| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A E Miele, F Draghi, A Arcovito, A Bellelli, M Brunori, C Travaglini-Allocatelli, B Vallon. Control of heme reactivity by diffusion: structural basis and functional characterization in hemoglobin mutants. Biochemistry. vol 40. issue 48. 2002-01-08. PMID:11724557. |
the observed kinetic heterogeneity between the alpha(yq) and beta(yq) chains in hb(yq) has been rationalized on the basis of the three-dimensional structure of the active site. |
2002-01-08 |
2023-08-12 |
human |
| B N Manjula, A Malavalli, M Prabhakaran, J M Friedman, A S Achary. Activation of the low oxygen affinity-inducing potential of the Asn108(beta)-->Lys mutation of Hb-Presbyterian on intramolecular alpha alpha-fumaryl cross-bridging. Protein engineering. vol 14. issue 5. 2001-12-10. PMID:11438759. |
thus, the results of the present study suggest that the enhanced neutralization of the positive charges in the middle of the central cavity of hb achieved by these two electrostatic modifications, one (the alpha alpha-fumaryl cross-bridge) acting directly and the other (the presbyterian mutation) acting indirectly through the mediation of chloride ion binding, facilitates the alpha alpha- fumaryl-hb presbyterian to access a low o(2) affinity t-state structure much more readily than either hb-presbyterian or alpha alpha-fumaryl hba. |
2001-12-10 |
2023-08-12 |
Not clear |
| R D Kidd, H M Baker, A J Mathews, T Brittain, E N Bake. Oligomerization and ligand binding in a homotetrameric hemoglobin: two high-resolution crystal structures of hemoglobin Bart's (gamma(4)), a marker for alpha-thalassemia. Protein science : a publication of the Protein Society. vol 10. issue 9. 2001-10-11. PMID:11514664. |
although hb bart's has a higher o(2) affinity than either adult (alpha(2)beta(2)) or fetal (alpha(2)gamma(2)) hbs, it has a lower affinity for o(2) than hbh (beta(4)). |
2001-10-11 |
2023-08-12 |
human |
| H W Kim, A G Greenbur. Contraction coupled endothelial nitric oxide release: a new paradigm for local vascular control? The Journal of surgical research. vol 100. issue 1. 2001-09-20. PMID:11516210. |
in isolated rat thoracic aorta, however, hemoglobin (hb), a nitric oxide scavenger, elicited contraction only when the vessels were precontracted with an alpha adrenergic agonist. |
2001-09-20 |
2023-08-12 |
rat |
| I W Kim, H S Lee, Y K Lee, M D Jang, J H Pa. Selectivity of amino-, cyano- and diol-bonded silica in reversed-phase liquid chromatography. Journal of chromatography. A. vol 915. issue 1-2. 2001-09-13. PMID:11358260. |
five characteristic interaction constants of the stationary phases, the hydrophobicity (v), polarizability (r), dipolarity (s), hydrogen bond (hb) acceptor basicity (a) and hb donor acidity strength (b) were determined by multiple regression analyses of logarithmic retention factors (k) for a set of test solutes measured on them in 10% (v/v) methanol-water vs. the solute properties represented by characteristic molecular volume (vx), excess polarization (r2), dipolarity/polarizability (pi*), hb donor acidity (alpha) and hb acceptor basicity (beta). |
2001-09-13 |
2023-08-12 |
Not clear |
| C L Harteveld, J Traeger-Synodinos, A Ragusa, M Fichera, E Kanavakis, C Kattamis, P Giordano, G Schilirò, L F Bernin. Different geographic origins of Hb Constant Spring [alpha(2) codon 142 TAA-->CAA]. Haematologica. vol 86. issue 1. 2001-06-14. PMID:11146568. |
different geographic origins of hb constant spring [alpha(2) codon 142 taa-->caa]. |
2001-06-14 |
2023-08-12 |
Not clear |
| C L Harteveld, J Traeger-Synodinos, A Ragusa, M Fichera, E Kanavakis, C Kattamis, P Giordano, G Schilirò, L F Bernin. Different geographic origins of Hb Constant Spring [alpha(2) codon 142 TAA-->CAA]. Haematologica. vol 86. issue 1. 2001-06-14. PMID:11146568. |
