler, Hannes Frischknech. A new highly unstable alpha chain variant causing alpha(+)-thalassemia: Hb Zurich Albisrieden [alpha59(E8)Gly-->Arg (alpha2)]. Hemoglobin. vol 28. issue 4. 2005-05-11. PMID:15658192. |
a new highly unstable alpha chain variant causing alpha(+)-thalassemia: hb zurich albisrieden [alpha59(e8)gly-->arg (alpha2)]. |
2005-05-11 |
2023-08-12 |
Not clear |
| Fabrizio Dutly, Jörg Fehr, Jeroen Simon Goede, Markus Morf, Heinz Troxler, Hannes Frischknech. A new highly unstable alpha chain variant causing alpha(+)-thalassemia: Hb Zurich Albisrieden [alpha59(E8)Gly-->Arg (alpha2)]. Hemoglobin. vol 28. issue 4. 2005-05-11. PMID:15658192. |
hb zurich albisrieden [alpha59(e8)gly-->arg (alpha2)] is not detected at the protein level and leads to alpha(+)-thalassemia (thal). |
2005-05-11 |
2023-08-12 |
Not clear |
| Alan R Cohen, Renzo Galanello, Dudley J Pennell, Melody J Cunningham, Elliott Vichinsk. Thalassemia. Hematology. American Society of Hematology. Education Program. 2005-04-21. PMID:15561674. |
alpha thalassemia is also being recognized with increasing frequency in north america, and newborn screening for hemoglobin barts in some states is leading to early detection of hb h disease and hb h constant spring. |
2005-04-21 |
2023-08-12 |
Not clear |
| Kanokwan Sanchaisuriya, Sunisa Chunpanich, Supan Fucharoen, Goonnapa Fucharoen, Pattara Sanchaisuriya, Yossombat Changtraku. Association of Hb Q-Thailand with homozygous Hb E and heterozygous Hb Constant Spring in pregnancy. European journal of haematology. vol 74. issue 3. 2005-03-24. PMID:15693792. |
interaction of the alpha(q-thailand) with the beta(e) globin chains in the proband 1 leads to a hb variant, namely the hb qe. |
2005-03-24 |
2023-08-12 |
human |
| M Molina, M A García Hernández, M J Navarro, M C De Gracia, T Ortuñ. [Change of EPO treatment from subcutaneous epoetin to intravenous epoetin or darbepoetin alpha]. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia. vol 24. issue 6. 2005-03-15. PMID:15683029. |
this prospective, two-arm, clinical trial assesses the effectiveness in maintaining the levels of haemoglobin (hb) between 11 and 13 g/d1 and the safety of changing the administration route (from subcutaneous to intravenous) of epoetin (rhuepo) alpha at equidose versus a changeover to darbepoetin alpha, taking the exact equivalence in peptide mass between the two as referent in patients with chronic renal insufficiency (cri) in haemodialysis. |
2005-03-15 |
2023-08-12 |
Not clear |
| Chih-Wei Wu, Pao-Chi Liao, Lung Yu, Shan-Tair Wang, Shur-Tzu Chen, Ching-Ming Wu, Yu-Min Ku. Hemoglobin promotes Abeta oligomer formation and localizes in neurons and amyloid deposits. Neurobiology of disease. vol 17. issue 3. 2005-03-07. PMID:15571973. |
immunoprecipitation of abeta in alzheimer's brain homogenate revealed a major co-precipitating 16-kda protein band, which was identified through mass spectrometry as hemoglobin (hb) alpha and beta chains. |
2005-03-07 |
2023-08-12 |
human |
| Lukana Ngiwsara, Chantragan Srisomsap, Pranee Winichagoon, Suthat Fucharoen, Jisnuson Svast. Two cases of compound heterozygosity for Hb Hekinan [alpha27(B8)Glu-->Asp (alpha1)] and alpha-thalassemia in Thailand. Hemoglobin. vol 28. issue 2. 2005-02-16. PMID:15182057. |
however ief gave good separation of hb hekinan and hb a, leading to estimates of hb hekinan (alpha hekinan 2/beta a 2 and alpha hekinan 2/beta e 2) level as 40-43% of total hb. |
2005-02-16 |
2023-08-12 |
Not clear |