| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Vallone, P Vecchini, V Cavalli, M Brunor. Site-directed mutagenesis in hemoglobin. Effect of some mutations at protein interfaces. FEBS letters. vol 324. issue 2. 1993-07-09. PMID:8508913. |
the role of selected amino acid residues in the monomer-monomer contacts of hb a has been studied by site-directed mutagenesis of the alpha chain bearing substitutions in the subunit surfaces. |
1993-07-09 |
2023-08-12 |
Not clear |
| T Lian, B Locke, T Kitagawa, M Nagai, R M Hochstrasse. Determination of Fe-CO geometry in the subunits of carbonmonoxy hemoglobin M Boston using femtosecond infrared spectroscopy. Biochemistry. vol 32. issue 22. 1993-07-08. PMID:8504100. |
we have undertaken ultrafast infrared (ir) spectroscopic studies in order to elucidate the geometry of bound co in the alpha and beta subunits of hemoglobin (hb) m boston 13co. |
1993-07-08 |
2023-08-12 |
human |
| T Lian, B Locke, T Kitagawa, M Nagai, R M Hochstrasse. Determination of Fe-CO geometry in the subunits of carbonmonoxy hemoglobin M Boston using femtosecond infrared spectroscopy. Biochemistry. vol 32. issue 22. 1993-07-08. PMID:8504100. |
hb m boston is a mutant human hb in which the distal histidine in the alpha subunits is replaced by a tyrosine. |
1993-07-08 |
2023-08-12 |
human |
| H Wajcman, C Vasseur, Y Blouquit, J Rosa, D Labie, A Najman, O Reman, M Leporrier, F Galactero. Unstable alpha-chain hemoglobin variants with factitious beta-thalassemia biosynthetic ratio: Hb Questembert (alpha 131[H14]Ser-->Pro) and Hb Caen (alpha 132[H15]Val-->Gly). American journal of hematology. vol 42. issue 4. 1993-06-16. PMID:8493987. |
unstable alpha-chain hemoglobin variants with factitious beta-thalassemia biosynthetic ratio: hb questembert (alpha 131[h14]ser-->pro) and hb caen (alpha 132[h15]val-->gly). |
1993-06-16 |
2023-08-12 |
Not clear |
| H Wajcman, C Vasseur, Y Blouquit, J Rosa, D Labie, A Najman, O Reman, M Leporrier, F Galactero. Unstable alpha-chain hemoglobin variants with factitious beta-thalassemia biosynthetic ratio: Hb Questembert (alpha 131[H14]Ser-->Pro) and Hb Caen (alpha 132[H15]Val-->Gly). American journal of hematology. vol 42. issue 4. 1993-06-16. PMID:8493987. |
hb questembert [alpha 131(h14)ser-->pro] was found in several members of a french family suffering from congenital heinz body anemia. |
1993-06-16 |
2023-08-12 |
Not clear |
| H Wajcman, C Vasseur, Y Blouquit, J Rosa, D Labie, A Najman, O Reman, M Leporrier, F Galactero. Unstable alpha-chain hemoglobin variants with factitious beta-thalassemia biosynthetic ratio: Hb Questembert (alpha 131[H14]Ser-->Pro) and Hb Caen (alpha 132[H15]Val-->Gly). American journal of hematology. vol 42. issue 4. 1993-06-16. PMID:8493987. |
hb caen [alpha 132(h15) val-->gly] is another unstable variant with the same globin biosynthesis abnormality. |
1993-06-16 |
2023-08-12 |
Not clear |
| I Cretegny, S J Edelstei. Double strand packing in hemoglobin S fibers. Journal of molecular biology. vol 230. issue 3. 1993-05-21. PMID:8478930. |
considerations on the stability of certain contacts derived from incomplete fibers, as well as studies of hb molecules composed of beta s chains and mutant alpha chains, suggest that the structural model with closer packing of the double strands provides a better correlation with the other experimental results. |
1993-05-21 |
2023-08-12 |
human |
| P Winichagoon, S Fucharoen, P Was. The molecular basis of alpha-thalassemia in Thailand. The Southeast Asian journal of tropical medicine and public health. vol 23 Suppl 2. 1993-05-07. PMID:1298997. |
the most common in this group is hb constant spring which arises from mutation of the termination codon in the alpha 2-gene resulting in an elongation of the alpha-globin chain. |
1993-05-07 |
2023-08-11 |
Not clear |
| F Kutlar, A Kutlar, E Nuguid, J Prchal, T H Huisma. Usefulness of HPLC methodology for the characterization of combinations of the common beta chain variants Hbs S, C, and O-Arab, and the alpha chain variant Hb G-Philadelphia. Hemoglobin. vol 17. issue 1. 1993-04-16. PMID:8454470. |
usefulness of hplc methodology for the characterization of combinations of the common beta chain variants hbs s, c, and o-arab, and the alpha chain variant hb g-philadelphia. |
1993-04-16 |
2023-08-12 |
Not clear |
| F Kutlar, A Kutlar, E Nuguid, J Prchal, T H Huisma. Usefulness of HPLC methodology for the characterization of combinations of the common beta chain variants Hbs S, C, and O-Arab, and the alpha chain variant Hb G-Philadelphia. Hemoglobin. vol 17. issue 1. 1993-04-16. PMID:8454470. |
we have analyzed the blood samples from seven members of two families that contained mixtures of different hemoglobin types due to the simultaneous presence of different beta chain variants and the alpha chain variant hb g-philadelphia. |