we investigated the independent origin of these termination codon mutations of the alpha 2-globin gene by determining the alpha-cluster haplotype and comparing the hematologic data from hb cs-hb h patients and their family members. |
2001-06-14 |
2023-08-12 |
Not clear |
| N R Naito, H L Hui, R W Noble, B M Hoffma. Determination of the hemoglobin surface domains that react with cytochrome b5. Biochemistry. vol 40. issue 7. 2001-05-31. PMID:11329273. |
because the dimer--dimer interface would be disrupted for monomers or alpha beta dimers, we studied the reaction of b(5) with alpha znm chains and (znm)hb beta w37e, which exists as alpha beta dimers in solution. |
2001-05-31 |
2023-08-12 |
Not clear |
| J D Lafferty, M A Crowther, J S Waye, D H Chu. A reliable screening test to identify adult carriers of the (--SEA) alpha zero-thalassemia deletion. Detection of embryonic zeta-globin chains by enzyme-linked immunosorbent assay. American journal of clinical pathology. vol 114. issue 6. 2001-05-17. PMID:11338482. |
the laboratory screening for adult carriers of (--sea) and other alpha zero-thalassemia deletions currently rests primarily with microscopic detection of hemoglobin h inclusion bodies within erythrocytes (hb h screen). |
2001-05-17 |
2023-08-12 |
Not clear |
| N B Roberts, A B Amara, M Morris, B N Gree. Long-term evaluation of electrospray ionization mass spectrometric analysis of glycated hemoglobin. Clinical chemistry. vol 47. issue 2. 2001-03-22. PMID:11159781. |
electrospray ionization mass spectrometry (esims) has been successfully applied to the identification of hemoglobin (hb) variants and the presence of glucose adducts (mass difference of 162 da) on the separate hb alpha and beta chains. |
2001-03-22 |
2023-08-12 |
Not clear |
| J S Kraus. The proportion of hybrid heterodimers in homozygous or doubly heterozygous beta chain variant hemoglobinopathies associated with alpha chain hemoglobin variants. Annals of clinical and laboratory science. vol 30. issue 4. 2001-02-15. PMID:11045763. |
four alpha genes exist on chromosome 16, but one or more of these genes can be deleted in association with hemoglobin (hb)g-philadelphia in cis to alpha-thalassemia-2 in african-americans. |
2001-02-15 |
2023-08-12 |
Not clear |
| D A Svistunenko, M A Sharpe, P Nicholls, C Blenkinsop, N A Davies, J Dunne, M T Wilson, C E Coope. The pH dependence of naturally occurring low-spin forms of methaemoglobin and metmyoglobin: an EPR study. The Biochemical journal. vol 351 Pt 3. 2001-01-18. PMID:11042113. |
nevertheless, the individual line width (g=6) is smaller in metmb than in methb, consistent with non-identical signals from the alpha and beta hb subunits. |
2001-01-18 |
2023-08-12 |
human |
| C H Tsai, T Y Fang, N T Ho, C H. Novel recombinant hemoglobin, rHb (beta N108Q), with low oxygen affinity, high cooperativity, and stability against autoxidation. Biochemistry. vol 39. issue 45. 2000-12-28. PMID:11076511. |
using our escherichia coli expression system, we have constructed rhb (beta n108q), a new recombinant hemoglobin (rhb), with the amino acid substitution located in the alpha(1)beta(1) subunit interface and in the central cavity of the hb molecule. |
2000-12-28 |
2023-08-12 |
human |
| C H Tsai, T Y Fang, N T Ho, C H. Novel recombinant hemoglobin, rHb (beta N108Q), with low oxygen affinity, high cooperativity, and stability against autoxidation. Biochemistry. vol 39. issue 45. 2000-12-28. PMID:11076511. |
