| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J M Goff, M R Jackson, M Taher, M A Cutting, B M Alving, C Krishnamurt. Physiologic responses of cross-linked hemoglobin in endotoxin-treated rats. Artificial cells, blood substitutes, and immobilization biotechnology. vol 27. issue 1. 1999-05-26. PMID:10063435. |
purified human cross-linked hemoglobin (alpha alpha hb) as well as recombinant human hemoglobin is undergoing clinical trials in the setting of acute blood loss and perioperative hemodilution. |
1999-05-26 |
2023-08-12 |
human |
| J M Goff, M R Jackson, M Taher, M A Cutting, B M Alving, C Krishnamurt. Physiologic responses of cross-linked hemoglobin in endotoxin-treated rats. Artificial cells, blood substitutes, and immobilization biotechnology. vol 27. issue 1. 1999-05-26. PMID:10063435. |
we have previously demonstrated that in rabbits with circulating plasma hb, such as alpha alpha hb, infusion of endotoxin (lps) impairs myocardial contractility which results in hypotension, tissue hypoperfusion and increased mortality. |
1999-05-26 |
2023-08-12 |
human |
| J M Goff, M R Jackson, M Taher, M A Cutting, B M Alving, C Krishnamurt. Physiologic responses of cross-linked hemoglobin in endotoxin-treated rats. Artificial cells, blood substitutes, and immobilization biotechnology. vol 27. issue 1. 1999-05-26. PMID:10063435. |
the untoward cardiovascular effects occurring after the combined infusion of lps and alpha alpha hb in this model are similar to those reported for other agents that inhibit nitric oxide (no) availability. |
1999-05-26 |
2023-08-12 |
human |
| J M Goff, M R Jackson, M Taher, M A Cutting, B M Alving, C Krishnamurt. Physiologic responses of cross-linked hemoglobin in endotoxin-treated rats. Artificial cells, blood substitutes, and immobilization biotechnology. vol 27. issue 1. 1999-05-26. PMID:10063435. |
to determine if the deleterious effects of alpha alpha hb and lps were species specific, we performed similar studies in rats. |
1999-05-26 |
2023-08-12 |
human |
| J M Goff, M R Jackson, M Taher, M A Cutting, B M Alving, C Krishnamurt. Physiologic responses of cross-linked hemoglobin in endotoxin-treated rats. Artificial cells, blood substitutes, and immobilization biotechnology. vol 27. issue 1. 1999-05-26. PMID:10063435. |
anesthetized sprague-dawley rats received lps (4 mg/kg or 40 mg/kg) alone or in combination with alpha alpha hb (0.7 g/kg). |
1999-05-26 |
2023-08-12 |
human |
| J M Goff, M R Jackson, M Taher, M A Cutting, B M Alving, C Krishnamurt. Physiologic responses of cross-linked hemoglobin in endotoxin-treated rats. Artificial cells, blood substitutes, and immobilization biotechnology. vol 27. issue 1. 1999-05-26. PMID:10063435. |
mean arterial blood pressures (map) increased in the group that received alpha alpha hb alone (105 +/- 8 to 120 +/- 7 mm hg, p = 0.2) and a decrease was noted in the groups that received low dose lps (4 mg/kg, p = 0.5) and high dose lps (40 mg/kg, p = 0.016). |
1999-05-26 |
2023-08-12 |
human |
| J M Goff, M R Jackson, M Taher, M A Cutting, B M Alving, C Krishnamurt. Physiologic responses of cross-linked hemoglobin in endotoxin-treated rats. Artificial cells, blood substitutes, and immobilization biotechnology. vol 27. issue 1. 1999-05-26. PMID:10063435. |
map in rats treated with the lps at either dose combined with alpha alpha hb remained unchanged. |
1999-05-26 |
2023-08-12 |
human |
| J M Goff, M R Jackson, M Taher, M A Cutting, B M Alving, C Krishnamurt. Physiologic responses of cross-linked hemoglobin in endotoxin-treated rats. Artificial cells, blood substitutes, and immobilization biotechnology. vol 27. issue 1. 1999-05-26. PMID:10063435. |
levels of urine nitrite, which was measured as a surrogate marker for plasma no, were significantly decreased at 2 hr in groups that received the combination of alpha alpha hb and lps at 4 mg/kg (p = 0.022) and 40 mg/kg (p = 0.003). |
1999-05-26 |
2023-08-12 |
human |
| J M Goff, M R Jackson, M Taher, M A Cutting, B M Alving, C Krishnamurt. Physiologic responses of cross-linked hemoglobin in endotoxin-treated rats. Artificial cells, blood substitutes, and immobilization biotechnology. vol 27. issue 1. 1999-05-26. PMID:10063435. |
no significant decrease was observed in animals treated only with alpha alpha hb (p = 0.21) or lps (4 mg/kg; p = 0.78 and 40 mg/kg; p = 0.65). |
1999-05-26 |
2023-08-12 |
human |
| J M Goff, M R Jackson, M Taher, M A Cutting, B M Alving, C Krishnamurt. Physiologic responses of cross-linked hemoglobin in endotoxin-treated rats. Artificial cells, blood substitutes, and immobilization biotechnology. vol 27. issue 1. 1999-05-26. PMID:10063435. |
survival was evaluated during 72 hr in animals that were infused with high dose lps (40 mg/kg) alone or in combination with alpha alpha hb and then allowed to recover. |
