| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Kister, N Griffon, J S Henthorn, M C Marden, C Poyart, I Papassotiriou, D Promé, F Galactéros, S C Davies, H Wajcma. Alteration of an intersubunit contact in hemoglobin variants: comparative study of modifications at position alpha 126 Asp (H9). Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. vol 320. issue 11. 1998-04-02. PMID:9499936. |
a comparative study of four of these alpha 126 hb variants is presented. |
1998-04-02 |
2023-08-12 |
human |
| K Adachi, T Yamaguchi, J Pang, S Surre. Effects of increased anionic charge in the beta-globin chain on assembly of hemoglobin in vitro. Blood. vol 91. issue 4. 1998-03-03. PMID:9454775. |
in addition, beta112 cys-->asp chains exist as monomers rather than beta4 tetramers in the absence of alpha chains, and the beta chain in hb betac112d tetramers was readily exchanged by addition of betas. |
1998-03-03 |
2023-08-12 |
human |
| J M Hempe, J N Granger, R D Crave. Capillary isoelectric focusing of hemoglobin variants in the pediatric clinical laboratory. Electrophoresis. vol 18. issue 10. 1998-02-06. PMID:9372271. |
the results show the use of the revised method for (i) posttranslationally modified hb present at low concentrations in normal blood, (ii) hb oxidation products produced by improper sample storage, (iii) differential diagnosis of s/beta + thalassemia, g-philadelphia trait, s/c-harlem disease, and hb h disease, (iv) sensitive detection of minor variants like hb a2' as indicators of an alpha globin mutation, and (v) neonatal screening using dried blood collected on filter paper. |
1998-02-06 |
2023-08-12 |
Not clear |
| K Yang, W Kang, C Lian. [The effect of anisodamine hydrochloride on globin chain synthesis in anemic mice]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 18. issue 6. 1998-01-27. PMID:9388944. |
we found that the synthesis of their globin chains remarkably increased and would last for approximately 10 days, while the results did not show any generation of fetal hb, possible effect of the drug might come from the raising of alpha and beta globin chains of the adult mice. |
1998-01-27 |
2023-08-12 |
mouse |
| X Hu, T G Spir. Tyrosine and tryptophan structure markers in hemoglobin ultraviolet resonance Raman spectra: mode assignments via subunit-specific isotope labeling of recombinant protein. Biochemistry. vol 36. issue 50. 1998-01-27. PMID:9398299. |
selective tyr labeling identified the alpha subunits as the locus of the y8a upshift observed in hb, supporting the previous inference that this shift is associated with the t-state h-bond involving the interfacial tyr alpha42 [rodgers, su, subramaniam, & spiro (1992) j. |
1998-01-27 |
2023-08-12 |
Not clear |
| G Ricco, O David, M I Parodi, S Bosio, P Scaravaglio, E Rabino-Mass. Studies on the oxygen transport in the clinical association between Hb-S and Hb-C. Panminerva medica. vol 39. issue 3. 1998-01-13. PMID:9360416. |
the right-shifted p50 from whole blood can be easily explained by the mild anemia with a parallel increase of 2,3-diphosphoglycerate (dpg), whereas the functional discrepancies between whole blood function and that of the purified hb-s and c could be due, at least in part, to the presence in vivo of consistent amounts of hybrid hb tetramers of the type alpha alpha beta s beta c. unfortunately, the mechanism promoting the formation (or dissolution) of hybrids are fundamentally unknown; so, either their presence and functional properties are very difficult to be explored. |
1998-01-13 |
2023-08-12 |
Not clear |
