| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vip Viprakasit, Voravarn S Tanphaichitr, Gavivann Veerakul, Worrawut Chinchang, Siripan Petrarat, Parichat Pung-Amritt, Douglas R Higg. Co-inheritance of Hb Pak Num Po, a novel alpha1 gene mutation, and alpha0 thalassemia associated with transfusion-dependent Hb H disease. American journal of hematology. vol 75. issue 3. 2004-04-01. PMID:14978697. |
the resulting frameshift gives rise to a highly unstable alpha globin chain, which we refer to as "hb pak num po," containing an additional 34 amino acids. |
2004-04-01 |
2023-08-12 |
Not clear |
| Shiro Mawatari, Kaori Murakam. Different types of glutathionylation of hemoglobin can exist in intact erythrocytes. Archives of biochemistry and biophysics. vol 421. issue 1. 2004-02-03. PMID:14678791. |
electrophoresis of the membranes showed a time dependent increase of membrane-bound hb alpha chain until 10 min, and immunoblotting study showed that membrane-bound hb alpha chain reacted with anti-glutathione antibody only after 10 min. |
2004-02-03 |
2023-08-12 |
human |
| Shiro Mawatari, Kaori Murakam. Different types of glutathionylation of hemoglobin can exist in intact erythrocytes. Archives of biochemistry and biophysics. vol 421. issue 1. 2004-02-03. PMID:14678791. |
concomitant with the hb alpha chain, membrane associated actin, spectrin, and glyceraldehyde 3-phosphate dehydrogenase reacted with the antibody. |
2004-02-03 |
2023-08-12 |
human |
| G Triol. [Guidelines for the treatment of anemia in chronic renal failure]. Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia. vol 20 Suppl 24. 2004-02-02. PMID:14666504. |
the target hb concentration is reached in most patients with mild anaemia after 2 months' treatment with 4.000-10.000 epoetin (20-50 mcg darbepoetin alpha) per week. |
2004-02-02 |
2023-08-12 |
Not clear |
| G Triol. [Guidelines for the treatment of anemia in chronic renal failure]. Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia. vol 20 Suppl 24. 2004-02-02. PMID:14666504. |
the target hb concentration 11-12 g/dl is maintained in 90-95% of the patients by administering 1.000-30.000 iu of epoetin (5-150 mcg darbepoetin alpha) per week in the presence of adequate reserves of iron. |
2004-02-02 |
2023-08-12 |
Not clear |
| Klaus Brandenburg, Patrick Garidel, Jörg Andra, Gudrun Jürgens, Mareike Müller, Alfred Blume, Michel H J Koch, Jack Levi. Cross-linked hemoglobin converts endotoxically inactive pentaacyl endotoxins into a physiologically active conformation. The Journal of biological chemistry. vol 278. issue 48. 2004-01-12. PMID:13679376. |
the interaction of purified alpha alpha cross-linked hemoglobin (alpha alpha hb) with a pentaacylated mutant lipopolysaccharide (plps) and the corresponding lipid a (pla) was studied biophysically and the effects correlated with data from biological assays, i.e. |
2004-01-12 |
2023-08-12 |
human |
| Klaus Brandenburg, Patrick Garidel, Jörg Andra, Gudrun Jürgens, Mareike Müller, Alfred Blume, Michel H J Koch, Jack Levi. Cross-linked hemoglobin converts endotoxically inactive pentaacyl endotoxins into a physiologically active conformation. The Journal of biological chemistry. vol 278. issue 48. 2004-01-12. PMID:13679376. |
fourier transform infrared spectroscopic and zeta-sizer experiments indicated an electrostatic as well as a non-electrostatic binding of alpha alpha hb to the hydrophilic and to the hydrophobic moieties of the endotoxins with an increase of the inclination angle of the pla backbone, with respect to the membrane surface, from 25 degrees to more than 50 degrees. |
2004-01-12 |
2023-08-12 |
human |
| Klaus Brandenburg, Patrick Garidel, Jörg Andra, Gudrun Jürgens, Mareike Müller, Alfred Blume, Michel H J Koch, Jack Levi. Cross-linked hemoglobin converts endotoxically inactive pentaacyl endotoxins into a physiologically active conformation. The Journal of biological chemistry. vol 278. issue 48. 2004-01-12. PMID:13679376. |
