| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Merritt, R T Jones, C Head, S N Thibodeau, V F Fairbanks, M H Steinberg, M B Coleman, G P Rodger. Hb Seal Rock [(alpha 2)142 term-->Glu, codon 142 TAA-->GAA]: an extended alpha chain variant associated with anemia, microcytosis, and alpha-thalassemia-2 (-3.7 Kb). Hemoglobin. vol 21. issue 4. 1997-09-29. PMID:9255612. |
her hematologic expression was similar to mild hb h disease, presumably because the seal rock mutation affects the alpha 2 gene that is normally responsible for approximately 70% of alpha-globin synthesis. |
1997-09-29 |
2023-08-12 |
Not clear |
| D Merritt, R T Jones, C Head, S N Thibodeau, V F Fairbanks, M H Steinberg, M B Coleman, G P Rodger. Hb Seal Rock [(alpha 2)142 term-->Glu, codon 142 TAA-->GAA]: an extended alpha chain variant associated with anemia, microcytosis, and alpha-thalassemia-2 (-3.7 Kb). Hemoglobin. vol 21. issue 4. 1997-09-29. PMID:9255612. |
her daughter had only hb seal rock trait, but was phenotypically alpha-thalassemia-2 trait due to the expression of the seal rock mutation on one of her alpha 2-globin genes, the other three alpha-globin genes being unaffected. |
1997-09-29 |
2023-08-12 |
Not clear |
| G Ivaldi, V Scimè-Degani, O David, M Baffico, M Baldi, D Leone, M Mazzocco, L Leone, A Piga, E Furian, G Ricc. A new fast-moving variant causing erythrocytosis and mild hemolysis: Hb Gàmbara [beta 82(EF6)Lys-->Glu]. Hemoglobin. vol 21. issue 4. 1997-09-29. PMID:9255613. |
the abnormal hemoglobin moved faster than hb a at alkaline electrophoresis, and split into two fractions, probably due to the formation of hybrid tetramers (alpha 2 beta a beta x). |
1997-09-29 |
2023-08-12 |
human |
| C Déon, J C Promé, D Promé, A Francina, P Groff, G Kalmes, F Galactéros, H Wajcma. Combined mass spectrometric methods for the characterization of human hemoglobin variants localized within alpha T9 peptide: identification of Hb Villeurbanne alpha 89 (FG1) His-->Tyr. Journal of mass spectrometry : JMS. vol 32. issue 8. 1997-09-17. PMID:9269086. |
combined mass spectrometric methods for the characterization of human hemoglobin variants localized within alpha t9 peptide: identification of hb villeurbanne alpha 89 (fg1) his-->tyr. |
1997-09-17 |
2023-08-12 |
human |
| C Déon, J C Promé, D Promé, A Francina, P Groff, G Kalmes, F Galactéros, H Wajcma. Combined mass spectrometric methods for the characterization of human hemoglobin variants localized within alpha T9 peptide: identification of Hb Villeurbanne alpha 89 (FG1) His-->Tyr. Journal of mass spectrometry : JMS. vol 32. issue 8. 1997-09-17. PMID:9269086. |
two of them, hb aztec [alpha 76(ef5) met-->thr] and hb m-iwate [alpha 87(f8) his-->tyr] were already known. |
1997-09-17 |
2023-08-12 |
human |
| C Déon, J C Promé, D Promé, A Francina, P Groff, G Kalmes, F Galactéros, H Wajcma. Combined mass spectrometric methods for the characterization of human hemoglobin variants localized within alpha T9 peptide: identification of Hb Villeurbanne alpha 89 (FG1) His-->Tyr. Journal of mass spectrometry : JMS. vol 32. issue 8. 1997-09-17. PMID:9269086. |
the third [alpha 89(fg1) his-->tyr] was novel and named hb villeurbanne. |
1997-09-17 |
2023-08-12 |
human |
| M Yagame, K Jinde, D Suzuki, N Saotome, H Takano, R Tanabe, H Sato, K Kurokawa, H Sakai, M Matsumae, H Mase, T Haran. A diabetic case with hemoglobin J-Meerut and low HbA1C levels. Internal medicine (Tokyo, Japan). vol 36. issue 5. 1997-09-09. PMID:9213173. |
