| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Díaz, F N Dulout, P Peral-Garcí. Greater genetic variability in Argentine Creole than in Thoroughbred horses based on serum protein polymorphisms. Genetics and molecular research : GMR. vol 1. issue 3. 2004-04-29. PMID:14963833. |
genetic polymorphism was analyzed for five blood proteins: albumin - al, esterase - es, alpha(1)b-glycoprotein - xk, transferrin - tf and hemoglobin - hb in 200 thoroughbred (tb) and 124 argentine creole (ac) horses. |
2004-04-29 |
2023-08-12 |
Not clear |
| Cristina Granetto, Sergio Ricci, Andrea Martoni, Giuseppe Pezzella, Franco Testore, Rodolfo Mattioli, Maria Lampignano, Fiorenzo Tacconi, Stella Porrozzi, Giampietro Gasparini, Giovanni Mantovan. Comparing the efficacy and safety of fixed versus weight-based dosing of epoetin alpha in anemic cancer patients receiving platinum-based chemotherapy. Oncology reports. vol 10. issue 5. 2004-04-21. PMID:12883695. |
fixed (10,000 iu) and weight-based (150 iu/kg) dosing regimens of epoetin alpha demonstrated similar efficacy in maintaining freedom from transfusion, increasing hb levels, and improving qol in anemic cancer patients undergoing platinum-based chemotherapy. |
2004-04-21 |
2023-08-12 |
Not clear |
| Mario Thevis, Rachel R Ogorzalek Loo, Joseph A Loo, Wilhelm Schänze. Doping control analysis of bovine hemoglobin-based oxygen therapeutics in human plasma by LC-electrospray ionization-MS/MS. Analytical chemistry. vol 75. issue 14. 2004-04-16. PMID:14570175. |
those specific fragments originate from the alpha- and beta-subunits of hemoglobin, such as bovine hb peptides alpha(69-90) (2367.2 da) or beta(40-58) (2089.9 da). |
2004-04-16 |
2023-08-12 |
human |
| Fadel M Ali, Wael S Mohamed, Mostafa R Mohame. Effect of 50 Hz, 0.2 mT magnetic fields on RBC properties and heart functions of albino rats. Bioelectromagnetics. vol 24. issue 8. 2004-04-13. PMID:14603473. |
the dielectric relaxation of hb molecules was measured in the frequency range of 0.1-10 mhz and the dielectric increment (deltaepsilon), relaxation time (tau), molecular radius (r), and cole-cole parameter (alpha) were calculated for all groups. |
2004-04-13 |
2023-08-12 |
rat |
| Giuseppina Lacerra, Rosario Testa, Maria De Angioletti, Gino Schilirò, Clementina Caresti. Hb Bronte or alpha93(FG5)Val-->Gly: a new unstable variant of the alpha2-globin gene, associated with a mild alpha(+)-thalassemia phenotype. Hemoglobin. vol 27. issue 3. 2004-04-02. PMID:12908799. |
hb bronte or alpha93(fg5)val-->gly: a new unstable variant of the alpha2-globin gene, associated with a mild alpha(+)-thalassemia phenotype. |
2004-04-02 |
2023-08-12 |
Not clear |
| Vip Viprakasit, Voravarn S Tanphaichitr, Gavivann Veerakul, Worrawut Chinchang, Siripan Petrarat, Parichat Pung-Amritt, Douglas R Higg. Co-inheritance of Hb Pak Num Po, a novel alpha1 gene mutation, and alpha0 thalassemia associated with transfusion-dependent Hb H disease. American journal of hematology. vol 75. issue 3. 2004-04-01. PMID:14978697. |
the resulting frameshift gives rise to a highly unstable alpha globin chain, which we refer to as "hb pak num po," containing an additional 34 amino acids. |
2004-04-01 |
2023-08-12 |
Not clear |
| Shiro Mawatari, Kaori Murakam. Different types of glutathionylation of hemoglobin can exist in intact erythrocytes. Archives of biochemistry and biophysics. vol 421. issue 1. 2004-02-03. PMID:14678791. |
electrophoresis of the membranes showed a time dependent increase of membrane-bound hb alpha chain until 10 min, and immunoblotting study showed that membrane-bound hb alpha chain reacted with anti-glutathione antibody only after 10 min. |
2004-02-03 |
