| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Rahbar, C Lee, V F Fáirbanks, D J McCormick, K Kubik, B J Madden, G Nozar. Hb Watts [alpha 74(EF3) or alpha 75(EF4)Asp-->0]: a shortened alpha chain variant due to the deletion of three nucleotides in exon 2 of the alpha 2-globin gene. Hemoglobin. vol 21. issue 4. 1997-09-29. PMID:9255611. |
hb watts [alpha 74(ef3) or alpha 75(ef4)asp-->0]: a shortened alpha chain variant due to the deletion of three nucleotides in exon 2 of the alpha 2-globin gene. |
1997-09-29 |
2023-08-12 |
Not clear |
| S Rahbar, C Lee, V F Fáirbanks, D J McCormick, K Kubik, B J Madden, G Nozar. Hb Watts [alpha 74(EF3) or alpha 75(EF4)Asp-->0]: a shortened alpha chain variant due to the deletion of three nucleotides in exon 2 of the alpha 2-globin gene. Hemoglobin. vol 21. issue 4. 1997-09-29. PMID:9255611. |
although the aspartic acid residues of 74 and 75 of the alpha chain are neither a heme nor an inter chain contact, the slight instability of hb watts may be due to disturbance of the central cavity of hemoglobin by the deletion of an aspartic acid residue in the ef helix. |
1997-09-29 |
2023-08-12 |
Not clear |
| S Rahbar, C Lee, V F Fáirbanks, D J McCormick, K Kubik, B J Madden, G Nozar. Hb Watts [alpha 74(EF3) or alpha 75(EF4)Asp-->0]: a shortened alpha chain variant due to the deletion of three nucleotides in exon 2 of the alpha 2-globin gene. Hemoglobin. vol 21. issue 4. 1997-09-29. PMID:9255611. |
hb watts is the first example of a trinucleotide deletion in the alpha 2-globin gene. |
1997-09-29 |
2023-08-12 |
Not clear |
| D Merritt, R T Jones, C Head, S N Thibodeau, V F Fairbanks, M H Steinberg, M B Coleman, G P Rodger. Hb Seal Rock [(alpha 2)142 term-->Glu, codon 142 TAA-->GAA]: an extended alpha chain variant associated with anemia, microcytosis, and alpha-thalassemia-2 (-3.7 Kb). Hemoglobin. vol 21. issue 4. 1997-09-29. PMID:9255612. |
hb seal rock [(alpha 2)142 term-->glu, codon 142 taa-->gaa]: an extended alpha chain variant associated with anemia, microcytosis, and alpha-thalassemia-2 (-3.7 kb). |
1997-09-29 |
2023-08-12 |
Not clear |
| D Merritt, R T Jones, C Head, S N Thibodeau, V F Fairbanks, M H Steinberg, M B Coleman, G P Rodger. Hb Seal Rock [(alpha 2)142 term-->Glu, codon 142 TAA-->GAA]: an extended alpha chain variant associated with anemia, microcytosis, and alpha-thalassemia-2 (-3.7 Kb). Hemoglobin. vol 21. issue 4. 1997-09-29. PMID:9255612. |
it is an extended alpha chain variant which, like hb constant spring, is present in small quantity and is expressed as an alpha-thalassemia. |
1997-09-29 |
2023-08-12 |
Not clear |
| D Merritt, R T Jones, C Head, S N Thibodeau, V F Fairbanks, M H Steinberg, M B Coleman, G P Rodger. Hb Seal Rock [(alpha 2)142 term-->Glu, codon 142 TAA-->GAA]: an extended alpha chain variant associated with anemia, microcytosis, and alpha-thalassemia-2 (-3.7 Kb). Hemoglobin. vol 21. issue 4. 1997-09-29. PMID:9255612. |
her hematologic expression was similar to mild hb h disease, presumably because the seal rock mutation affects the alpha 2 gene that is normally responsible for approximately 70% of alpha-globin synthesis. |
1997-09-29 |
2023-08-12 |
Not clear |
| D Merritt, R T Jones, C Head, S N Thibodeau, V F Fairbanks, M H Steinberg, M B Coleman, G P Rodger. Hb Seal Rock [(alpha 2)142 term-->Glu, codon 142 TAA-->GAA]: an extended alpha chain variant associated with anemia, microcytosis, and alpha-thalassemia-2 (-3.7 Kb). Hemoglobin. vol 21. issue 4. 1997-09-29. PMID:9255612. |
