| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Podstawka, C Rajani, J R Kincaid, L M Proniewic. Resonance raman studies of heme structural differences in subunits of deoxy hemoglobin. Biopolymers. vol 57. issue 4. 2000-09-13. PMID:10861384. |
low frequency resonance raman (rr) spectra are reported for deoxy hemoglobin (hb), its isolated subunits, its analogue bearing methine-deuterated hemes in all four subunits (hb-d(4)), and the hybrids bearing the deuterated heme in only one type of subunit, which are [alpha(d4)beta(h4)](2) and [alpha(h4)beta(d4)](2). |
2000-09-13 |
2023-08-12 |
Not clear |
| Z He, L Lian, T Asakura, J E Russel. Functional effects of replacing human alpha- and beta-globins with their embryonic globin homologues in defined haemoglobin heterotetramers. British journal of haematology. vol 109. issue 4. 2000-08-31. PMID:10929046. |
these haemoglobins differ from adult hb a (alpha2beta2) by the substitution of embryonic zeta for adult alpha globin (hb zeta2beta2), or embryonic epsilon for adult beta globin (hb alpha2epsilon2). |
2000-08-31 |
2023-08-12 |
mouse |
| M J Rao, A Malavalli, B N Manjula, R Kumar, M Prabhakaran, D P Sun, N T Ho, C Ho, R L Nagel, A S Achary. Interspecies hybrid HbS: complete neutralization of Val6(beta)-dependent polymerization of human beta-chain by pig alpha-chains. Journal of molecular biology. vol 300. issue 5. 2000-08-25. PMID:10903876. |
the alpha(2)(p)beta(2)(s) retains normal tetrameric structure (alpha(2)beta(2)) of human hb and an o(2) affinity comparable to that of hbs in 50 mm hepes buffer; but, its o(2) affinity is slightly higher than that of hbs in the presence of allosteric effectors (chloride, dpg and phosphate). |
2000-08-25 |
2023-08-12 |
human |
| M J Rao, A Malavalli, B N Manjula, R Kumar, M Prabhakaran, D P Sun, N T Ho, C Ho, R L Nagel, A S Achary. Interspecies hybrid HbS: complete neutralization of Val6(beta)-dependent polymerization of human beta-chain by pig alpha-chains. Journal of molecular biology. vol 300. issue 5. 2000-08-25. PMID:10903876. |
the (1)h-nmr spectroscopy detected distinct differences between the heme environments and alpha(1)beta(1) interfaces of pig hb and hbs, while their alpha(1)beta(2) interfaces appear very similar. |
2000-08-25 |
2023-08-12 |
human |
| M J Rao, A Malavalli, B N Manjula, R Kumar, M Prabhakaran, D P Sun, N T Ho, C Ho, R L Nagel, A S Achary. Interspecies hybrid HbS: complete neutralization of Val6(beta)-dependent polymerization of human beta-chain by pig alpha-chains. Journal of molecular biology. vol 300. issue 5. 2000-08-25. PMID:10903876. |
the interspecies hybrid alpha(2)(h)beta(2)(p) resembles pig hb; the pig beta-chain dictated the conformation of the heme environment of the human alpha-subunit, and to the alpha(1)beta(1) interfaces of the hybrid. |
2000-08-25 |
2023-08-12 |
human |
| E Bissé, N Zorn, I Heinrichs, A Eigel, A Van Dorsselaer, H Wieland, J Kister, M C Marde. Characterization of a new electrophoretically silent hemoglobin variant. Hb saale OR alpha 2beta 2 84(EF8)Thr --> Ala. The Journal of biological chemistry. vol 275. issue 28. 2000-08-16. PMID:10770934. |
hb saale or alpha 2beta 2 84(ef8)thr --> ala. a new abnormal hemoglobin was detected in a young german anemic patient by cation-exchange high performance liquid chromatography (hplc). |
2000-08-16 |
2023-08-12 |
Not clear |
| T Uchida, T Kinoshita, N Hirabayashi, H Saito, K Harano, T Haran. Hemoglobin Pitié-Salpétrière [beta 34 (B16) Val-->Phe] showing erythrocytosis and mild hemolysis in a Japanese man. International journal of hematology. vol 71. issue 3. 2000-07-26. PMID:10846826. |
