| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Göke, B Wagner, H C Fehmann, B Gök. Glucose-dependency of the insulin stimulatory effect of glucagon-like peptide-1 (7-36) amide on the rat pancreas. Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie. vol 193. issue 2. 1993-07-22. PMID:8516568. |
in the perfused pancreas, 25 nmol/l glp-1 induced a strong insulin release at 5 mmol/l glucose, but under basal glucose (2.8 mmol/l) only a slight enhancement of insulin secretion occurred during the late phase (30 to 54 min) of perfusion (p < 0.05). |
1993-07-22 |
2023-08-12 |
rat |
| R Göke, B Wagner, H C Fehmann, B Gök. Glucose-dependency of the insulin stimulatory effect of glucagon-like peptide-1 (7-36) amide on the rat pancreas. Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie. vol 193. issue 2. 1993-07-22. PMID:8516568. |
in conclusion, a slight but not dose-dependent stimulation of insulin secretion by supramaximal glp-1 loads under basal glucose levels was found. |
1993-07-22 |
2023-08-12 |
rat |
| W S Zawalich, K C Zawalich, H Rasmusse. Influence of glucagon-like peptide-1 on beta cell responsiveness. Regulatory peptides. vol 44. issue 3. 1993-06-03. PMID:8484020. |
the postulated incretin factor glucagon-like peptide-1 (glp-1) causes a glucose-dependent increase in insulin secretion from perifused rat islets. |
1993-06-03 |
2023-08-12 |
rat |
| W S Zawalich, K C Zawalich, H Rasmusse. Influence of glucagon-like peptide-1 on beta cell responsiveness. Regulatory peptides. vol 44. issue 3. 1993-06-03. PMID:8484020. |
a significant synergistic effect of glp-1 (10 nm) and 10 microm carbachol, a cholinergic agonist, on insulin secretion was observed in the presence of 6 mm glucose. |
1993-06-03 |
2023-08-12 |
rat |
| C Orskov, A Wettergren, J J Hols. Biological effects and metabolic rates of glucagonlike peptide-1 7-36 amide and glucagonlike peptide-1 7-37 in healthy subjects are indistinguishable. Diabetes. vol 42. issue 5. 1993-05-28. PMID:8482423. |
glp-1 7-36 amide and glp-1 7-37 equipotently stimulated insulin secretion (integrated hormone response 0-60 min, 631 +/- 211 vs. 483 +/- 177 pmol/h x l-1) and c-peptide secretion (integrated hormone response 9064 +/- 1804 vs. 9954 +/- 2031 pmol/h x l-1) and equipotently lowered plasma glucose (integrated decrease 48.3 +/- 5.7 vs. 46.2 +/- 8.4 mmol/h x l-1) and plasma glucagon (integrated decrease 80.4 +/- 24.3 vs. 156.0 +/- 34.6 pmol/h x l-1). |
1993-05-28 |
2023-08-12 |
human |
| M A Nauck, E Bartels, C Orskov, R Ebert, W Creutzfeld. Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations. The Journal of clinical endocrinology and metabolism. vol 76. issue 4. 1993-05-18. PMID:8473405. |
gastric inhibitory polypeptide (gip) and glucagon-like peptide-1-(7-36) amide (glp-1) are glucose-dependent insulinotropic gut hormones that may explain the greater insulin secretory response with oral compared to i.v. |
1993-05-18 |
2023-08-12 |
human |
| M A Nauck, E Bartels, C Orskov, R Ebert, W Creutzfeld. Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations. The Journal of clinical endocrinology and metabolism. vol 76. issue 4. 1993-05-18. PMID:8473405. |
when, in seven volunteers, a lower dose (0.15 pmol/kg.min) of glp-1 was infused during isoglycemic glucose infusion experiments only for the duration of elevated plasma levels in the oral glucose challenges (0-30 min), a significant, but transient, increment in insulin and c-peptide concentrations was observed, which was equivalent to 26 +/- 10% of the estimated incretin effect. |
1993-05-18 |
2023-08-12 |
human |
| B A Clark, A Sclater, F H Epstein, D Elah. Effect of glucose, insulin, and hypertonicity on atrial natriuretic peptide levels in man. Metabolism: clinical and experimental. vol 42. issue 2. 1993-05-14. PMID:8474320. |
to determine the effects of hyperglycemia and hyperinsulinemia on atrial natriuretic peptide (anp) levels in man, we studied normotensive nondiabetic volunteers (aged 25 to 63 years) during infusion of insulin and/or 20% dextrose (glucose clamp technique) to achieve three different states of "glycemia/hyperinsulinemia," as follows: (1) euglycemia for 2 hours during infusion of insulin (80 mu.m-2.min-1), resulting in plasma insulin levels of approximately 1,200 pmol/l (n = 9); (2) moderate stable hyperglycemia at a level of 11 mmol/l (198 mg/dl) for 2 hours, with infusion of glucagon-like peptide-1 (7-37) amide (glp-1) during the second hour, which increased endogenous insulin responses to approximately 2,100 pmol/l (n = 9); and (3) marked stable hyperglycemia at a level of 18.5 mmol/l (330 mg/dl) for 2 hours, with endogenous insulin responses of approximately 720 pmol/l (n = 9). |
1993-05-14 |
2023-08-12 |
human |
| A Wettergren, B Schjoldager, P E Mortensen, J Myhre, J Christiansen, J J Hols. Truncated GLP-1 (proglucagon 78-107-amide) inhibits gastric and pancreatic functions in man. Digestive diseases and sciences. vol 38. issue 4. 1993-05-05. PMID:8462365. |