her daughter had only hb seal rock trait, but was phenotypically alpha-thalassemia-2 trait due to the expression of the seal rock mutation on one of her alpha 2-globin genes, the other three alpha-globin genes being unaffected. |
1997-09-29 |
2023-08-12 |
Not clear |
| G Ivaldi, V Scimè-Degani, O David, M Baffico, M Baldi, D Leone, M Mazzocco, L Leone, A Piga, E Furian, G Ricc. A new fast-moving variant causing erythrocytosis and mild hemolysis: Hb Gàmbara [beta 82(EF6)Lys-->Glu]. Hemoglobin. vol 21. issue 4. 1997-09-29. PMID:9255613. |
the abnormal hemoglobin moved faster than hb a at alkaline electrophoresis, and split into two fractions, probably due to the formation of hybrid tetramers (alpha 2 beta a beta x). |
1997-09-29 |
2023-08-12 |
human |
| C Déon, J C Promé, D Promé, A Francina, P Groff, G Kalmes, F Galactéros, H Wajcma. Combined mass spectrometric methods for the characterization of human hemoglobin variants localized within alpha T9 peptide: identification of Hb Villeurbanne alpha 89 (FG1) His-->Tyr. Journal of mass spectrometry : JMS. vol 32. issue 8. 1997-09-17. PMID:9269086. |
combined mass spectrometric methods for the characterization of human hemoglobin variants localized within alpha t9 peptide: identification of hb villeurbanne alpha 89 (fg1) his-->tyr. |
1997-09-17 |
2023-08-12 |
human |
| C Déon, J C Promé, D Promé, A Francina, P Groff, G Kalmes, F Galactéros, H Wajcma. Combined mass spectrometric methods for the characterization of human hemoglobin variants localized within alpha T9 peptide: identification of Hb Villeurbanne alpha 89 (FG1) His-->Tyr. Journal of mass spectrometry : JMS. vol 32. issue 8. 1997-09-17. PMID:9269086. |
two of them, hb aztec [alpha 76(ef5) met-->thr] and hb m-iwate [alpha 87(f8) his-->tyr] were already known. |
1997-09-17 |
2023-08-12 |
human |
| C Déon, J C Promé, D Promé, A Francina, P Groff, G Kalmes, F Galactéros, H Wajcma. Combined mass spectrometric methods for the characterization of human hemoglobin variants localized within alpha T9 peptide: identification of Hb Villeurbanne alpha 89 (FG1) His-->Tyr. Journal of mass spectrometry : JMS. vol 32. issue 8. 1997-09-17. PMID:9269086. |
the third [alpha 89(fg1) his-->tyr] was novel and named hb villeurbanne. |
1997-09-17 |
2023-08-12 |
human |
| M Yagame, K Jinde, D Suzuki, N Saotome, H Takano, R Tanabe, H Sato, K Kurokawa, H Sakai, M Matsumae, H Mase, T Haran. A diabetic case with hemoglobin J-Meerut and low HbA1C levels. Internal medicine (Tokyo, Japan). vol 36. issue 5. 1997-09-09. PMID:9213173. |
high performance liquid chromatography and isoelectric focusing indicated that her abnormal hemoglobin was hb j-meerut [alpha 120(h3)ala-->glu] and it accounted for 28.3% of the total hemoglobin. |
1997-09-09 |
2023-08-12 |
Not clear |
| A S Rudolph, A Sulpizio, P Hieble, V MacDonald, M Chavez, G Feuerstei. Liposome encapsulation attenuates hemoglobin-induced vasoconstriction in rabbit arterial segments. Journal of applied physiology (Bethesda, Md. : 1985). vol 82. issue 6. 1997-08-22. PMID:9173947. |
we have investigated whether encapsulation of stroma-free hb (sfhb) or cross-linked hb (alpha alpha-hb) in liposomes modulates hb vasoactivity in isolated blood vessels. |
1997-08-22 |
2023-08-12 |
rabbit |
| A S Rudolph, A Sulpizio, P Hieble, V MacDonald, M Chavez, G Feuerstei. Liposome encapsulation attenuates hemoglobin-induced vasoconstriction in rabbit arterial segments. Journal of applied physiology (Bethesda, Md. : 1985). vol 82. issue 6. 1997-08-22. PMID:9173947. |