| T H Huisma. Levels of Hb A2 in heterozygotes and homozygotes for beta-thalassemia mutations: influence of mutations in the CACCC and ATAAA motifs of the beta-globin gene promoter. Acta haematologica. vol 98. issue 4. 1998-01-08. PMID:9401495. |
a review of these data confirms the suggestion that the increase in hb a2 levels results from at least two mechanisms: in a posttranslational system, the formation of alpha delta-dimers is promoted when excess alpha-chains are available, while certain promoter mutations increase the transcription of the delta-globin gene in cis because of a change in the binding of transcription factors. |
1998-01-08 |
2023-08-12 |
human |
| F A Highsmith, C M Driscoll, B C Chung, M D Chavez, V W Macdonald, J M Manning, L E Lippert, R L Berger, J R Hes. An improved process for the production of sterile modified haemoglobin solutions. Biologicals : journal of the International Association of Biological Standardization. vol 25. issue 3. 1997-12-12. PMID:9324994. |
the process for manufacturing bulk quantities of sterile solutions of human haemoglobin (hb) cross-linked between the alpha chains (alphaalphahb) with bis(3,5-dibomosalicyl) fumarate (dbbf) was modified to: (1) improve product purity; (2) increase product yield; (3) eliminate non-united states pharmacopoeia materials; (4) reduce reagent costs; and (5) reduce production time. |
1997-12-12 |
2023-08-12 |
human |
| S O Brennan, J R Matthew. Hb Auckland [alpha 87(F8) His-->Asn]: a new mutation of the proximal histidine identified by electrospray mass spectrometry. Hemoglobin. vol 21. issue 5. 1997-11-21. PMID:9322075. |
hb auckland [alpha 87(f8) his-->asn]: a new mutation of the proximal histidine identified by electrospray mass spectrometry. |
1997-11-21 |
2023-08-12 |
Not clear |
| S O Brennan, J R Matthew. Hb Auckland [alpha 87(F8) His-->Asn]: a new mutation of the proximal histidine identified by electrospray mass spectrometry. Hemoglobin. vol 21. issue 5. 1997-11-21. PMID:9322075. |
hb auckland is a newly described unstable hemoglobin with a mutation of alpha 97(f8)his-->asn. |
1997-11-21 |
2023-08-12 |
Not clear |
| S K Ballas, R N Gay, F F Cheha. Is Hb A2 elevated in adults with sickle-alpha-thalassemia (beta(S)/beta(S); -alpha/-alpha)? Hemoglobin. vol 21. issue 5. 1997-11-21. PMID:9322076. |
in order to determine whether the elevation of hb a2 is typical of ss with a two alpha gene deletion or is due to undiagnosed s-beta(o)-thalassemia with a two alpha gene deletion we looked for the presence or absence of beta(o)-thalassemia by molecular techniques. |
1997-11-21 |
2023-08-12 |
Not clear |
| S K Ballas, R N Gay, F F Cheha. Is Hb A2 elevated in adults with sickle-alpha-thalassemia (beta(S)/beta(S); -alpha/-alpha)? Hemoglobin. vol 21. issue 5. 1997-11-21. PMID:9322076. |
the remaining 12 patients were homozygous for the sickle gene, had relatively elevated hb levels, increased hb a2 values, and hb f levels similar to those in patients with ss and four or three alpha genes. |
1997-11-21 |
2023-08-12 |
Not clear |
| N S Smetanina, T P Molchanova, T H Huisma. Analysis of mRNA from red cells of patients with thalassemia and hemoglobin variants. Hemoglobin. vol 21. issue 5. 1997-11-21. PMID:9322078. |
details about these polymerase chain reaction-based methods are reviewed, and information about their usefulness in studying alpha-thalassemia, beta-thalassemia, sickle cell anemia and other beta-globin gene abnormalities, hb lepore heterozygosity, and heterozygosity for alpha 2- or alpha 1-globin gene mutations will be provided. |
1997-11-21 |
2023-08-12 |
human |
