| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M A el-Hazmi, A S Wars. On the molecular interactions between alpha-thalassaemia and sickle cell gene. Journal of tropical pediatrics. vol 39. issue 4. 1993-11-23. PMID:8411313. |
co-existing triple alpha-gene arrangement, alpha alpha alpha anti 3.7/, with hb as did not influence the haematological analytes. |
1993-11-23 |
2023-08-12 |
Not clear |
| M A el-Hazmi, A S Wars. On the molecular interactions between alpha-thalassaemia and sickle cell gene. Journal of tropical pediatrics. vol 39. issue 4. 1993-11-23. PMID:8411313. |
in hb ss, presence of alpha alpha alpha anti 3.7/ resulted in a severe sickle cell anaemia (sca) with a high severity index (> 11) and with frequent crises, transfusion requirements and hospitalizations. |
1993-11-23 |
2023-08-12 |
Not clear |
| J Traeger-Synodinos, E Kanavakis, M Tzetis, A Kattamis, C Kattami. Characterization of nondeletion alpha-thalassemia mutations in the Greek population. American journal of hematology. vol 44. issue 3. 1993-11-19. PMID:8213764. |
of the 16 nondeletion chromosomes, nine had the polyadenylation signal mutation (alpha polya alpha), two the ivsi 5' pentanucleotide deletion (alpha hph alpha), two the hb icaria mutation (alpha ic alpha), and one the initiation codon mutation (alpha nco alpha). |
1993-11-19 |
2023-08-12 |
Not clear |
| A Togi, K Ishimori, M Unno, T Konno, I Morishima, G Miyazaki, K Ima. Effects of intra- and intersubunit hydrogen bonds on the R-T transition in human hemoglobin as studied with alpha 42(C7) and beta 145(HC2) mutations. Biochemistry. vol 32. issue 38. 1993-11-02. PMID:8399142. |
one of the hydrogen bonds we focused on is formed between tyr-42 alpha and asp-99 beta in the alpha 1-beta 2 interface of hb a, which is one of the hydrogen bonds characteristic of the t state. |
1993-11-02 |
2023-08-12 |
human |
| A Togi, K Ishimori, M Unno, T Konno, I Morishima, G Miyazaki, K Ima. Effects of intra- and intersubunit hydrogen bonds on the R-T transition in human hemoglobin as studied with alpha 42(C7) and beta 145(HC2) mutations. Biochemistry. vol 32. issue 38. 1993-11-02. PMID:8399142. |
hb his-42 alpha, in which tyr-42 alpha is replaced by his to perturb this hydrogen bond, showed that the ligand-free r to t transition rate was decreased by 20-fold compared with that for hb a. |
1993-11-02 |
2023-08-12 |
human |
| A Togi, K Ishimori, M Unno, T Konno, I Morishima, G Miyazaki, K Ima. Effects of intra- and intersubunit hydrogen bonds on the R-T transition in human hemoglobin as studied with alpha 42(C7) and beta 145(HC2) mutations. Biochemistry. vol 32. issue 38. 1993-11-02. PMID:8399142. |
hb phe-145 beta, in which tyr-145 beta is replaced by phe and the intrasubunit hydrogen bond between tyr-145 beta and val-98 beta is lacking, also showed a slow r-t transition rate as observed in hb his-42 alpha. |
1993-11-02 |
2023-08-12 |
human |
| A Urabe, H Mizoguchi, F Takaku, T Miyazaki, A Yachi, Y Niitsu, Y Miura, Y Mutoh, S Fujioka, T Nomur. [Phase II clinical study of recombinant human erythropoietin on the anemia associated with multiple myeloma]. [Rinsho ketsueki] The Japanese journal of clinical hematology. vol 34. issue 8. 1993-11-02. PMID:8411646. |
safety and efficacy of recombinant human erythropoietin (epoetin alpha) were investigated in anemic patients with multiple myeloma whose hemoglobin (hb) concentration was less than 10g/dl. |
1993-11-02 |
2023-08-12 |
human |
| A Urabe, H Mizoguchi, F Takaku, T Miyazaki, A Yachi, Y Niitsu, Y Miura, Y Mutoh, S Fujioka, T Nomur. [Phase II clinical study of recombinant human erythropoietin on the anemia associated with multiple myeloma]. [Rinsho ketsueki] The Japanese journal of clinical hematology. vol 34. issue 8. 1993-11-02. PMID:8411646. |
epoetin alpha (3,000iu/body) was given subcutaneously daily for two weeks and the dosage was increased to 6,000iu, 12,000iu and 24,000iu every two weeks when the increment of hb was insufficient. |
1993-11-02 |
2023-08-12 |
human |
| A Urabe, H Mizoguchi, F Takaku, T Miyazaki, A Yachi, Y Niitsu, Y Miura, Y Mutoh, S Fujioka, T Nomur. [Phase II clinical study of recombinant human erythropoietin on the anemia associated with multiple myeloma]. [Rinsho ketsueki] The Japanese journal of clinical hematology. vol 34. issue 8. 1993-11-02. PMID:8411646. |
these results suggest that high-dose subcutaneous epoetin alpha treatment is effective for anemia associated with multiple myeloma in terms of increasing hb concentration and reducing blood transfusion. |
1993-11-02 |
2023-08-12 |
human |
| A Urabe, H Mizoguchi, F Takaku, T Miyazaki, A Yachi, Y Niitsu, Y Miura, Y Mutoh, S Fujioka, T Nomur. [Phase II clinical study of recombinant human erythropoietin on the anemia of myelodysplastic syndrome]. [Rinsho ketsueki] The Japanese journal of clinical hematology. vol 34. issue 8. 1993-11-02. PMID:8411647. |