rhb (alpha l29f, beta n108q) is stabilized against auto- and no-induced oxidation as compared to rhb (beta n108q), but exhibits lower oxygen affinity at ph below 7.4 and good cooperativity as compared to hb a. proton nuclear magnetic resonance (nmr) studies show that rhb (beta n108q) has similar tertiary structure around the heme pockets and quaternary structure in the alpha(1)beta(1) and alpha(1)beta(2) subunit interfaces as compared to those of hb a. |
2000-12-28 |
2023-08-12 |
human |
| J Traeger-Synodinos, I Papassotiriou, A Metaxotou-Mavrommati, C Vrettou, A Stamoulakatou, E Kanavaki. Distinct phenotypic expression associated with a new hyperunstable alpha globin variant (Hb heraklion, alpha1cd37(C2)Pro>0): comparison to other alpha-thalassemic hemoglobinopathies. Blood cells, molecules & diseases. vol 26. issue 4. 2000-12-22. PMID:11042028. |
distinct phenotypic expression associated with a new hyperunstable alpha globin variant (hb heraklion, alpha1cd37(c2)pro>0): comparison to other alpha-thalassemic hemoglobinopathies. |
2000-12-22 |
2023-08-12 |
Not clear |
| J Traeger-Synodinos, I Papassotiriou, A Metaxotou-Mavrommati, C Vrettou, A Stamoulakatou, E Kanavaki. Distinct phenotypic expression associated with a new hyperunstable alpha globin variant (Hb heraklion, alpha1cd37(C2)Pro>0): comparison to other alpha-thalassemic hemoglobinopathies. Blood cells, molecules & diseases. vol 26. issue 4. 2000-12-22. PMID:11042028. |
in a child with clinical and hematological features consistent with beta-thalassemia intermedia, dna analysis excluded any beta-globin gene mutations but characterized a novel deletion cd37(c2)pro>0 (hb heraklion) in the alpha1 globin gene, in trans to a common mediterranean nondeletion alpha-thalassemia mutation (alpha(hph)alpha). |
2000-12-22 |
2023-08-12 |
Not clear |
| M Nagai, M Aki, R Li, Y Jin, H Sakai, S Nagatomo, T Kitagaw. Heme structure of hemoglobin M Iwate [alpha 87(F8)His-->Tyr]: a UV and visible resonance Raman study. Biochemistry. vol 39. issue 43. 2000-11-30. PMID:11052661. |
(1989) biochemistry 28, 2418-2422] have proved that f8-tyrosinate is covalently bound to fe(iii) heme in the alpha subunit of hb m iwate. |
2000-11-30 |
2023-08-12 |
Not clear |
| M Nagai, M Aki, R Li, Y Jin, H Sakai, S Nagatomo, T Kitagaw. Heme structure of hemoglobin M Iwate [alpha 87(F8)His-->Tyr]: a UV and visible resonance Raman study. Biochemistry. vol 39. issue 43. 2000-11-30. PMID:11052661. |
coordination of distal his(e7) to the fe(ii) heme in the reduced alpha subunit of hb m iwate was proved by the observation of the nu(fe)(-)(his) rr band in the 441.6-nm excited rr spectrum at the same frequency as that of its isolated alpha chain. |
2000-11-30 |
2023-08-12 |
Not clear |
| J Y Kim, S S Park, H L Jung, D H Keum, H Park, Y H Chang, Y J Lee, H I Ch. Hb Madrid [beta115(G17)Ala-->Pro] in a Korean family with chronic hemolytic anemia. Hemoglobin. vol 24. issue 2. 2000-11-13. PMID:10870884. |
hb madrid, in which the alanine residue at beta115 (g17) is replaced by proline, results in a moderately severe hemolytic anemia due to the disruption of an alpha helical region and the weakening of an alpha1 beta1 contact (1,2). |
2000-11-13 |
2023-08-12 |
Not clear |
| M R Wenning, E M Kimura, F F Costa, S T Saad, S Gervásio, S B de Jorge, E Borges, N M Silva, M F Sonat. alpha-globin genes: thalassemic and structural alterations in a Brazilian population. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 33. issue 9. 2000-11-07. PMID:10973135. |
of the seven patients with hb h disease, all of italian descent, two had the -(alpha)20.5/-alpha3.7 genotype, one had the --med/-alpha3.7 genotype, one had the --med/alphahphalpha genotype and three showed interaction of the -alpha3.7 deletion with an unusual, unidentified form of non-deletional alpha-thalassemia [-alpha3.7/(alphaalpha)t]. |
2000-11-07 |
2023-08-12 |
Not clear |