postprandial insulin and glucagon concentrations were similar with and without truncated glp-1 infusion in spite of significantly lower blood glucose levels (5.2 +/- 0.2 versus 3.7 +/- 0.3), indicating that glp-1 stimulated insulin secretion and inhibited glucagon secretion. |
1993-05-05 |
2023-08-12 |
human |
| G G Holz, W M Kühtreiber, J F Habene. Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37). Nature. vol 361. issue 6410. 1993-03-02. PMID:8381211. |
glucagon-like-peptide-1(7-37) (glp-1) is an intestinally derived hormone that may be useful for the treatment of niddm because it acts in vivo to increase the level of circulating insulin, and thus lower the concentration of blood glucose. |
1993-03-02 |
2023-08-12 |
Not clear |
| G G Holz, W M Kühtreiber, J F Habene. Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37). Nature. vol 361. issue 6410. 1993-03-02. PMID:8381211. |
this therapeutic effect may result from the ability of glp-1 to compensate for a defect in the glucose signalling pathway that regulates insulin secretion from beta-cells. |
1993-03-02 |
2023-08-12 |
Not clear |
| M A Nauck, M M Heimesaat, C Orskov, J J Holst, R Ebert, W Creutzfeld. Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. The Journal of clinical investigation. vol 91. issue 1. 1993-02-24. PMID:8423228. |
both gip and glp-1 [7-36 amide] dose-dependently augmented insulin secretion (insulin, c-peptide) in both groups (p < 0.05). |
1993-02-24 |
2023-08-12 |
human |
| H C Fehmann, R Göke, B Gök. Glucagon-like peptide-1(7-37)/(7-36)amide is a new incretin. Molecular and cellular endocrinology. vol 85. issue 1-2. 1992-10-19. PMID:1382025. |
at the pancreatic beta cell glp-1 is a potent insulin secretagogue in the presence of elevated glucose levels, defining glucagon-like peptide-1 as a new incretin. |
1992-10-19 |
2023-08-11 |
Not clear |
| G Waeber, P Nico. [Various molecular mechanisms involved in the pathogenesis of type II diabetes and their potential therapeutic importance]. Schweizerische medizinische Wochenschrift. vol 122. issue 30. 1992-09-08. PMID:1496338. |
the first phase of glucose-induced insulin secretion by the beta pancreatic cell can be partly restored by the administration of a peptide discovered by a molecular approach, the glucagon-like peptide 1 (glp-1). |
1992-09-08 |
2023-08-11 |
human |
| E G Siegel, A Schulze, W E Schmidt, W Creutzfeld. Comparison of the effect of GIP and GLP-1 (7-36amide) on insulin release from rat pancreatic islets. European journal of clinical investigation. vol 22. issue 3. 1992-06-16. PMID:1582439. |
comparison of the effect of gip and glp-1 (7-36amide) on insulin release from rat pancreatic islets. |
1992-06-16 |
2023-08-11 |
rat |
| E G Siegel, A Schulze, W E Schmidt, W Creutzfeld. Comparison of the effect of GIP and GLP-1 (7-36amide) on insulin release from rat pancreatic islets. European journal of clinical investigation. vol 22. issue 3. 1992-06-16. PMID:1582439. |
after ingestion of glucose both gip (gastric inhibitory polypeptide, glucose-dependent insulinotropic polypeptide) and glp-1(7-36amide) (glucagon-like polypeptide-1, 7-36amide) may play a physiological role in augmenting insulin release. |
1992-06-16 |
2023-08-11 |
rat |
| E G Siegel, A Schulze, W E Schmidt, W Creutzfeld. Comparison of the effect of GIP and GLP-1 (7-36amide) on insulin release from rat pancreatic islets. European journal of clinical investigation. vol 22. issue 3. 1992-06-16. PMID:1582439. |
at 16.7 mmol l-1 glucose both gip and glp-1(7-36amide) 2 x 10(-10) mol l-1 significantly increased insulin release; 10(-10) mol l-1 of either hormone had no significant effect. |
1992-06-16 |
2023-08-11 |
rat |
| E G Siegel, A Schulze, W E Schmidt, W Creutzfeld. Comparison of the effect of GIP and GLP-1 (7-36amide) on insulin release from rat pancreatic islets. European journal of clinical investigation. vol 22. issue 3. 1992-06-16. PMID:1582439. |
these data show comparable effects of high concentrations of gip and glp-1(7-36amide) on glucose-induced insulin release; at presumably physiological concentrations, however, glp-1(7-36amide) was clearly more effective. |
1992-06-16 |
2023-08-11 |
rat |
| A Ohneda, K Ohneda, M Ohneda, F Koizumi, S Ohashi, K Kawai, S Suzuk. The structure-function relationship of GLP-1 related peptides in the endocrine function of the canine pancreas. The Tohoku journal of experimental medicine. vol 165. issue 3. 1992-05-13. PMID:1807008. |
glp-1 (7-36) and (7-37), as well as glucagon enhanced insulin release during glucose infusion, whereas neither glp-1 (1-37), (7-20), (6-37) nor (8-37) stimulated insulin release. |
1992-05-13 |
2023-08-11 |
Not clear |
| A Ohneda, K Ohneda, M Ohneda, F Koizumi, S Ohashi, K Kawai, S Suzuk. The structure-function relationship of GLP-1 related peptides in the endocrine function of the canine pancreas. The Tohoku journal of experimental medicine. vol 165. issue 3. 1992-05-13. PMID:1807008. |
when arginine was infused, glp-1 (7-20), (7-36), (7-37), and glucagon enhanced insulin release. |
1992-05-13 |
2023-08-11 |
Not clear |