the safety and efficacy of recombinant human erythropoietin (epoetin alpha) were investigated in anemic patients with myelodysplastic syndrome (mds) whose hemoglobin (hb) concentration was less than 10g/dl. |
1993-11-02 |
2023-08-12 |
human |
| A Urabe, H Mizoguchi, F Takaku, T Miyazaki, A Yachi, Y Niitsu, Y Miura, Y Mutoh, S Fujioka, T Nomur. [Phase II clinical study of recombinant human erythropoietin on the anemia of myelodysplastic syndrome]. [Rinsho ketsueki] The Japanese journal of clinical hematology. vol 34. issue 8. 1993-11-02. PMID:8411647. |
epoetin alpha was given subcutaneously daily at a dose of 3,000iu/body for two weeks and the dosage was increased to 6,000iu, 12,000iu, and 24,000iu at two week interval when the increment of hb was insufficient. |
1993-11-02 |
2023-08-12 |
human |
| A Urabe, H Mizoguchi, F Takaku, T Miyazaki, A Yachi, Y Niitsu, Y Miura, Y Mutoh, S Fujioka, T Nomur. [Phase II clinical study of recombinant human erythropoietin on the anemia of myelodysplastic syndrome]. [Rinsho ketsueki] The Japanese journal of clinical hematology. vol 34. issue 8. 1993-11-02. PMID:8411647. |
these results suggest that the high dose subcutaneous epoetin alpha treatment is effective for the anemia associated with mds in terms of increasing hb concentration and reducing blood transfusion. |
1993-11-02 |
2023-08-12 |
human |
| P E Keipert, A Gonzales, C L Gomez, V W MacDonald, J R Hess, R M Winslo. Acute changes in systemic blood pressure and urine output of conscious rats following exchange transfusion with diaspirin-crosslinked hemoglobin solution. Transfusion. vol 33. issue 9. 1993-10-28. PMID:8212113. |
this report describes acute changes in systemic blood pressure and urine output observed after a 50-percent isovolemic exchange transfusion (et) with diaspirin-crosslinked hemoglobin (alpha alpha hb). |
1993-10-28 |
2023-08-12 |
rat |
| P E Keipert, A Gonzales, C L Gomez, V W MacDonald, J R Hess, R M Winslo. Acute changes in systemic blood pressure and urine output of conscious rats following exchange transfusion with diaspirin-crosslinked hemoglobin solution. Transfusion. vol 33. issue 9. 1993-10-28. PMID:8212113. |
stroma-free hb was crosslinked between the alpha chains by using a 14c-labeled diaspirin, bis(3,5-dibromosalicyl)fumarate. |
1993-10-28 |
2023-08-12 |
rat |
| P E Keipert, A Gonzales, C L Gomez, V W MacDonald, J R Hess, R M Winslo. Acute changes in systemic blood pressure and urine output of conscious rats following exchange transfusion with diaspirin-crosslinked hemoglobin solution. Transfusion. vol 33. issue 9. 1993-10-28. PMID:8212113. |
forty conscious, chronically cannulated rats underwent et with 14c-labeled alpha alpha hb solution (8.0 g/dl [80 g/l]). |
1993-10-28 |
2023-08-12 |
rat |
| P E Keipert, A Gonzales, C L Gomez, V W MacDonald, J R Hess, R M Winslo. Acute changes in systemic blood pressure and urine output of conscious rats following exchange transfusion with diaspirin-crosslinked hemoglobin solution. Transfusion. vol 33. issue 9. 1993-10-28. PMID:8212113. |
reversed-phase high-performance liquid chromatography and sodium dodecyl sulfate-polyacrylamide gel electrophoresis confirmed the presence of crosslinked alpha alpha hb molecules in the urine. |
1993-10-28 |
2023-08-12 |
rat |
| P E Keipert, A Gonzales, C L Gomez, V W MacDonald, J R Hess, R M Winslo. Acute changes in systemic blood pressure and urine output of conscious rats following exchange transfusion with diaspirin-crosslinked hemoglobin solution. Transfusion. vol 33. issue 9. 1993-10-28. PMID:8212113. |
the plasma half-life for alpha alpha hb was 5 hours (administered dose, 2.4 g hb/kg body weight). |
1993-10-28 |
2023-08-12 |
rat |
| P E Keipert, A Gonzales, C L Gomez, V W MacDonald, J R Hess, R M Winslo. Acute changes in systemic blood pressure and urine output of conscious rats following exchange transfusion with diaspirin-crosslinked hemoglobin solution. Transfusion. vol 33. issue 9. 1993-10-28. PMID:8212113. |
thus, infusion of alpha alpha hb caused a transient systemic hypertension, and intramolecular crosslinking alone was not enough to exclude completely the filtration of alpha alpha hb by the kidneys. |
1993-10-28 |
2023-08-12 |
rat |
| T J Shen, N T Ho, V Simplaceanu, M Zou, B N Green, M F Tam, C H. Production of unmodified human adult hemoglobin in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 17. 1993-10-05. PMID:8367471. |
these results have been confirmed by edman degradation studies of the amino-terminal sequences of the alpha and beta chains of these two recombinant hb (rhb) samples. |
1993-10-05 |
2023-08-12 |
human |
| R P Roy, R L Nagel, A S Achary. Molecular basis of the inhibition of beta s-chain-dependent polymerization by mouse alpha-chain. Semisynthesis of chimeras of human and mouse alpha-chains. The Journal of biological chemistry. vol 268. issue 22. 1993-09-07. PMID:8344926. |
of these, only alpha 78 and alpha 116 are the known hemoglobin (hb) s polymer contact sites. |
1993-09-07 |
2023-08-12 |
mouse |