2023-08-12 |
human |
| Shiro Mawatari, Kaori Murakam. Different types of glutathionylation of hemoglobin can exist in intact erythrocytes. Archives of biochemistry and biophysics. vol 421. issue 1. 2004-02-03. PMID:14678791. |
concomitant with the hb alpha chain, membrane associated actin, spectrin, and glyceraldehyde 3-phosphate dehydrogenase reacted with the antibody. |
2004-02-03 |
2023-08-12 |
human |
| G Triol. [Guidelines for the treatment of anemia in chronic renal failure]. Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia. vol 20 Suppl 24. 2004-02-02. PMID:14666504. |
the target hb concentration is reached in most patients with mild anaemia after 2 months' treatment with 4.000-10.000 epoetin (20-50 mcg darbepoetin alpha) per week. |
2004-02-02 |
2023-08-12 |
Not clear |
| G Triol. [Guidelines for the treatment of anemia in chronic renal failure]. Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia. vol 20 Suppl 24. 2004-02-02. PMID:14666504. |
the target hb concentration 11-12 g/dl is maintained in 90-95% of the patients by administering 1.000-30.000 iu of epoetin (5-150 mcg darbepoetin alpha) per week in the presence of adequate reserves of iron. |
2004-02-02 |
2023-08-12 |
Not clear |
| Klaus Brandenburg, Patrick Garidel, Jörg Andra, Gudrun Jürgens, Mareike Müller, Alfred Blume, Michel H J Koch, Jack Levi. Cross-linked hemoglobin converts endotoxically inactive pentaacyl endotoxins into a physiologically active conformation. The Journal of biological chemistry. vol 278. issue 48. 2004-01-12. PMID:13679376. |
the interaction of purified alpha alpha cross-linked hemoglobin (alpha alpha hb) with a pentaacylated mutant lipopolysaccharide (plps) and the corresponding lipid a (pla) was studied biophysically and the effects correlated with data from biological assays, i.e. |
2004-01-12 |
2023-08-12 |
human |
| Klaus Brandenburg, Patrick Garidel, Jörg Andra, Gudrun Jürgens, Mareike Müller, Alfred Blume, Michel H J Koch, Jack Levi. Cross-linked hemoglobin converts endotoxically inactive pentaacyl endotoxins into a physiologically active conformation. The Journal of biological chemistry. vol 278. issue 48. 2004-01-12. PMID:13679376. |
fourier transform infrared spectroscopic and zeta-sizer experiments indicated an electrostatic as well as a non-electrostatic binding of alpha alpha hb to the hydrophilic and to the hydrophobic moieties of the endotoxins with an increase of the inclination angle of the pla backbone, with respect to the membrane surface, from 25 degrees to more than 50 degrees. |
2004-01-12 |
2023-08-12 |
human |
| Klaus Brandenburg, Patrick Garidel, Jörg Andra, Gudrun Jürgens, Mareike Müller, Alfred Blume, Michel H J Koch, Jack Levi. Cross-linked hemoglobin converts endotoxically inactive pentaacyl endotoxins into a physiologically active conformation. The Journal of biological chemistry. vol 278. issue 48. 2004-01-12. PMID:13679376. |
small angle synchrotron radiation x-ray diffraction measurements indicated a reorientation of the lipid a aggregates from a multilamellar into a cubic structure as a result of alpha alpha hb interaction. |
2004-01-12 |
2023-08-12 |
human |
| Klaus Brandenburg, Patrick Garidel, Jörg Andra, Gudrun Jürgens, Mareike Müller, Alfred Blume, Michel H J Koch, Jack Levi. Cross-linked hemoglobin converts endotoxically inactive pentaacyl endotoxins into a physiologically active conformation. The Journal of biological chemistry. vol 278. issue 48. 2004-01-12. PMID:13679376. |
thus, in the absence of alpha alpha hb, the molecular shape of the pentaacyl samples was cylindrical with a moderate inclination of the diglucosamine backbone, whereas, in the presence of the protein, the shape was conical, and the inclination angle was high. |