it was suggested that the slightly unstable state of hb p-s caused by the looseness of alpha 1 beta 1 contact could result in mild hemolysis. |
2000-07-26 |
2023-08-12 |
Not clear |
| R E Weber, A Fago, A L Val, A Bang, M L Van Hauwaert, S Dewilde, F Zal, L Moen. Isohemoglobin differentiation in the bimodal-breathing amazon catfish Hoplosternum littorale. The Journal of biological chemistry. vol 275. issue 23. 2000-07-20. PMID:10747999. |
the amino acid sequences for the alpha and beta chains of hb(ca) obtained by edman degradation and cdna sequencing show unusual substitutions at the phosphate-binding site that are discussed in terms of its reverse bohr effect and anion sensitivities. |
2000-07-20 |
2023-08-12 |
Not clear |
| K Adachi, Y Zhao, T Yamaguchi, S Surre. Assembly of gamma- with alpha-globin chains to form human fetal hemoglobin in vitro and in vivo. The Journal of biological chemistry. vol 275. issue 17. 2000-06-02. PMID:10777526. |
soluble gamma-globin chains were expressed in bacteria and purified to assess the mechanism of gamma- and alpha-chain assembly to form hb f. formation of hb f in vitro following incubation of equimolar mixtures of gamma and alpha chains was about 4 x 10(5)-fold slower than assembly of alpha and beta chains to form hb a in vitro. |
2000-06-02 |
2023-08-12 |
human |
| K Adachi, Y Zhao, T Yamaguchi, S Surre. Assembly of gamma- with alpha-globin chains to form human fetal hemoglobin in vitro and in vivo. The Journal of biological chemistry. vol 275. issue 17. 2000-06-02. PMID:10777526. |
results of assembly for gamma(116ile-->his) and gamma(112thr-->asp) chains with alpha chains were similar to that of beta chains, whereas assembly of gamma(112thr-->cys) and alpha chains was similar to wild type gamma chains, indicating that amino acid differences at alpha1beta1 and alpha1gamma1 interaction sites between gamma116 ile and beta116 his are responsible for the different assembly rates in vitro in the formation of hb f and hb a. homoassembly in vitro of individual gamma chains as assessed by size-exclusion chromatography shows that gamma and gamma(112thr-->cys) chains form stable dimers like alphabeta and alphagamma that do not dissociate readily into monomers like beta chains. |
2000-06-02 |
2023-08-12 |
human |
| K Adachi, Y Zhao, T Yamaguchi, S Surre. Assembly of gamma- with alpha-globin chains to form human fetal hemoglobin in vitro and in vivo. The Journal of biological chemistry. vol 275. issue 17. 2000-06-02. PMID:10777526. |
however, yields of soluble hb f expressed in bacteria were similar to hb a, and no unassembled alpha and gamma chains were detected. |
2000-06-02 |
2023-08-12 |
human |
| K Inaba, K Ishimori, K Imai, I Morishim. Substitution of the heme binding module in hemoglobin alpha- and beta-subunits. Implication for different regulation mechanisms of the heme proximal structure between hemoglobin and myoglobin. The Journal of biological chemistry. vol 275. issue 17. 2000-06-02. PMID:10777528. |
consequently, the heme environmental structure of the betaalpha(hbm)-subunit in tetrameric alpha(2)[betaalpha(hbm)(2)] was similar to that of the beta-subunit in native tetrameric hb a, and the structural conversion by the module substitution was not clear in the hemoglobin subunits. |
2000-06-02 |
2023-08-12 |
Not clear |
| Y Qiu, D H Maillett, J Knapp, J S Olson, A F Rigg. Lamprey hemoglobin. Structural basis of the bohr effect. The Journal of biological chemistry. vol 275. issue 18. 2000-06-01. PMID:10788466. |