| J S Waye, B Eng, M Patterson, D H Chui, E Nisbet-Brown, N F Olivier. Novel mutation of the alpha 2-globin gene initiation codon (ATG-->A-G) in a Vietnamese girl with Hb H disease. Hemoglobin. vol 21. issue 5. 1997-11-21. PMID:9322079. |
novel mutation of the alpha 2-globin gene initiation codon (atg-->a-g) in a vietnamese girl with hb h disease. |
1997-11-21 |
2023-08-12 |
Not clear |
| K Tsujita, T Shiraishi, K Kakinum. Microspectrophotometry of nitric oxide-dependent changes in hemoglobin in single red blood cells incubated with stimulated macrophages. Journal of biochemistry. vol 122. issue 2. 1997-11-10. PMID:9378701. |
human rbc treated with various concentrations of no showed spectral changes due to the conversion of oxy hb to methemoglobin (met hb), in which the change in absorption differences at alpha (557 590 nm) and beta (542-525 nm) bands showed a linear relationship with the concentration of no up to 100 microm. |
1997-11-10 |
2023-08-12 |
human |
| K Yeowell-O'Connell, W Pauwels, M Severi, Z Jin, M R Walker, S M Rappaport, H Veuleman. Comparison of styrene-7,8-oxide adducts formed via reaction with cysteine, N-terminal valine and carboxylic acid residues in human, mouse and rat hemoglobin. Chemico-biological interactions. vol 106. issue 1. 1997-10-16. PMID:9305409. |
the rate constants for cysteine adducts vary dramatically between species [2.04, 10.7, 133 l (mol hb)-1 h-1 (alpha binding) for humans, mice and rats, respectively] and [0.078, 2.16, 20.4 l (mol hb)-1 h-1 (beta binding), respectively]. |
1997-10-16 |
2023-08-12 |
mouse |
| S Rahbar, C Lee, V F Fáirbanks, D J McCormick, K Kubik, B J Madden, G Nozar. Hb Watts [alpha 74(EF3) or alpha 75(EF4)Asp-->0]: a shortened alpha chain variant due to the deletion of three nucleotides in exon 2 of the alpha 2-globin gene. Hemoglobin. vol 21. issue 4. 1997-09-29. PMID:9255611. |
hb watts [alpha 74(ef3) or alpha 75(ef4)asp-->0]: a shortened alpha chain variant due to the deletion of three nucleotides in exon 2 of the alpha 2-globin gene. |
1997-09-29 |
2023-08-12 |
Not clear |
| S Rahbar, C Lee, V F Fáirbanks, D J McCormick, K Kubik, B J Madden, G Nozar. Hb Watts [alpha 74(EF3) or alpha 75(EF4)Asp-->0]: a shortened alpha chain variant due to the deletion of three nucleotides in exon 2 of the alpha 2-globin gene. Hemoglobin. vol 21. issue 4. 1997-09-29. PMID:9255611. |
although the aspartic acid residues of 74 and 75 of the alpha chain are neither a heme nor an inter chain contact, the slight instability of hb watts may be due to disturbance of the central cavity of hemoglobin by the deletion of an aspartic acid residue in the ef helix. |
1997-09-29 |
2023-08-12 |
Not clear |
| S Rahbar, C Lee, V F Fáirbanks, D J McCormick, K Kubik, B J Madden, G Nozar. Hb Watts [alpha 74(EF3) or alpha 75(EF4)Asp-->0]: a shortened alpha chain variant due to the deletion of three nucleotides in exon 2 of the alpha 2-globin gene. Hemoglobin. vol 21. issue 4. 1997-09-29. PMID:9255611. |
hb watts is the first example of a trinucleotide deletion in the alpha 2-globin gene. |
1997-09-29 |
2023-08-12 |
Not clear |
| D Merritt, R T Jones, C Head, S N Thibodeau, V F Fairbanks, M H Steinberg, M B Coleman, G P Rodger. Hb Seal Rock [(alpha 2)142 term-->Glu, codon 142 TAA-->GAA]: an extended alpha chain variant associated with anemia, microcytosis, and alpha-thalassemia-2 (-3.7 Kb). Hemoglobin. vol 21. issue 4. 1997-09-29. PMID:9255612. |
hb seal rock [(alpha 2)142 term-->glu, codon 142 taa-->gaa]: an extended alpha chain variant associated with anemia, microcytosis, and alpha-thalassemia-2 (-3.7 kb). |
1997-09-29 |
2023-08-12 |
Not clear |