high performance liquid chromatography and isoelectric focusing indicated that her abnormal hemoglobin was hb j-meerut [alpha 120(h3)ala-->glu] and it accounted for 28.3% of the total hemoglobin. |
1997-09-09 |
2023-08-12 |
Not clear |
| A S Rudolph, A Sulpizio, P Hieble, V MacDonald, M Chavez, G Feuerstei. Liposome encapsulation attenuates hemoglobin-induced vasoconstriction in rabbit arterial segments. Journal of applied physiology (Bethesda, Md. : 1985). vol 82. issue 6. 1997-08-22. PMID:9173947. |
we have investigated whether encapsulation of stroma-free hb (sfhb) or cross-linked hb (alpha alpha-hb) in liposomes modulates hb vasoactivity in isolated blood vessels. |
1997-08-22 |
2023-08-12 |
rabbit |
| A S Rudolph, A Sulpizio, P Hieble, V MacDonald, M Chavez, G Feuerstei. Liposome encapsulation attenuates hemoglobin-induced vasoconstriction in rabbit arterial segments. Journal of applied physiology (Bethesda, Md. : 1985). vol 82. issue 6. 1997-08-22. PMID:9173947. |
sfhb and alpha alpha-hb caused significant inhibition of carbachol-induced relaxation at 0.5 mg/dl, whereas encapsulation inhibited vessel relaxation at 30- to 60-fold higher hb concentrations. |
1997-08-22 |
2023-08-12 |
rabbit |
| A S Rudolph, A Sulpizio, P Hieble, V MacDonald, M Chavez, G Feuerstei. Liposome encapsulation attenuates hemoglobin-induced vasoconstriction in rabbit arterial segments. Journal of applied physiology (Bethesda, Md. : 1985). vol 82. issue 6. 1997-08-22. PMID:9173947. |
mechanistic studies of the vasoconstrictor activity of hb demonstrated that acellular alpha alpha-hb had no effect on norepinephrine release in the rabbit ear artery. |
1997-08-22 |
2023-08-12 |
rabbit |
| R Migita, A Gonzales, M L Gonzales, K D Vandegriff, R M Winslo. Blood volume and cardiac index in rats after exchange transfusion with hemoglobin-based oxygen carriers. Journal of applied physiology (Bethesda, Md. : 1985). vol 82. issue 6. 1997-08-22. PMID:9173969. |
we have measured plasma volume and cardiac index in rats after 50% isovolemic exchange transfusion with human hemoglobin cross-linked between the alpha-chains with bis(3,5-dibromosalicyl)fumarate (alpha alpha hb) and with bovine hemoglobin modified with polyethylene glycol (peghb). |
1997-08-22 |
2023-08-12 |
human |
| R Migita, A Gonzales, M L Gonzales, K D Vandegriff, R M Winslo. Blood volume and cardiac index in rats after exchange transfusion with hemoglobin-based oxygen carriers. Journal of applied physiology (Bethesda, Md. : 1985). vol 82. issue 6. 1997-08-22. PMID:9173969. |
alpha alpha hb and peghb differ in colloid osmotic pressure (23.4 and 118.0 torr, respectively), oxygen affinity (oxygen half-saturation pressure of hemoglobin = 30.0 and 10.2 torr, respectively), viscosity (1.00 and 3.39 cp, respectively), and molecular weight (64,400 and 105,000, respectively). |
1997-08-22 |
2023-08-12 |
human |
| R Migita, A Gonzales, M L Gonzales, K D Vandegriff, R M Winslo. Blood volume and cardiac index in rats after exchange transfusion with hemoglobin-based oxygen carriers. Journal of applied physiology (Bethesda, Md. : 1985). vol 82. issue 6. 1997-08-22. PMID:9173969. |
blood volumes in peghb-treated animals were significantly elevated (74.0 +/- 3.5 ml/kg) compared with animals treated with alpha alpha hb (49.0 +/- 1.2 ml/kg) or ringer lactate (48.0 +/- 2.0 ml/kg) or with controls (58.2 +/- 1.9 ml/kg). |