1999-05-26 |
2023-08-12 |
human |
| J M Goff, M R Jackson, M Taher, M A Cutting, B M Alving, C Krishnamurt. Physiologic responses of cross-linked hemoglobin in endotoxin-treated rats. Artificial cells, blood substitutes, and immobilization biotechnology. vol 27. issue 1. 1999-05-26. PMID:10063435. |
the survival of rats treated with lps alone or the combination was 29% at the end of 24 hr and was 100% for rats receiving only alpha alpha hb. |
1999-05-26 |
2023-08-12 |
human |
| J M Goff, M R Jackson, M Taher, M A Cutting, B M Alving, C Krishnamurt. Physiologic responses of cross-linked hemoglobin in endotoxin-treated rats. Artificial cells, blood substitutes, and immobilization biotechnology. vol 27. issue 1. 1999-05-26. PMID:10063435. |
the data suggest that the toxicity of alpha alpha hb appears to be a species specific phenomenon. |
1999-05-26 |
2023-08-12 |
human |
| L Mazzarella, R D'Avino, G di Prisco, C Savino, L Vitagliano, P C Moody, A Zagar. Crystal structure of Trematomus newnesi haemoglobin re-opens the root effect question. Journal of molecular biology. vol 287. issue 5. 1999-05-19. PMID:10222199. |
in comparison to t. bernacchii hb 1, the role of the three mutations thr41 (c6)alpha-->ile, ala97 (g3)alpha-->ser and his41 (c7)beta-->tyr at the alpha1beta2-interface is discussed. |
1999-05-19 |
2023-08-12 |
Not clear |
| J E Knapp, M A Oliveira, Q Xie, S R Ernst, A F Riggs, M L Hacker. The structural and functional analysis of the hemoglobin D component from chicken. The Journal of biological chemistry. vol 274. issue 10. 1999-03-30. PMID:10037733. |
chicken hb d differs most from human oxyhemoglobin in the ab and gh corners of the alpha subunits and the ef corner of the beta subunits. |
1999-03-30 |
2023-08-12 |
human |
| G Sahni, S A Khan, A S Achary. Chemistry of the "molecular trap" of protease-catalyzed splicing reaction of complementary segments of alpha-subunit of hemoglobin A. Journal of protein chemistry. vol 17. issue 7. 1999-03-18. PMID:9853682. |
unlike the other protease-catalyzed protein/peptide splicing reactions of fragment complementing systems, the enzymic condensation of nonassociating segments of hb alpha is facilitated by the organic cosolvent induced alpha-helical conformation of product acting as the "molecular trap" of the splicing reaction. |
1999-03-18 |
2023-08-12 |
human |
| P R Ferrini, A Grossi, A M Vannucchi, G Barosi, R Guarnone, N Piva, P Musto, E Ballear. A randomized double-blind placebo-controlled study with subcutaneous recombinant human erythropoietin in patients with low-risk myelodysplastic syndromes. British journal of haematology. vol 103. issue 4. 1999-02-19. PMID:9886322. |
60% of non-pretransfused patients responded to epoetin alpha (hb 8.35< or = 0.73 to 10.07+/-1.87 g/dl), whereas a slight decrease was observed in the placebo group (8.4+/-0.66 to 8.19+/-0.92 g/dl) (p=0.0004). |
1999-02-19 |
2023-08-12 |
human |
| M C Marden, L Kiger, C Poyart, S J Edelstei. Identifying the conformational state of bi-liganded haemoglobin. Cellular and molecular life sciences : CMLS. vol 54. issue 12. 1999-02-03. PMID:9893711. |
from studies of dimer-tetramer equilibria of various pure and hybrid forms, it was concluded that a tetramer with two ligands bound on the same alpha beta dimer (species 21, an asymmetric hybrid) shows an enhanced tetramer stability, similar to singly liganded hb, relative to the other three types of doubly liganded tetramers which resemble the triply liganded forms [ackers et al. |
1999-02-03 |
2023-08-12 |
Not clear |
| T Yonetan. [Nitric oxide and hemoglobin]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 112. issue 3. 1998-12-08. PMID:9793069. |
under physiological conditions ([no] <<< [hb]), no is sequestered by deoxy hb to form alpha-nitrosyl hb, alpha (fe-no)2 beta (fe)2, where no is tightly (kd = 10(-12) m) bound to the alpha-subunits. |
1998-12-08 |
2023-08-12 |
Not clear |
| A Y Segbena, C Prehu, H Wajcman, J Bardakdjian-Michau, K Messie, L Feteke, A Vovor, M David, J Feingold, F Galactero. Hemoglobins in Togolese newborns: Hb S, Hb C, Hb Bart's, and alpha-globin gene status. American journal of hematology. vol 59. issue 3. 1998-11-19. PMID:9798658. |
within the alpha alpha/alpha alpha and the -alpha/alpha alpha groups, several individuals with or without hb bart's were found; they did not differ from the others by their red blood cell (rbc) parameters but by their levels of fetal hemoglobin (hb f). |
1998-11-19 |
2023-08-12 |
Not clear |
| R A POP. Hemoglobin loci: mice classified for their Hb and Sol alleles. Science (New York, N.Y.). vol 140. issue 3569. 1998-11-01. PMID:13972291. |
two loci which influence the structure of the alpha and beta chains of hemoglobin have been identified and are designated sol and hb. |
1998-11-01 |
2023-08-12 |
mouse |