sfhb and alpha alpha-hb caused significant inhibition of carbachol-induced relaxation at 0.5 mg/dl, whereas encapsulation inhibited vessel relaxation at 30- to 60-fold higher hb concentrations. |
1997-08-22 |
2023-08-12 |
rabbit |
| A S Rudolph, A Sulpizio, P Hieble, V MacDonald, M Chavez, G Feuerstei. Liposome encapsulation attenuates hemoglobin-induced vasoconstriction in rabbit arterial segments. Journal of applied physiology (Bethesda, Md. : 1985). vol 82. issue 6. 1997-08-22. PMID:9173947. |
mechanistic studies of the vasoconstrictor activity of hb demonstrated that acellular alpha alpha-hb had no effect on norepinephrine release in the rabbit ear artery. |
1997-08-22 |
2023-08-12 |
rabbit |
| R Migita, A Gonzales, M L Gonzales, K D Vandegriff, R M Winslo. Blood volume and cardiac index in rats after exchange transfusion with hemoglobin-based oxygen carriers. Journal of applied physiology (Bethesda, Md. : 1985). vol 82. issue 6. 1997-08-22. PMID:9173969. |
we have measured plasma volume and cardiac index in rats after 50% isovolemic exchange transfusion with human hemoglobin cross-linked between the alpha-chains with bis(3,5-dibromosalicyl)fumarate (alpha alpha hb) and with bovine hemoglobin modified with polyethylene glycol (peghb). |
1997-08-22 |
2023-08-12 |
human |
| R Migita, A Gonzales, M L Gonzales, K D Vandegriff, R M Winslo. Blood volume and cardiac index in rats after exchange transfusion with hemoglobin-based oxygen carriers. Journal of applied physiology (Bethesda, Md. : 1985). vol 82. issue 6. 1997-08-22. PMID:9173969. |
alpha alpha hb and peghb differ in colloid osmotic pressure (23.4 and 118.0 torr, respectively), oxygen affinity (oxygen half-saturation pressure of hemoglobin = 30.0 and 10.2 torr, respectively), viscosity (1.00 and 3.39 cp, respectively), and molecular weight (64,400 and 105,000, respectively). |
1997-08-22 |
2023-08-12 |
human |
| R Migita, A Gonzales, M L Gonzales, K D Vandegriff, R M Winslo. Blood volume and cardiac index in rats after exchange transfusion with hemoglobin-based oxygen carriers. Journal of applied physiology (Bethesda, Md. : 1985). vol 82. issue 6. 1997-08-22. PMID:9173969. |
blood volumes in peghb-treated animals were significantly elevated (74.0 +/- 3.5 ml/kg) compared with animals treated with alpha alpha hb (49.0 +/- 1.2 ml/kg) or ringer lactate (48.0 +/- 2.0 ml/kg) or with controls (58.2 +/- 1.9 ml/kg). |
1997-08-22 |
2023-08-12 |
human |
| R Migita, A Gonzales, M L Gonzales, K D Vandegriff, R M Winslo. Blood volume and cardiac index in rats after exchange transfusion with hemoglobin-based oxygen carriers. Journal of applied physiology (Bethesda, Md. : 1985). vol 82. issue 6. 1997-08-22. PMID:9173969. |
heart rate reduction after alpha alpha hb exchange is opposite to that expected with blood volume contraction, suggesting that alpha alpha hb may have a direct myocardial depressant action. |
1997-08-22 |
2023-08-12 |
human |
| R Migita, A Gonzales, M L Gonzales, K D Vandegriff, R M Winslo. Blood volume and cardiac index in rats after exchange transfusion with hemoglobin-based oxygen carriers. Journal of applied physiology (Bethesda, Md. : 1985). vol 82. issue 6. 1997-08-22. PMID:9173969. |
the apparently slow elimination of peghb during the 2 h after its injection is a consequence of plasma volume expansion: when absolute hemoglobin (concentration x plasma volume) is compared for peghb and alpha alpha hb, no difference in their elimination rates is found. |
1997-08-22 |
2023-08-12 |
human |