u. s. a 83, 8487-8491) proposed that the dimeric interface of the hb resembles either the alpha(1)beta(2) interface of mammalian hbs or the contacts in clam hb where the e and f helices form the interface. |
2000-06-01 |
2023-08-12 |
Not clear |
| M A el-Hazmi, A S Wars. Alpha thalassaemia in Yemeni children with sickle cell disease. Journal of tropical pediatrics. vol 45. issue 6. 2000-02-25. PMID:10667010. |
the frequency of alpha-gene deletion in the total yemeni group (26 scd + 19 hb aa) was 0.311 for one alpha-gene deletion (-alpha/alpha alpha) and 0.13 for two alpha-gene deletions (-alpha/-alpha). |
2000-02-25 |
2023-08-12 |
Not clear |
| M A el-Hazmi, A S Wars. Alpha thalassaemia in Yemeni children with sickle cell disease. Journal of tropical pediatrics. vol 45. issue 6. 2000-02-25. PMID:10667010. |
when separated on the basis of the hb phenotype the alpha-gene deletion frequency was significantly higher (-alpha/alpha alpha = 0.346 and -alpha/-alpha = 0.231) in the scd patients compared to the normal hb aa group (-alpha/alpha alpha = 0.263 and -alpha/-alpha = 0). |
2000-02-25 |
2023-08-12 |
Not clear |
| M A el-Hazmi, A S Wars. Alpha thalassaemia in Yemeni children with sickle cell disease. Journal of tropical pediatrics. vol 45. issue 6. 2000-02-25. PMID:10667010. |
in the hb aa group one child had triple alpha-gene arrangement (alpha alpha alpha/alpha alpha) giving an overall frequency of triple alpha-gene as 0.022. |
2000-02-25 |
2023-08-12 |
Not clear |
| S Srinivasulu, A Malavalli, M Prabhakaran, R L Nagel, A S Achary. Inhibition of beta(S)-chain dependent polymerization by synergistic complementation of contact site perturbations of alpha-chain: application of semisynthetic chimeric alpha-chains. Protein engineering. vol 12. issue 12. 2000-02-11. PMID:10611404. |
accordingly, the polymerization inhibitory activity of hb le-lamentin (lm) mutation [his20(alpha)-->gln], a contact site sequence difference, engineered into human-horse chimeric alpha-chain has been investigated to map such a synergistic complementation. |
2000-02-11 |
2023-08-12 |
mouse |
| J Traeger-Synodinos, C L Harteveld, E Kanavakis, P C Giordano, C Kattamis, L F Bernin. Hb Aghia Sophia [alpha62(E11)Val-->0 (alpha1)], an "in-frame" deletion causing alpha-thalassemia. Hemoglobin. vol 23. issue 4. 1999-12-23. PMID:10569720. |
in this report we describe a case of hb h disease due to the interaction of the --(med 1) deletion with a new alpha(+)-thalassemia determinant. |
1999-12-23 |
2023-08-12 |
Not clear |
| J Traeger-Synodinos, C L Harteveld, E Kanavakis, P C Giordano, C Kattamis, L F Bernin. Hb Aghia Sophia [alpha62(E11)Val-->0 (alpha1)], an "in-frame" deletion causing alpha-thalassemia. Hemoglobin. vol 23. issue 4. 1999-12-23. PMID:10569720. |
substitutions of valine e11 with other amino acid residues in the alpha as well as beta polypeptide chains lead, in the heterozygous carrier, either to hb m disease or to congenital non-spherocytic hemolytic anemia. |
1999-12-23 |
2023-08-12 |
Not clear |
| P Lacan, A Francina, G Souillet, M Aubry, N Couprie, L Dementhon, M Becch. Two new alpha chain variants: Hb Boghé [alpha58(E7)His-->Gln, alpha2], a variant on the distal histidine, and Hb CHarolles [alpha103(G10)His-Tyr, alpha1]. Hemoglobin. vol 23. issue 4. 1999-12-23. PMID:10569723. |
two new alpha chain variants: hb boghé [alpha58(e7)his-->gln, alpha2], a variant on the distal histidine, and hb charolles [alpha103(g10)his-tyr, alpha1]. |
1999-12-23 |
2023-08-12 |
Not clear |