small angle synchrotron radiation x-ray diffraction measurements indicated a reorientation of the lipid a aggregates from a multilamellar into a cubic structure as a result of alpha alpha hb interaction. |
2004-01-12 |
2023-08-12 |
human |
| Klaus Brandenburg, Patrick Garidel, Jörg Andra, Gudrun Jürgens, Mareike Müller, Alfred Blume, Michel H J Koch, Jack Levi. Cross-linked hemoglobin converts endotoxically inactive pentaacyl endotoxins into a physiologically active conformation. The Journal of biological chemistry. vol 278. issue 48. 2004-01-12. PMID:13679376. |
thus, in the absence of alpha alpha hb, the molecular shape of the pentaacyl samples was cylindrical with a moderate inclination of the diglucosamine backbone, whereas, in the presence of the protein, the shape was conical, and the inclination angle was high. |
2004-01-12 |
2023-08-12 |
human |
| Klaus Brandenburg, Patrick Garidel, Jörg Andra, Gudrun Jürgens, Mareike Müller, Alfred Blume, Michel H J Koch, Jack Levi. Cross-linked hemoglobin converts endotoxically inactive pentaacyl endotoxins into a physiologically active conformation. The Journal of biological chemistry. vol 278. issue 48. 2004-01-12. PMID:13679376. |
the cytokine-inducing capability in human mononuclear cells, negligible for the pure pentaacylated compounds, increased markedly in the presence of alpha alpha hb in a concentration-dependent manner. |
2004-01-12 |
2023-08-12 |
human |
| Klaus Brandenburg, Patrick Garidel, Jörg Andra, Gudrun Jürgens, Mareike Müller, Alfred Blume, Michel H J Koch, Jack Levi. Cross-linked hemoglobin converts endotoxically inactive pentaacyl endotoxins into a physiologically active conformation. The Journal of biological chemistry. vol 278. issue 48. 2004-01-12. PMID:13679376. |
the data can be understood in the light of a reaggregation of the endotoxins because of alpha alpha hb binding, with the endotoxin backbones then readily accessible for serum and membrane proteins. |
2004-01-12 |
2023-08-12 |
human |
| Ching-Hsuan Tsai, Virgil Simplaceanu, Nancy T Ho, Tong-Jian Shen, Daojing Wang, Thomas G Spiro, Chien H. Site mutations disrupt inter-helical H-bonds (alpha14W-alpha67T and beta15W-beta72S) involved in kinetic steps in the hemoglobin R-->T transition without altering the free energies of oxygenation. Biophysical chemistry. vol 100. issue 1-3. 2003-12-04. PMID:12646359. |
the binding of oxygen to these rhbs is highly cooperative, with a hill coefficient of approximately 2.8, compared to approximately 3.1 for hb a. proton nuclear magnetic resonance (nmr) studies show that rhb (alphat67v), rhb (betas72a), rhb (alphat67v, betas72a), and hb a have similar quaternary structures in the alpha(1)beta(2) subunit interfaces. |
2003-12-04 |
2023-08-12 |
human |
| Chunyan Xu, Dror Tobi, I Baha. Allosteric changes in protein structure computed by a simple mechanical model: hemoglobin T<-->R2 transition. Journal of molecular biology. vol 333. issue 1. 2003-11-05. PMID:14516750. |
the major difference between the dynamics of the t and r2 forms is the loss of the hinge-bending role of alpha(1)-beta(2) (or alpha(2)-beta(1)) interfacial residues at alpha phe36-his45 and beta thr87-asn102 in the r2 form, which implies a decreased cooperativity in the higher affinity (r2) form of hb, consistent with many experimental studies. |
2003-11-05 |
2023-08-12 |
Not clear |
| F D Couto, A B L De Albuquerque, E V Adorno, J P De Moura Neto, L De Freitas Abbehusen, J L B De Oliveira, M G Dos Reis, M De Souza Gonçalve. alpha-Thalassemia 2, 3.7 kb deletion and hemoglobin AC heterozygosity in pregnancy: a molecular and hematological analysis. Clinical and laboratory haematology. vol 25. issue 1. 2003-10-29. PMID:12542439. |
statistical analysis of ac group patients with normal alpha genes and alpha-thal23.7kb carriers showed differences in mcv (p = 0.001); mch (p = 0.003) and hb c concentrations (p = 0.011). |
2003-10-29 |
2023-08-12 |