2004-01-12 |
2023-08-12 |
human |
| Klaus Brandenburg, Patrick Garidel, Jörg Andra, Gudrun Jürgens, Mareike Müller, Alfred Blume, Michel H J Koch, Jack Levi. Cross-linked hemoglobin converts endotoxically inactive pentaacyl endotoxins into a physiologically active conformation. The Journal of biological chemistry. vol 278. issue 48. 2004-01-12. PMID:13679376. |
the cytokine-inducing capability in human mononuclear cells, negligible for the pure pentaacylated compounds, increased markedly in the presence of alpha alpha hb in a concentration-dependent manner. |
2004-01-12 |
2023-08-12 |
human |
| Klaus Brandenburg, Patrick Garidel, Jörg Andra, Gudrun Jürgens, Mareike Müller, Alfred Blume, Michel H J Koch, Jack Levi. Cross-linked hemoglobin converts endotoxically inactive pentaacyl endotoxins into a physiologically active conformation. The Journal of biological chemistry. vol 278. issue 48. 2004-01-12. PMID:13679376. |
the data can be understood in the light of a reaggregation of the endotoxins because of alpha alpha hb binding, with the endotoxin backbones then readily accessible for serum and membrane proteins. |
2004-01-12 |
2023-08-12 |
human |
| Ching-Hsuan Tsai, Virgil Simplaceanu, Nancy T Ho, Tong-Jian Shen, Daojing Wang, Thomas G Spiro, Chien H. Site mutations disrupt inter-helical H-bonds (alpha14W-alpha67T and beta15W-beta72S) involved in kinetic steps in the hemoglobin R-->T transition without altering the free energies of oxygenation. Biophysical chemistry. vol 100. issue 1-3. 2003-12-04. PMID:12646359. |
the binding of oxygen to these rhbs is highly cooperative, with a hill coefficient of approximately 2.8, compared to approximately 3.1 for hb a. proton nuclear magnetic resonance (nmr) studies show that rhb (alphat67v), rhb (betas72a), rhb (alphat67v, betas72a), and hb a have similar quaternary structures in the alpha(1)beta(2) subunit interfaces. |
2003-12-04 |
2023-08-12 |
human |
| Chunyan Xu, Dror Tobi, I Baha. Allosteric changes in protein structure computed by a simple mechanical model: hemoglobin T<-->R2 transition. Journal of molecular biology. vol 333. issue 1. 2003-11-05. PMID:14516750. |
the major difference between the dynamics of the t and r2 forms is the loss of the hinge-bending role of alpha(1)-beta(2) (or alpha(2)-beta(1)) interfacial residues at alpha phe36-his45 and beta thr87-asn102 in the r2 form, which implies a decreased cooperativity in the higher affinity (r2) form of hb, consistent with many experimental studies. |
2003-11-05 |
2023-08-12 |
Not clear |
| F D Couto, A B L De Albuquerque, E V Adorno, J P De Moura Neto, L De Freitas Abbehusen, J L B De Oliveira, M G Dos Reis, M De Souza Gonçalve. alpha-Thalassemia 2, 3.7 kb deletion and hemoglobin AC heterozygosity in pregnancy: a molecular and hematological analysis. Clinical and laboratory haematology. vol 25. issue 1. 2003-10-29. PMID:12542439. |
statistical analysis of ac group patients with normal alpha genes and alpha-thal23.7kb carriers showed differences in mcv (p = 0.001); mch (p = 0.003) and hb c concentrations (p = 0.011). |
2003-10-29 |
2023-08-12 |
Not clear |
| F D Couto, A B L De Albuquerque, E V Adorno, J P De Moura Neto, L De Freitas Abbehusen, J L B De Oliveira, M G Dos Reis, M De Souza Gonçalve. alpha-Thalassemia 2, 3.7 kb deletion and hemoglobin AC heterozygosity in pregnancy: a molecular and hematological analysis. Clinical and laboratory haematology. vol 25. issue 1. 2003-10-29. PMID:12542439. |
analysis of aa and ac group patients with normal alpha genes showed differences in rbc (p = 0.033), hb concentration (p = 0.003) and mchc (p < 0.0001). |
2003-10-29 |
2023-08-12 |
Not clear |