1997-08-22 |
2023-08-12 |
human |
| R Migita, A Gonzales, M L Gonzales, K D Vandegriff, R M Winslo. Blood volume and cardiac index in rats after exchange transfusion with hemoglobin-based oxygen carriers. Journal of applied physiology (Bethesda, Md. : 1985). vol 82. issue 6. 1997-08-22. PMID:9173969. |
heart rate reduction after alpha alpha hb exchange is opposite to that expected with blood volume contraction, suggesting that alpha alpha hb may have a direct myocardial depressant action. |
1997-08-22 |
2023-08-12 |
human |
| R Migita, A Gonzales, M L Gonzales, K D Vandegriff, R M Winslo. Blood volume and cardiac index in rats after exchange transfusion with hemoglobin-based oxygen carriers. Journal of applied physiology (Bethesda, Md. : 1985). vol 82. issue 6. 1997-08-22. PMID:9173969. |
the apparently slow elimination of peghb during the 2 h after its injection is a consequence of plasma volume expansion: when absolute hemoglobin (concentration x plasma volume) is compared for peghb and alpha alpha hb, no difference in their elimination rates is found. |
1997-08-22 |
2023-08-12 |
human |
| T H Huisma. Hb E and alpha-thalassemia; variability in the assembly of beta E chain containing tetramers. Hemoglobin. vol 21. issue 3. 1997-07-24. PMID:9140719. |
a decrease in hb e level was observed which was directly related to the type of alpha-thalassemia that was present; the lowest percentage of hb e (and hb a2) was 10.2%, seen in two persons with hb constant spring (cs)-hb h disease (alpha cs alpha/--). |
1997-07-24 |
2023-08-12 |
human |
| T H Huisma. Hb E and alpha-thalassemia; variability in the assembly of beta E chain containing tetramers. Hemoglobin. vol 21. issue 3. 1997-07-24. PMID:9140719. |
moreover, this single observation suggests an equal synthesis of beta a and beta e chains, the low level of hb e in adult heterozygotes being primarily the result of a greatly decreased rate of assembly of alpha beta e dimers. |
1997-07-24 |
2023-08-12 |
human |
| J T de Araújo, L Bodemeier, B Schmidt, R C Affons. Four adult hemoglobin types in one mulatto family. Revista do Instituto de Medicina Tropical de Sao Paulo. vol 38. issue 3. 1997-07-24. PMID:9163985. |
the hybrid hb cg-phila is formed by the combination velocity of the subunits alpha 2g-phila beta 2; therefore the proportion of the hybrid hb cg-phila is lower than hb g-phila and hb c. the identification and molecular characterization of hb g-phila showed the position alpha 2(68) asn-->lys beta 2 and hb c showed alpha 2 beta 2(6) glu-->lys. |
1997-07-24 |
2023-08-12 |
Not clear |
| L F de Figueiredo, M Mathru, D Solanki, V W Macdonald, J Hess, G C Krame. Pulmonary hypertension and systemic vasoconstriction may offset the benefits of acellular hemoglobin blood substitutes. The Journal of trauma. vol 42. issue 5. 1997-07-10. PMID:9191666. |
we tested the hypothesis that the pharmacologic properties of a small volume of alpha alpha-cross-linked hemoglobin (alpha alpha hb) could effectively resuscitate pigs subjected to hemorrhage. |
1997-07-10 |
2023-08-12 |
Not clear |
| C Oner, A Gürgey, R Oner, H Balkan, F Gümrük, E Baysal, C Alta. The molecular basis of Hb H disease in Turkey. Hemoglobin. vol 21. issue 1. 1997-07-07. PMID:9028822. |
in two patients, homozygosity for the polyadenylation signal mutation [alpha (pa-2)alpha] was found to be responsible for hb h disease. |
1997-07-07 |
2023-08-12 |
Not clear |