Not clear |
| F D Couto, A B L De Albuquerque, E V Adorno, J P De Moura Neto, L De Freitas Abbehusen, J L B De Oliveira, M G Dos Reis, M De Souza Gonçalve. alpha-Thalassemia 2, 3.7 kb deletion and hemoglobin AC heterozygosity in pregnancy: a molecular and hematological analysis. Clinical and laboratory haematology. vol 25. issue 1. 2003-10-29. PMID:12542439. |
analysis of aa and ac group patients with normal alpha genes showed differences in rbc (p = 0.033), hb concentration (p = 0.003) and mchc (p < 0.0001). |
2003-10-29 |
2023-08-12 |
Not clear |
| Kazuhiko Adachi, Yi Yang, Vinaysagar Lakka, Suzanne Wehrli, Konda S Reddy, Saul Surre. Significance of beta116 His (G18) at alpha1beta1 contact sites for alphabeta assembly and autoxidation of hemoglobin. Biochemistry. vol 42. issue 34. 2003-10-07. PMID:12939154. |
the importance of beta(116his) (g-18) and gamma(116ile) at one of the alpha1beta1 or alpha1gamma1 interaction sites for homo-dimer formation and assembly in vitro of beta and gamma chains, respectively, with alpha chains to form human hb a and hb f was assessed using recombinant beta(116his)(-->)(asp), beta(116his)(-->)(ile), and beta(112cys)(-->)(thr,116his)(-->)(ile) chains. |
2003-10-07 |
2023-08-12 |
human |
| Kazuhiko Adachi, Yi Yang, Vinaysagar Lakka, Suzanne Wehrli, Konda S Reddy, Saul Surre. Significance of beta116 His (G18) at alpha1beta1 contact sites for alphabeta assembly and autoxidation of hemoglobin. Biochemistry. vol 42. issue 34. 2003-10-07. PMID:12939154. |
these results indicate that amino acid hydrophobicity at the g-18 position in non-alpha chains plays a key role in homotetramer, dimer, and monomer formation, which in turn plays a critical role in assembly with alpha chains to form hb a and hb f. these results also suggest that stable dimer formation of gamma-globin chains must not occur in vivo, since this would inhibit association with alpha chains to form hb f. the role of beta(116his) (g-18) in heterotetramer-induced stabilization of the bond with oxygen in hemoglobin was also assessed by evaluating autoxidation rates using recombinant hb tetramers containing these variant globin chains. |
2003-10-07 |
2023-08-12 |
human |
| Kazuhiko Adachi, Yi Yang, Vinaysagar Lakka, Suzanne Wehrli, Konda S Reddy, Saul Surre. Significance of beta116 His (G18) at alpha1beta1 contact sites for alphabeta assembly and autoxidation of hemoglobin. Biochemistry. vol 42. issue 34. 2003-10-07. PMID:12939154. |
in addition, nmr spectra of the heme area of these two hemoglobin variant tetramers showed similar resonance peaks, which are different from those of hb a. oxygen-binding properties of alpha(2)beta(2)(116his)(-->)(asp) and alpha(2)beta(2)(116his)(-->)(ile), however, showed slight alteration compared to hb a. |
2003-10-07 |
2023-08-12 |
human |
| In-Whan Kim, Myung Duk Jang, Young Kyun Ryu, Eun Hee Cho, Young Kyu Lee, Jung Hag Par. Dipolarity, hydrogen-bond basicity and hydrogen-bond acidity of aqueous poly(ethylene glycol) solutions. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. vol 18. issue 12. 2003-07-29. PMID:12502089. |
we determined using the solvatochromic comparison method the dipolarity/polarizability (pi*), hydrogen bond (hb) accepting basicity (beta) and hb donating acidity (alpha) of aqueous solutions of pegs of variegated molecular weights at different concentrations in order to understand the influence of the polymer on these properties of water. |
2003-07-29 |
2023-08-12 |
Not clear |
| Suthat Fucharoen, Pranee Winichagoo. Thalassemia and abnormal hemoglobin. International journal of hematology. vol 76 Suppl 2. 2003-07-17. PMID:12430905. |
heterogeneity in the clinical manifestation of beta thalassemic diseases may occur from the nature of beta globin gene mutation, alpha thalassemia gene interaction and difference in the amount of hb f production which is partly associated with a specific beta globin haplotype. |
2003-07-17 |
2023-08-12 |
Not clear |