1993-04-16 |
2023-08-12 |
Not clear |
| W C Wang, H Carter, H C Choitz, R Hall, T K Hine, D L Jue, W F Moo-Pen. Characterization of Hb Volga [beta 27(B9)Ala-->Asp] and Hb J-Wenchang-Wuming [alpha 11(A9)Lys-->Gln] in the population of the United States. Hemoglobin. vol 17. issue 1. 1993-04-16. PMID:8454471. |
characterization of hb volga [beta 27(b9)ala-->asp] and hb j-wenchang-wuming [alpha 11(a9)lys-->gln] in the population of the united states. |
1993-04-16 |
2023-08-12 |
Not clear |
| P Ferranti, A Parlapiano, A Malorni, P Pucci, G Marino, G Cossu, L Manca, B Masal. Hemoglobin Ozieri: a new alpha-chain variant (alpha 71(E20)Ala-->Val). Characterization using FAB- and electrospray-mass spectrometric techniques. Biochimica et biophysica acta. vol 1162. issue 1-2. 1993-04-13. PMID:8448185. |
a new silent hemoglobin variant, hb ozieri (alpha 71(e20)ala-->val), was observed in five apparently unrelated newborn babies during a screening for hemoglobinopathies on the island of sardinia. |
1993-04-13 |
2023-08-12 |
Not clear |
| E A Mesri, R J Kreitman, Y M Fu, S E Epstein, I Pasta. Heparin-binding transforming growth factor alpha-Pseudomonas exotoxin A. A heparan sulfate-modulated recombinant toxin cytotoxic to cancer cells and proliferating smooth muscle cells. The Journal of biological chemistry. vol 268. issue 7. 1993-04-06. PMID:8444864. |
to study the effect of the heparin-binding domain in a chimeric toxin targeted to the egf receptor, we fused the dna sequence corresponding to the putative nh2-terminal heparin-binding (hb) domain of hb-egf to chimeric toxins composed of tgf alpha and two different recombinant forms of pseudomonas exotoxin (pe). |
1993-04-06 |
2023-08-12 |
Not clear |
| C Poyart, V Baudin, J Pagnie. [Molecular engineering of hemoglobin for transfusion]. Revue francaise de transfusion et d'hemobiologie : bulletin de la Societe nationale de transfusion sanguine. vol 35. issue 6. 1993-03-24. PMID:1288540. |
the coexpression of beta globin chains and alpha globin subunits linked by a peptide bond results in the direct synthesis of stabilized and fully functional hb tetramers. |
1993-03-24 |
2023-08-11 |
human |
| S E Murphy, K A Colett. Two types of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone hemoglobin adducts, from metabolites which migrate into or are formed in red blood cells. Cancer research. vol 53. issue 4. 1993-03-10. PMID:8428358. |
we propose that hb mediates alpha hydroxylation of nnk at the methylene carbon. |
1993-03-10 |
2023-08-12 |
rat |
| A D Adekile, T H Huisma. Hb F in sickle cell anemia. Experientia. vol 49. issue 1. 1993-03-05. PMID:7679078. |
we have reviewed the methodology for an accurate quantitation of hb f in the blood of patients with sickle cell anemia, values observed in hundreds of patients of different (racial or ethnic) backgrounds and with differences in severity of the disease, and the various factors that affect the level of hb f. the latter include sex, age, genetic background or chromosomal haplotypes, variations in the sequences of the locus control region(s) 5' to the epsilon-globin gene, and the presence of an alpha chain deficiency or alpha-thalassemia. |
1993-03-05 |
2023-08-12 |
Not clear |
| D Williamson, J V Langdown, T Myles, C Mason, J S Henthorn, S C Davie. Polycythaemia and microcytosis arising from the combination of a new high oxygen affinity haemoglobin (Hb luton, alpha 89 His-->Leu) and alpha thalassaemia trait. British journal of haematology. vol 82. issue 3. 1993-02-19. PMID:1486044. |
polycythaemia and microcytosis arising from the combination of a new high oxygen affinity haemoglobin (hb luton, alpha 89 his-->leu) and alpha thalassaemia trait. |
1993-02-19 |
2023-08-11 |
Not clear |
| F Y Zeng, S Fucharoen, S Z Huang, G P Rodger. Hb Q-Thailand [alpha 74(EF3)Asp-->His]: gene organization, molecular structure, and DNA diagnosis. Hemoglobin. vol 16. issue 6. 1993-02-19. PMID:1487419. |
hb q-thailand [alpha 74(ef3)asp-->his]: gene organization, molecular structure, and dna diagnosis. |
1993-02-19 |
2023-08-11 |
Not clear |
| F Y Zeng, S Fucharoen, S Z Huang, G P Rodger. Hb Q-Thailand [alpha 74(EF3)Asp-->His]: gene organization, molecular structure, and DNA diagnosis. Hemoglobin. vol 16. issue 6. 1993-02-19. PMID:1487419. |
hb q-thailand [alpha 74(ef3)asp-->his] is often found in thailand, china, and other southeast asian countries. |
1993-02-19 |
2023-08-11 |
Not clear |
| F Y Zeng, S Fucharoen, S Z Huang, G P Rodger. Hb Q-Thailand [alpha 74(EF3)Asp-->His]: gene organization, molecular structure, and DNA diagnosis. Hemoglobin. vol 16. issue 6. 1993-02-19. PMID:1487419. |
the hb q-thailand gene is located on the alpha 1 gene of chromosome #16, while the -4.2 kb or leftward deletion involves the alpha 2 gene). |
1993-02-19 |
2023-08-11 |
Not clear |